The University of Southampton
Biological Sciences

Professor Lindy Holden-Dye BSc, MSc, PhD

Chair in Neuroscience, Principal Investigator (Neuropharmacology & physiology)

Professor Lindy Holden-Dye's photo
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Professor Lindy Holden-Dye holds a personal Chair in Neuroscience within the Centre for Biological Sciences at the University of Southampton. Her interests focus on fundamental processes of neuronal communication and she has established research expertise in invertebrate preparations. Much of her work resonates with issues concerning mental health such as addiction and neurodegeneration. Her expertise in invertebrate neuroscience, and in particular nematode neural systems and the model genetic organism Caenorhabditis elegans positions her well to participate in drug discovery and mode of action programmes for novel antiparasitics. For the last two decades she has has collaborated with industry to improve prospects for parasitic nematode control The experimental approaches deployed in her research group encompass genetics through to whole animal physiology and incorporate novel methods for tracking animal behaviour and signal processing.

I love to share my passion for experimental research, neuroscience and discovery with our undergraduate students

Career history

Professor of Neuroscience. University of Southampton, UK.
Past chair - SoNG Advisory Board
Reader. School of Biological Sciences, University of Southampton, UK.
Post-doctoral Research Fellow. Department of Neurophysiology, University of Southampton, UK.

Academic qualifications

PhD Neuropharmacology. University of Southampton, UK.
MSc Biochemical Pharmacology. University of Southampton, UK.
BSc Physiology. University College, Cardiff, UK.

Research

Publications

Teaching

Contact

Research interests

I am interested in the fundamental processes of neuronal communication and have established research expertise in simple invertebrate preparations. Much of my work now resonates with issues concerning mental health such as addiction and neurodegeneration. My expertise in invertebrate neuroscience, and in particular nematode neural systems and C. elegans, positions me well to participate in drug discovery and mode of action programmes for novel antiparasitics. For the last decade I have collaborated with industry to improve prospects for parasitic nematode control. The experimental approaches deployed in my research encompass genetics through to whole animal physiology and incorporate novel methods for tracking animal behaviour and signal processing.

PhD Supervision

Caroline Rivers. Chemical biology of the interaction between plants and pathogenic nematodes. Bayer CropScience.
Samah Zaroug
Euan Scott. Probing Bacterial Pathogenicity using C. elegans as the Biosensor. BBSRC, Public Health England

Research group(s)

Biomedical Sciences

Affiliate research group(s)

Institute for Life Sciences (IfLS), Southampton Neuroscience Group (SoNG)

Research project(s)

Are GTGs a new class of plant anion channels regulating pH in the endomembrane system?

Given the significant sequence similarity between members of the GTG/GPHR family, we are testing whether the GTG/GPHR family has a conserved physiological function in diverse organisms.

Generation of a screening platform for the Cys-loop superfamily of ligand gated ion channels

Structural/functional studies of the ligand binding domains of nicotinic acetylcholine receptors.

Characterisation of cue-dependent behaviour in plant parasitic nematodes: the neurobiology of host plant invasion

The neurobiology of plant parasitic nematodes.

Exploiting C. elegans to provide insight into neural substrates of human alcohol dependence

Changes in the pattern of behavior with increasing alcohol intake in humans reflect its complex effects on the brain.

Article(s)

Book Section(s)

Conference(s)

Module coordinator

BIOL1011 Foundations of Physiology I 
BIOL1013 Cell Communications Foundations of Physiology
BIOL2016 Pharmacology A
BIOL2014 Neuroscience 
BIOL2017 Pharmacology B
BIOL3021 Cellular and Molecular Neuroscience 
BIOL3027 Selective toxicity 
BIOL3018 Molecular Pharmacology 
BIOL3020 Systems Neuroscience 
BIOL3025 Neuropharmacology of CNS Disorders

Contributions to postgraduate teaching programme

BIOL3050 Short Research Project
BIOL3034 In-depth Research Project
BIOL3031 Literature-based Research Project
BIOL3032 Literature-based Research Project
BIOL2016 Pharmacology A
BIOL2014 Neuroscience

Other teaching related responsibilities

Neuroscience tutorials for second year
Contribution to two modules at Winchester School of Art, one in fashion design and the other in graphic arts by providing briefs for neuroscience inspired projects (2 launches in this academic year).
Contribution to Faculty of Medicine, Scientific Basis of Medicine module (Alcohol)

Professor Lindy Holden-Dye
Centre for Biological Sciences Faculty of Natural & Environmental Sciences Life Sciences Building 85 University of Southampton Highfield Campus Southampton SO17 1BJ

Room Number: 85/3051

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