Centre for Biological Sciences

V Hugh Perry

BSc, MA, DPhil.

Primary position:
Professor of Experimental Neuropathology

Background

The University of Southampton

Career history

Chair Neuroscience and Mental Health Board. MRC, UK.
2011-present: Visiting Professor in the College of Medicine & Veterinary Medicine. University of Edinburgh, UK.
1998-present: Professor of Experimental Neuropathology. University of Southampton, UK.
1996-1998: Professor of Experimental Neuropathology. University of Oxford, UK.
Locke Royal Society Research Fellow,UK.
Wellcome Trust Senior Research Fellow, UK.
1977-1996: Research Fellow, University of Oxford, UK.

Professor V Hugh Perry's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Gómez-Nicola, Diego, Suzzi, Stefano, Vargas-Caballero, Mariana, Fransen, Nina L., Al-Malki, Hussain, Cebrian-silla, A., García-verdugo , Jm, Riecken, K., Fehse, B. and Perry, V. Hugh (2014) Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration. Brain (doi:10.1093/brain/awu155). (PMID: 24941947).
Gomez-Nicola, Diego, Schetters, Sjoerd and Perry, V.H. (2014) Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease. Glia (doi:10.1002/glia.22660). (PMID:24648328).
Perry, V. Hugh and Holmes, Clive (2014) Microglial priming in neurodegenerative disease. Nature Reviews Neurology (doi:10.1038/nrneurol.2014.38).
Asuni, Ayodeji A, Gray, Bryony, Bailey, Joanne, Skipp, Paul, Perry, V Hugh and O'Connor, Vincent (2014) Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration. Journal of Biological Chemistry, 289, (7), 4532-4545. (doi:10.1074/jbc.M113.502690). (PMID:24366862).
Wright, G., Sharifi, Y., Newman, Tracey A., Davies, N.A., Vairappan, B., Perry, V.H. and Jalan, R. (2014) Characterization of temporal microglia and astrocyte immune responses in bile-duct ligated rat models of cirrhosis. Liver International, 1-22. (doi:10.1111/liv.12481). (Submitted).
Murinello, S., Mullins, R.F., Lotery, A.J., Perry, V.H. and Teeling, Jessica L. (2014) Fcy receptor upregulation is associated with immune complex inflammation in the mouse retina and early age-related macular degeneration. Investigative Ophthalmology & Visual Science, 55, (1), 247-258. (doi:10.1167/iovs.13-11821). (PMID:24334446).
Perry, V. Hugh and Teeling, Jessica (2013) Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration. [in special issue: Macrophage Heterogeneity, Subsets and Human Disease] Seminars in Immunopathology, 35, (5), 601-612. (doi:10.1007/s00281-013-0382-8). (PMID:23732506).
Carare, Roxana, Teeling, Jessica, Hawkes, Cheryl A, Püntener, Ursula, Weller, Roy O, Nicoll, James AR and Perry, Victor (2013) Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer’s disease. Acta Neuropathologica, 1, (1), 48-[11pp]. (doi:10.1186/2051-5960-1-48). (PMID:24252464).
Kwan, Joseph, Pickering, Ruth M., Kunkel, Dorit, Fitton, Carolyn, Jenkinson, Damian, Perry, V. Hugh and Ashburn, Ann on behalf of the Stroke Association Rehabilitation Research Centre (2013) Impact of stroke-associated infection on long-term survival: a cohort study. Journal of Neurology Neurosurgery & Psychiatry, 84, (3), 297-304. (doi:10.1136/jnnp-2012-302552 ). (PMID:23160703).
Gómez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V Hugh (2013) Regulation of microglial proliferation during chronic neurodegeneration. The Journal of Neuroscience, 33, (6), 2481-2493. (doi:10.1523/JNEUROSCI.4440-12.2013 ). (PMID:23392676).
Boche, D., Perry, V.H. and Nicoll, J.A.R. (2013) Review. Activation patterns of microglia and their identification in the human brain. Neuropathology and Applied Neurobiology, 39, (1), 3-18. (doi:10.1111/nan.12011). (PMID:23252647).
Garland, Patrick, Broom, Lucy J., Quraishe, Shmma, Dalton, P.D., Skipp, Paul, Newman, T.A. and Perry, V.H. (2012) Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton. PLoS ONE, 7, (10), e47552-[8pp]. (doi:10.1371/journal.pone.0047552). (PMID:23115653).
Caleo, Matteo, Restani, Laura, Vannini, Eleonora, Siskova, Zuzana, Al-Malki, Hussain, Morgan, Ruth, O'Connor, Vincent and Perry, V Hugh (2012) The role of activity in synaptic degeneration in a protein misfolding disease, prion disease. PLoS ONE, 7, (7), e41182. (doi:10.1371/journal.pone.0041182). (PMID:22815961).
Hart, Adam D., Wyttenbach, Andreas and Perry, V. Hugh et al. (2012) Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences. [in special issue: Aging, Brain, Behavior and Immunity] Brain, Behavior and Immunity, 26, (5), 754-765. (doi:10.1016/j.bbi.2011.11.006). (PMID:22155499).
Teeling, Jessica L., Carare, Roxana O., Glennie, Martin J. and Perry, V. Hugh (2012) Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction. Acta Neuropathologica, 124, (4), 479-490. (doi:10.1007/s00401-012-0995-3).
Galea, James, Cruickshank, Garth, Teeling, Jessica L., Boche, Delphine, Garland, Patrick, Perry, V. Hugh and Galea, Ian (2012) The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage. Journal of Neurochemistry, 121, (5), 785-792. (doi:10.1111/j.1471-4159.2012.07716.x). (PMID:22380637).
Puentener, U., Booth, S., Perry, V. Hugh and Teeling, Jessica L. (2012) Long term impact of systemic bacterial infection on the cerebral vasculature and microglia. Journal of Neuroinflammation
Moreno, Beatriz, Jukes, John-Paul, Vergara-Irigaray, Nuria, Errea, O., Villoslada, Pablo, Perry, V.H. and Newman, T.A. (2011) Systemic inflammation induces axon injury during brain inflammation. Annals of Neurology, 70, (6), 932-942. (doi:10.1002/ana.22550). (PMID:22190366).
