The University of Southampton
Courses

BIOL3026 Pathophysiology of the Lung

Module Overview

The unit comprises lectures on the risk factors, pathophysiology and therapy for three very common but distinct lung diseases, asthma, COPD and cystic fibrosis. We will examine current therapies and the development of new approaches based on our understanding of the underlying disease mechanisms. In addition to an in depth exploration of pulmonary disease pathology we will examine the role of early life factors such as infections and genetics influences the outcomes in chronic lung disease.

Aims and Objectives

Module Aims

The aim of this module is to give students a sound background in modern molecular medicine using examples from pulmonary health and disease. The course focuses on three common lung diseases, asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis and seeks to outline the pathology of these three very distinct lung diseases and different approaches to their treatment. It will also highlight the ability of different external factors to influence outcomes in chronic lung disease.

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • Explain the role of mast cells and eosinophils in allergic disease.
  • Identify the cells responsible for the synthesis of immunoglobulin E
  • Identify the major pharmacological targets available to treat allergy and asthma and emerging therapeutic targets.
  • Discuss our current understanding of the influence of early life factors on the development of allergic disease.
  • Describe the main characteristics of chronic obstructive pulmonary disease (COPD) and current hypotheses pertaining to its pathology.
  • Identify the problems associated with treating COPD and some of the potential therapeutic strategies.
  • Describe the clinical symptoms and cellular pathology underlying cystic fibrosis.
  • Discuss the concepts and technical approaches to cystic fibrosis therapy.

Syllabus

The unit comprises lectures on the risk factors, pathophysiology and therapy for three very common but distinct lung diseases, asthma, COPD and cystic fibrosis. We will examine current therapies and the development of new approaches based on our understanding of the underlying disease mechanisms. In addition to an in depth exploration of pulmonary disease pathology we will examine the role of early life factors such as infections and genetics influences the outcomes in chronic lung disease.

Learning and Teaching

Teaching and learning methods

Lectures and independent study

TypeHours
Independent Study126
Lecture24
Total study time150

Assessment

Summative

MethodPercentage contribution
Written exam  (2 hours) 100%

Referral

MethodPercentage contribution
Written exam  (2 hours) 100%
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