Chemistry

Philip A Gale

MA DPhil DSc (Oxon) FRSC CChem CSci

Primary position:
Head of Chemistry, Professor of Supramolecular Chemistry

Background

The University of Southampton

Phil Gale's Publications and Citation Metrics

Philip A. Gale received his BA (Hons) in 1992 and his MA and DPhil in 1995 from the University of Oxford. In 1995, he moved to the University of Texas at Austin where he spent two years as a Fulbright Scholar. In 1997 he was awarded a Royal Society University Research Fellowship and returned to the Department of Chemistry at Oxford. In 1999 he moved as a Lecturer to the University of Southampton and was promoted to Senior Lecturer in 2002, Reader in 2005 and to a Personal Chair in Supramolecular Chemistry in 2007. Phil is currently the Head of Chemistry at the University of Southampton. In 2014 he was awarded a Doctor of Science degree by the University of Oxford and was listed by Thomson Reuters as a Highly Cited Researcher in chemistry.

Phil's research interests focus on the supramolecular chemistry of anionic species and in particular the molecular recognition, sensing and lipid bilayer transport of anions. Transmembrane anion transporters have potential applications in the development of future treatments for cystic fibrosis and cancer.

He is the author or co-author of over 200 publications including an Oxford Chemistry Primer on Supramolecular Chemistry with Paul Beer and David Smith (1999) and an RSC Monograph in Supramolecular Chemistry entitled Anion Receptor Chemistry with Jonathan Sessler and Won-Seob Cho (2006). He is the co-editor in chief (with Jonathan Steed) of a new 8-volume reference work published by Wiley entitled Supramolecular Chemistry: from molecules to nanomaterials.

Phil has won a number of research prizes including the RSC 2014 Supramolecular Chemistry Award, a Royal Society Wolfson Research Merit Award (2013-2018), the RSC Corday Morgan medal and prize (2005), the Society/Journal of Porphyrins and Phthalocyanines Young Investigator Award (2004) and the Bob Hay Lectureship (2004).

In 2010 he was awarded a JSPS invitation fellowship that he took up at Kyushu University, Japan in 2011. In 2012 he was appointed as a guest Professor by Xiamen University, China (2012-2014), giving the prestigious Tan Kah Kee chemistry lecture there in 2013. He has recently been awarded a University of Canterbury Erskine Visiting Fellowship and will spend two months in Christchurch, New Zealand in 2014. 

Phil serves as the Chair of Chemical Society Reviews Editorial Board and is an member of the Advisory Board of Chemical Science. He is also the co-editor of the journal Supramolecular Chemistry, and a member of the international editorial advisory boards of Coordination Chemistry Reviews and the Encyclopaedia of Supramolecular Chemistry.

He is the Head of the UK's National Crystallography Service based in Chemistry at Southampton. In 2004 he joined the International Scientific Committee of the International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC) and organised this meeting in the UK in 2011. Phil is also a member of EPSRC College and served on France's ANR Laboratories of Excellence Jury in 2011 and 2012. He is a member of the management group of COST Action CM1005 Supramolecular Chemistry in Water and in 2013 served on the ERC Consolidator Grant Panel (PE05). In 2012 he was elected chair of the RSC Macrocyclic and Supramolecular Chemistry Group.

Professor Philip A Gale's photo

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Publications

The University of Southampton's electronic library (e-prints)

