The University of Southampton
Courses

# MATH6143 Survival Models

## Module Overview

This module introduces some of the fundamental ideas and issues of lifetime and time-to-event data analysis, as used in actuarial practice, biomedical research and demography

### Aims and Objectives

#### Module Aims

To introduce some of the fundamental ideas and issues of lifetime and time-to-event data analysis, as used in actuarial practice, biomedical research and demography.

#### Learning Outcomes

##### Learning Outcomes

Having successfully completed this module you will be able to:

• the key features of lifetime data, including censoring, and of probability models for lifetime data: survival function, hazard and force of mortality
• the theory underlying survival models and their estimation and of how to use R to fit models, including the Kaplan-Meier estimate of the survival function, parametric models and the Cox regression model
• models for human mortality, including how to compute and interpret the life table in a variety of contexts
• binomial and Poisson models of mortality and models of mortality and similar events which are specified as continuous-time discrete-state Markov processes
• the need to graduate crude data on mortality rates and an understanding of how to compare crude mortality rates against a standard of graduated set of rates
• analyse and interpret data, and especially to adopt a critical approach to numerical data
• solve problems, and especially to apply ideas learnt in one context to other contexts

### Syllabus

• Introduction to concepts of modelling, survival data and survival models; censoring; survival and hazard functions. • Estimating the survivor function non-parametrically (Kaplan-Meier and Nelson-Aalen estimators); parametric survival models; estimation using maximum likelihood. • Regression models for survival data; proportional hazards; the Cox regression model; accelerated failure time models. • Introduction to continuous-time, discrete-state Markov models; two-state and multiple-state models; Kolmogorov equations; estimating the parameters of multiple-state models. • Models for human mortality; the life table: theory and applications. • Comparison of models of mortality: Binomial, Poisson and multiple-state models. Estimation and inference using maximum likelihood and other methods. • Exposure to risk; the principle of correspondence; estimating the exposed-to-risk with aggregate data. • Comparison of mortality experiences; mortality rates and standardised mortality ratios; statistical tests appropriate for the comparison. • Graduation of mortality data; reasons for graduation; methods of graduation; tests of adherence to data and smoothness of a graduation. • Using R to analyse lifetime and survival data

### Learning and Teaching

#### Teaching and learning methods

Lectures, problem classes, computer laboratories

TypeHours
Teaching48
Independent Study102
Total study time150

#### Resources & Reading list

Reading List. A suggested reading list for each part, and starting references for each assessment, will be made available on Blackboard

D. Collett (2003). Modelling survival data in medical research..

A. Hinde (1998). Demographic methods.

### Assessment

#### Summative

MethodPercentage contribution
Data analysis project 20%
Exam  (120 minutes) 80%

#### Referral

MethodPercentage contribution
Exam 100%

#### Repeat Information

Repeat type: Internal & External

#### Co-requisites

To study this module, you will need to also study the following module(s):

CodeModule
MATH6122Probability and Mathematical Statistics

### Costs

#### Costs associated with this module

Students are responsible for meeting the cost of essential textbooks, and of producing such essays, assignments, laboratory reports and dissertations as are required to fulfil the academic requirements for each programme of study.

In addition to this, students registered for this module typically also have to pay for:

##### Books and Stationery equipment

Course texts are provided by the library and there are no additional compulsory costs associated with the module

Please also ensure you read the section on additional costs in the University’s Fees, Charges and Expenses Regulations in the University Calendar available at www.calendar.soton.ac.uk.