Arundell, Martin, Perry, V. Hugh and Newman, Tracey A. (2011) Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid prototyping moulding process. Lab on a Chip, 11, (17), 3001-3005. (doi:10.1039/C1LC20120D). (PMID:21776485).
Holmes, C., Cunningham, C., Zotova, E., Culliford, D. and Perry, V.H. (2011) Proinflammatory cytokines, sickness behavior, and Alzheimer disease. Neurology, 77, (3), 212-218. (doi:10.1212/WNL.0b013e318225ae07). (PMID:21753171).
Lunnon, Katie, Teeling, Jessica L., Tutt, Alison L., Cragg, Mark S., Glennie, Martin J. and Perry, V. Hugh (2011) Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration. Journal of Immunology, 186, (12), 7215-7224. (doi:10.4049/jimmunol.0903833).
de Sousa, Aline Andrade, Reis, Renata, Bento-Torres, João, Trévia, Nonata, Lins, Nara Alves de Almeida, Passos, Aline, Santos, Zaire, Diniz, José Antonio Picanço, Vasconcelos, Pedro Fernando da Costa, Cunningham, Colm, Perry, Victor Hugh and Picanço Diniz, Cristovam Wanderley (2011) Influence of enriched environment on viral encephalitis outcomes: behavioral and neuropathological changes in albino Swiss mice. PLoS ONE, 6, (1), e15597. (doi:10.1371/journal.pone.0015597).
Williams, Charlotte L, Teeling, Jessica L, Perry, V. Hugh and Fleming, Tom P. (2011) Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring. BMC Biology, 9, 49-61. (doi:10.1186/1741-7007-9-49). (PMID:21771319).
Hughes, Martina M., Field, Robert H., Perry, V.H., Murray, Carol L. and Cunningham, Colm (2010) Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation. Glia, 58, (16), 2017-2030. (doi:10.1002/glia.21070). (PMID:20878768).
Perry, V. Hugh and O'Connor, Vincent (2010) The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective. ASN Neuro, 2, (5), e00047-[11pp]. (doi:10.1042/AN20100024). (PMID:20967131).
Sisková, Zuzana, Mahad, Don Joseph, Pudney, Carianne, Campbell, Graham, Cadogan, Mark, Asuni, Ayodeji, O'Connor, Vincent and Perry, Victor Hugh CNS Inflammation Group, University of Southampton and The Mitochondrial Research Group, Newcastle University (2010) Morphological and functional abnormalities in mitochondria associated with synaptic degeneration in prion disease. American Journal of Pathology, 177, (3), 1411-1421. (doi:10.2353/ajpath.2010.091037). (PMID:20651247).
Perry, V Hugh (2010) Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathologica, 120, (3), 277-286. (doi:10.1007/s00401-010-0722-x). (PMID:20644946).
Diniz, Daniel G., Foro, César A. R., Rego, Carla M. D., Gloria, David A., De Oliveira, Fabio R. R., Paes, Juliana M. P., De Sousa, Aline A., Tokuhashi, Tatyana P., Trindade, Lucas S., Turiel, Maíra C. P., Vasconcelos, Erick G. R., Torres, João B., Cunnigham, Colm, Perry, Victor Hugh, Da Costa Vasconcelos, Pedro F. and Diniz, Cristovam W. P. (2010) Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes. European Journal of Neuroscience, 32, (3), 509-519. (doi:10.1111/j.1460-9568.2010.07296.x). (PMID:20704596 ).
Perry, V. Hugh, Nicoll, James A.R. and Holmes, Clive (2010) Microglia in neurodegenerative disease. Nature Reviews Neurology, 6, (4), 193-201. (doi:10.1038/nrneurol.2010.17).
Sisková, Zuzana, Sanyal, Nik K, Orban, Adam, O'Connor, Vincent and Perry, V Hugh (2010) Reactive hypertrophy of synaptic varicosities within the hippocampus of prion-infected mice. Biochemical Society Transactions, 38, (2), 471-475. (doi:10.1042/BST0380471). (PMID:20298205).
Asuni, Ayodeji A., Perry, V. Hugh and O'Connor, Vincent (2010) Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease. Biochemical Society Transactions, 38, (2), 545-551. (doi:10.1042/BST0380545). (PMID:20298219).
Teeling, J.L., Cunningham, C., Newman, Tracey A. and Perry, V.H. (2010) The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: implications for a role of COX-1. Brain, Behavior and Immunity, 24, (3), 409-419. (doi:10.1016/j.bbi.2009.11.006). (PMID:19931610).
Asuni, A.A., Hilton, K., Siskova, Z., Lunnon, K., Reynolds, R., Perry, V.H. and O'Connor, V. (2010) Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease. Neuroscience, 165, (3), 662-674. (doi:10.1016/j.neuroscience.2009.10.047).
Sanderson, David J., Cunningham, Colm, Deacon, Robert M.J., Bannerman, David M, Perry, V. Hugh and Rawlins, J. Nicholas P. (2009) A double dissociation between the effects of sub-pyrogenic systemic inflammation and hippocampal lesions on learning. Behavioural Brain Research, 201, (1), 103-111. (doi:10.1016/j.bbr.2009.01.038).
Gray, B.C., Siskova, Z., Perry, V.H. and O'Connor, V. (2009) Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology. Neurobiology of Disease, 35, (1), 63-74. (doi:10.1016/j.nbd.2009.04.001).
Cunningham, Colm, Campion, Suzanne, Lunnon, Katie, Murray, Carol L, Woods, Jack F. C., Deacon, Robert M.J., Rawlins, Nicholas P and Perry, V.Hugh (2009) Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biological Psychiatry, 65, (4), 304-312. (doi:10.1016/j.biopsych.2008.07.024).
Holmes, C., Cunningham, C., Zotova, Elina, Woolford, J., Dean, C. , Kerr, S. , Culliford, D. J. and Perry, V. (2009) Systematic inflammation and disease progression in Alzheimer disease. Neurology , 73, (10), 768-774. (doi:10.1212/WNL.0b013e3181b6bb95). (PMID:19738171).
Siskova, Zuzana, Page, Anton, O'Connor, Vincent and Perry, Victor Hugh (2009) Degenerating synaptic boutons in prion disease. Microglia activation without synaptic stripping. The American Journal of Pathology, 175, (4), 1610-1621. (doi:10.2353/ajpath.2009.090372).