Article

Karagiannidis, Louise E., Haynes, Cally J. E., Holder, Katie J., Kirby, Isabelle L., Moore, Stephen J., Wells, Neil J. and Gale, Philip A. (2014) Highly effective yet simple transmembrane anion transporters based upon ortho-phenylenediamine bis-ureas. Chemical Communications (doi:10.1039/c4cc05519e).
Gale, Philip A. and Caltagirone, Claudia (2014) Tutorial Review. Anion sensing by small molecules and molecular ensembles. Chemical Society Reviews, 1-16. (doi:10.1039/C4CS00179F).
Hiscock, Jennifer R., Sambrook, Mark R., Cranwell, Philippa B., Watts, Pat, Vincent, Jack C., Xuereb, David J., Wells, Neil J., Raja, Robert and Gale, Philip A. (2014) Tripodal molecules for the promotion of phosphoester hydrolysis. Chemical Communications, 50, (47), 6217-6220. (doi:10.1039/C4CC00333K).
Haynes, Cally J.E., Busschaert, Nathalie, Kirby, Isabelle L., Herniman, Julie, Light, Mark E., Wells, Neil J., Marques, Igor, Félix, Vítor and Gale, Philip A. (2014) Acylthioureas as anion transporters: the effect of intramolecular hydrogen bonding. Organic & Biomolecular Chemistry, 12, (1), 62-72. (doi:10.1039/c3ob41522h).
Busschaert, Nathalie, Karagiannidis, Louise E., Wenzel, Marco, Haynes, Cally J. E., Wells, Neil J., Young, Philip G., Makuc, Damjan, Plavec, Janez, Jolliffe, Katrina A. and Gale, Philip A. (2014) Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport. Chemical Science, 5, (3), 1118-1127. (doi:10.1039/C3SC52006D).
Busschaert, Nathalie, Jaramillo-Garcia, Javier, Light, Mark E., Herniman, Julie, Langley, G. John and Gale, Philip A. (2014) An anion-binding fluorinated alcohol isophthalamide isostere. RSC Advances , 4, (11), 5389-5393. (doi:10.1039/C3RA45956J).
Valkenier, Hennie, Haynes, Cally J.E., Herniman, Julie, Gale, Philip A. and Davis, Anthony P. (2014) Lipophilic balance – a new design principle for transmembrane anion carriers. Chemical Science, 5, (3), 1128-1134. (doi:10.1039/c3sc52962b).
Marques, Igor, Colaço, Ana R., Costa, Paulo Jorge, Busschaert, Nathalie, Gale, Philip A and Felix, Vitor (2014) Tris-thiourea tripodal-based molecules as chloride transmembrane transporters: insights from molecular dynamics simulations. Soft Matter, 10, 3608-3621. (doi:10.1039/c3sm52140k).
Gale, Philip A., Busschaert, Nathalie, Haynes, Cally J. E., Karagiannidis, Louise E. and Kirby, Isabelle L. (2014) Anion receptor chemistry: highlights from 2011 and 2012. Chemical Society Reviews, 43, (1), 205-241. (doi:10.1039/c3cs60316d).
Busschaert, Nathalie, Elmes, Robert B. P., Czech, Dawid D., Wu, Xin, Kirby, Isabelle L., Peck, Evan M., Hendzel, Kevin D., Shaw, Scott K., Chan, Bun, Smith, Bradley D., Jolliffe, Katrina A. and Gale, Philip A. (2014) Thiosquaramides: pH switchable anion transporters. Chemical Science, 5, 3617-3626. (doi:10.1039/c4sc01629g).
Kirby, Isabelle L., Brightwell, Mark, Pitak, Mateusz B., Wilson, Claire, Coles, Simon J. and Gale, Philip A. (2014) Systematic experimental charge density analysis of anion receptor complexes. Physical Chemistry Chemical Physics, 16, 10943-10958. (doi:10.1039/c3cp54858a).
Kirby, Isabelle L., Pitak, Mateusz B., Wenzel, Marco, Wilson, Claire, Sparkes, Hazel A., Coles, Simon J. and Gale, Philip A. (2013) Systematic structural analysis of a series of anion receptor complexes. CrystEngComm, 15, (44), 9003-9010. (doi:10.1039/c3ce41503a).
Gale, Philip A., Busschaert, Nathalie, Bradberry, Samuel J., Wenzel, Marco, Haynes, Cally, Hiscock, Jennifer R., Kirby, Isabelle, Karagiannidis, Louise E., Moore, Stephen J., Wells, Neil, Herniman, Julie, Langley, John, Horton, Peter, Light, Mark E., Marques, Igor, Costa, Paulo Jorge, Felix, Vitor and Frey, J.G. (2013) Towards predictable transmembrane transport: QSAR analysis of anion binding and anion transport. Chemical Science, 4, (8), 3036-3045. (doi:10.1039/C3SC51023A).
Gale, Philip A., Pérez-Tomás, Ricardo and Quesada, Roberto (2013) Anion transporters and biological systems. Accounts of Chemical Research, 130403084748005. (doi:10.1021/ar400019p).
Busschaert, Nathalie and Gale, Philip A. (2013) Small-molecule lipid-bilayer anion transporters for biological applications. Angewandte Chemie International Edition, 52, (5), 1374-1382. (doi:10.1002/anie.201207535).
Gale, Philip A, Felix, Vitor, Pérez Tomás, Ricardo, Soto Cerrato, Vanessa, Haynes, Cally, Moore, Stephen, González, Jorge, Light, Mark E., Sutton, Jennifer, Marques, Igor, Herniman, Julie and Langley, John (2013) Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas. Chemical Science, 4, (1), 103-117. (doi:10.1039/C2SC21112B).
Moore, Stephen J., Haynes, Cally J. E., González, Jorge, Sutton, Jennifer L., Brooks, Simon J., Light, Mark E., Herniman, Julie, Langley, G. John, Soto-Cerrato, Vanessa, Pérez-Tomás, Ricardo, Marques, Igor, Costa, Paulo J., Félix, Vítor and Gale, Philip A. (2013) Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas. Chemical Science, 4, (1), 103-117. (doi:10.1039/c2sc21112b).
Karagiannidis, Louise E., Hiscock, Jennifer R. and Gale, Philip A. (2013) The influence of stereochemistry on anion binding and transport. [in special issue: Special Issue Honouring Professor Rocco Ungaro] Supramolecular Chemistry, 25, (9-11), 626-630. (doi:10.1080/10610278.2013.806809).
Haynes, Cally J. E., Berry, Stuart N., Garric, Joachim, Herniman, Julie, Hiscock, Jennifer R., Kirby, Isabelle L., Light, Mark E., Perkes, Gregory and Gale, Philip A. (2013) Small neutral molecular carriers for selective carboxylate transport. Chemical Communications, 49, (3), 246-248. (doi:10.1039/C2CC37468D).
Reid, Brodie L., Briggs, Steven, Karagiannidis, Louise E, Muzzioli, Sara, Raiteri, Paolo, Light, Mark E., Stagni, Stefano, Brulatti, Pierpaolo, Gale, Philip A., Ogden, Mark Ian and Massi, Massimiliano (2013) Blue emitting C2-symmetrical dibenzothiazolyl substituted pyrrole, furan and thiophene. Journal of Materials Chemistry C (doi:10.1039/c3tc00760j).
Haav, Kristjan, Kadam, Sandip A., Toom, Lauri, Gale, Philip A., Busschaert, Nathalie, Wenzel, Marco, Hiscock, Jennifer R., Kirby, Isabelle L., Haljasorg, Tõiv, Lõkov, Märt and Leito, Ivo (2013) Accurate method to quantify binding in supramolecular chemistry. The Journal of Organic Chemistry, 78, (16), 7796-7808. (doi:10.1021/jo400626p).
Keltie, Sam M., Gale, Philip A., Light, Mark E. and Tromp, Moniek (2013) A linear rod-packing coordination polymer constructed from a non-linear dicarboxylate and the [Zn4O]6+cluster. Journal of Coordination Chemistry, 66, (17), 3058-3062. (doi:10.1080/00958972.2013.824075).
Constable, Edwin C. and Gale, Philip A. (2013) Celebrating the 100th Anniversary of the Nobel Prize in Chemistry awarded to Alfred Werner. Chemical Society Reviews, 42, (4), 1427-1428. (doi:10.1039/c2cs90118h). (PMID:23334306).
Cranwell, Philippa B., Hiscock, Jennifer R., Haynes, Cally J. E., Light, Mark E., Wells, Neil J. and Gale, Philip A. (2012) Anion recognition and transport properties of sulfamide-, phosphoric triamide- and thiophosphoric triamide-based receptors. Chemical Communications, 49, (9), 874-876. (doi:10.1039/C2CC38198B).
Bates, Gareth W., Davidson, James E., Forgan, Ross S., Gale, Philip A., Henderson, David K., King, Michael G., Light, Mark E., Moore, Stephen J., Tasker, Peter A. and Tong, Christine C. (2012) A dual host approach to NiSO4extraction. [in special issue: Sixth International Symposium on Macrocyclic and Supramolecular Chemistry (6-ISMSC)] Supramolecular Chemistry, 24, (2), 117-126. (doi:10.1080/10610278.2011.631706).
Hiscock, Jennifer R., Gale, Philip A., Lalaoui, Noémie, Light, Mark E. and Wells, Neil J. (2012) Benzimidazole-based anion receptors exhibiting selectivity for lactate over pyruvate. Organic & Biomolecular Chemistry, 10, (38), 7780-7788. (doi:10.1039/C2OB26299A).
Gale, Philip A, Pérez Tomás, Ricardo, Wenzel, Marco, Light, Mark E., Morley, Rebeka, Bradberry, Samuel, Soto Cerrato, Vanessa and Gomez Iglesias, Patricia (2012) Towards “drug-like” indole-based transmembrane anion transporters. Chemical Science (doi:10.1039/C2SC20551C).
