The University of Southampton
Centre for Human Development, Stem Cells and RegenerationResearch themes

Bone repair in osteoarthritis and rheumatoid arthritis

 

Arthritis is a major cause of pain and disability, particularly with an ageing population. Different types of arthritis are associated with varying degrees of inflammation, which contributes to joint damage. When an arthritic joint fails, patients require joint replacement surgery.  Bone tissue engineering strategies represent a future alternative to this surgery.

 

Our research is centred on investigating how this inflammation, driven by chemicals called cytokines present in arthritic joints, will affect the success of these bone tissue engineering strategies.  Joint lining cells (‘synovium') from patients having joint replacement surgery are used as a source of these chemicals.  Established chick and mouse models of bone formation are then being used to investigate their effects.  In collaboration with Nigel Arden at the University of Oxford, we are also looking to determine the influence of not just these local but also systemic markers of inflammation on patient outcomes after joint replacement surgery.

Different types of arthritis are associated with varying degrees of inflammation, which contributes to joint damage. Femoral heads from an osteoporotic, osteoarthritic and rheumatoid patient.
Arthritic femoral heads

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