Galea, Ian, Felton, Leigh M., Waters, Sara, van Rooijen, Nico, Perry, V. Hugh and Newman, Tracey A. (2008) Immune-to-brain signalling: the role of cerebral CD163-positive macrophages. Neuroscience Letters, 448, (1), 41-46. (doi:10.1016/j.neulet.2008.09.081). (PMID:18852025).
Ransohoff, Richard M. and Perry, V.Hugh (2008) Microglial physiology: unique stimuli, specialized responses. Annual Review of Immunology, 27, 119-145. (doi:10.1146/annurev.immunol.021908.132528).
Perry, V. Hugh and O'connor, Vincent (2008) C1q: the perfect complement for a synaptic feast? Nature Reviews Neuroscience, 9, (11), 807-811. (doi:10.1038/nrn2394).
Asuni, Ayodeji A., Cunningham, Colm, Vigneswaran, Piranavhan, Perry, V. Hugh and O'Connor, Vincent (2008) Unaltered SNARE complex formation in an in vivo model of prion disease. Brain Research, 1233, 1-7. (doi:10.1016/j.brainres.2008.07.083).
Wang, Jing, Wu, Su, Jin, Xin, Li, Mingtao, Chen, Shiyong, Teeling, Jessica L., Perry, V. Hugh and Gu, Jun (2008) Retinoic acid-inducible gene-I mediates late phase induction of TNF-α by lipopolysaccharide. Journal of Immunology, 180, (12), 8011-8019. (PMID:18523264).
Palin, Karine, Cunningham, Colm, Forse, Penny, Perry, V. Hugh and Platt, Nick (2008) Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration. Neurobiology of Disease, 30, (1), 19-29. (doi:10.1016/j.nbd.2007.11.012). (PMID:18255301).
Carare, R.O., Bernardes-Silva, M., Newman, T.A., Page, A.M., Nicoll, J.A.R., Perry, V.H. and Weller, R.O. (2008) Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathology & Applied Neurobiology, 34, (2), 131-144. (doi:10.1111/j.1365-2990.2007.00926.x).
Bucks, Romola. S., Gidron, Yori, Harris, Petra, Teeling, Jessica, Wesnes, Keith. A. and Perry, V. Hugh (2008) Selective effects of upper respiratory tract infection on cognition, mood and emotion processing: A prospective study. Brain, Behavior, and Immunity, 22, (3), 399-407. (doi:10.1016/j.bbi.2007.09.005).
Watkins, Adam J., Ursell, Elizabeth, Panton, Rose, Papenbrock, Thomas, Hollis, Lisa, Cunningham, Colm, Wilkins, Adrian, Perry, V.Hugh, Sheth, Bhavwanti, Kwong, Wing Yee, Eckert, Judith Joana, Wild, Arthur E., Hanson, Mark A., Osmond, Clive and Fleming, Tom P. (2008) Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease. Biology of Reproduction, 78, (2), 299-306. (doi:10.1095/biolreprod.107.064220). (PMID:17989357).
Kwan, Joseph, Jenkinson, Damian, Vassallo, Mike, Englyst, Nicola and Perry, V. Hugh (2008) Systemic infections after acute stroke. Aging Health, 4, (1), 85-94. (doi:10.2217/1745509X.4.1.85).
Carare, R.O., Teeling, J., Perry, V.H., Nicoll, J.A.R. and Weller, R.O. (2008) Immune complexes formed in the brain disrupt the perivascular drainage of solutes and interstitial fluid: significance for immunotherapy in Alzheimer's disease. Neuropathology and Applied Neurobiology, 34, (Supplement 1), p.2. (doi:10.1111/j.1365-2990.2007.00921.x).
Dantzer, Robert., Capuron, Lucile, Irwin, Michael.R., Millers, Andrew.H., Ollat, Helene, Perry, Victor Hugh, Rousey, Sarah and Yirmiyag, Raz (2008) Identification and treatment of symptoms associated with inflammation in medically ill patients. Psychoneuroendocrinology, 33, (1), 18-29. (doi:10.1016/j.psyneuen.2007.10.008).
Teeling, J.L., Carare, R.O., Nicoll, J.A.R., Weller, R.O. and Perry, V.H. (2008) Biological consequences of immune complexes formation in the brain; implications for immunotherapy to treat Alzheimer's disease. Neuropathology and Applied Neurobiology, 34, (s1), 1-1.
Galea, Ian, Bernardes-Silva, Martine, Forse, Penny A., van Rooijen, Nico, Liblau, Roland S. and Perry, V. Hugh (2007) An antigen-specific pathway for CD8 T cells across the blood-brain barrier. Journal of Experimental Medicine, 204, (9), 2023-2030. (doi:10.1084/jem.20070064).
Teeling, J.L., Felton, L.M., Deacon, R.M.J., Cunningham, C., Rawlins, J.N.P. and Perry, V.H. (2007) Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines. Brain, Behavior, and Immunity, 21, (6), 836-850. (doi:10.1016/j.bbi.2007.01.012).
Broom, Kerry A., Anthony, Daniel C., Lowe, John P., Griffin, Julian L., Scott, Helen, Blamire, Andrew M., Styles, Peter, Perry, V. Hugh and Sibson, Nicola R. (2007) MRI and MRS alterations in the preclinical phase of murine prion disease: Association with neuropathological and behavioural changes. Neurobiology of Disease, 26, (3), 707-717. (doi:10.1016/j.nbd.2007.04.001).
Cunningham, Colm, Campion, Suzanne, Teeling, Jessica, Felton, Leigh and Perry, V.H. (2007) The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C). Brain, Behavior, and Immunity, 21, (4), 490-502. (doi:10.1016/j.bbi.2006.12.007).
Perry, V.H., Cunningham, C. and Holmes, C. (2007) Systemic infections and inflammation affect chronic neurodegeneration. Nature Reviews Immunology, 7, (2), 161-167. (doi:10.1038/nri2015).
Bechmann, Ingo, Galea, Ian and Perry, V. Hugh (2007) What is the blood-brain barrier (not)? Trends in immunology, 28, (1), 5-11. (doi:10.1016/j.it.2006.11.007).
Galea, Ian, Bechmann, Ingo and Perry, V.Hugh (2007) What is immune privilege (not)? Trends in Immunology, 28, (1), 12-18. (doi:10.1016/j.it.2006.11.004).
Felton, L.M., Waters, S. and Perry, V.H. (2006) Endothelin-1-induced focal cerebral ischaemia: Neuronal death in the absence of an inflammatory response. Journal of Neuroimmunology, 178, supplement 1, 248-248. (doi:10.1016/j.jneuroim.2006.07.002 ).