Sambrook, Mark R., Hiscock, Jennifer R., Cook, Alexandra, Green, A. Christopher, Holden, Ian, Vincent, Jack C. and Gale, Philip A. (2012) Hydrogen bond-mediated recognition of the chemical warfare agent soman (GD). Chemical Communications, 48, (45), 5605-5607. (doi:10.1039/C2CC31096A).
Hiscock, Jennifer R., Gale, Philip A. and Hynes, Michael J. (2012) Tris-(2-aminoethyl)amine-based tripodal trisindolylureas: new receptors for sulphate. Supramolecular Chemistry, 24, (5), 355-360. (doi:10.1080/10610278.2012.671486).
Busschaert, Nathalie, Kirby, Isabelle L., Young, Sarah, Coles, Simon J., Horton, Peter N., Light, Mark E. and Gale, Philip A. (2012) Squaramides as potent transmembrane anion transporters. Angewandte Chemie International Edition, 51, (18), 4426-4430. (doi:10.1002/anie.201200729).
Haynes, Cally J.E., Moore, Stephen J., Hiscock, Jennifer R., Marques, Igor, Costa, Paulo Jorge, Félix, Vítor and Gale, Philip A. (2012) Tunable transmembrane chloride transport by bis-indolylureas. Chemical Science, 3, 1436-1444. (doi:10.1039/C2SC20041D).
Barba-Bon, Andrea, Costero, Ana M., Parra, Margarita, Gil, Salvador, Martínez-Máñez, Ramón, Sancenón, Félix, Gale, Philip A. and Hiscock, Jennifer R. (2012) Neutral 1,3-Diindolylureas for nerve agent remediation. Chemistry - A European Journal, 19, (5), 1586-1590. (doi:10.1002/chem.201202028).
Wenzel, Marco, Hiscock, Jennifer R. and Gale, Philip A. (2012) Anion receptor chemistry: highlights from 2010. Chemical Society Reviews, 41, (1), 480-520. (doi:10.1039/c1cs15257b).
Coles, Simon J. and Gale, Philip A. (2012) Changing and challenging times for service crystallography. Chemical Science, (3), 683-689. (doi:10.1039/C2SC00955B).
Park, In-Won, Yoo, Jaeduk, Kim, Bohyang, Adhikari, Suman, Kim, Sung Kuk, Yeon, Yerim, Haynes, Cally J. E., Sutton, Jennifer L., Tong, Christine C., Lynch, Vincent M., Sessler, Jonathan L., Gale, Philip A. and Lee, Chang-Hee (2012) Oligoether-strapped calix[4]pyrrole: an ion-pair receptor displaying cation-dependent chloride anion transport. Chemistry: A European Journal (doi:10.1002/chem.201103239).
Gale, Philip A., Hiscock, Jennifer R., Lalaoui, Noémie, Light, Mark E., Wells, Neil J. and Wenzel, Marco (2011) Benzimidazole-based anion receptors: tautomeric switching and selectivity. Organic & Biomolecular Chemistry (doi:10.1039/C1OB06800H).
Busschaert, Nathalie, Wenzel, Marco, Light, Mark E., Iglesias-Hernández, Paulina, Pérez-Tomás, Ricardo and Gale, Philip A. (2011) Structure–activity relationships in tripodal transmembrane anion transporters: the effect of fluorination. Journal of the American Chemical Society, 133, (35), 14136-14148. (doi:10.1021/ja205884y). (PMID:21846096).
Makuc, Damjan, Hiscock, Jennifer R., Light, Mark E., Gale, Philip A. and Plavec, Janez (2011) NMR studies of anion-induced conformational changes in diindolylureas and diindolylthioureas. Beilstein Journal of Organic Chemistry, 7, 1205-1214. (doi:10.3762/bjoc.7.140).
Makuc, Damjan, Hiscock, Jennifer R, Light, Mark E, Gale, Philip A and Plavec, Janez (2011) NMR studies of anion-induced conformational changes in diindolylureas and diindolylthioureas. Beilstein Journal of Organic Chemistry, 7, 1205-1214. (doi:10.3762/bjoc.7.140).
Karagiannidis, Louise E., Gale, Philip A., Light, Mark E., Massi, Massimiliano and Ogden, Mark I. (2011) Further insight into the coordination of 2,5-dicarbothioamidopyrroles: the case of Cu and Co complexes. Dalton Transactions (doi:10.1039/C1DT10441A).
Chapman, Rebecca P., Hiscock, Jennifer R., Gale, Philip A. and Bryce, David L. (2011) A solid-state35/37Cl NMR study of a chloride ion receptor and a GIPAW-DFT study of chlorine NMR interaction tensors in organic hydrochlorides. Canadian Journal of Chemistry, 89, (7), 822-834. (doi:10.1139/V10-177).
Wenzel, Marco, Light, Mark E., Davis, Anthony P. and Gale, Philip A. (2011) Thiourea isosteres as anion receptors and transmembrane transporters. Chemical Communications, 47, 7641-7643. (doi:10.1039/C1CC12439K).
Haynes, Cally J. E. and Gale, Philip A. (2011) Transmembrane anion transport by synthetic systems. Chemical Communications (doi:10.1039/C1CC12061A).
Moore, Stephen J., Fisher, Matthew G., Yano, Masafumi, Tong, Christine C. and Gale, Philip A. (2011) A synergistic approach to anion antiport. Dalton Transactions (doi:10.1039/C1DT10213C).
Gale, Philip A. (2011) From anion receptors to transporters. Accounts of Chemical Research, 44, (3), 216-226. (doi:10.1021/ar100134p).
Moore, Stephen J., Fisher, Matthew G., Yano, Masafumi, Tong, Christine C. and Gale, Philip A. (2011) A dual host approach to transmembrane transport of salts. Chemical Communications, 47, (2), 689-691. (doi:10.1039/C0CC04430J). (PMID:21103515 ).
Gale, Philip A. (2011) Anion receptor chemistry. Chemical Communications, 47, (1), 82-86. (doi:10.1039/c0cc00656d).
Andrews, Natalie J., Haynes, Cally J.E., Light, Mark E., Moore, Stephen J., Tong, Christine C., Davis, Jeffery T., Harrell Jr., William A. and Gale, Philip A. (2011) Structurally simple lipid bilayer transport agents for chloride and bicarbonate. Chemical Science, 2, (2), 256-260. (doi:10.1039/C0SC00503G).
Gale, Philip A., Sessler, Jonathan L. and Steed, Jonathan (2011) Editorial. Supramolecular chemistry - introducing the latest web themed issue. Chemical Communications, 47, (21), 5931-5932. (doi:10.1039/C1CC90048J).
Hiscock, Jennifer R., Gale, Philip A., Caltagirone, Claudia, Hursthouse, Michael B. and Light, Mark E. (2010) Fluorescent carbazolylurea- and carbazolylthiourea-based anion receptors and sensors. Supramolecular Chemistry, 22, (11), 647-652. (doi:10.1080/10610271003637087).
Edwards, Peter R., Hiscock, Jennifer R., Gale, Philip A. and Light, Mark E. (2010) Carbamate complexation by urea-based receptors: studies in solution and the solid state. Organic & Biomolecular Chemistry, 8, (1), 100-106. (doi:10.1039/b917140a).
Caltagirone, Claudia, Bill, Nathan L., Gross, Dustin E., Light, Mark E., Sessler, Jonathan L. and Gale, Philip A. (2010) Bis-cation salt complexation by meso-octamethylcalix[4]pyrrole: linking complexes in solution and in the solid state. Organic & Biomolecular Chemistry, 8, (1), 96. (doi:10.1039/b916113a).
Gale, Philip A., Hiscock, Jennifer , Moore, Stephen J., Caltagirone, Claudia, Hursthouse, Michael B. and Light, Mark E. (2010) Anion-Anion proton transfer in hydrogen bonded complexes. Chemistry - An Asian Journal, 5, (3), 555-561. (doi:10.1002/asia.200900230).
Gale, Philip A. and Gunnlaugsson, Thorfinnur (2010) Editorial. Preface: supramolecular chemistry of anionic species themed issue. Chemical Society Reviews, 39, (10), 3595-3596. (doi:10.1039/C0CS90020F).
Gale, Philip A. and Gunnlaugsson, Thorfinnur (2010) Preface: supramolecular chemistry of anionic species themed issue. Chemical Society Reviews, 39, (10), 3595-3596. (doi:10.1039/C0CS90020F).
Yano, Masafumi, Tong, Christine, Light, Mark E., Schmidtchen, Franz P. and Gale, Philip A. (2010) Calix[4]pyrrole-based anion transporters with tuneable transport properties. Organic & Biomolecular Chemistry, 8, (19), 4356-4363. (doi:10.1039/C0OB00128G).
Busschaert, Nathalie, Gale, Philip A., Haynes, Cally J. E., Light, Mark E., Moore, Stephen J., Tong, Christine C., Davis, Jeffery T. and Harrell, Jr., William A. (2010) Tripodal transmembrane transporters for bicarbonate. Chemical Communications, 46, (34), 6252-6254. (doi:10.1039/C0CC01684E). (PMID:20694202).
Gale, Philip A. (2010) Anion receptor chemistry: highlights from 2008 and 2009. Chemical Society Reviews, 39, (10), 3746-3771. (doi:10.1039/c001871f).
Gale, Philip A. and Lee, Chang-Hee (2010) Calix[n]pyrroles as anion and ion-pair complexants. Topics in Heterocyclic Chemistry, 25, 39-73. (doi:10.1007/7081_2010_30).
Gale, Philip A., Hiscock, Jennifer, Jie, Chen Zhu, Hursthouse, Michael B. and Light, Mark E. (2010) Acyclic indole and carbazole-based sulfate receptors. Chemical Science, 1, (2), 215-220. (doi:10.1039/C0SC00202J).
