The University of Southampton
Courses

BIOL2010 Flow of Genetic Information

Module Overview

This module focuses on nucleic acid and protein biogenesis with particular emphasis on the flow of genetic information from DNA to RNA to proteins and key regulatory steps. Material relating to both prokaryotic and eukaryotic organisms will be covered.

Aims and Objectives

Module Aims

The aim of this module is to extend and develop the first year Biochemistry modules. The module focuses on nucleic acid and protein biogenesis with particular emphasis on the flow of genetic information from DNA to RNA to proteins and key regulatory steps. Material relating to both prokaryotic and eukaryotic organisms will be covered.

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • Identify the major findings of the human genome project
  • Compare and contrast the organisation of typical eukaryotic and prokaryotic genomes
  • Identify the problems for the replication of DNA created by its structure
  • Provide evidence of understanding of the processes of initiation and termination of DNA replication and ascribe functions to enzymes/proteins at the replication fork
  • Explain how information is transferred from DNA to RNA and explain how it is regulated in both eukaryotic and prokaryotic organisms
  • Describe the post-transcriptional modifications (processes of mechanisms) associated of protein coding RNA in eukaryotes
  • Identify processes that lead to DNA damage and the mechanisms and enzymes involved in DNA repair
  • Describe the process of information transfer from mRNA to protein including the roles for ribosomal proteins and translation factors

Syllabus

This module covers the flow of genetic information from the organisation of genomes, both prokaryotic and eukaryotic, genome replication, the biosyntheses of RNA and proteins. Where appropriate the regulatory mechanisms controlling key stages will be studied. Students will be made aware of genome projects and their impact on biological sciences.

Special Features

N/A

Learning and Teaching

Teaching and learning methods

Teaching will be by 11x 2 hour lectures and a final 2 hour revision lecture. Teaching will be supplemented with 3 tutorials in which students have to present on a topic related to aspects of the course and/or to provide scientific summaries on the topic and receive feedback. Continual assessment (course work) is in the form of five practicals undertaken in pairs, although the write-up is on an individual basis.

TypeHours
Practical classes and workshops15
Independent Study109
Lecture24
Total study time148

Assessment

Summative

MethodPercentage contribution
Class practicals 25%
Written exam  (2 hours) 75%

Referral

MethodPercentage contribution
Coursework 25%
Written exam  (2 hours) 75%

Linked modules

Pre-requisites: BIOL1007 OR BIOL1010 and BIOL1008 OR BIOL1022

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