Rankine, E.L., Hughes, P.M., Botham, M.S., Perry, V.H. and Felton, L.M. (2006) Brain cytokine synthesis induced by an intraparenchymal injection of LPS is reduced in MCP-1-deficient mice prior to leucocyte recruitment. European Journal of Neuroscience, 24, (1), 77-86. (doi:10.1111/j.1460-9568.2006.04891.x).
Boche, D., Cunningham, C., Docagne, F., Scott, H. and Perry, VH. (2006) TGF-beta1 regulates the inflammatory response during chronic neurodegeneration. Neurobiology Disease, 22, (3), 638-650. (doi:10.1016/j.nbd.2006.01.004).
Carare-Nnadi, R., Bernardes-Silva, M., Subash, M., Perry, V.H. and Weller, R.O. (2006) Connections between perivascular interstitial fluid drainage pathways in the brain: Significance for Alzheimer's disease and neuroimmunology. Neuropathology and Applied Neurobiology, 32, p.223. (doi:10.1111/j.1365-2990.2006.00749.x).
Carare-Nnadi, R., Bernardes-Silva, M., Subash, M., Perry, V.H. and Weller, R.O. (2006) Connections between perivascular interstitial fluid drainage pathways in the brain: significance for Alzheimer's disease and neuroimmunology. Neuropathology and Applied Neurobiology, 32, (2), p.223. (doi:10.1111/j.1365-2990.2006.00749.x).
Perry, V.H., Cunningham, C. and Holmes, C. (2006) Interaction between systemic inflammation and brain inflammation in chronic neurodegeneration. Journal of Neurochemistry, 96, (s1), 141-142. (doi:10.1111/j.1471-4159.2006.wednesdaysession4.x).
Schley, D., Carare-Nnadi, R., Please, C.P., Perry, V.H. and Weller, R.O. (2006) Mechanisms to explain the reverse perivascular transport of solutes out of the brain. Journal of Theoretical Biology, 238, (4), 962-974. (doi:10.1016/j.jtbi.2005.07.005).
Gray, B.C., Skipp, P., Connor, V.M. and Perry, V.H. (2006) Increased expression of glial fibrillary acidic protein fragments and mu-calpain activation within the hippocampus of prion-infected mice. Biochemical Society Transactions, 34, (1), 51-54.
Felton, LM., Cunningham, C., Rankine, EL., Waters, S., Boche, D. and Perry, VH. (2005) MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease. Neurobiology of Disease, 20, (2), 283-295. (doi:10.1016/j.nbd.2005.03.008).
Cunningham, Colm, Wilcockson, David C., Campion, Suzanne, Lunnon, Katie and Perry, V. Hugh (2005) Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. The Journal of Neuroscience, 25, (40), 9275-9284. (doi:10.1523/JNEUROSCI.2614-05.2005).
Newman, Tracey A., Galea, Ian, van Rooijen, Nico and Perry, V. Hugh (2005) Blood-derived dendritic cells in an acute brain injury. Journal of Neuroimmunology, 166, (1-2), 167-172. (doi:10.1016/j.jneuroim.2005.04.026).
Stuckey, D.J., Anthony, D.C., Lowe, J.P., Miller, J., Palm, W.M., Styles, P., Perry, V.H., Blamire, A.M. and Sibson, N.R. (2005) Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy. Journal of Leukocyte Biology, 78, (2), 393-400. (doi:10.1189/jlb.1203604).
Fang, C., Bernardes-Silva, M., Coleman, M.P. and Perry, V.H. (2005) The cellular distribution of the Wld(S) chimeric protein and its constituent proteins in the CNS. Neuroscience, 135, (4), 1107-1118. (doi:10.1016/j.neuroscience.2005.06.078).
Campbell, S.J., Perry, V.H., Pitossi, F.J., Butchart, A.G., Chertoff, M., Waters, S., Dempster, R. and Anthony, D.C. (2005) Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver. American Journal of Pathology, 166, 1487-1497.
Cunningham, C., Wilcockson, DC., Boche, D. and Perry, VH. (2005) Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease. Journal of Virology, 79, (8), 5174-5184. (doi:10.1128/JVI.79.8.5174-5184.2005).
Gidron, Yori, Perry, Hugh and Glennie, Martin (2005) Does the vagus nerve inform the brain about preclinical tumours and modulate them? Lancet Oncology, 6, (4), 245-248. (doi:10.1016/S1470-2045(05)70096-6). (PMID:15811620).
Docagne, F., Campbell, S.J., Bristow, A.F., Poole, S., Vigues, S., Guaza, C., Perry, V.H. and Anthony, D.C. (2005) Differential regulation of type I and type II interleukin-1 receptors in focal brain inflammation. European Journal of Neuroscience, 21, (5), 1205-1214. (doi:10.1111/j.1460-9568.2005.03965.x).
Cunningham, C., Deacon, RMJ., Chan, K., Boche, D., Rawlins, JNP. and Perry, VH. (2005) Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits. Neurobiology of Disease, 18, (2), 258-269. (doi:10.1016/j.nbd.2004.08.015).
Galea, Ian, Palin, Karine, Newman, Tracey A., Van Rooijen, Nico, Perry, V. Hugh and Boche, Delphine (2005) Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain. Glia, 49, (3), 375-384. (doi:10.1002/glia.20124).
Deacon, R.M.J., Reisel, D., Perry, V.H., Nicholas, J. and Rawlins, P. (2005) Hippocampal scrapie infection impairs operant DRL performance in mice. Behavioural Brain Research, 157, (1), 99-105.
Broom, Kerry A., Anthony, Daniel C., Blamire, Andrew M., Waters, Sara, Styles, Peter, Perry, Victor Hugh and Sibson, Nicola R. (2005) MRI reveals that early changes in cerebral blood volume precede blood-brain barrier breakdown and overt pathology in MS-like lesions in rat brain. Journal of Cerebral Blood Flow & Metabolism, 25, (2), 204-216. (doi:10.1038/sj.jcbfm.9600020).
Carare-Nnadi, R., Bernardes-Silva, M., Subash, M., Perry, V.H. and Weller, R.O. (2005) Perivascular pathways for the clearance of interstitial fluid from the brain and the pathology of Alzheimer's disease. Neuropathology and Applied Neurobiology, 31, (2), 210-245. (doi:10.1111/j.1365-2990.2005.00644.x).
