Medicine

Nicholas Clarke

ChM, FRCS, FRCS.Ed

Primary position:
Consultant Orthopaedic Surgeon
Other positions:
Honorary Professor of Orthopaedics

Background

The University of Southampton

Having been an orthopaedic consultant for over 20 years and specializing in paediatric orthopaedics, this has become the primary clinical and research focus. A co-founder of the International Hip Dysplasia Institute, member of council of the British Orthopaedic Association, member of several influential working groups, such as the National Coding Definitions and HRG Working Group and widely published in leading peer reviewed international journals. Giving lectures to an international audience by invitation including key note lectures at major conferences worldwide. Involved with both undergraduate and postgraduate medical teaching, as well as research and development within the University and the Trust.

Qualifications

MBChB, University of Bristol, 1974
FRCS, England, 1979
FRCS, Edinburgh, 1979
ChM, “Joint stress and blood supply in the pathogenesis of femoral capital epiphyseal dysplasia in congenital dislocation of the hip”., University of Bristol, 1987
DM, University of Southampton, 2012

Professor Nicholas Clarke's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Culliford, David, Maskell, Joe, Judge, A., Arden, N.K., Cooper, C., Mullee, M., Raftery, J., Carr, A., Price, A., Javaid, K., Beard, D., Altman, D., Clarke, N., Latham, J., Glynn-Jones, S. and Barrett, D. COAST Study group (2013) A population-based survival analysis describing the association of body mass index on time to revision for total hip and knee replacements: results from the UK general practice research database. BMJ Open, 3, (11), 1-9. (doi:10.1136/bmjopen-2013-003614). (PMID:24285628).
Clarke, Nicholas M.P., Reading, Isabel C., Corbin, Charles, Taylor, Colm C. and Bochmann, Thomas (2012) Twenty years experience of selective secondary ultrasound screening for congenital dislocation of the hip. Archives of Disease in Childhood, 97, (5), 423-429. (doi:10.1136/archdischild-2011-301085). (PMID:22412044).
Faust, Saul N., Clark, Julia, Pallett, Ann and Clarke, Nicholas M.P. (2012) Managing bone and joint infection in children. Archives of Disease in Childhood (doi:10.1136/archdischild-2011-301089). (PMID:22440930).
Clarke, Nicholas M.P. and Page, Jonathan E. (2012) Vitamin D deficiency: a paediatric orthopaedic perspective. Current Opinion in Pediatrics, 24, (1), 46-49. (doi:10.1097/MOP.0b013e32834ec8eb). (PMID:22189396).
Roposch, Andreas, Liu, Liang Q., Hefti, Fritz, Clarke, Nicholas M.P. and Wedge, John H. (2011) Standardized diagnostic criteria for developmental dysplasia of the hip in early infancy. Clinical Orthopaedics and Related Research, 469, (12), 3451-3461. (doi:10.1007/s11999-011-2066-9). (PMID:21952742).
Davies, Justin H., Reed, Joseph M., Blake, Elizabeth, Priesemann, Max , Jackson, Alan A. and Clarke, Nicholas M.P. (2011) Epidemiology of vitamin D deficiency in children presenting to a pediatric orthopaedic service in the UK. Journal of Pediatric Orthopaedics, 31, (7), 798-802. (doi:10.1097/BPO.0b013e31822f1af1).
Kurup, Harish V. and Clarke, Nicholas M.P. (2011) Sugioka transtrochanteric valgus osteotomy for hinge abduction in children. Journal of Pediatric Orthopaedics, 31, (7), 727-731. (doi:10.1097/BPO.0b013e31822f0670). (PMID:21926868).
McGillion, S and Clarke, N.M.P. (2011) lateral growth arrest of the proximal femoral physis – a new technique for serial radiological observation. Journal of Children's Orthopaedics, 5, (3), 201-207. (doi:10.1007/s11832-011-0339-1).
Taylor, Colm C. and Clarke, N.M.P. (2011) Amputation and intraosseous access in infants. BMJ, 342, (d2778) (doi:10.1136/bmj.d2778). (PMID:21622504).