Gale, Philip A., Tong, Christine C., Haynes, Cally J. E., Adeosun, Olubukunola, Gross, Dustin E., Karnas, Elizabeth, Sedenberg, Elaine M., Quesada, Roberto and Sessler, Jonathan L. (2010) Octafluorocalix[4]pyrrole: a chloride/bicarbonate antiport agent. Journal of the American Chemical Society, 132, (10), 3240-3241. (doi:10.1021/ja9092693).
Caltagirone, Claudia, Mulas, Andrea, Isaia, Francesco, Lippolis, Vito, Gale, Philip A. and Light, Mark E. (2009) Metal-induced pre-organisation for anion recognition in a neutral platinum-containing receptor. Chemical Communications, (41), 6279-6281. (doi:10.1039/b912942a).
Makuc, Damjan, Lenarčič, Martina, Bates, Gareth W., Gale, Philip A. and Plavec, Janez (2009) Anion-induced conformational changes in 2,7-disubstituted indole-based receptors. Organic and Biomolecular Chemistry, 7, (17), 3505-3511. (doi:10.1039/B908947K).
Edwards, Peter R., Hiscock, Jennifer R. and Gale, Philip A. (2009) Stabilisation of alkylcarbamate anions using neutral hydrogen bond donors. Tetrahedron Letters, 50, (34), 4922-4924. (doi:10.1016/j.tetlet.2009.06.058).
Fisher, Matthew G., Gale, Philip A., Hiscock, Jennifer R., Hursthouse, Michael B., Light, Mark Edward, Schmidtchen, Franz P. and Tong, Christine C. (2009) 1,2,3-triazole-strapped calix[4]pyrrole: a new membrane transporter for chloride. Chemical Communications, (21), 3017-3019. (doi:10.1039/b904089g).
Hiscock, Jennifer, Caltagirone, Claudia, Light, Mark Edward, Hursthouse, Michael B. and Gale, Philip A. (2009) Fluorescent carbazolylurea anion receptors. Organic and Biomolecular Chemistry, 7, (9), 1781-1783. (doi:10.1039/b900178f).
Davis, Jeffery T., Gale, Philip A., Okunola, Oluyomi A., Prados, Pilar, Iglesias-Sánchez, Jose Carlos, Torroba, Tomás and Quesada, Roberto (2009) Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes. Nature Chemistry, 1, (2), 138-144. (doi:10.1038/nchem.178).
Caltagirone, Claudia, Gale, Philip A., Hiscock, Jennifer R., Hursthouse, Michael B., Light, Mark Edward and Tizzard, Graham J (2009) 2-Amidoindole-based anion receptors. Supramolecular Chemistry, 21, (1-2), 125-130. (doi:10.1080/10610270802348243).
Caltagirone, Claudia and Gale, Philip A. (2009) Anion receptor chemistry: highlights from 2007. Chemical Society Reviews, 38, (2), 520-563. (doi:10.1039/b806422a).
Caltagirone, Claudia, Hiscock, Jennifer R., Hursthouse, Michael B., Light, Mark Edward and Gale, Philip A. (2008) 1,3-diindolylureas and 1,3-diindolythioureas: anion complexation studies in solution and the solid State. Chemistry - A European Journal, 14, (33), 10236-10243. (doi:10.1002/chem.200801639).
Fisher, Matthew G., Gale, Philip A., Light, Mark E. and Loeb, Stephen J. (2008) Metal–organic anion receptors: trans-functionalised platinum complexes. Chemical Communications, (44), 5695-5697. (doi:10.1039/b816002c).
Tong, Christine C., Quesada, Roberto, Sessler, Jonathan L. and Gale, Philip A. (2008) meso-Octamethylcalix[4]pyrrole: an old yet new transmembrane ion-pair transporter. Chemical Communications, 47, 6321-6323. (doi:10.1039/b814988g ).
Fisher, Matthew G., Gale, Philip A., Light, Mark E. and Quesada, Roberto (2008) Hydrogen bonded networks in N–alkyl substituted thiourea platinum (II) oxocarbodianion and carboxylate salts. CrystEngComm, 10, (9), 1180-1190. (doi:10.1039/b803260b).
Arroyo, Marta, Birkin, Peter R., Gale, Philip A., García-Garrido, Sergio E. and Light, Mark E. (2008) Anion-triggered electrodeposition in ferrocene-functionalised ortho-phenylenediamine-based receptors. New Journal of Chemistry, 32, (7), 1221-1227. (doi:10.1039/b715125j).
Bates, Gareth W., Gale, Philip A., Light, Mark E., Ogden, Mark I. and Warriner, Colin N. (2008) Structural diversity in the first metal complexes of 2,5-dicarboxamidopyrroles and 2,5-dicarbothioamidopyrroles. Dalton Transactions, (31), 4106-4112. (doi:10.1039/b802506a).
Gross, Dustin E., Schmidtchen, Franz P., Antonius, Wiebke, Gale, Philip A., Lynch, Vincent M. and Sessler, Jonathan L. (2008) Cooperative binding of calix[4]pyrrole-anion complexes and alkylammonium cations in halogenated solvents. Chemistry - A European Journal, 14, (26), 7822. (doi:10.1002/chem.200800899).
Arroyo, Marta, Birkin, Peter R., Gale, Philip A., García-Garrido, Sergio E. and Light, Mark E. (2008) Anion-triggered electrodeposition in ferrocene-functionalised ortho-phenylenediamine-based receptors. New Journal of Chemistry, 32, (7), 1221-1227. (doi:10.1039/b715125j).
Bates, Gareth W. and Gale, Philip A. (2008) An introduction to anion receptors based on organic frameworks. Structure and Bonding, 129, 1-44. (doi:10.1007/430_2007_069).
Brooks, S.J., Caltagirone, C., Cossins, A.J., Gale, P.A. and Light, M.E. (2008) Fluorescent anthracene-based anion receptors. Supramolecular Chemistry, 20, (4), 349-355. (doi:10.1080/10610270701258121).
Bates, Gareth W., Gale, Philip A. and Light, Mark E. (2008) Interactions of organic halide and nitrate salts with meso-octamethylcalix[4]pyrrole. Supramolecular Chemistry, 20, (1 & 2), 23-28. (doi:10.1080/10610270601089378).
Caltagirone, Claudia, Bates, Gareth W., Gale, Philip A. and Light, Mark E. (2008) Anion binding vs. sulfonamide deprotonation in functionalised ureas. Chemical Communications, (1), 61-63. (doi:10.1039/b713431b).
Fisher, Matthew G., Gale, Philip A., Light, Mark Edward and Quesada, Roberto (2008) Hydrogen bonded networks in N-alkyl substituted thiourea platinum (II) oxocarbodianion and carboxylate salts. CrystEngComm, 10, (9), 1180-1190. (doi:10.1039/b803260b).
Gale, Philip A., Garcia-Garrido, Sergio E. and Garric, Joachim (2008) Anion receptors based on organic frameworks: highlights from 2005 and 2006. Chemical Society Reviews, 37, (1), 151-190. (doi:10.1039/b715825d).
Caltagirone, Claudia, Gale, Philip A., Hiscock, Jennifer R., Brooks, Simon J., Hursthouse, Michael B. and Light, Mark Edward (2008) 1,3-Diindolylureas: high affinity dihydrogen phosphate receptors. Chemical Communications, 26, 3007-3009. (doi:10.1039/b806238b).
Fisher, Matthew G., Gale, Philip A., Light, Mark Edward and Loeb, Stephen J. (2008) Metal-organic anion receptors: trans-functionalised platinum complexes. Chemical Communications, 44, 5695-5697. (doi:10.1039/b816002c).
Brooks, S.L., Garcia-Garrido, S.E., Light, M.E., Cole, P.A. and Gale, P.A. (2007) Conformational control of selectivity and stability in hybrid amide/urea macrocycles. Chemistry-a European Journal, 13, (12), 3320-3329. (doi:10.1002/chem.200601647).
Santacroce, Paul V., Davis, Jeffery T., Light, Mark E., Gale, Philip A., Iglesias-Sánchez, José Carlos, Prados, Pilar and Quesada, Roberto (2007) Conformational control of transmembrane Cl- transport. Journal of the American Chemical Society, 129, (7), 1886-1887. (doi:10.1021/ja068067v).
Garcia-Garrido, S.E., Caltagirone, C., Light, M.E. and Gale, P.A. (2007) Acridinone-based anion receptors and sensors. Chemical Communications, (14), 1450-1452. (doi:10.1039/b618072h).
Dehaen, W., Gale, P.A., Garcia-Garrido, S.E., Kostermans, M. and Light, M.E. (2007) Anion recognition by N-confused calix[4]pyrrole-alpha-carbaldehyde and its Knoevenagel reaction derivatives. New Journal of Chemistry, 31, (5), 691-696. (doi:10.1039/b616467f).
Gale, P.A. (2007) Supramolecular chemistry anniversary. Chemical Society Reviews, 36, (2), 141-142.
Fisher, M.G., Gale, P.A. and Light, M.E. (2007) A simple benzimidazole-based receptor for barbiturate and urea neutral guests that functions in polar solvent mixtures. New Journal of Chemistry, 31, (9), 1583-1584. (DOI:10.1039/b705854c).
Brooks, S.J., Gale, P.A. and Light, M.E. (2007) Extending the hydrogen-bonding array in ortho-phenylenediamine based bis-ureas. Supramolecular Chemistry, 19, (1-2), 9-15. (doi:10.1080/10610270600879076).
Brooks, Simon J., García-Garrido, Sergio E., Light, Mark E., Cole, Pamela A. and Gale, Philip A. (2007) Conformational control of selectivity and stability in hybrid amide/urea macrocycles. Chemistry - A European Journal, 13, (12), 3320-3329. (doi:10.1002/chem.200601647).
Dixon, Sally, Brown, Richard C. D. and Gale, Philip (2007) A biaryl cross-coupling strategy for functionalisation of benzocrown ethers. Chemical Communications, (34), 3565-3567. (doi:10.1039/B709861h).
