Structural changes of proteins are important for the control of cellular processes and failure to function correctly can lead to disease. We are studying the nature of protein-ligand interactions that have well-characterised biological functions with atomic resolution. The role of protein dynamics in molecular recognition processes is a particular focus of my work.
Nuclear Magnetic Resonance (NMR)
Molecular and Cellular Biosciences
Affiliate research group(s)
Institute for Complex Systems Simulation (ICSS)
Using a combination of liquid and solid-state NMR spectroscopy we aim to understand how serum amyloid-P component recognises amyloid fibrils and the role this plays in their stabilization.
Identifying the functions of rhamnogalacturonan II during root development using an inducible RNAi-based gene knockdown approach in Arabidopsis thaliana.
Using the model organism Pseudomonas aeruginosa to investigate mechanisms by which drinking water biofilms harbour important pathogenic microorganism and how these interactions within multi-species biofilms can enhance genetic adaptation and evolution of microbial pathogens.
Dr Joern Werner
Faculty of Natural & Environmental Sciences
Life Sciences Building 85
University of Southampton
Telephone:(023) 8059 2484