Haidar, Saadallah George, Culliford, D.J., Gent, Edward David and Clarke, N.M.P. (2011) Distance from the growth plate and Its relation to the outcome of unicameral bone cyst treatment. Journal of Children's Orthopaedics, 5, (2), 151-156. (doi:10.1007/s11832-010-0323-1).
Bolland, Benjamin J., Wahed, Abdul, Al-Hallao, Sariyah, Culliford, D.J. and Clarke, Nicholas M.P. (2010) Late reduction in congenital dislocation of the hip and the need for secondary surgery: radiologic predictors and confounding variables. Journal of Pediatric Orthopaedics, 30, (7), 676-682. (doi:10.1097/BPO.0b013e3181efb8c7). (PMID:20864852).
Kanczler, Janos, Ginty, P., White, L., Clarke, N., Howdle, S., Shakesheff, K. and Oreffo, R. (2010) The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation. Biomaterials, 31, (6), 1241-1250. (doi:10.1016/j.biomaterials.2009.10.059).
Culliford, David, Maskell, Joseph, Beard, D., Murray, D., Price , Alison, Arden, Nigel K., Azagra, R., Carr, Arthur, Clarke, Nicholas, Cooper, Cyrus, Javaid, K., Mullee, Mark and Raftery, James and the COAST Study Group (2010) Temporal trends in hip and knee replacement in the United Kingdom: 1991-2006. The Journal of Bone and Joint Surgery, 92B, (1), 130-135. (doi:10.1302/0301-620X.92B1.22654 ).
Clarke, N.M.P. and Kendrick, Tony (2009) Easily missed: Slipped capital femoral epiphysis. British Medical Journal, 339 (doi:10.1136/bmj.b4457).
Ahmad, N., Marsh, P., Monk, A., Pallett, A., Saeed, K., Clarke, N.M.P. and Faust, S.N. (2009) Detection of uncultured organisms in paediatric bone and joint infections by a multiplex real-time PCR panel. Archives of Disease in Childhood, 94, supplement 1, A1-A8.
Clarke, N.M.P. and Kendrick, Tony (2009) Slipped capital femoral epiphysis. British Medical Journal, 339, (4457), 1198-1199. (doi:10.1136/bmj.b4457).
Lacey, E.K.F. and Clarke, N.M.P. (2008) The big idea: Paediatric oncological pathology – a new phenomenon. Journal of the Royal Society of Medicine, 101, (6), 324-326. (doi:10.1258/jrsm.2008.070207).
Lacey, E.K.F. and Clarke, N.M.P. (2008) The big idea: paediatric oncological pathology - a new phenomenon. Journal of the Royal Society of Medicine, 101, (6), 324-326. (doi:10.1258/jrsm.2008.070207).
Weichert, Stefan, Sharland, Mike, Clarke, Nicholas and Faust, Saul N. (2008) Acute haematogenous osteomyelitis in children: is there any evidence for how long we should treat? Current Opinion in Infectious Diseases, 21, (3), 258-262. (doi:10.1097/QCO.0b013e3283005441).
Clarke, N.M.P. and Sakthivel, K. (2008) The diagnosis and management of congenital dislocation of the hip. Paediatrics and Child Health, 18, (6), 268-271. (doi:10.1016/j.paed.2008.03.007).
Luther, A.Z. and Clarke, N.M.P. (2008) Developmental Dysplasia of the Hip and Occult Neurologic Disorders. Clinical Orthopaedics and Related Research, 466, (4), 871-877. (doi:10.1007/s11999-008-0118-6).
Kanczler, J.M., Ginty, P.J., Barry, J.J., Clarke, N.M., Howdle, S.M., Shakesheff, K.M. and Oreffo, R.O. (2008) The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation. Biomaterials, 29, (12), 1892-1900. (doi:10.1016/j.biomaterials.2007.12.031).
Langley, Clare R., Garrett, Simon J.W., Urand, Jill, Kohler, Janice and Clarke, Nick M.P. (2008) Primary multifocal osseous Hodgkin's lymphoma. World Journal of Surgical Oncology, 6, (34) (doi:10.1186/1477-7819-6-34). (PMID:18346271).
Barham, Guy and Clarke, Nicholas M.P. (2008) Genetic regulation of embryological limb development with relation to congenital limb deformity in humans. Journal of Children's Orthopaedics, 2, (1), 1-9. (doi:10.1007/s11832-008-0076-2).
da Silva, M.A., Yamada, N., Clarke, N.M. and Roach, H.I. (2008) Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage. Journal of Orthopaedic Research, 27, (5), 593-601. (doi:10.1002/jor.20799).
Gent, Edward, Antapur, Prasad, Mehta, Rajnikant L., Vastara, Vastara M. and Clarke, Nicholas M.P. (2007) Predicting the outcome of Legg-Calve-Perthes' disease in children under six years old. Journal of Children's Orthopaedics, 1, (1), 27-32. (doi:10.1007/s11832-007-0007-7).
