Centre for Biological Sciences

BIOL1005 Cellular & genetic mechanisms

Module Overview

The aim of this module is to provide an introduction to Cell Biology and Genetics from general principles to modern day applications; you should aim to understand, appreciate, be familiar with, and realise the significance of the module contents.

Module Details

Title: Cellular & genetic mechanisms
Code: BIOL1005
Year: 1
Semester: 2

CATS points: 15 ECTS points: 7.5
Level: Undergraduate
Co-ordinator(s): Dr Chris Jackson

Pre-requisites and / or co-requisites

A-level Biology grade B or equivalent

Programmes in which this module is compulsory

ProgrammeUCAS CodeProgramme length

Aims and objectives

Aims:

The aim of this module is to provide an introduction to Cell Biology and Genetics from general principles to modern day applications; you should aim to understand, appreciate, be familiar with, and realise the significance of the module contents.

Learning Outcomes:

The aim of this module is to provide an introduction to Cell Biology and Genetics from general principles to modern day applications; you should aim to understand and appreciate the significance of the module contents.
By the end of this module you should be able to describe the following:
The features of prokaryote and Eukaryote cells, the composition and spatial organisation of the cell. The structure and features of major organelle systems including the nucleus, the secretory vacuolar system (endoplasmic reticulum, golgi, lysosomes), mitochondria, plant cells with chloroplasts and cytoplasmic vacuole. Plasma membrane and mechanisms of transport into and out of the cell. Protein production and sorting. The cytoskeleton and its role in the cell.
Chromatin structure, gene regulation, and the ways in which molecular biology throws light on gene function and the genetic regulation of cell specialisation. Techniques of recombinant DNA and cloning, its use and implications in biotechnology and genetic engineering. Cancer, tumorigenesis and the cell cycle. Cell determination and differentiation and the role of stem cells in cell replacement in humans. The transmission of genetic material in cell division by mitosis or meiosis, the control of these processes and how cell division fits within the cell cycle. Human Spermatogenesis and Oogenesis in relation to cell division. The phenomenon and implications of Chromosome karyogamy, variation in chromosome number (polyploidy and aneuploidy). The analysis of genetic variation in inheritance and transmission genetics including epistasis. Sex determination, sex linkage, human pedigree analysis. The contents can be liable to change from year to year.
The laboratory practicals should enable you to understand the application and be able to describe the theory behind the practical experiments. Develop practical expertise relevant to the experiments performed and be able to interpret the results. Present practicals include: Immunocytochemistry and Cell Proliferation, DNA restriction & electrophoresis, induction of B-galactosidase in E.coli, PCR, Mitosis and chromosome karyogamy.

Syllabus

This module is an introduction to Cell Biology & Genetics from general principles to modern day applications. For more details, refer to Learning Outcomes.

Learning and teaching

Study time allocation

Contact hours: 39
Private study hours: 111
Total study time: 150 hours

Teaching and learning methods

Lectures, wet practicals, Blackboard, formative and summative assessment, and independent study.

Resources and reading list

RECOMMENDED BOOKS
Because this module extends from Cell Biology to Human Pedigree Analysis there is no one text that covers all aspects. There are three recommended text, depending on your degree programme you should have or purchase one and refer to the other two in the short loan section of the library (there should be at least 20 copies of each).

  1. For Biology and Zoology students and others more interested in cellular to whole organism Biology: Campbell, N.A. & Reece, J.B. . Biology. . Pearson - Benjamin & Cummings (already purchased for BIOL1004)
  2. For Biomedical Sci, Biochemistry & Pharmacology students and others more interested in Biochemistry to Physiology/Cell Biology: Alberts, B et al . Molecular Biology of the Cell. . Garland Science (Text Book for many molecular modules in years 1, 2 & 3

The following book is a good general genetics text but does not support the cellular component of this module. It does not support any other modules so is best to use the library copies or for purchase for those particularly interested in genetics

Klug, W.S. et al. . Concepts of Genetics . Pearson-Benjamin Cummings.

Assessment

Assessment methods

Assessment Method Summative / Formative % contribution to final mark  Final element of assessment (√) 
Blackboard quizzes associated with lectures Formative    
WWW Assessment Sites Formative    
Continual assessment will be based on laboratory practicals Summative 30%  
Exam: A two hour paper, with just two sections.
- Section 1 (35%), will be a compulsory series statements with true/false answers
- Section 2 (35%), Unseen exam paper. Two answers from a choice of four questions equal marks for each question
Summative 70%
Re-assessment Method Summative / Formative % contribution to final mark Final element of assessment (√)
If you have to take referral examinations in September the paper format will be different; you will answer three essay type questions from a choice of five. The questions are unseen before the examination and there is no true/false section. The 30% element practical continual assessment mark is carried over. Summative 70% √