The University of Southampton

CHEM3025 Advanced Chemistry II for Students on Placement – Distance Learning

Module Overview

Advanced Chemistry II for students on placement

Aims and Objectives

Module Aims

This unit delivers core chemistry teaching to students on placement away from the University. This will be achieved with interactive resources designed for online delivery, including lecture-style presentations, formative problems and regular summative assessments. Further support will be given at support forums in which students will return to Southampton for workshops and other activities.

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

  • Further develop independent learning and time management skills.
  • Improve standard of written and oral presentation.
  • Understand fundamental organic reactions including further transformations and principles.
  • Discuss the synthesis of macrocyclic ligands and their complexes, stability and applications.
  • Explain the roles of different metals in biological systems.
  • Consolidate and deepen understanding of aspects of physical chemistry


Synthetic methods in organic chemistry Students will gain new insights into the factors governing the mechanistic, stereochemical and regiochemical course of many modern synthetic processes. Throughout the course the usefulness of the chemistry discussed with be highlighted through topical applications in industry and academe. The first part will focus on radical reactions and their use in organic synthesis, including structure, stability and reactions of carbon-centred radicals. A series of systems will be developed to illustrate chain reactions, carbon-carbon bond formation, addition and intramolecular reactions including ring closure. Kinetic, electronic, steric and stereochemical factors will be examined. The second part considers the use of carbanions and stereocontrol in organic synthesis. This will include methods for carbanion formation, directed metallation of aromatic compounds, dianion chemistry, sulfur stabilised species, olefination and asymetric synthesis. Macrocyclic and bioinorganic chemistry This course will first consider macrocyclic ligands and kinetic and thermodynamic aspects of their stabilisation of coordination complexes (rates of formation and dissociation, entropy, enthalpy, preorganisation). Specific topics examined include the selectivity of crown ethers to coordinating different metals, cyclisation methods (template vs high dilution), ring closure reactions for N-, O-, S- containing macrocycles, and transition metal complexes (synthesis, properties, redox reactions and stabilisation of unusual oxidation states). The significance of macrocycles in bioinorganic chemistry will be explained. In the second part the reasons why particular elements are used in biological systems will be considered: group 1 and 2 metals in biological systems (bioavailability, chemical potentials, membrane transport, biomineralisation); transport and storage of metals and oxygen, focusing on iron; biological redox processes, the chemistry of vitamin B12 and copper and cobalt species; structural and catalytic properties of zinc; metals in medicine including the uses of platinum and technetium. Atmospheric Chemistry • The evolution and structure of the atmosphere. • The importance of chemical cycles and of trace species in the atmosphere. • Review of fundamental kinetics, thermodynamics and spectroscopy relevant to atmospheric chemistry • Models used to simulate atmospheric processes; kinetics and photochemistry applied to the atmosphere • Chemistry of the Stratosphere: The Ozone Layer, “Spray Cans” and Ozone depletion and the Ozone Hole • Chemistry of the Natural and Polluted Troposphere: Cars, Smog, Acid Rain • Climate Change and global warming. • Laboratory and field methods to study species, reactions and transport of importance in the atmosphere. • Remote sensing techniques: Spectroscopy

Learning and Teaching

Teaching and learning methods

Distance learning packs and support forums

Guided independent study200
Completion of assessment task6
Total study time300

Resources & Reading list

P W Atkins and J de Paula (2007). Elements of Physical Chemistry. 

F A Carey and R J Sundberg (1990). Advanced organic chemistry. 

D E Fenton (1995). Bio-coordination Chemistry. 

M B Smith. Organic synthesis. 

E C Constable (1999). Coordination chemistry of macrocyclic compounds. 



MethodPercentage contribution
Assessment 50%
In-class Test 25%
Learning Pack Assessment 25%


MethodPercentage contribution
Assessment 50%
Coursework 50%

Linked modules

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