Bates, Gareth W., Triyanti, (No initials), Light, Mark E., Albrecht, Markus and Gale, Philip A. (2007) 2,7-functionalized indoles as receptors for anions. Journal of Organic Chemistry, 72, (23), 8921-8927. (doi:10.1021/jo701702p).
Gale, Philip A., Garric, Joachim, Light, Mark E., McNally, Beth A. and Smith, Bradley D. (2007) Conformational control of HCl co-transporter: imidazole functionalised isophthalamide vs. 2,6-dicarboxamidopyridine. Chemical Communications, 2007, (17), 1736-1738. (doi:10.1039/b703259E).
Light, M.E., Gale, P.A. and Navakhun, K. (2006) N,N '-Bis(3-nitrophenyl)isophthalamide tetrabutylammonium chloride. Acta Crystallographica Section E-Structure Reports Online, 62, 01097-01098. (doi:10.1107/S1600536806005447).
Brooks, Simon J., Edwards, Peter R., Gale, Philip A. and Light, Mark E. (2006) Carboxylate complexation by a family of easy-to-make ortho-phenylenediamine based bis-ureas: studies in solution and the solid state. New Journal of Chemistry, 30, (1), 65-70. (doi:10.1039/b511963d).
Sessler, Jonathan L., Gross, Dustin E., Cho, Won-Seob, Lynch, Vincent M., Schmidtchen, Franz P., Bates, Gareth W., Light, Mark E. and Gale, Philip A. (2006) Calix[4]pyrrole as a chloride anion receptor: Solvent and countercation effects. Journal of the American Chemical Society, 128, (37), 12281-12288. (doi:10.1021/ja064012h).
Brooks, Simon J., Gale, Philip A. and Light, Mark E. (2006) Anion-binding modes in a macrocyclic amidourea. Chemical Communications, (41), 4344-4346. (doi:10.1039/b610938a).
Gale, Philip A. (2006) Structural and molecular recognition studies with acyclic anion receptors. Accounts of Chemical Research, 39, (7), 465-475. (doi:10.1021/ar040237q).
Gale, P.A. and Quesada, R. (2006) Anion coordination and anion-templated assembly: Highlights from 2002 to 2004. Coordination Chemistry Reviews, 250, (23-24), 3219-3244. (doi:10.1016/j.ccr.2006.05.020).
Bates, Gareth W., Gale, Philip A. and Light, Mark E. (2006) Ionic liquid-calix[4]pyrrole complexes: pyridinium inclusion in the calixpyrrole cup. Crystengcomm, 8, (4), 300-302. (doi:10.1039/b600251j).
Brooks, Simon J., Gale, Philip A. and Light, Mark E. (2006) Network formation by a pyrrole functionalized isophthalamide. Crystengcomm, 8, (12), 877-882. (doi:10.1039/b612524g).
Sessler, Jonathan L., Pantos, G. Dan, Gale, Philip A. and Light, Mark E. (2006) Synthesis and anion binding properties of N,N'-bispyrrol-2-yl-2,5-diamidopyrrole. Organic Letters, 8, (8), 1593-1596. (doi:10.1021/ol060193g S1523-7060(06)00193-3).
Evans, Louise S., Gale, Philip A., Light, Mark E. and Quesada, Roberto (2006) Pyrrolylamidourea based anion receptors. New Journal of Chemistry, 30, (7), 1019-1025. (doi:10.1039/b603223k).
Szymanska, Iwona, Radecka, Hanna, Radecki, Jerzy, Gale, Philip A. and Warriner, Colin N. (2006) Ferrocene-substituted calix[4]pyrrole modified carbon paste electrodes for anion detection in water. Journal of Electroanalytical Chemistry, 591, (2), 223-228. (doi:10.1016/j.jelechem.2006.04.007).
Light, M.E., Gale, P.A. and Brooks, S.J. (2006) Bis(tetrabutylammonium) isophthalate 1-phenyl-3- [2,4,5-tris(3-phenylureido)phenyl] urea: a synchrotron study. Acta Crystallographica Section E-Structure Reports Online, 62, (5), o1905-o1907. (doi:10.1107/S1600536806009135).
Gale, P. A. (2006) Special issue: Anion coordination chemistry II - Preface. Coordination Chemistry Reviews, 250, (23-24), p.2917. (doi:10.1016/j.ccr.2006.08.004).
Evans, Louise S., Gale, Philip A., Light, Mark E. and Quesada, Roberto (2006) Anion binding vs. deprotonation in colorimetric pyrrolylamidothiourea based anion sensors. Chemical Communications, (9), 965-967. (doi:10.1039/b517308f).
Bates, Gareth W., Kostermans, Maarten, Dehaen, Wim, Gale, Philip A. and Light, Mark E. (2006) Organic salt inclusion: the first crystal structures of anion complexes of N-confused calix[4] pyrrole. Crystengcomm, 8, (6), 445-448. (doi:10.1039/b604128k).
Gale, Philip A., Light, Mark E., McNally, Beth, Navakhun, Korakot, Sliwinski, Kate E. and Smith, Bradley D. (2005) Co-transport of H+/Cl- by a synthetic prodigiosin mimic. Chemical Communications, (30), 3773-3775. (doi:10.1039/b503906a).
Light, Mark E., Gale, Philip A. and Navakhun, Korakot (2005) 1,4-Phenylene-bis-(3,4-dichloro-5-phenylcarbamoyl- 1H-pyrrole-2-carboxamide) bis(tetrabutylammonium chloride) acetonitrile disolvate. Acta Crystallographica Section E - Structure Reports Online, E61, (5), o1300-o1301. (doi:10.1107/S1600536805010688).
Custelcean, Radu, Delmau, Lætitia H., Moyer, Bruce A., Sessler, Jonathan L., Cho, Won-Seob., Gross, Dustin, Bates, Gareth W., Brooks, Simon J., Light, Mark E. and Gale, Philip A. (2005) Calix[4]pyrrole: An old yet new ion-pair receptor. Angewandte Chemie-International Edition, 44, (17), 2537-2542. (doi:10.1002/anie.200462945).
Brooks, Simon J., Evans, Louise S., Gale, Philip A., Hursthouse, Michael B. and Light, Mark E. (2005) 'Twisted' isophthalamide analogues. Chemical Communications, 2005, (6), 734-736. (doi:10.1039/b413654c).
Vega, Ismael El Drubi, Gale, Philip A., Light, Mark E. and Loeb, Stephen J. (2005) NH vs. CH hydrogen bond formation in metal-organic anion receptors containing pyrrolylpyridine ligands. Chemical Communications, (39), 4913-4915. (doi: 10.1039/b510506d).
Coles, Simon J., Gale, Philip A., Hursthouse, Michael B., Light, Mark E. and Warriner, Colin N. (2004) Crystallographic and solution anion binding studies of bis-amidofurans and thiophenes. Supramolecular Chemistry, 16, (7), 469-486. (doi: 10.1080/10610270410001713303).
Vega, Ismael El Drubi, Gale, Philip A., Hursthouse, Michael B. and Light, Mark E. (2004) Anion binding properties of 5,5’-dicarboxamido-dipyrrolylmethanes. Organic and Biomolecular Chemistry, 2, (20), 2935-2941. (doi:10.1039/b409115a). (Submitted).
Evans, Louise S. and Gale, Philip A. (2004) Imide linked '4+4' macrocycles formed by condensation of isophthaloyl dichloride and tetra- or penta-fluoroaniline. Chemical Communications, (11), 1286-1287. (doi:10.1039/b401614a).
Bondy, Chantelle R., Gale, Philip A. and Loeb, Stephen J. (2004) Metal-organic anion receptors: arranging urea hydrogen-bond donors to encapsulate sulfate ions. Journal of the American Chemical Society, 126, 5030-5031. (doi:10.1021/ja039712q).
Sessler, J.L., Gale, P A., Anzenbacher, P., Kral, V., Moyer, B.A., Marquez, M., Cho, W.S., An, D.Q., Shriver, J., Fowler, C.J., Levitskaia, T.G. and Magda, D.J. (2004) Oligopyrrole-based anion binding agents. Abstracts of Papers of the American Chemical Society, 227, U1237-U1237.
Loeb, S.J., Bondy, C.R. and Gale, P.A. (2004) Metal-organic anion receptors: an alternative scheme for arranging hydrogen-bond donors. Abstracts of Papers of the American Chemical Society, 227, U1231.
Gale, Phillip A., Hursthouse, Michael B., Light, Mark E. and Warriner, Colin N. (2004) Anion complexation properties of thiophene-2,4-and-2,5-biscarboxamides. Collection of Czechoslovak Chemical Communications, 69, (6), 1301-1308. (doi: 10.1135/cccc20041301).
Li, Rongqing, Evans, Louise S., Larsen, David S., Gale, Philip A. and Brooker, Sally (2004) Synthesis and anion binding behaviour of diamide derivatives of pyrrole-2,5-diacetic acid. New Journal of Chemistry, 28, (11), 1340-1343. (doi: 10.1039/b412654h).
Gale, Philip A. (2003) A "holey" supramolecular approach to the detection of enzyme activity. ChemBioChem, 4, (12), 1299-1302. (doi: 10.1002/cbic.200300716).
Gale, Philip A. (2003) Anion and ion-pair receptor chemistry: highlights from 2000 and 2001. Coordination Chemistry Reviews, 240, (1-2), 191-221. (doi:10.1016/S0010-8545(02)00258-8).
Sessler, J. L., Berthon-Gelloz, G., Gale, P. A., Camiolo, S., Anslyn, E. V., Anzenbacher, P., Furuta, H., Kirkovits, G. J., Lynch, V. M., Maeda, H., Morosini, P., Scherer, M., Shriver, J. and Zimmerman, R. S. (2003) Oligopyrrole-based solid state self-assemblies. Polyhedron, 22, (22), 2963-2983. (doi:10.1016/S0277-5387(03)00436-4).