Hefti, Fritz and Clarke, N.M.P. (2007) The management of Legg-Calvé-Perthes’ disease: is there a consensus? Journal of Children's Orthopaedics, 1, (1), 19-25. (doi:10.1007/s11832-007-0010-z).
Sharma, H., Taylor, G.R. and Clarke, N.M. (2007) A review of K-wire related complications in the emergency management of paediatric upper extremity trauma. Annals of The Royal College of Surgeons of England, 89, (3), 252-258. (doi:10.1308/003588407X155482.).
Stevenson, A.J., Shelwalle, S.B. and Clarke, N.M.P. (2007) Pseudoparalysis in the Pavlik Harness: beware septic arthritis. Journal of Children's Orthopaedics, 1, (5), 287-289. (doi:10.1007/s11832-007-0052-2).
Uglow MG, M.G., Senbaga, N., Pickard, R. and Clarke, N.M.P (2007) Relapse rates following stage surgery in the treatment of recalcitrant talipes equinovarus: 9-16 year outcome study. Journal of Children's Orthopaedics, 1, (2), 115-119. (doi:10.1007/s11832-007-0024-6).
Jain, N.P., Jowett, A.J. and Clarke, N.M. (2007) Learning curves in orthopaedic surgery: a case for super-specialisation? Annals of the Royal College of Surgeons of England, 89, (2), 143-146. (doi:10.1308/003588407X155798).
Gent, Edward, Antapur, Prasad, Fairhurst, Joanne, Taylor, Graeme R. and Clarke, Nicholas M.P. (2006) Perthes' disease in the very young child. Journal of Pediatric Orthopaedics B, 15, (1), 16-22.
Melton, Joel Thomas Kirk, Clarke, Nicholas M.P. and Roach, Helmtrud I. (2006) Matrix metalloproteinase-9 induces the formation of cartilage canals in the chondroepiphysis of the neonatal rabbit. Journal of Bone and Joint Surgery (American), 88, 155-161. (doi:10.2106/JBJS.F.00542).
Yamada, N., Cheung, K.S.C., Tilley, S., Clarke, N.M.P., Oreffo, R.O.C., Kokobun, S., Bronner, F. and Roach, H.I. (2006) Does epigenetics play a role in the pathology of osteoarthritis? Journal of Bone and Joint Surgery, 88-B, (Supplement III), p.403.
Roach, H.I., Inglis, S., Partridge, K., Oreffo, R. and Clarke, N.M.P. (2006) Can epigenetic changes in DNA metylations explain the altered gene expression in osteoarthritis? Journal of Bone and Joint Surgery, 88-B, (Supplement III), 385-386.
Sakthivel, V.K., Goddard, M., Sabouni, M.Y. and Clarke, N.M.P. (2006) Selective screening for DDH in Wessex: the Southampton experience. Journal of Bone and Joint Surgery, 88-B, (Supplement III), p.435.
Cheung, K.S.C., Yamada, N., Tilley, S., Clarke, N.M.P. and Roach, H.I. (2006) Expression of ADAM-TS4 by chondrocytes in osteoarthritis in relation to changes in DNA methylation status. Journal of Bone and Joint Surgery - British Volume, 88, (Supplement III), p.404.
Roach, Helmtrud I., Yamada, Norikazu, Cheung, Kelvin S.C., Tilley, Simon, Clarke, Nicholas M.P., Oreffo, Richard O.C., Kokubun, Shoichi and Bronner, Felix (2005) Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis & Rheumatism, 52, (10), 3110-3124. (doi:10.1002/art.21300).
Kapoor, V., Theruvil, B., Edwards, S.E., Taylor, G.R., Clarke, N.M.P. and Uglow, M. G. (2005) Flexible intramedullary nailing of displaced diaphyseal forearm fractures in children. Injury, 36, (10), 1221-1225. (doi:10.1016/j.injury.2005.06.033).
Kwong, Kevin S.C. (2004) Acoustical technique for screening developmental dysplasia of the hip is not new. Journal of Pediatric Orthopedics, 24, (1), 136.
Yang, Xuebin B., Whitaker, Martin J., Sebald, Walter, Clarke, Nicholas, Howdle, Steven M., Shakesheff, Kevin M. and Oreffo, Richard O.C. (2004) Human osteoprogenitor bone formation using encapsulated bone morphogenetic protein 2 in porous polymer scaffolds. Tissue Engineering, 10, (7), 1037-1045. (doi:10.1089/ten.2004.10.1037).
Uglow, M.G. and Clarke, N.M.P. (2004) The management of slipped capital femoral epiphysis. Journal of Bone and Joint Surgery.British Volume, 86, (5), 631-635. (doi:10.1302/0301-620X.86B5).