Dunn, Nicholas, Mullee, Mark, Perry, V. Hugh and Holmes, Clive (2005) Association between dementia and infectious disease: evidence from a case-control study. Alzheimer Disease and Associated Disorders, 19, (2), 91-94.
Gomes-Leal, W., Corkill, D.J., Freire, M.A., Picanco-Diniz, C.W. and Perry, V.H. (2004) Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury. Experimental Neurology, 190, (2), 456-467. (doi:10.1016/j.expneurol.2004.06.028).
Ferrari, C.C., Depino, A.M., Prada, F., Muraro, N., Campbell, S., Podhajcer, O., Perry, V.H., Anthony, D.C. and Pitossi, F.J. (2004) Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain. American Journal of Pathology, 165, 1827-1837.
Perry, V.H. (2004) A model way to study rare diseases. European Journal of Cancer, 40, 2189-2189. (doi:10.1016/j.ejca.2004.08.016).
Tian, G., Wilcockson, D., Perry, V.H., Rudd, P.M., Dwek, R.A., Platt, F.M. and Platt, N. (2004) Inhibition of alpha-glucosidases I and II increases the cell surface expression of functional class A macrophage scavenger receptor (SR-A) by extending its half-life. Journal of Biological Chemistry, 279, (38), 39303-39309. (doi:10.1074/jbc.M405219200).
Campbell, S.J., Perry, V.H., Pitossi, F., Butchart, A.G., Chertoff, M., Waters, S. and Anthony, D.C. (2004) Hepatic CC chemokines control the magnitude of the inflammatory response within the injured rodent brain. Journal of Neuroimmunology, 154, (1-2), 33. (doi:10.1016/j.jneuroim.2004.06.010).
Sun, D., Newman, T.A., Perry, V.H. and Weller, R.O. (2004) Cytokine-induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis. Neuropathology and Applied Neurobiology, 30, (4), 374-384. (doi:10.1111/j.1365-2990.2003.00546.x).
Picanço-Diniz, CW., Boche, D., Gomes-Leal, W., Perry, VH. and Cunningham, C. (2004) Neuropil and neuronal changes in hippocampal NADPH-diaphaorase histochemistry in the ME7 model of murine prion disease. Neuropathology and Applied Neurobiology, 30, (3), 292-303. (doi:10.1111/j.1365-2990.2004.00537.x).
Campbell, Sandra J., Finlay, Malcolm, Clements, John M., Wells, Graham, Miller, Karen M., Perry, V. Hugh and Anthony, Daniel C. (2004) Reduction of excitotoxicity and associated leukocyte recruitment by a broad-spectrum matrix metalloproteinase inhibitor. Journal of Neurochemistry, 89, (6), 1378-1386. (doi:10.1111/j.1471-4159.2004.02441.x).
Palin, Karine, Verrier, Danièle, Tridon, Viviane, Hurst, Jane, Perry, V. Hugh, Dantzer, Robert and Lestage, Jacques (2004) Influence of the course of brain inflammation on the endogenous IL-1 beta/IL-1Ra balance in the model of brain delayed-type hypersensitivity response to bacillus Calmette-Guerin in Lewis rats. Journal of Neuroimmunology, 149, (1-2), 22-30. (doi:10.1016/j.jneuroim.2003.12.005).
Newman, T., Carare-Nnadi, R., Bernardes-Silva, M., Weller, R. and Perry, V. H. (2004) Traffic of antigen presenting cells to and from the brain. Neuroimmunology, 154, (1-2), 1-230.
Tian, Gang, Wilcockson, David, Perry, V.Hugh, Rudd, Pauline M., Dwek, Raymond A., Platt, Frances M. and Platt, Nick (2004) Inhibition of α-glucosidases I and II increases the cell surface expression of functional class A macrophage scavenger receptor (SR-A) by extending its half-life. Journal of Biological Chemistry, 279, (38), 39303-39309. (doi:10.1074/jbc.M405219200).
Ferrari, C., Prada, F., Muraro, N., Depino, A., Perry, V.H., Anthony, D.C. and Pitossi, F. (2003) Functional effects of the chronic expression of IL-1 beta in the striatum. Journal of Neurochemistry, 87, (Supplement 1), 160-160. (doi:10.1046/j.1474-1644.2003.2175_15.x).
Hughes, P.M., Anthony, D.C., Ruddin, M., Botham, M.S., Rankine, E.L., Sablone, M., Baumann, D., Mir, A.K. and Perry, V.H. (2003) Focal lesions in the rat central nervous system induced by endothelin-1. Journal of Neuropathology & Experimental Neurology, 62, (12), 1276-1286.
Anthony, D.C., Campbell, S.J. and Perry, V.H. (2003) CINC-1 is an early hepatic acute phase protein induced by focal brain injury that causes leukocyte mobilization and liver injury. Journal of Neurochemistry, 87, (1), 9-9.
Boche, D., Cunningham, C., Gauldie, J. and Perry, VH. (2003) Transforming growth factor-beta1-mediated neuroprotection against excitotoxic injury in vivo. Journal of Cerebral Blood Flow and Metabolism, 23, (10), 1174-1182. (doi:10.1097/01.WCB.0000090080.64176.44).
Bowen, H., Lapham, A., Phillips, E., Yeung, I., Alter-Koltunoff, M., Levi, B.Z., Perry, V.H., Mann, D.A. and Barton, C.H. (2003) Characterization of the murine Nramp1 promoter - Requirements for transactivation by Miz-1. Journal of Biological Chemistry, 278, (38), 36017-36026. (doi:10.1074/jbc.M304301200).
Holmes, C., El-Okl, M., Williams, A.L., Cunningham, C., Wilcockson, D. and Perry, V.H. (2003) Systemic infection, interleukin 1 beta, and cognitive decline in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 74, 788-789. (doi:10.1136/jnnp.74.6.788).
Holmes, C., El-Okl, M., Williams, A.L., Cunningham, C., Wilcockson, D. and Perry, V.H. (2003) Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 74, (6), 788-789. (doi:10.1136/jnnp.74.6.788).
Cunningham, C., Deacon, R., Wells, H., Boche, D., Waters, E., Picanco Diniz, C., Scott, H., Rawlins, JNP. and Perry, VH. (2003) Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease. European Journal of Neuroscience, 17, (10), 2147-2155. (doi:10.1046/j.1460-9568.2003.02662.x).