Sessler, Jonathon L., Camiolo, Salvatore and Gale, Philip A. (2003) Pyrrolic and polypyrrolic anion binding agents. Coordination Chemistry Reviews, 240, (1-2), 17-55. (doi:10.1016/S0010-8545(03)00023-7).
Warriner, Colin N., Gale, Philip A., Light, Mark E. and Hursthouse, Michael B. (2003) Pentapyrrolic calix[4]pyrrole. Chemical Communications, 15, 1810-1811. (doi:10.1039/b303959e). (Submitted).
Camiolo, Salvatore, Gale, Philip A., Hursthouse, Michael B. and Light, Mark E. (2003) Nitrophenyl derivatives of pyrrole 2,5-diamides: structural behaviour, anion binding and colour change signalled deprotonation. Organic & Biomolecular Chemistry, 1, (4), 741-744. (doi: 10.1039/b210848h).
Coles, Simon J., Frey, Jeremy G., Gale, Philip A., Hursthouse, Michael B., Light, Mark E., Navakhun, Korakot and Thomas, Gemma L. (2003) Anion-directed assembly: the first fluoride-directed double helix. Chemical Communications, 5, 568-569. (doi:10.1039/b210847j).
Coles, Simon J., Denuault, Guy, Gale, Philip A., Horton, Peter N., Hursthouse, Michael B., Light, Mark E. and Warriner, Colin N. (2003) Mono- and bis-ferrocene 2,5-diamidopyrrole clefts: solid-state assembly, anion binding and electrochemical properties. Polyhedron, 22, (5), 699-709. (doi:10.1016/S0277-5387(02)01401-8).
Vega, Ishmael El Drubi, Camiolo, Salvatore, Gale, Phillip A., Hursthouse, Michael B. and Light, Mark E. (2003) Anion complexation properties of 2,2'-bisamidodipyrrolylmethanes. Chemical Communications, (14), 1686-1687. (doi: 10.1039/b303532h).
Camiolo, Salvatore, Gale, Philip A., Hursthouse, Michael B., Light, Mark E. and Warriner, Colin N. (2003) 2,5-Diamidofuran anion receptors. Tetrahedron Letters, 44, (7), 1367-1369. (doi:10.1016/S0040-4039(02)02883-6).
Gale, Philip A. (2003) Preface. Coordination Chemistry Reviews, 240, (1-2), 1. (doi:10.1016/S0010-8545(03)00022-5).
Camiolo, Salvatore, Coles, Simon J., Gale, Philip A., Hursthouse, Michael B. and Tizzard, Graham J. (2003) Crown ether appended amidopyrrole clefts. Supramolecular Chemistry, 15, (3), 231-234. (doi: 10.1080/1024123021000036348).
Camiolo, Salvatore, Gale, Philip A., Hursthouse, Michael B. and Light, Mark E. (2003) Nitrophenylamide derivatives of 2,5-diamidopyrroles: structural behaviour, anion binding and colour change signalled deprotonation. Organic and Biomolecular Chemistry, 126, (4), 741-744. (doi:10.1039/b210848h).
Gale, Philip A., Navakhun, Korakot, Camiolo, Salvatore, Light, Mark E. and Hursthouse, Michael B. (2002) Anion-anion assembly: a new class of anionic supramolecular polymer containing 3,4-dichloro-2,5-diamido-substituted pyrrole anion dimers. Journal of the American Chemical Society, 124, (38), 11228-11229. (doi:10.1021/ja027118v).
Coles, S. J., Gale, P. A., Hursthouse, M. B. and Warriner, C. N. (2002) Tetramethyl biphenyl-3,5,3',5'-tetracarboxylate benzene sesquisolvate. Acta Crystallographica Section E-Structure Reports Online, 58, (8), o887-o888. (doi:10.1107/S1600536802010978).
Woods, Christopher J., Camiolo, Salvatore, Light, Mark E., Coles, Simon J., Hursthouse, Michael B., King, Michael A., Gale, Philip A. and Essex, Jonathan W. (2002) Fluoride-selective binding in a new deep cavity calix[4]pyrrole: experiment and theory. Journal of the American Chemical Society, 124, (29), 8644-8652. (doi:10.1021/ja025572t).
Sessler, Jonathan L., Král, Vladimir, Shishkanova, Tatiana V. and Gale, Philip A. (2002) Cytosine substituted calix[4]pyrroles: neutral receptors for 5'-guanosine monophosphate. Proceedings of the National Academy of Sciences of the United States of America, 99, (8), 4848-4853. (doi:10.1073/pnas.062633799).
Sessler, Jonathan L., Král, Vladimír, Shishkanova, Tatiana V. and Gale, Philip A. (2002) Cytosine substituted calix[4]pyrroles: Neutral receptors for 5’-guanosine monophosphate. Proceedings of the National Academy of Sciences of the United States of America, 99, (8), 4848-4853. (doi:10.1073/pnas.062633799).
Camiolo, Salvatore, Gale, Philip A., Hursthouse, Michael B., Light, Mark E. and Shi, Andy J. (2002) Solution and solid-state studies of 3,4-dichloro-2,5-diamidopyrroles: formation of an unusual anionic narcissistic dimer. Chemical Communications, (7), 758-759. (doi:10.1039/b200980c).
Bondy, Chantelle R., Gale, Philip A. and Loeb, Stephen J. (2002) Amido complexes of platinum(II) as receptors for the nitrate ion. Journal of Supramolecular Chemistry, 2, 93-96. (doi:10.1016/S1472-7862(02)00084-9).
Navakhun, Korakot, Gale, Philip A., Camiolo, Salvatore, Light, Mark E. and Hursthouse, Michael B. (2002) Pendant arm pyrrolic amide cleft anion receptors. Chemical Communications, 18, 2084-2085. (doi:10.1039/b204295a).
Denuault, Guy, Gale, Philip A., Hursthouse, Michael B., Light, Mark E. and Warriner, Colin N. (2002) Anion complexation and electrochemical behaviour of ferrocene-appended amido-pyrrole clefts. New Journal of Chemistry, 26, 811-813. (doi:10.1039/b202989h).
Lynch, Vincent M., Gale, Phillip A., Sessler, Jonathan L. and Madeiros, David (2001) Room-temperature monoclinic and low-temperature triclinic phase-transition structures of meso-octamethylcalix [4] pyrrole-dimethyl sulfoxide (1/1). Acta Crystallographica Section C: Crystal Structure Communications, 57, (12), 1426-1428. (doi: 10.1107/S0108270101015931).
Light, M. E., Camiolo, S., Gale, P. A. and Hursthouse, M. B. (2001) Methyl 5-methyl-3,4-diphenyl-1H-pyrrole-2-carboxylate. Acta Crystallographica Section E-Structure Reports Online, 57, (12), O1245-O1246. (doi:10.1107/S1600536801019225).
Kirkovits, Gregory J., Shriver, James A., Gale, Philip A. and Sessler, Jonathan L. (2001) Synthetic ditopic receptors. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 41, (1-4), 69-75. (doi: 10.1023/A:1014468126351).
Gale, Philip A., Anzenbacher, Pavel and Sessler, Jonathan L. (2001) Calixpyrroles II. Coordination Chemistry Reviews, 222, 57-102. (doi:10.1016/S0010-8545(01)00346-0).
Gale, P. A., Hursthouse, M. B., Light, M. E., Sessler, J. L., Warriner, C. N. and Zimmerman, R. S. (2001) Ferrocene-substituted calix 4 pyrrole: a new electrochemical sensor for anions involving CH center...anion hydrogen bonds. Tetrahedron Letters, 42, (38), 6759-6762. (doi:10.1016/S0040-4039(01)01337-5).
Gale, Philip A., Hursthouse, Michael B., Light, Mark E., Sessler, Jonathan L., Warriner, Colin N. and Zimmerman, Rebecca S. (2001) Ferrocene substituted calix[4]pyrrole: a new electrochemical sensor for anions involving CH...anion hydrogen bonds. Tetrahedron Letters, 42, (38), 6759-6762. (doi:10.1016/S0040-4039(01)01337-5).
Gale, P.A., Camiolo, S., Hursthouse, M.B., Light, M.E., Coles, S.J., Loeb, S.J., Bondy, C.R., Chapman, C.P., Ogden, M.I., White, A.H. and Skelton, B.W. (2001) New organic and inorganic hydrogen bond donating anion receptors. Abstracts of Papers of the American Chemical Society, 222, U517-U517.
Light, M.E., Camiolo, S., Gale, P A. and Hursthouse, M.B. (2001) Anion-anion one-dimensional chain formation within cationic channels in tetrabutylammonium dihydrogenphosphate dichloromethane solvate. Acta Crystallographica Section E-Structure Reports Online, 57, (8), O727-O729. (doi: 10.1107/S1600536801011746).
Sessler, J. L., Kral, V., Gale, P. A., Anzenbacher, P., Davis, J. A., Bucher, C., Shriver, J., Zimmerman, R., Miyaji, H., Genge, J., Andrioletti, B., Try, A., Black, C. B. and Marquez, M. (2001) Polypyrrole-based anion binding agents. Abstracts of Papers of the American Chemical Society, 222, U517.
Light, M.E., Gale, P.A. and Hursthouse, M.B. (2001) Anion-anion dimerization in tetrabutylammonium hydrogensulfate. Acta Crystallographica Section E - Structure Reports Online, 57, (8), O705-O706. (doi:10.1107/S1600536801011321).
Gale, Phillip A. (2001) Anion receptor chemistry: highlights from 1999. Coordination Chemistry Reviews, 213, (1), 79-128. (doi: 10.1016/S0010-8545(00)00364-7).
Camiolo, S., Coles, S.J., Gale, P.A., Hursthouse, M.B. and Sessler, J.L. (2001) Tetrabutylammonium meso-octamethylcalix[4]pyrrole fluoride dichloromethane solvate. Acta Crystallographica Section E-Structure Reports Online, 57, (9), o816-o818. (doi:10.1107/S1600536801012880).
