Dr Timothy Millar BSc (Hons), PhD
Lecturer in Pharmacology
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Dr Timothy Millar is Lecturer in Pharmacology within Medicine at the University of Southampton.
Research Focus : Cell trafficking and angiogenesis in inflammation and cancer
Inflammation is a required consequence of infection to return the body to homeostasis. Inappropriate inflammation can lead to compromised function. Conversely, in the surveillance of self, the immune system requires the ability to discern normal tissue from malignancy. The trafficking of immune cells into tissue follows a cascade of events and signals and the decision to initiate or regulate inflammation is controlled by the local microenvironment. The vascular endothelium plays a major role in the control of cell trafficking for both cells of the immune system and cancer cells during the process of metastasis. The ability to control new blood vessel growth but maintain immune surveillance would enhance our ability to tailor cellular recruitment into areas of inflammation and tumours growth. By dissecting the role of the endothelium and trafficking cells in these contexts, we expect to provide novel therapeutic targets.
Our research aims to target the vasculature to control inflammation in asthma and skin disease, cancer metastasis and immune surveillance to provide novel targets for the treatment of disease utilising functional in vitro human models and nanobiotechnology.
Examples of work streams:
1) Development of novel flow systems for the determination of leukocyte endothelial interaction.
2) Utilising derivetised nanoparticles in the control of new vessel formation and cancer cell killing in relation to tumours and their metastasis.
3) Fundamental assessment of stress signalling in the endothelium and its control by small molecules inhibitors.
4) Development of in vitro models of cancer cell metastasis and recruitment.
Impacts and achievements:
Managing to integrate University wide collaborations in endothelial function and targeting which will grow in the coming months and years.
BSc (Hons) Biological Sciences, University of Birmingham (1992)
PhD, University of Bath (2000)
Postgraduate Certificate in Academic Practice, University of Southampton (2008)
Sep 2003 - Sep ’06 CIHR Postdoctoral Training Fellowship in
Translational Research, Immunology Research Group, University of Calgary, Calgary, Alberta, Canada.
Oxygen sensing, MAPkinase signalling and leukocyte recruitment to the endothelium during ischaemia reperfusion
Jan 2000, Jun ‘03 Postdoctoral Research Fellow
Bone and Joint Research Group, Department of Medical Sciences, University of Bath, Bath. Nitric oxide and peroxynitrite generation from xanthine oxidase, its various roles as an antibiotic and inflammatory mediator.
Aug 95 – Dec 99 PhD student, Bone and Joint Research Unit,
University of London, London / Bone and Joint Research Group, University of Bath, Bath. Novel aspects of the activity and function of xanthine oxidase
Jan 94 - Jun 95 Research Assistant, Coagulation Research, St Thomas’ Hospital, London. Fibrinogen binding to human melanoma cells and its effect on metastatic potential
Jan 93 – Dec 93 Research Assistant, Biochemical Sciences, Wellcome Foundation Ltd, Beckenham, Kent. Neutrophil priming and secretion: signalling through phospholipase D