Campbell, Sandra J., Hughes, Paula M., Iredale, John P., Wilcockson, David C., Waters, Sara, Docagne, Fabian, Perry, V. Hugh and Anthony, Daniel C. (2003) CINC-1 is identified as an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury. The Federation of American Societies for Experimental Biology (FASEB) Journal, 17, (9), 1168-1170. (doi:10.1096/fj.02-0757fje).
Jeyakumar, M., Thomas, R., Elliot-Smith, E., Smith, D.A., Spoel, A.C., Azzo, A., Perry, V.H., Butters, T.D., Dwek, R.A. and Platt, F.M. (2003) Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis. Brain, 126, (4), 974-987. (doi:10.1093/brain/awg089).
Perry, V.H., Newman, T.A. and Cunningham, C. (2003) The impact of systemic infection on the progression of neurodegenerative disease. Nature Reviews Neuroscience, 4, (2), 103-112. (doi:10.1038/nrn1032).
Bowen, H., Lapham, A., Phillips, E., Yeung, I., Alter-Koltunoff, M., Levi, B., Perry, V. H., Mann, D. A. and Barton, C. H. (2003) Characterization of the murine nramp1 promoter. The Journal of Biological Chemistry, 278, (38), 36017-36026. (doi:10.1074/jbc.M304301200).
Sibson, N.R., Blamire, A.M., Perry, V.H., Gauldie, J., Styles, P. and Anthony, D.C. (2002) TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway. Brain, 125, (11), 2446-2459.
Coleman, M.P. and Perry, V.H. (2002) Axon pathology in neurological disease: a neglected therapeutic target. Trends in Neurosciences, 25, (10), 532-537. (doi:10.1016/S0166-2236(02)02255-5).
Campbell, Sandra J., Wilcockson, David C., Butchart, Angus G., Perry, V. Hugh and Anthony, Daniel C. (2002) Altered chemokine expression in the spinal cord and brain contributes to differential interleukin-1 beta-induced neutrophil recruitment. Journal of Neurochemistry, 83, (2), 432-441. (doi:10.1046/j.1471-4159.2002.01166.x).
Bowen, H., Biggs, T.E., Baker, S.T., Phillips, E., Perry, V.H., Mann, D.A. and Barton, C.H. (2002) c-Myc represses the murine Nramp I promoter. Biochemical Society Transactions, 30, (4), 774-777.
Jeyakumar, Mylvaganam, Smith, David, Eliott-Smith, Elena, Cortina-Borja, Mario, Reinkensmeier, Gabriele, Butters, Terry D., Lemm, Thorsten, Sandhoff, Konrad, Perry, V. Hugh, Dwek, Raymond A. and Platt, Frances M. (2002) An inducible mouse model of late onset Tay-Sachs disease. Neurobiology of Disease, 10, (3), 201-210. (doi:10.1006/nbdi.2002.0511).
Combrinck, M.I., Perry, V.H. and Cunningham, C. (2002) Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease. Neuroscience, 112, (1), 7-11. (doi:10.1016/S0306-4522(02)00030-1).
Perry, VH., Cunningham, C. and Boche, D. (2002) Atypical inflammation in the central nervous system in prion disease. Current Opinion in Neurology, 15, (3), 349-354.
Hughes, Paula M., Allegrini, Peter R., Rudin, Markus, Perry, V. Hugh, Mir, Anis K. and Wiessner, Christoph (2002) Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke model. Journal of Cerebral Blood Flow & Metabolism, 22, (3), 308-317. (doi:10.1097/00004647-200203000-00008).
Wilcockson, David C., Campbell, Sandra J., Anthony, Daniel C. and Perry, V. Hugh (2002) The systemic and local acute phase response following acute brain injury. Journal of Cerebral Blood Flow & Metabolism, 22, (3), 318-326. (doi:10.1097/00004647-200203000-00009).
Hughes, P.M., Botham, M.S., Frentzel, S., Mir, A. and Perry, V.H. (2002) Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Glia, 37, (4), 314-327. (doi:10.1002/glia.10037).
Hughes, P.M., Wells, G.M.A., Perry, V.H., Brown, M.C. and Miller, K.M. (2002) Comparison of matrix metalloproteinase expression during Wallerian degeneration in the central and peripheral nervous systems. Neuroscience, 113, (2), 273-287. (doi:10.1016/S0306-4522(02)00183-5).
Mankowski, J.L., Queen, S.E., Tarwater, P.M., Fox, K.J. and Perry, V.H. (2002) Accumulation of beta-amyloid precursor protein in axons correlates with CNS expression of SIV gp41. Journal of Neuropathology & Experimental Neurology, 61, (1), 85-90. (PMID:11829347).
Bowen, H., Biggs, T.E., Phillips, E., Baker, S.T., Perry, V.H., Mann, D.A. and Barton, C.H. (2002) c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter. Journal of Biological Chemistry, 277, (38), 34997-35006. (doi:10.1074/jbc.M204232200).
Mack, Till G.A., Reiner, Michael, Beirowski, Bogdan, Mi, Weiqian, Emanelli, Monica, Wagner, Diana, Thomson, Derek, Gillingwater, Tom, Court, Felipe, Conforti, Laura, Fernando, F. Shama, Tarlton, Andrea, Anderssen, Christian, Addicks, Klaus, Magni, Giulio, Ribchester, Richard R., Perry, V. Hugh and Coleman, Michael P. (2001) Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nature Neuroscience, 4, (12), 1199-1206. (doi: 10.1038/nn770).
Mack, T.G.A., Reiner, M., Beirowski, B., Mi, W.Q., Emanuelli, M., Wagner, D., Thomson, D., Gillingwater, T., Court, F., Conforti, L., Fernando, F.S., Tarlton, A., Andressen, C., Addicks, K., Magni, G., Ribchester, R.R., Perry, V.H. and Coleman, M.P. (2001) Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nature Neuroscience, 4, 1199-1206. (doi:10.1038/nn770).
Newman, T.A., Woolley, S.T., Hughes, P.M., Sibson, N.R., Anthony, D.C. and Perry, V.H. (2001) T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases. Brain, 124, (11), 2203-2214. (doi:10.1093/brain/124.11.2203).
Bernardes-Silva, Martine, Anthony, Daniel C., Issekutz, Andrew C. and Perry, V. Hugh (2001) Recruitment of neutrophils across the blood-brain barrier: the role of E- and P-selectins. Journal of Cerebral Blood Flow & Metabolism, 21, (9), 1115-1124. (doi:10.1097/00004647-200109000-00009).