Bondy, Chantelle R., Gale, Philip A. and Loeb, Stephen J. (2001) Platinum(II) nicotinamide complexes as receptors for oxo-anions. Chemical Communications, (8), 729-730. (doi: 10.1039/b101440o).
Beer, Paul D. and Gale, Philip A. (2001) Anion recognition and sensing: the state of the art and future perspectives. Angewandte Chemie International Edition, 40, (3), 486-516. (doi: 10.1002/1521-3773(20010202)40:3<486::AID-ANIE486>3.0.CO;2-P).
Mahoney, Joseph M., Marshall, R. Andrew, Beatty, Alicia M., Smith, Bradley D., Camiolo, Salvatore and Gale, Philip A. (2001) Complexation of alkali chloride contact ion-pairs using a 2,5-diamidopyrrole crown macrobicycle. Journal of Supramolecular Chemistry, 1, 289-292. (doi:10.1016/S1472-7862(02)00068-0).
Camiolo, Salvatore, Gale, Philip A., Light, Mark E. and Hursthouse, Michael B. (2001) A new bis-amidinium calix[4]arene difluorphosphinate network: an unexpected but not unwelcome guest. Supramolecular Chemistry, 13, (5), 613-618.
Gale, Philip A., Camiolo, Salvatore, Chapman, Christopher P., Light, Mark E. and Hursthouse, Michael B. (2001) Hydrogen-bonding pyrrolic amide cleft anion receptors. Tetrahedron Letters, 42, (30), 5095-5097. (doi:10.1016/S0040-4039(01)00896-6).
Camiolo, S., Coles, S.J., Gale, P.A., Hursthouse, M.B. and Paver, M.A. (2001) meso-Octacyclopropylcalix[4]pyrrole ethanol solvate. Acta Crystallographica Section E-Structure Reports Online, 57, (3), o258-o260. (doi:10.1107/S1600536801002719).
Gale, Philip A., Bleasdale, Ellen R. and Chen, George Z. (2001) Synthesis and electrochemical polymerisation of calix[4]pyrroles containing N-substituted pyrrole moieties. Supramolecular Chemistry, 13, (4), 557-564.
Coles, Simon J., Gale, Philip A. and Hursthouse, Michael B. (2001) The first example of an anion–pyrrole complex. CrystEngComm, 3, (53), 1-3. (doi: 10.1039/b109813f).
Camiolo, Salvatore, Gale, Philip A., Ogden, Mark I., Skelton, Brian W. and White, Allan H. (2001) Solid-state and solution studies of bis-carboxylate binding by bis-amidinium calix[4]arenes. Journal of the Chemical Society, Perkin Transactions 2, 1294-1298. (doi:10.1039/b102831f).
Gale, Philip A., Camiolo, Salvatore, Tizzard, Graham J., Chapman, Christopher P., Light, Mark E., Coles, Simon J. and Hursthouse, Michael B. (2001) 2-Amidopyrroles and 2,5-diamidopyrroles as simple anion binding agents. Journal of Organic Chemistry, 66, (23), 7849-7853. (doi:10.1021/jo016020g).
Camiolo, Salvatore, Coles, Simon J., Gale, Philip A., Hursthouse, Michael B., Mayer, Thomas A. and Paver, Michael A. (2000) Hydrogen bonding networks and anion coordination in (η6-arene)Cr(CO)3 complexes: metal carbonyls as hydrogen bond acceptors. Chemical Communications, (4), 275-276. (doi:10.1039/a909861e).
Camiolo, Salvatore and Gale, Philip A. (2000) Fluoride recognition in 'super-extended cavity' calix[4]pyrroles. Chemical Communications, (13), 1129-1130. (doi:10.1039/b003229h).
Miyaji, Hidekazu, Anzenbacher Jr., Pavel, Sessler, Jonathan L., Bleasdale, Ellen R. and Gale, Philip A. (1999) Anthracene-linked calix[4]pyrroles: fluorescent chemosensors for anions. Chemical Communications, (17), 1723-1724. (doi:10.1039/a905054j).
Gale, Philip A. (1998) Bis-amidinium calixarenes: Templates for self-assembled receptors. Tetrahedron Letters, 39, (22), 3873-3876. (doi:10.1016/S0040-4039(98)00650-9).
Gale, Philip A., Genge, John W., Král, Vladimír, McKervey, M. Anthony, Sessler, Jonathan L. and Walker, Andrew (1997) First synthesis of an expanded calixpyrrole. Tetrahedron Letters, 38, (49), 8443-8444. (doi:10.1016/S0040-4039(97)10275-1).
Sessler, Jonathan L., Gebauer, Andreas and Gale, Philip A. (1997) Anion binding and electrochemical properties of calix[4]pyrrole ferrocene conjugates. Gazzetta Chimica Italiana, 127, 723-726.
Gale, Philip A., Sessler, Jonathan L., Allen, William E., Tvermoes, Nicolai A. and Lynch, Vincent (1997) Calix[4]pyrroles: C-rim substitution and tunability of anion binding strength. Chemical Communications, (7), 665-666. (doi:10.1039/a700685c).
Allen, William E., Gale, Philip A., Brown, Christopher T., Lynch, Vincent M. and Sessler, Jonathan L. (1996) Binding of neutral substrates by calix[4]pyrroles. Journal of the American Chemical Society, 118, (49), 12471-12472. (doi:10.1021/ja9632217).
Sessler, Jonathan L., Andrievsky, Andrei, Gale, Philip A. and Lynch, Vincent (1996) Anion binding: self-assembly of polypyrrolic macrocycles. Angewandte Chemie International Edition in English, 35, (23-24), 2782-2785. (doi:10.1002/anie.199627821).
Gale, Philip A., Sessler, Jonathan L., Lynch, Vincent and Sansom, Petra I. (1996) Synthesis of a new cylindrical calix[4]arene-calix[4]pyrrole pseudo dimer. Tetrahedron Letters, 37, (44), 7881-7884. (doi:10.1016/0040-4039(96)01805-9).
Gale, Philip A., Sessler, Jonathan L., Král, Vladimír and Lynch, Vincent (1996) Calix[4]pyrroles: old yet new anion-binding agents. Journal of the American Chemical Society, 118, (21), 5140-5141. (doi:10.1021/ja960307r).
Beer, Paul D., Gale, Philip A., Chen, Zheng and Drew, Michael G.B. (1996) New bis- and tris-ferrocenoyl and tris-benzoyl lower-rim substituted calix[5]arene esters: synthesis, electrochemistry and x-ray crystal structures. Supramolecular Chemistry, 7, (4), 241-255. (doi:10.1080/10610279608035195).
Chen, Zheng, Gale, Philip A. and Beer, Paul D. (1995) Synthesis and electrochemical polymerization of calix[4]arenes containing N-substituted pyrrole moieties. Journal of Electroanalytical Chemistry, 393, (1-2), 113-117. (doi:10.1016/0022-0728(95)04029-N).
Chen, Zheng, Fox, Judith M., Gale, Philip A., Pilgrim, Alexandra J., Beer, Paul D. and Rosseinsky, Matthew J. (1995) Effects of calixarenes on the electrochemical reduction of buckminsterfullerene, C60. Journal of Electroanalytical Chemistry, 392, (1-2), 101-105. (doi:10.1016/0022-0728(95)04137-D).
Beer, Paul D., Crane, Christopher G., Danks, Jonathan P., Gale, Philip A. and McAleer, Jerome F. (1995) Towards conformationally dependent redox-responsive molecular switches. New polyferrocene bis benzo crown ether receptors. Journal of Organometallic Chemistry, 490, (1-2), 143-148. (doi:10.1016/0022-328X(94)05191-D).
Beer, Paul D., Gale, Philip A. and Hesek, Dusan (1995) A neutral upper to lower rim linked bis-calix[4]arene receptor that recognises anionic guest species. Tetrahedron Letters, 36, (5), 767-770. (doi:10.1016/0040-4039(94)02363-G).
Beer, Paul D., Chen, Zheng, Drew, Michael G.B. and Gale, Philip A. (1995) Synthesis and X-ray crystal structure of a new redox-active calix[5]arene containing a totally included ethanol molecule. Journal of the Chemical Society, Chemical Communications, (18), 1851-1852. (doi:10.1039/c39950001851).
Beer, Paul D., Chen, Zheng, Drew, Michael G.B. and Gale, Philip A. (1994) Metal, ammonium and alkyl ammonium cation recognition by a novel calix[4]arenediquinone crown ether. Journal of the Chemical Society Chemical Communications, (19), 2207-2208. (doi:10.1039/c39940002207).
Chen, Zheng, Gale, Philip A., Heath, Jennifer A. and Beer, Paul D. (1994) Electrochemical studies of the conformational and sodium cation complexation properties of calix[4]arenediquinones. Journal of the Chemical Society Faraday Transactions, 90, (19), 2931-2938. (doi:10.1039/ft9949002931).
Beer, Paul D., Chen, Zheng, Gale, Philip A., Heath, Jennifer A., Knubley, Rachel J., Ogden, Mark I. and Drew, Michael G.B. (1994) Cation recognition by new diester- and diamide-calix[4]arenediquinones and a diamide-benzo-15-crown-5-calix[4]arene. [in special issue: On the 50th Anniversary of Calixarenes] Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 19, (1-4), 343-359. (doi:10.1007/BF00708992).
Beer, Paul D., Drew, Michael G.B., Gale, Philip A., Leeson, Philip B. and Ogden, Mark I. (1994) Structures of potassium encapsulated within the 1,3-alternate conformation of calix[4]arenes. Journal of the Chemical Society Dalton Transactions, (23), 3479-3485. (doi:10.1039/dt9940003479).