Gent, E. and Clarke, N.M.P. (2004) Joint replacement for sequelae of childhood hip disorders. Journal of Pediatric Orthopedics, 24, (2), 235-240.
Smith, James O., Oreffo, Richard O.C., Clarke, Nicholas M.P. and Roach, Helmtrud I. (2003) Changes in the antiangiogenic properties of articular cartilage in osteoarthritis. Journal of Orthopaedic Science, 8, (6), 849-857. (doi:10.1007/s00776-003-0717-8).
Roach, Helmtrud I., Clarke, Nicholas M.P., Langley-Evans, Simon and Cooper, Cyrus (2003) Catabolic and anabolic phases of osteodystrophy in aged rats. Journal of Bone and Mineral Metabolism, 21, (5), 299-306. (doi:10.1007/s00774-003-0424-8).
Elbourne, D., Dezateux, C., Arthur, R., Clarke, N. M. P., Gray, A., Quinn, A., Gardner, F., Russell, G. and UK Collaborative Hip Trial Group (2003) Ultrasonography in neonatal hip instability reduced the need for splints. The Journal of Bone and Joint Surgery, 85-A, (8), 1623. (PMID:12925657).
Oreffo, Richard O.C., Lashbrooke, Benjamin, Roach, Helmtrud I., Clarke, Nicholas M. and Cooper, Cyrus (2003) Maternal protein deficiency affects mesenchymal stem cell activity in the developing offspring. Bone, 33, (1), 100-107. (doi:10.1016/S8756-3282(03)00166-2).
Roach, Helmtrud I., Mehta, Gautam, Oreffo, Richard O.C., Clarke, Nicholas M.P. and Cooper, Cyrus (2003) Temporal analysis of rat growth plates: cessation of growth with age despite presence of a physis. Journal of Histochemistry and Cytochemistry, 51, (3), 373-383.
Kevern, Liam, Warwick, David, Wellesley, Diana, Senbaga, Raj and Clarke, N.M. (2003) Prenatal ultrasound: detection and diagnosis of limb abnormalities. Journal of Pediatric Orthopedics, 23, (2), 251-253.
Yang, Xuebin, Tare, Rahul S., Partridge, Kris A., Roach, Helmtrud, Clarke, Nicholas M.P., Howdle, Steven M., Shakesheff, Kevin M. and Oreffo, Richard O.C. (2003) Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering. Journal of Bone and Mineral Research, 18, (1), 47-57. (doi:10.1359/jbmr.2003.18.1.47).
Harvey, Adrian R., Uglow, Michael G. and Clarke, Nicholas M.P. (2003) Clinical and functional outcome of relapse surgery in severe congenital talipes equinovarus. Journal of Pediatric Orthopaedics B, 12, (1), 49-55.
Yang, X.B., Green, D.W., Roach, H.I., Clarke, N.M.P., Anderson, H.C., Howdle, S.M., Shakesheff, K.M. and Oreffo, R.O.C. (2003) Novel osteoinductive biomimetic scaffolds stimulate human osteoprogenitor activity: implications for skeletal repair. Connective Tissue Research, 44, (Supplement 1), 312-317. (doi:10.1080/713713599).
Kane, Tim P.C., Harvey, J.R., Richards, R.H., Burby, N.G. and Clarke, N.M.P. (2003) Radiological outcome of innocent infant hip clicks. Journal of Pediatric Orthopaedics B, 12, (4), 259-263.
Clarke, N.M.P., Taylor, Graeme, Gordon, Eric J., Luhmann, Scott J., Szymansky, Deborah A. and Schoenecker, Perry (2003) Differing approaches to the surgical correction of snapping hip. Journal of Bone and Joint Surgery, 85, (2), 383-384.
Mehta, G., Roach, H.I., Langley-Evans, S., Taylor, P., Reading, I., Oreffo, R.O.C., Aihie-Sayer, A., Clarke, N.M.P. and Cooper, C. (2002) Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats. Calcified Tissue International, 71, (6), 493-498. (doi:10.1007/s00223-001-2104-9).
Tare, Rahul S., Oreffo, Richard O.C., Sato, Kenzo, Rauvala, Heikki, Clarke, Nicholas M.P. and Roach, Helmtrud I. (2002) Effects of targeted overexpression of pleiotrophin on postnatal bone development. Biochemical and Biophysical Research Communications, 298, (3), 324-332. (doi:10.1016/S0006-291X(02)02456-7).
Tare, Rahul S., Oreffo, Richard O.C., Clarke, Nicholas M.P. and Roach, Helmtrud I. (2002) Pleiotrophin/Osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation. Journal of Bone and Mineral Research, 17, (11), 2009-2020. (doi:10.1359/jbmr.2002.17.11.2009).