Deacon, Robert M.J., Raley, Josephine M., Perry, V. Hugh and Rawlins, J. Nicholas P. (2001) Burrowing into prion disease: motivation, emotion, feeding, drinking. Neuroreport, 12, (9), 2053-2057.
Guenther, K., Deacon, R.M.J., Perry, V.H. and Rawlins, J.N.P. (2001) Early behavioural changes in scrapie-affected mice and the influence of dapsone. European Journal of Neuroscience, 14, (2), 401-409. (doi:10.1046/j.0953-816x.2001.01645.x).
Biggs, T.E., Baker, S.T., Botham, M.S., Dhital, A., Barton, C.H. and Perry, V.H. (2001) Nramp1 modulates iron homoeostasis in vivo and in vitro: evidence for a role in cellular iron release involving de- acidification of intracellular vesicles. European Journal of Immunology, 31, (7), 2060-2070. (doi:10.1002/1521-4141(200107)31:7<2060::AID-IMMU2060>3.0.CO;2-L).
Mudher, A.K., Yee, B., Smith, A.D. and Perry, V.H. (2001) Deafferentation of the hippocampus results in the induction of AT8 positive 'granules' in the rat. Neuroscience Letters, 301, (1), 5-8. (doi:10.1016/S0304-3940(01)01593-2).
Walsh, D.T., Betmouni, S. and Perry, V.H. (2001) Absence of detectable IL-1 beta production in murine prion disease: A model of chronic neurodegeneration. Journal of Neuropathology & Experimental Neurology, 60, (2), 173-182.
Jeyakumar, Mylvaganam, Norflus, Francine, Tifft, Cynthia.J., Cortina-Borja, Mario, Butters, Terry.D., Proia, Richard.L., Perry, V.Hugh, Dwek, Raymond .A. and Platt, Frances.M. (2001) Enhanced survival in Sandhoff disease mice receiving a combination of substrate deprivation therapy and bone marrow transplantation. Blood, 97, (1), 327-329. (doi:10.1182/blood.V97.1.327).
Yamada, Elizabeth S., Silveira, Luiz Carlos L., Perry, V. Hugh and Franco, Edna Cristina S. (2001) M and P retinal ganglion cells of the owl monkey: morphology, size and photoreceptor convergence. Vision Research, 41, (2), 119-131. (doi:10.1016/S0042-6989(00)00244-3).
Mudher, A.K., Yee, B., Smith, A.D. and Perry, V.H. (2001) Deafferentation of the hippocampus results in the induction of AT8 positive `granules' in the rat. Neuroscience Letters, 301, (1), 5-8. (doi:10.1016/S0304-3940(01)01593-2).
Blamire, A.M., Anthony, D.C., Rajagopalan, B., Sibson, N.R., Perry, V.H. and Styles, P. (2000) Interleukin-1β-induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study. Journal of Neuroscience, 20, (21), 8153-8159.
Minghetti, L., Greco, A., Cardone, F., Puopolo, M., Ladogana, A., Almonti, S., Cunningham, C., Perry, V.H., Pocchiari, M. and Levi, G. (2000) Increased brain synthesis of prostaglandin E-2 and F-2-isoprostane in human and experimental transmissible spongiform encephalopathies. Journal of Neuropathology & Experimental Neurology, 59, (10), 866-871.
Anthony, D.C., Hughes, P. and Perry, V.H. (2000) The evidence for primary axonal loss in multiple sclerosis. Revista de Neurologia, 30, (12), 1203-1208.
Perry, V. Hugh (2000) Persistent pathogens in the parenchyma of the brain. Journal of NeuroVirology, 6, (Supplement 1), S86-S89.
Minghetti, L., Walsh, D.T., Levi, G. and Perry, V.H. (1999) In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines. Journal of Neuropathology & Experimental Neurology, 58, (11), 1184-1191.
Perry, V.H. and Anthony, D.C. (1999) Axon damage and repair in multiple sclerosis. Philosophical Transactions of the Royal Society B: Biological Sciences, 354, (1390), 1641-1647.
Bolton, S.J., Russelakis-Carneiro, M., Betmouni, S. and Perry, V.H. (1999) Non-nuclear histone H1 is upregulated in neurones and astrocytes in prion and Alzheimer's diseases but not in acute neurodegeneration. Neuropathology and Applied Neurobiology, 25, (5), 425-432. (doi:10.1046/j.1365-2990.1999.00171.x).
Betmouni, S., Clements, J. and Perry, V.H. (1999) Vacuolation in murine prion disease: an informative artifact. Current Biology, 9, (18), R677-R679. (doi:10.1016/S0960-9822(99)80437-0).
Russelakis-Carneiro, M., Betmouni, S. and Perry, V.H. (1999) Inflammatory response and retinal ganglion cell degeneration following intraocular injection of ME7. Neuropathology and Applied Neurobiology, 25, (3), 196-206. (doi:10.1046/j.1365-2990.1999.00184.x).
Mudher, A.K., Mellanby, J., McMath, H., Perry, V.H. and Greene, J.R.T. (1999) Heparin injection into the adult rat hippocampus induces seizures in the absence of macroscopic abnormalities. Neuroscience, 89, (2), 329-333. (doi:10.1016/S0306-4522(98)00533-8).
Schnell, L., Fearn, S., Schwab, M.E., Perry, V.H. and Anthony, D.C. (1999) Cytokine-induced acute inflammation in the brain and spinal cord. Journal of Neuropathology & Experimental Neurology, 58, (3), 245-254.
Betmouni, S. and Perry, V.H. (1999) The acute inflammatory response in CNS following injection of prion brain homogenate or normal brain homogenate. Neuropathology & Applied Neurobiology, 25, (1), 20-28. (doi: 10.1046/j.1365-2990.1999.00153.x).
Perry, V.H. (1998) Reluctant remyelination: the missing precursors. Brain, 121, (12), 2219-2220.
Perry, V.H., Bolton, S.J., Anthony, D.C. and Betmouni, S. (1998) The contribution of inflammation to acute and chronic neurodegeneration. Research in Immunology, 149, (7), 721-725. (doi:10.1016/S0923-2494(99)80046-7).
Coleman, M.P., Conforti, L., Buckmaster, E.A., Tarlton, A., Ewing, R.M., Brown, M.C., Lyon, M.F. and Perry, V.H. (1998) An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse. Proceedings of the National Academy of Sciences, 95, (17), 9985-9990. (doi:10.1073/pnas.95.17.9985). (PMID:9707587).