Book

Sessler, Jonathan L., Gale, Philip A. and Cho, Won-Seob (2006) Anion Receptor Chemistry, London, UK, Royal Society of Chemistry, 400pp. (Monographs in Supramolecular Chemistry).
Beer, Paul D., Gale, Philip A. and Smith, David K. (1999) Supramolecular chemistry, Oxford, GB, Oxford University Press, 96pp. (Oxford Chemistry Primers, 74).

Book Section

Gale, Philip A. and Haynes, Cally J.E. (2012) Anion receptors containing heterocyclic rings. In, Steed , Jonathan W. and Gale , Philip A. (eds.) Supramolecular Chemistry: from Molecules to Nanomaterials, 8 Volume Set. London, GB, Wiley-Blackwell. (doi:10.1002/9780470661345.smc062).
Steed, Jonathan W., Atwood, Jerry L. and Gale, Philip A. (2012) Definition and emergence of supramolecular chemistry. In, Steed , Jonathan W. and Gale , Philip A. (eds.) Supramolecular Chemistry: from Molecules to Nanomaterials, 8 Volume Set. London, GB, Wiley-Blackwell. (doi:10.1002/9780470661345.smc002).
Gale, Philip A. and Quesada, Roberto (2009) Developments in anion coordination and anion templated assembly. In, Ariga, Katsuhiko and Nalwa, Hari Singh (eds.) Bottom-Up Nanofabrication. California, US, American Scientific Publishers, 417-434. (Nanotechnology Book Series, 3).
Brooks, Simon J. and Gale, Philip A. (2005) Cyclic and acyclic amidopyrrole containing anion receptors. In, Gloe, Karsten (ed.) Macrocyclic Chemistry: Current Trends and Future Perspectives. Dordrecht, The Netherlands, Springer, 153-172.
Gale, Philip A. (2004) Amide and Urea based anion receptors. In, Atwood, Jerry L. and Steed, Jonathan W. (eds.) Encyclopedia of Supramolecular Chemistry. New York, USA, Marcel Dekker Inc, 31-41. (Submitted). (DOI: 10.1081/E-ESMC 120012830).
Evans, Louise S. and Gale, Philip A. (2003) Anion-Templated Self-Assembly: Inorganic Compounds. In, Schwarz, James A., Contescu, Cristian I. and Putyera, Karol (eds.) Dekker Encyclopedia of Nanoscience and Nanotechnology. New York, Dekker, 55-68. (Submitted). (DOI: 10.1081/E-NN 120018336).
Camiolo, Salvatore, Gale, Philip A. and Sessler, Jonathan L. (2002) Pyrrole and polypyrrole based anion receptoes. In, Atwood, Jerry L. and Steed, Jonathan W. (eds.) Encyclopedia of Supramolecular Chemistry. New York, Dekker, 1176-1185. (Submitted). (DOI: 10.1081/E-ESMC 120012773).

Conference or Workshop Item

Gale, Philip A. (2004) Cyclic and Acyclic Pyrrole Based Anion Receptors. At 3rd International Conference on Porphyrins and Phthalocyanines, New Orleans, Louisiana, USA, 11 - 16 Jul 2004.
Gale, Philip A. (2004) Molecular recognition and structural chemistry of some new anion receptors. At 227th American Chemical Society National Meeting and Exposition, Anaheim, California, 28 Mar - 01 Apr 2004.
Gale, Philip A. (2002) 2,5-Diamidopyrrole clefts and other new anion receptors. At 37th Midwest regional meeting of the American Chemical Society, Lawrence, Kansas, USA, 23 - 25 Oct 2002.
 

Research

Research Interests

Anions are ubiquitous in the Natural world. Chloride anions are present in large quantities in the oceans; nitrate and sulfate are present in acid rain; and carbonates in biomineralised materials. Anthropogenic anions including pertechnetate, a radioactive product of nuclear fuel reprocessing, and phosphate and nitrates from agriculture and other human activities, constitute major pollution hazards. Anions are also critical to the maintenance of life. Indeed, without exaggeration, the recognition, transport or transformation of anions is involved at some level in almost every conceivable biochemical operation. It is essential in the formation of the majority of enzyme–substrate and enzyme–cofactor complexes as well as in the interaction between proteins and RNA or DNA. ATP, phosphocreatine and other high-energy anionic phosphate derivatives, power processes as diverse and important as biosynthesis, molecular transport and muscle contraction while serving as the energy currency for a host of enzymatic transformations. Anion channels and carriers are involved in the transport of small anions such chloride, phosphate and sulfate and thus serve to regulate the flux of key metabolites into and out of cells while maintaining osmotic balance.

Supramolecular chemistry is the area of chemistry involved with the control of molecular interactions to produce useful new devices and molecular assemblies. Our work in molecular recognition involves the design and synthesis of smart molecules for use as receptors or sensors for other ionic (in our group frequently anionic) or molecular species. Design is at the heart of our work – we are frequently inspired by biological systems – but are not limited by them – we ultimately design and make new molecules ourselves that allows us to explore a wide range of molecular geometries and functional groups (and is a lot of fun!). So we can take a molecule from the drawing board through to use as a sensor, selective extraction agent or membrane transport agent for a particular chemical species. A wide range of skills are need to do this including synthesis and also the ability to study how molecules interact with each other using NMR and UV/vis spectroscopies, isothermal titration calorimetry and electrochemistry. Working with the world-leading crystallographers in the school we also study the structure of receptors and complexes in the solid state. Our specific interests are in the structural chemistry, selective recognition and sensing of anionic species. Anions have historically been neglected species in molecular recognition and it has only been since the late 1980s that significant effort has been devoted to the problem of selective anion complexation and recognition.

Research keywords

Supramolecular Chemistry, Anion Receptor Chemistry, Coordination Chemistry, Hydrogen bonding, Membrane Transport.

Research funding

2013 DSTL MOD CDE 28704 Generation after next chemical, biological & radiological hazard mitigation systems. (£85k)

2012-2015 EU Interreg “A-I Chem Channel” D.C. Harrowven, R.C.D. Brown, B. Linclau, R.J. Whitby, R. Raja, E. Stulz, P.A. Gale. £613666.

2012-2015 EPSRC Responsive Mode: “Synthetic Anionophores with Therapeutic Potential – A coordinated two centre approach (£317k to Southampton, P.A Gale (PI)) (£683k to Bristol A.P. Davis (PI) (Bristol) and D.N. Sheppard (Bristol)).

2010-2015 EPSRC UK National Crystallography Service (£3.57m).

2008-2012 EPSRC Project “Selective receptors for the transmembrane transport of bicarbonate (£425k) EPSRC-NSF Collaboration in conjunction with Prof. Jeff Davis (University of Maryland).

2006-2010 EU Marie Curie Transfer of Knowledge Partnership “Food-BioSens” (€95k) Collaborative grant with Prof Jerzy Radecki, Poland.

2006-2009 EPSRC Project studentship “C-Cycle” (£105k)

2006-2009 EPSRC “Supramolecular Approaches to Membrane Co-transport of HCl” (£208k)

Primary research group:  Functional Inorganic, Materials and Supramolecular Chemistry

Research projects

Gale: Membrane Transporters for Anions

Gale: Hydrogen bonding receptors for guest binding

Contact

Professor Philip A Gale
Chemistry
University of Southampton
Highfield
Southampton
SO17 1BJ

Room Number: 30/4037

Telephone: (023) 8059 3332
Email: philip.gale@soton.ac.uk