Nnadi, Colin, Chalwa, Tanya, Redfern, Andrew, Argent, Julie, Fairhurst, Joanna and Clarke, Nicholas M.P. (2002) Radiograph evaluation in children with acute hip pain. Journal of Pediatric Orthopaedics, 22, (3), 342-344. (PMID:11961451).
Cashman, J.P., Round, J., Taylor, G. and Clarke, N.M.P. (2002) The natural history of developmental dysplasia of the hip (DDH) after early supervised treatment in the Pavlik Harness: A prospective longitudinal follow-up. Journal of Bone and Joint Surgery - British Volume, 84, (3), 418-25. (PMID:12002504).
Cashman, J.P., Round, J., Taylor, G. and Clarke, N.M. (2002) The natural history of developmental dysplasia of the hip after early supervised treatment in the Pavlik harness. A prospective, longitudinal follow-up. Journal of Bone and Joint Surgery. British Volume, 84, (3), 418-425. (doi:10.1302/0301-620X.84B3.12230).
Partridge, Kris, Yang, Xuebin, Clarke, Nicholas M.P., Okubo, Yasunori, Bessho, Kazuhisa, Sebald, Walter, Howdle, Steven M., Shakesheff, Kevin M. and Oreffo, Richard O.C. (2002) Adenoviral BMP-2 gene transfer in mesenchymal stem cells: in vitro and in vivo bone formation on biodegradable polymer scaffolds. Biochemical and Biophysical Research Communications, 292, (1), 144-152. (doi:10.1006/bbrc.2002.6623).
Harvey, A.R., Barlow, L.W. and Clarke, N.M.P. (2002) Early femoral loosening of the titanium 3M Capitol cemented hip : A lesson re-learned. Hip International, 12, (1), 17-22.
Howard, Daniel, Partridge, Kris, Yang, Xuebin, Clarke, Nicholas M.P., Okubo, Yasunori, Bessho, Kazuhisa, Howdle, Steven M., Shakesheff, Kevin M. and Oreffo, Richard O.C. (2002) Immunoselection and adenoviral genetic modulation of human osteoprogenitors: in vivo bone formation on PLA scaffold. Biochemical and Biophysical Research Communications, 299, (2), 208-215. (doi:10.1016/S0006-291X(02)02561-5).
Elbourne, Diana, Dezateux, Carol, Arthur, Rosemary, Clarke, N.M.P., Gray, Alastair, King, Andy, Quinn, Anne, Gardner, Frances and Russell, Glynn (2002) Ultrasonography in the diagnosis and management of developmental hip dysplasia (UK Hip Trial): clinical and economic results of a multicentre randomised controlled trial. The Lancet, 360, (9350), 2009-2017. (doi:10.1016/S0140-6736(02)12024-1).
Nnadi, Colin, Chawla, Tanya, Redfern, Andrew, Argent, Julie, Fairhurst, Joanna and Clarke, Nicolas (2002) Radiograph evaluation in children with acute hip pain. Journal of Pediatric Orthopedics, 22, (3), 342-344.
Yang, X.B., Roach, H.I., Clarke, N.M.P., Howdle, S.M., Quirk, R., Shakesheff, K.M. and Oreffo, R.O.C. (2001) Human osteoprogenitor growth and differentiation on synthetic biodegradable structures after surface modification. Bone, 29, (6), 523-531. (doi:10.1016/S8756-3282(01)00617-2).
Gilbert, James A., Roach, Helmtrud I. and Clarke, Nicholas M. P. (2001) Histological abnormalities of the calcaneum in congenital talipes equinovarus. Journal of Orthopaedic Science, 6, (6), 519-526. (PMID:11793174).
Gilbert, James A., Roach, Helmtrud I. and Clarke, Nicholas M.P. (2001) Histological abnormalities of the calcaneum in congenital talipes equinovarus. Journal of Orthopaedic Science, 6, (6), 519-526. (doi:10.1007/s007760100007).
Phillips, S. A., Griffiths, W. E. G. and Clarke, N. M. P. (2001) The timing of reduction and stabilisation of the acute, unstable, slipped upper femoral epiphysis. Journal of Bone and Joint Surgery - British Volume, 83-B, (7), 1046-1049. (PMID:11603521).
Phillips, S.A., Griffiths, W.E.G. and Clarke, N.M.P. (2001) The timing of reduction and stabilisation of the acute, unstable, slipped upper femoral epiphysis. Journal of Bone and Joint Surgery.British Volume, 83-B, (7), 1046-1049. (doi:10.1302/0301-620X.83B7.11640).
Uglow, M. G. and Clarke, Nicholas M. P. (2000) Relapse in staged surgery for congenital talipes equinovarus. Journal of Bone and Joint Surgery, British Volume, 82-B, (5), 739-743. (PMID:10963177).
