BIOL1005 Cell Biology & Genetics
Aims and Objectives
The aim of this module is to provide an introduction to Cell Biology and Genetics from general principles to modern day applications; you should aim to understand, appreciate, be familiar with, and realise the significance of the module contents.
Having successfully completed this module you will be able to:
- Comprehend and describe the features of prokaryote and Eukaryote cells, the composition and spatial organisation of the cell. The structure and features of major organelle systems including the nucleus, the secretory vacuolar system (endoplasmic reticulum, golgi, lysosomes), mitochondria, plant cells with chloroplasts and cytoplasmic vacuole. Plasma membrane and mechanisms of transport into and out of the cell. Protein production and sorting. The cytoskeleton and its role in the cell.
- Comprehend and describe chromatin structure, gene regulation, and the ways in which molecular biology throws light on gene function and the genetic regulation of cell specialisation. Techniques of recombinant DNA and cloning, its use and implications in biotechnology and genetic engineering. Cancer, tumorigenesis and the cell cycle. Cell determination and differentiation and the role of stem cells in cell replacement in humans. The transmission of genetic material in cell division by mitosis or meiosis, the control of these processes and how cell division fits within the cell cycle. Human Spermatogenesis and Oogenesis in relation to cell division. The phenomenon and implications of Chromosome karyogamy, variation in chromosome number (polyploidy and aneuploidy). The analysis of genetic variation in inheritance and transmission genetics including epistasis. Sex determination, sex linkage, human pedigree analysis. The contents can be liable to change from year to year.
- The laboratory practicals should enable you to understand the application and be able to describe the theory behind the practical experiments. Develop practical expertise relevant to the experiments performed and be able to interpret the results. Present practicals include: Immunocytochemistry and Cell Proliferation, DNA restriction & electrophoresis, induction of B-galactosidase in E.coli, Mitosis and chromosome karyogamy.
This module is an introduction to Cell Biology & Genetics from general principles to modern day applications. For more details content see above
Learning and Teaching
Teaching and learning methods
Lectures, wet practicals, Blackboard, formative and summative assessment, and independent study
|Practical classes and workshops||12|
|Total study time||150|
Resources & Reading list
Campbell, N.A. & Reece, J.B. Biology.
Klug, W.S. et al.. Concepts of Genetics.
Alberts, B et al. Molecular Biology of the Cell.
|Written exam (1 hours)||75%|
Repeat type: Internal & External