MB BS DM FRCPsych
- Primary position:
- Professor of Psychiatry
Professor Baldwin became Head of the Mental Health Group in 2008 and was awarded a Personal Chair in 2010. He trained in medicine at Charing Cross Hospital Medical School, London and then in psychiatry at St Mary's Hospital Medical School and the Maudsley Hospital, London.
Professor Baldwin leads a group that aims to improve clinical outcomes in patients with mood and anxiety disorders. This involves investigating the role of neurobiological and psychological factors in causing and maintaining illness; through improving trial design when evaluating efficacy and tolerability of treatment interventions; by assessing the effectiveness and acceptability of treatment interventions in wider clinical practice; through identifying more accurately those patient groups at particular risk of poor outcomes; and by offering a specialist clinical service to patients with chronic and treatment-resistant conditions.
He leads the Anxiety Disorders Research Network, an international multi-centre independent collaborative cross-disciplinary research grouping, with support from the European College of Neuropsychopharmacology (ECNP).
He is an Honorary Consultant Psychiatrist in Southern Health NHS Foundation Trust, where he leads the tertiary referral specialist service for patients with mood and anxiety disorders.
MB BS Medicine and Surgery, University of London 1984
DM University of Southampton 2004
MRCPsych 1988 and FRCPsych 2002
Lecturer in Psychiatry 1987-1988, St Mary’s Hospital Medical School
Clinical Research Fellow 1988-1990, St Mary’s Hospital Medical School
Honorary Senior Lecturer in Psychiatry, 1992-1994 Imperial College London
Senior Lecturer in Psychiatry 1994-2006, Southampton
Reader in Psychiatry 2006-2010, Southampton
Professor of Psychiatry 2010 onwards, Southampton
The University of Southampton's electronic library (e-prints)
Investigating the role of neurobiological and psychological factors in causing and maintaining illness
This includes investigations of attentional and interpretative biases in patients with anxiety disorders, before and after pharmacological treatment, and by conducting similar studies in first-degree relatives and healthy controls, designed to reveal endophenotypes for anxiety disorders. A similar approach is used to explore neuropsychological factors in causing and maintaining sleep disorders.
Improving trial design when evaluating efficacy and tolerability of treatment interventions
I work in partnership with pharmaceutical and biotechnology companies, through the University Research and Enterprise service, to refine the design of randomised controlled trials and facilitate development of improved psychotropic drugs. This has led to better understanding of the relative efficacy and safety of antidepressant and anxiolytic drugs, and of the mechanisms underlying antidepressant-associated sexual dysfunction, and then relationship between an early onset of clinical effect and the likelihood of responding to pharmacological treatment.
Assessing the effectiveness and acceptability of treatment interventions in wider clinical practice
Current collaborative studies include an evaluation of clinical and cost-effectiveness of antidepressant drugs in the treatment of negative symptoms of schizophrenia, and an investigation of the effects of mindfulness-based cognitive therapy in patients with highly recurrent unipolar depressive disorder and persistent mild depressive symptoms.
Identifying more accurately those patient groups at particular risk of poor outcomes
This includes identification of demographic and clinical factors associated with completed suicide after discharge from psychiatric inpatient care. Current research into attempted and completed suicide includes an investigation of suicides on the island of Jersey between 2000 and 2009.
Leading the Anxiety Disorders Research Network
This is an international multi-centre independent collaborative cross-disciplinary research grouping, with support from the ECNP. It currently includes 22 research groups in 16 centres across 10 countries, and aims to address currently unmet needs in anxiety and related disorders. This is achieved by harmonising research and clinical databases and refining research methodologies; by evaluating innovative interventions, particularly in previously neglected patient groups; and by building a platform for pragmatic randomised controlled effectiveness trials. 10 of the ADRN centres are involved in the European and South African Research Network in Anxiety Disorders (EUSARNAD) programme which I coordinate. The EUSARNAD is supported by the Marie Curie Actions (People) International Research Staff Exchange Scheme (PIRES-GA2010-269213).
Offering a specialist clinical research-lead service to patients with chronic and treatment-resistant conditions
Patients with mood and anxiety disorders are referred by secondary care services, across the south of England. Approximately 50% have recurrent unipolar depressive disorder, 25% bipolar disorder, and 25% an anxiety disorder, as the primary diagnosis. Around 50 patients are seen as new referrals each year.
Anyone interested in graduate studentships or post-doctoral positions (clinical) within the Mental Health Group are encouraged to contact Professor Baldwin directly.
Academic unit: Clinical and Experimental Sciences
Postgraduate student supervision
- 2013 Ben Ainsworth PhD
- 2012 David Bartram PhD
- 2007 Pippa Biswas DM
- 2006 Andrew Mayers PhD
- Daniel Meron DM
- Nupur Tiwari DM
- Louise Baker PhD
- Hesham Elnazer DM
- Michael Breen PhD
- Conal Twomey PhD
- Verity Pinkney PhD
- Joanna Miler PhD
- Claire Bakhtiar PhD
Faculty of Medicine
Head of Mental Health Group
Deputy Director of Clinical Neuroscience and Psychiatry Academic Sub-Unit
National and international responsibilities
Editor of Human Psychopharmacology
Responsible for liaison between the ECNP and European Medicines Agency
Medical Patron of the Anxiety UK
Past President of Depression Alliance
Vice Chair of the MOD Research Ethics Committee
BM5. Delivers lectures in Year 2 and seminars in Year 3.
BMedSci. Offers up to 4 project placements (joint supervision) in area of mood and anxiety disorders.
BSc Biomedical Science. ‘Masterclass’ on affective disorders.
Personal tutor for students throughout BM4, BM5 and BM6 curricula.
Professor David Baldwin
University Department of Psychiatry
Academic Centre, College Keep
4-12 Terminus Terrace
Southampton SO14 3DT
Phone: +44 (0) 23 8071 8520
Fax: +44 (0) 23 8071 8532
Room Number: College Keep/22