Book Section

Gomez-Nicola, Diego and Perry, V. Hugh (2014) Neurodegenerative diseases. In, Tremblay, Marie-Eve and Sierra, Amanda (eds.) Microglia in Health and Disease. New York, US, Springer .
Fabriek, Babs O., Galea, Ian, Perry, V. Hugh and Dijkstra, Christine D. (2005) Cerebral perivascular macrophages and the blood brain barrier. In, de Vries, Elga and Prat, Alexandre (eds.) The Blood-Brain Barrier and its Microenvironment: Basic Physiology to Neurological Disease. London, UK, Informa Healthcare.

Conference or Workshop Item

Gomez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V.H. (2013) Regulation of microglial proliferation during chronic neurodegneration. At XI European Meeting on Glial Cells in Health and Disease, Berlin, DE, 03 - 06 Jul 2013.
Gomez-Nicola, Diego, Suzzi, Stefano, Fransen, Nina L. and Perry, V.H. (2013) Regulation of neurogenesis in prion disease. At BNA 22nd Annual Meeting, London, GB, 25 - 30 Jun 2013.
Gomez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V. Hugh (2012) Dynamics and regulation of microglial proliferation in prion disease. At 8th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience, Barcelona, ES, 14 - 18 Jul 2012. (Submitted).
Suzzi, Stefano, Weber, K, Fehse, B, Perry, V. Hugh and Gomez-Nicola, Diego (2012) Regulation of neurogenesis in prion disease. At 8th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience, Barcelona, ES, 14 - 18 Jul 2012. (Submitted).
Gomez-Nicola, Diego, Fransen, Nina L., Suzzi, Stefano and Perry, V. Hugh (2012) Dynamics and regulation of microglial proliferation in prion disease. 10th European Congress of Neuropathology, Edinburgh, GB, 06 - 09 Jun 2012.
Gomez-Nicola, Diego and Perry, V. Hugh (2011) Regulation of neurogenesis in prion disease. At The Cambridge Neural Stem Cell Symposium, Cambridge, GB, 05 - 06 Sep 2011.
Gomez-Nicola, Diego and Perry, V. Hugh (2011) Dynamics of microglial proliferation in prion disease. At British Neuroscience Association 21st Biennial Meeting, Harrogate, GB, 17 - 20 Apr 2011.
Kwan, J., Perry, V.H., Pickering, R., Hyndman, D., Fitton, Carolyn and Ashburn, A. (2010) The impact of stroke-associated infection on survival in the first three years. At The 5th UK Stroke Forum, Glasgow City, GB, 30 Nov - 02 Dec 2010.
Boche, D., Holmes, C., Perry, VH., Vlachouli, C., Thompson, P. and Nicoll, J.A.R. (2006) Neuroinflammation and Alzheimer's disease: implications of Abeta immunotherapy. In, 8th International Conference of Neuroimmunology (ISNI 2006) , 267-268. (doi:10.1016/j.jneuroim.2006.07.002).
Weller, R.O., Carare-Nnadi, R., Yow, H.Y., Boche, D., Mazanti, I., Bridges, L.R., Perry, V.H. and Nicoll, J.A. (2006) Cerebrovascular disease impedes the perivascular elimination of amyloid-beta from the brain in Alzheimer's disease. In, XVIth Congress of the International Society of Neuropathology, San Francisco, US, 15 Sep 2006. , S79. (doi:10.1111/j.1750-3639.2006.00019.x).
Felton, L.M., Cunningham, C., Rankine, E.L., Waters, S., Boche, D. and Perry, V.H. (2005) MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease. In, Abstracts of the XVIIIth World Congress of Neurology , S51. (doi:10.1016/S0022-510X(05)80203-5).
Boche, D., Cunningham, C., Scott, H. and Perry, V.H. (2002) TGF-beta1 and murine prion disease. In, Fifth European Meeting on Glial Cell Function in Health and Disease (Euroglia 2002) , S27. (doi:10.1002/glia.6002).
 

Research

Research Interests

Inflammation in the CNS and its contribution to Neurological Disease

The inflammatory response evolved to protect organisms against injury and infection. Following an injury or infection a complex cascade of events leads to the delivery of blood-borne leucocytes to sites of injury to kill potential pathogens and promote tissue repair. However, the powerful inflammatory response has the capacity to cause damage to normal tissue and dysregulation of the innate or acquired immune response is involved in different pathologies. It has long been known that Multiple Sclerosis is an inflammatory disease of the brain but it is now recognized that inflammation may contribute to diseases such as stroke, traumatic brain injury, HIV-related dementia, Alzheimer's disease and prion disease. The recognition of an inflammatory component in the pathology of these different diseases has come from the development of new techniques and reagents for the study of inflammation biology in brain pathology. It is now known that the resident macrophages of the central nervous system (CNS), the microglia, may exist in many different states of activation and contribute to the outcome of neurological disease in diverse ways. The goal of my research group the CNS Inflammation Group is to discover how inflammation contributes to the outcome of neurological disease. This information may help in the development of therapies to treat acute and chronic neurodegenerative conditions, which at present are largely untreated.

Inflammation biology in the brain is a complex subject and requires expertise in many different areas. We have collaborations with academic laboratories across the University of Southampton, the UK, as well as with laboratories across Europe.

Primary research group:  Biomedical Sciences

Affiliate research groups:  Institute for Life Sciences (IfLS), Southampton Neuroscience Group (SoNG)

Research projects

Acute brain injury

Acute injury to a tissue results in activation of a rapid innate inflammatory response. This response is dominated by local changes in the vasculature, and the recruitment of neutrophils and monocytes from the blood to the site of injury.

How does protein misfolding damage glial cells and affects neuronal survival?

Understanding the consequences of protein misfolding and aggregation during dementia: the role of glial cells.

An integrated approach to CNS inflammation: cooperation between antibodies and CD8 T cells

Using novel cell-labelling techniques and functionalised nanoparticles, we track macrophages and T cell recruitment to the brain and assess the role of cell mediated and humoral immunity in the initiation and/or progression of CNS inflammation.

Immune Mediated Brain Injury

Multiple Sclerosis is often described as an inflammatory demyelinating disease with relative sparing of axons. However, we have shown that the T-cells and macrophages recruited to the sites of inflammation damage axons and that this axon damage occurs early in the disease.

Immune-to-brain communication in immune-mediated lung inflammation; studies of neuronal mechanisms and the impact of immunomodulators

Using immunocytochemistry, molecular biology and formal behavioural testing techniques we investigate the biological nature of immune-to-brain communication elicited by immune-mediated lung disease.

Inflammation in chronic neurodegeneration and the contribution of systemic inflammation

We are investigating the microglia activation in a model of prion disease, mouse scrapie.

Linking the immune system to the central nervous system: a role for antibodies and Fcγ receptors in neuronal damage.

Using immunocytochemistry, molecular biology and formal behavioural testing techniques we investigate antibody-mediated neuronal damage in lupus.

The impact of systemic bacterial and viral infections on innate immune responses in the brain

Using immunocytochemistry, cell biology, imaging and formal behavioural testing techniques we investigate how systemic infections impact on the brain.

The role of IgG Fc receptors in the pathogenesis of age related macular degeneration and its implications for therapeutic intervention.

Using novel models for AMD, we will investigate the functional role of antibodies in disease onset and progression.

Understanding oligodendrocyte progenitor dynamics and myelin loss in Alzheimer’s Disease

Oligodendrocyte progenitor cells (OPCs) may be altered in Alzheimer’s disease.

Does Wlds mediate protection in a Drosophila model of tauopathies?

Can Wlds protect against axonal dysfunction and degeneration in a transgenic model of Alzheimer’s disease?

Contributions

Professional Affiliations

Chair Neuroscience and Mental Health Board, Medical Research Council, UK
Editorial Boards of a number of journals
Ad hoc consultant to Biotech and Pharma

Contact

Professor V Hugh Perry
Centre for Biological Sciences
Mailpoint 840 (room LD80b)
Level D Laboratories and Pathology Block
Southampton General Hospital
Tremona Road
Southampton SO16 6YD

Phone: 023 8079 6103

Room Number: SGH/LD840