The University of Southampton
Courses

BIOL3017 Molecular and Structural Basis of Disease

Module Overview

The course provides an insight into how molecular studies can be employed to further medical research and aid in the development of novel treatments and therapeutics. The course will cover a number of areas including the analysis of genetic diseases, amyloid diseases, the role of kinases in cancer, molecular understanding of diabetes, viral and bacterial infections.

Aims and Objectives

Module Aims

This module is designed for the biomedical scientists and biochemists to explore the molecular aspects of human disease and how this has contributed to knowledge based treatment strategies and the development of novel therapeutics.

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • Understand the molecular basis of genetic diseases.
  • Demonstrate how genes are linked to particular disorders through positional cloning.
  • Understand the molecular processes that lead to development of amyloid diseases and demonstrate how this knowledge is driving the development of potential therapeutic strategies
  • Describe the molecular details of selected protein kinases and their inhibitors in cancer development and treatment.
  • Molecular understanding of diabetes and insulin.
  • Provide a molecular description of viral infection and demonstrate how this has contributed to the development of therapeutic compounds.

Syllabus

The course provides an insight into how molecular studies can be employed to further medical research and aid in the development of novel treatments and therapeutics. The course will cover a number of areas including the analysis of genetic diseases, amyloid diseases, the role of kinases in cancer, molecular understanding of diabetes, viral and bacterial infections. The lectures will: (i) emphasise selected medical examples where biochemical knowledge has provided an essential foundation for the understanding or management of human disease; (ii) describe the different types of genetic diseases and detail how they are identified and characterised; (iii) explain how our detailed knowledge of the molecular structure of enzymes and proteins has led to a molecular description of disease and infection, and (iv) how this molecular understanding of disease has contributed to knowledge based treatment strategies and the design of new therapeutics.

Learning and Teaching

Teaching and learning methods

Lectures. Students are strongly encouraged to attempt exam questions from previous years and to submit these for comments and feedback.

TypeHours
Lecture24
Independent Study126
Total study time150

Assessment

Summative

MethodPercentage contribution
Written exam  (2 hours) 100%

Referral

MethodPercentage contribution
Written exam  (2 hours) 100%
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