Uglow, M. G. and Clarke, N. M. P. (2000) The functional outcome of staged surgery for the correction of Talipes Equinovarus. Journal of Pediatric Orthopaedics, 20, (4), 517-523. (PMID:10912611).
Roach, H.I. and Clarke, N.M.P. (2000) Physiological cell death of chondrocytes in vivo is not confined to apoptosis: new observations on the mammalian growth plate. Journal of Bone and Joint Surgery - British Volume, 82, (4), 601-613. (PMID:10855892).
O'Hara, L., Barlow, I. W. and Clarke, Nicholas M. P. (2000) Displaced supracondylar humeral fractures in children. Audit changes practice. Journal of Bone and Joint Surgery, British Volume, 82, (2), 204-210. (PMID:10755427).
Roach, Helmtrud I. and Clarke, Nicholas M.P. (1999) "Cell paralysis" as an intermediate stage in the programmed cell death of epiphyseal chondrocytes during development. Journal of Bone and Mineral Research, 14, (8), 1367-1378. (doi:10.1359/jbmr.1999.14.8.1367). (PMID:10457269).
O'Connor, D., Clarke, N.M.P., Hegarty, S.E. and Fairhurst, J.J. (1998) The natural history of popliteal cysts in children: an ultrasound study. The Knee, 5, (4), 248-251. (doi:10.1016/S0968-0160(98)00004-0).
Roach, Helmtrud I., Baker, Janice E. and Clarke, Nicholas M.P. (1998) Initiation of the bony epiphysis in long bones: Chronology of interactions between the vascular system and the chondrocytes. Journal of Bone and Mineral Research, 13, (6), 950-961. (doi:10.1002/(ISSN)1523-4681). (PMID:9626626).
Ward, P.J., Clarke, N.M.P. and Fairhurst, J.J. (1998) The role of magnetic resonance imaging in the investigation of spinal dysraphism in the child with lower limb abnormality. Journal of Pediatric Orthopaedics B, 7, (2), 141-143. (PMID:9597591).
Cox, P.J.A. and Clarke, N.M.P. (1997) Improving the outcome of paediatric orthopaedic trauma: an audit of inpatient management in Southampton. Annals of The Royal College of Surgeons of England, 79, (6), 441-446. (PMID:9422873).
Taylor, G.R. and Clarke, N.M.P. (1997) Monitoring the treatment of developmental dysplasia of the hip with the Pavlik harness – The role of ultrasound. Journal of Bone and Joint Surgery, 79-B, (5), 719-723. (PMID:9331021).
Taylor, G.R., Gent, E. and Clarke, N.M.P. (1997) Biepicondylar fracture dislocation of a child's elbow. Injury, 28, (1), 71-72. (doi:10.1016/S0020-1383(96)00138-6). (PMID:9196632).
Craigen, M.A.C. and Clarke, N.M.P. (1996) Bilateral 'Jones' fractures of the fifth metatarsal following relapse of talipes equinovarus. Injury, 27, (8), 599-601. (PMID:8994571).
Uglow, M.G. and Clarke, N.M.P. (1996) Congenital dislocation of the hip in extrauterine pregnancy. Journal of Bone and Joint Surgery, 78, (5), 751-753. (PMID:8836063).
Williams, C. R. P., O'Flynn, E., Clarke, Nicholas M. P. and Morris, R. J. (1996) Torticollis secondary to ocular pathology. Journal of Bone and Joint Surgery, British Volume, 78, (4), 620-624. (PMID:8682831).
Taylor, G.R. and Clarke, N.M.P. (1995) Surgical release of the 'snapping iliopsoas tendon'. Journal of Bone and Joint Surgery, 77, (6), 881-883. (PMID:7593099).
Taylor, G.R. and Clarke, N.M.P. (1995) Recurrent irritable hip in childhood. Journal of Bone and Joint Surgery, 77-B, (5), 749-751. (PMID:7559703).
Johnson, K.A., Fairhurst, K.K. and Clarke, N.M.P. (1995) Oculoauriculovertebral spectrum: New manifestations. Pediatric Radiology, 25, (6), 446-448. (doi:10.1007/BF02019062 ). (PMID:7491197).
Craigen, M.A.C. and Clarke, N.M.P. (1995) Familial congenital pseudarthrosis of the ulna. Journal of Hand Surgery: Journal of the British Society for Surgery of the Hand, 20, (3), 331-332. (doi:10.1016/S0266-7681(05)80088-9). (PMID:7561407).
Taylor, G. R. and Clarke, N. M. P. (1994) Management of irritable hip: a review of hospital admission policy. Archives of Disease in Childhood, 71, (1), 59-63. (doi:10.1136/adc.71.1.59). (PMID:8067794).
