V Hugh Perry
BSc, MA, DPhil.
- Primary position:
- Professor of Experimental Neuropathology
- Research Fellow, University of Oxford (1977-1996).
- Locke Royal Society Research Fellow, Wellcome Trust Senior Research Fellow.
- Professor of Experimental Neuropathology, University of Oxford. (1996-1998)
- Professor of Experimental Neuropathology, University of Southampton (1998- present)
- Visiting Professor in the College of Medicine & Veterinary Medicine, University of Edinburgh (2011- present)
- Chair Neuroscience and Mental Health Board, MRC
The University of Southampton's electronic library (e-prints)
Conference or Workshop Item
Inflammation in the CNS and its contribution to Neurological Disease
The inflammatory response evolved to protect organisms against injury and infection. Following an injury or infection a complex cascade of events leads to the delivery of blood-borne leucocytes to sites of injury to kill potential pathogens and promote tissue repair. However, the powerful inflammatory response has the capacity to cause damage to normal tissue and dysregulation of the innate or acquired immune response is involved in different pathologies. It has long been known that Multiple Sclerosis is an inflammatory disease of the brain but it is now recognized that inflammation may contribute to diseases such as stroke, traumatic brain injury, HIV-related dementia, Alzheimer's disease and prion disease. The recognition of an inflammatory component in the pathology of these different diseases has come from the development of new techniques and reagents for the study of inflammation biology in brain pathology. It is now known that the resident macrophages of the central nervous system (CNS), the microglia, may exist in many different states of activation and contribute to the outcome of neurological disease in diverse ways. The goal of my research group the CNS Inflammation Group is to discover how inflammation contributes to the outcome of neurological disease. This information may help in the development of therapies to treat acute and chronic neurodegenerative conditions, which at present are largely untreated.
Inflammation biology in the brain is a complex subject and requires expertise in many different areas. We have collaborations with academic laboratories across the University of Southampton, the UK, as well as with laboratories across Europe.
Primary research group: Biomedical Sciences
Acute injury to a tissue results in activation of a rapid innate inflammatory response. This response is dominated by local changes in the vasculature, and the recruitment of neutrophils and monocytes from the blood to the site of injury.
Understanding the consequences of protein misfolding and aggregation during dementia: the role of glial cells.
Using novel cell-labelling techniques and functionalised nanoparticles, we track macrophages and T cell recruitment to the brain and assess the role of cell mediated and humoral immunity in the initiation and/or progression of CNS inflammation.
Multiple Sclerosis is often described as an inflammatory demyelinating disease with relative sparing of axons. However, we have shown that the T-cells and macrophages recruited to the sites of inflammation damage axons and that this axon damage occurs early in the disease.
Immune-to-brain communication in immune-mediated lung inflammation; studies of neuronal mechanisms and the impact of immunomodulators
Using immunocytochemistry, molecular biology and formal behavioural testing techniques we investigate the biological nature of immune-to-brain communication elicited by immune-mediated lung disease.
We are investigating the microglia activation in a model of prion disease, mouse scrapie.
Linking the immune system to the central nervous system: a role for antibodies and Fcγ receptors in neuronal damage.
Using immunocytochemistry, molecular biology and formal behavioural testing techniques we investigate antibody-mediated neuronal damage in lupus.
Using immunocytochemistry, cell biology, imaging and formal behavioural testing techniques we investigate how systemic infections impact on the brain.
The role of IgG Fc receptors in the pathogenesis of age related macular degeneration and its implications for therapeutic intervention.
Using novel models for AMD, we will investigate the functional role of antibodies in disease onset and progression.
- Chair Neuroscience and Mental Health Board, Medical Research Council, UK
- Editorial Boards of a number of journals
- Ad hoc consultant to Biotech and Pharma
Professor V Hugh Perry
Centre for Biological Sciences
Mailpoint 840 (room LD80b)
Level D Laboratories and Pathology Block
Southampton General Hospital
Southampton SO16 6YD
Phone: 023 8079 6103
Room Number: SGH/LD840