CHEM1041 Fundamentals of Organic Chemistry I for non-chemists
Aims and Objectives
The aim of this course is to provide a core for future studies in chemistry and allied subjects, in aspects of Organic Chemistry as specified below Teaching in this course recognises the diversity of our intake in terms of A level syllabus followed and choice of non-Chemistry A level subjects (maths, physics, etc.). The aim of this organic chemistry course is to introduce students to many of the key concepts of structure and reactivity in organic chemistry: Structure – of molecules: functional groups, isomerism including stereochemistry and optical activity, nomenclature, introduction to infrared spectroscopy (functional groups); bonding (electronic structure, orbitals, hybridisation and shape); conformational analysis of linear and cyclic molecules. Reactivity – drawing and predicting resonance structures and reaction mechanisms by using curly arrows; understanding electron-rich and electron-deficient sites and species; acidity (alcohols, phenols, carboxylic acids, sulfonic acids, as well as halogen, nitrogen and carbon acids); basicity (conjugate bases of all classes of acids studied, and including such common bases as BuLi, LDA, NaH, hydroxide and alkoxides, amines); connections between electronic effects and acidity/basicity; aromaticity and introduction of the reactivity of aromatic compounds compared to alkenes; nucleophilic substitution at sp³ carbon (SN1 and SN2 mechanisms).
Having successfully completed this module you will be able to:
- Recognise and name a wide range of functional groups and interpret their IR spectra
- Draw representations of the chemical structure of organic molecules using a concise notation.
- Understand and use sawhorse and Newman projections, 3D structures of organic molecules including cyclic structures
- Name a wide range of organic molecules, including stereochemistry
- Describe the structure (including electronic configuration) of organic molecules in terms of orbitals, hybridisation and conformation, including stereoisomerism
- Understand the relative stability of conformations of linear and cyclic organic molecules.
- Identify electron-rich and electron-poor sites within molecules, by using the concepts of electronegativity, inductive effects and mesomeric (resonance) effects
- Apply the curly arrow notation to describe both resonance and reaction mechanisms
- Predict the relative acidity and basicity of organic molecules, and describe these properties with the concepts of pKa and pKaH
- Explain the connections between electronic effects and acidity/basicity
- Explain the concept of aromaticity and identify both aromatic and non-aromatic molecules
- Describe nucleophilic substitution reactions by both the SN1 and SN2 mechanisms
- Explain the factors that influence SN1 and SN2 reaction rates, including the roles of steric effects, orbital effects and electronic effects.
Structure – of molecules: functional groups, isomerism including optical activity, nomenclature, introduction to infrared spectroscopy (functional groups); bonding (orbitals, hybridisation and shape of organic species); conformational analysis. Reactivity – curly arrows, electron-rich and electron-deficient species, acidity (alcohols, phenols, carboxylic acids, and C—H acids); basicity (BuLi, LDA, hydroxide and alkoxides, amines); resonance; aromaticity and introduction of the reactivity of aromatic compounds compared to alkenes; nucleophilic substitution at sp³ carbon (SN1 and SN2 mechanisms).
Learning and Teaching
Teaching and learning methods
Lectures, problem-solving seminars with group working and tutor support Feedback is provided • In tutorials through assistance with the set work. • Through the marks achieved in the in online tests. • Through generic feedback following the examinations. • Upon request by viewing of marked examination scripts
|Wider reading or practice||17|
|Preparation for scheduled sessions||24|
|Total study time||75|
Resources & Reading list
James Keeler and Peter Wothers (2008). Chemical Stucture and Reactivity.
Andrew Burrows, John Holman, Andrew Parsons, Gwen Pilling, and Gareth Price (2009). Chemistry3: Introducing inorganic, organic, and physical chemistry.
J Clayden, N Greeves and S Warren (2012). Organic Chemistry (2nd Edition).
|Examination (1.5 hours)||100%|
|Exam (1.5 hours)||100%|
Pre-requisite: A-Level Chemistry or the equivalent