Boeree, N.R. and Clarke, N.M.P. (1994) Ultrasound imaging and secondary screening for congenital dislocation of the hip. Journal of Bone and Joint Surgery, 76, (4), 525-533. (PMID:8027133).
Clarke, N. M. P. (1994) Role of ultrasound in congenital hip dysplasia. Archives of Disease in Childhood, 70, (5), 362-363. (doi:10.1136/adc.70.5.362). (PMID:8017953).
Germon, T.J., Clarke, N.M.P and Watt, I. (1994) Post-traumatic lymphocoele. Injury, 25, (1), 65-66. (PMID:8132315).
Argent, J.D., Fairhurst, J.J. and Clarke, N.M.P. (1994) Subcutaneous granuloma annulare: four cases and review of the literature. Pediatric Radiology, 24, (7), 527-529. (PMID:7885793).
Thomas, R.D., Fairhurst, J.J. and Clarke, N.M.P. (1993) Madelung's deformity masquerading as a bone tumour. Skeletal Radiology, 22, (5), 329-331. (PMID:8372361).
Richards, R.H., Palmer, J.D. and Clarke, N.M.P. (1992) Observations on the removal of metal implants. Injury, 23, (1), 25-28. (doi:10.1016/0020-1383(92)90120-H). (PMID:1541494).
Lankamer, V. G., Clarke, N. M. P. and Witherow, P. (1991) Complications of splintage in congenital dislocation of the hip. Archives of Disease in Childhood, 66, (11), 1322-1325. (doi:10.1136/adc.66.11.1322). (PMID:1755647).
Palmer, J.D., Clarke, N.M.P., Pickard, J.D. and Weller, R.W. (1991) Unusual sciatica: Traumatic rupture of the ligamentum flavum. British Journal of Neurosurgery, 5, (5), 523-524. (PMID:1764235).
Gardiner, HM and Clarke, Nicholas M.P. (1990) A sonographic study of the morphology of the preterm neonatal hip. Journal of Pediatric Orthopaedics, 10, (5), 633-637. (PMID:2203819).
Richards, R. H. and Clarke, N. M. P. (1989) Locked posterior fracture-dislocation of the shoulder. Injury, 20, (5), 297-300. (doi:10.1016/0020-1383(89)90174-5). (PMID:2613316).
Clarke, N.M., Clegg, J. and Al-Chalabi, A.N. (1989) Ultrasound screening of hips at risk for CDH. Failure to reduce the incidence of late cases. Journal of Bone and Joint Surgery, 71-B, (1), 9-12. (PMID:2644290).
Scammell, B. E. and Clarke, N. M. P. (1987) The unrestrained coach passenger – an injury complex. Injury, 18, (1), 1-4. (PMID:3440605).
Clarke, Nicholas M.P. (1986) Sonographic Clarification of the Problems of Neonatal Hip Instability. Journal of Pediatric Orthopaedics, 6, (5), 527-32. (PMID:3531234).
Harcke, H. Theodore, Lee, Myung Soo, Sinning, Lisa, Clarke, Nicholas M. P., Borns, Patricia F. and MacEwen, G. Dean (1986) Ossification centre of the infant hip: sonographic and radiographic correlations. American Journal of Roentgenology, 147, (2), 317-321. (PMID:3524161).
Brookes, S., Starkie, C.M. and Clarke, N.M. (1985) Osteosarcoma after the fourth decade. A clinical pathological review. Archives of Orthopaedic and Trauma Surgery, 104, (2), 100-105. (PMID:3863549).
Harcke, H.T., Clarke, N.M.P., Lee, M.S., Borns, P.F. and MacEwan, G.D. (1984) Examination of the infant hip with real-time ultrasonography. Journal of Ultrasound Medicine, 3, (3), 131-137. (PMID:6726860).
Clarke, N.M.P., Blakemore, M.E. and Thompson, A.G. (1983) Osteochondritis of the trochlear epiphysis. Journal of Pediatric Orthopaedics, 3 (5), 601-604. (PMID:6655057).
Hampton, R. and Clarke, N.M.P. (1983) A guide to the photography of cleared small bone specimens. Journal of Biological Photography, 51, (3), 85-87. (PMID:6674298).
Clarke, N.M.P. and McCollum, C.M. (1983) Iliac artery aneurysm simulating nerve root compression. Journal of Royal College of Surgeons Edinburgh, 3, 196-197. (PMID:6875997).
Clarke, N.M.P. and Cleak, D.K. (1983) Intervertebral lumbar disc prolapse in children and adolescents. Journal of Pediatric Orthopaedics, 3, (2), 202-206. (PMID:6863525).
Clarke, N.M.P., Smith, D.N. and Paul, C.J. (1979) Pathological fracture of tibia in patient with corticosteroid-dependent psoriasis treated by functional bracing. BMJ, 2, (6189), 527-528. (PMID:497673).

