BSc, MSc, PhD
- Primary position:
- Director of Enterprise
- Other positions:
- Chair in Neuroscience, Principal Investigator (Neuropharmacology & physiology)
BSc Physiology University College, Cardiff;
MSc Biochemical Pharmacology, University of Southampton;
PhD Neuropharmacology, University of Southampton;
Post-doctoral Research Fellow, Department of Neurophysiology;
Reader, School of Biological Sciences, University of Southampton;
Professor of Neuroscience, University of Southampton.
The University of Southampton's electronic library (e-prints)
Conference or Workshop Item
Holden-Dye L and Walker RJ. Anthelmintic Drugs. (2007) WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook. http://www.wormbook.org.
Franks CJ, Holden-Dye L, Bull K, Luedtke S, Walker RJ. (2006) Anatomy, physiology and pharmacology of Caenorhabditis elegans pharynx: a model to define gene function in a simple neural system. Invert Neurosci. 6:105-22
I am interested in the fundamental processes of neuronal communication and have established research expertise in simple invertebrate preparations. Much of my work now resonates with issues concerning mental health such as addiction and neurodegeneration. My expertise in invertebrate neuroscience, and in particular nematode neural systems and C. elegans, positions me well to participate in drug discovery and mode of action programmes for novel antiparasitics. For the last decade I have collaborated with industry to improve prospects for parasitic nematode control. The experimental approaches deployed in my research encompass genetics through to whole animal physiology and incorporate novel methods for tracking animal behaviour and signal processing.
Affiliate research group: Southampton Neurosciences Group (SoNG)
Bioinformatic identification and physiological analysis of ethanol-related genes in C. elegans
Using the model organism, Caenorhabditis elegans, to investigate the broad molecular, cellular and systems level impacts of acute and chronic ethanol treatment.
Characterisation of cue-dependent behaviour in plant parasitic nematodes: the neurobiology of host plant invasion
The neurobiology of plant parasitic nematodes.
Exploiting C. elegans to provide insight into neural substrates of human alcohol dependence
A molecular genetic and behavioural analysis of the neuroadaptive responses to ethanol exposure.
Anthelmintic mode of action studies
Deploying molecular genetic, pharmacological and behavioural studies to define the mode of action of novel antiparasitic compounds.
Hybrid Biodevices for Analysis of Nematodes
Development of microfluidic chips for trapping and recording behaviour and electrophysiological signals from nematodes
Primary research group: Biomedical Sciences
Given the significant sequence similarity between members of the GTG/GPHR family, we are testing whether the GTG/GPHR family has a conserved physiological function in diverse organisms.
|Module name||Semester||# Lectures||Lecture topic(s)|
|BIOL1011||Physiology 1||1||7||The nervous system and muscle|
|BIOL1013||Physiology 2||2||1||Synaptic signalling|
|BIOL2016||Pharmacology A||1||5||Quantitative analysis of drug receptor interactions|
|BIOL2016||Pharmacology A||1||6||Autonomic nervous system|
|Neuroscience||1||1||Introduction to neuroscience|
|BIOL2014||Neuroscience||1||2||Physiology of pain|
|BIOL2017||Pharmacology B||2||3||Pharmacology of pain|
|BIOL2017||Pharmacology B||2||2||Endocrine pharmacology|
|BIOL3021||Cellular and Molecular Neuroscience||1||4||Receptor signalling|
|BIOL3018||Molecular Pharmacology||2||4||Dopamine receptors|
|BIOL3020||Systems Neuroscience||2||4||Foraging behaviour|
|Neuropharmacology of CNS Disorders||2||13||Introduction, addiction, schizophrenia|
|Human Brain and Society||2||tba||tba|
other teaching-related responsibilities:
- Contributions to postgraduate teaching programme
- Short laboratory (BIOL3050) project leader in semester one (Neurobiology of C. elegans)
- Laboratory (BIOL3034) and Library project supervisor (BIOL3031 and BIOL3032)
- Practical involvement for Pharmacology and Neuroscience BIOL2016 and BIOL2014
- Neuroscience tutorials for second year
- Contribution to two modules at Winchester School of Art, one in fashion design and the other in graphic arts by providing briefs for neuroscience inspired projects (2 launches in this academic year).
- Contribution to Faculty of Medicine, Scientific Basis of Medicine module (Alcohol)
Professor Lindy Holden-Dye
Faculty of Natural & Environmental Sciences
University of Southampton
Room Number: 85/3051