Book Section

Faust, S.N., Clark, J. and Clarke, N (2011) Bone and joint infections. In, Sharland, Mike, Cant, Andrew, Davies, E. Graham, Elliman, David A.C., Esposito, Susanna, Finn, Adam, Gray, Finn, Heath, Paul T., Lyall, Hermione, Pollard, Andrew J., Ramsay, Mary E., Riordan, Andrew and Shingadia, Delane (eds.) Manual of Childhood Infections. Oxford, GB, Oxford University Press, 38-43.
Sakthivel, Vel K. and Clarke, N.M.P. (2006) Orthopaedics. In, Beattie, Mark and Champion, Mike (eds.) Essential Revision Notes in Paediatrics for MRCPCH. 2nd edition. Knutsford, UK, PasTest, 821-842.
Clarke, N.M.P. (2003) Slipped capitol femoral epiphysis. In, Bulstrode, Christopher, Buckwalter, Joseph, Carr, Andrew, Marsh, Larry, Fairbank, Jeremy, Wilson-MacDonald, James and Bowden, Gavin (eds.) Oxford Textbook of Orthopaedics and Trauma [3 volume set]. Oxford, UK, Oxford University Press. (Oxford Textbook Series).
 

Research

Research Interests

Current research interests include Vitamin D deficiency in children; developmental hip dysplasia and prophylactic hip positioning for stable hips following breech birth, being conducted via the International Hip Dysplasia Institute (www.hipdysplasia.org), being one of the founder members.

In collaboration with Great Ormond Street Hospital, a study into Genome-wide association study of developmental dysplasia of the hip in children and adolescents.

Additionally, in collaboration with the University of California San Francisco, a study into the molecular genetic analysis of limb malformations.

A board member of the recently formed International Perthes’ Study Group, based in Texas, and currently involved in multiple research projects relating to Legg Calvé Perthes’ disease (LCPD).

Over 100 papers published in leading peer reviewed academic journals on all aspects of paediatric orthopaedics.

Academic unit:  Human Development and Health

Responsibilities


4th year trauma, orthoapedic and rheumatology attachment co-ordinator.
Supervisor of undergraduate student projects.
Postgraduate teaching in orthopaedics.
Member of the editorial board of the Journal of Children’s Orthopaedics and Journal of Pediatric Orthopaedics.

Contact

Professor Nicholas Clarke
Phone: (023) 8079 6140
Fax: (023) 8079 4020
Email: ortho@soton.ac.uk

Room Number: SGH/AC68 SAB/MP817