The University of Southampton
Medicine
Email:
N.S.Macklon@soton.ac.uk

Professor Nicholas Stephen Macklon MB ChB, MD, FRCOG

Professor of Obstetrics and Gynaecology, Honorary Consultant Gynaecologist , Director, Complete Fertility Centre, Southampton

Professor Nicholas Stephen Macklon's photo
Related links

Professor Nicholas Stephen Macklon is Professor of Obstetrics and Gynaecology within Medicine at the University of Southampton.

Nick Macklon trained in Edinburgh, and carried out his doctoral research in Glasgow before taking a Fellowship in Fetal Medicine in Rotterdam where he was subsequently appointed Senior Lecturer and Director of the Assisted Conception Unit. In 2005 he was appointed Professor of Periconceptional Medicine and Infertility at the Utrecht University Medical Centre, where he became Head of the Department of Reproductive Medicine and Gynaecology. In 2009 he was appointed to the Chair in Obstetrics and Gynaecology in Southampton, where he is also Director of the Complete Fertility Centre Southampton.

Professor Macklon has published more than 100 Pubmed cited articles in the fields of ovarian stimulation and endometrial receptivity.
In addition to contributing chapters to standard texts in the field, he has published two books, the award winning IVF in the Medically Complicated Patient, and more recently the Textbook of Periconceptional Medicine. External appointments include Past Chairman of the ESHRE Special Interest Group on Reproductive Endocrinology, Founding Board Member of the Dutch Society of Reproductive Medicine. He is currently editorial board member of Reproduction, Fertility and Sterility and Reproductive Biomedicine Online. He holds Visiting Professorships in Adelaide University, Australia, and Utrecht University, The Netherlands.

Qualifications

MB, ChB, University of Edinburgh (1987)
Membership of Royal College of Obstetricians and Gynaecologists (1992)
Diploma in Advanced Obstetric Ultrasound RCOG & RCR (1994)
MD, University of Edinburgh (1996)
UK Specialist Register (No. 3265453) (1996-present)
Dutch Specialist Register (S.R.C.) (1997-present)
Fellowship of the Royal College of Obstetricians and Gynaecologists (2005)
Subspecialist in Reproductive Medicine, Dutch College of O and G (2006-present)

Appointments held

Professor and Head of Department, Obstetrics and Gynaecology, University of Southampton (2009-present)

Director, Complete Fertility Centre Southampton (HFEA Person Responsible) (2009-present)

Honorary Professor of Periconceptional Medicine, University Medical Centre Utrecht (2009-present)

Head, Dept of Reproductive Medicine and Gynaecology, UMC Utrecht (2008–2009)

Professor of Infertility and Periconceptional Medicine and Consultant in Obstetrics and Gynaecology, UMC Utrecht (2005–2009)

Senior Lecturer in Obstetrics and Gynaecology, Erasmus MC, Rotterdam (1997-2005)

Head, Division of Reproductive Medicine (2004-2005)

Head, Obstetrics and Gynaecology Outpatient Clinic (2000-2001)

Deputy Head, Division of Reproductive Medicine (1999-2003)

Head, Assisted Conception Unit (1997-2001)

Clinical Lecturer and Senior Registrar in Obstetrics and Gynaecology, University of Glasgow (1994-1997)

Subspecialist Fellow in Fetal-Maternal Medicine, Erasmus Medical Centre Rotterdam (1995-1996)

Academic Registrar in Obstetrics and Gynaecology, University of Glasgow (1993-1994)

Research Fellow in Obstetrics and Gynaecology, University of Glasgow (1992-1993)

Specialist Registrar in Obstetrics and Gynaecology, Royal Infirmary of Edinburgh (1991-1992)

Senior House Officer in Neonatal Paediatrics, Royal Infirmary of Edinburgh (1989-1990)

Senior House Officer in Obstetrics and Gynaecology, Royal Infirmary of Edinburgh (1988-1989)

House Officer in Surgery Hereford County Hospital (1988)

House Officer in Medicine, Eastern General Hospital Edinburgh (1987-1988)

Research

Responsibilities

Publications

Teaching

Contact

Research interests

The major challenge which remains to be addressed in the treatment of infertility is failure of the embryo to implant. Moreover, peri-implantation and periconceptional events are now recognized as key determinants of perinatal outcomes and long term health in the offspring. My groups current research therefore focuses on developing novel means of assessing and modulating endometrial receptivity in the human, embryo-endometrial interactions, and periconceptional determinants of health.

I currently supervise a number of PhD projects in these fields in Utrecht and Southampton, as listed above.

Our newly built tertiary Fertility Centre which includes IVF treatment provides a superb setting in which to pursue our work in these fields. Our location adjacent to the Institute of Developmental Science, within the Academic Unit of Human Developmental Health, provides a unique combination of facilities and collaborative opportunities to further our work in this field.

Current ongoing research themes include:

The embryo selection window and recurrent miscarriage

Working with Jan Brosens, we have developed a novel paradigm for the role of human decidualised endometrium to sense embryo quality and prevent implantation of poorly viable embryos. We are now investigating how this selection mechansism may be disrupted in women with recurrent miscarriage.

The fate of the early human embryo

Our group coined the now widely used term describing the ‘Black Box of early Pregnancy Loss’ Over the past few years we have carried out a number of studies aimed understanding the fate of the preimplantation and post implantation human embryo. These studies involve in-vitro culture system to study chromosome repair mechanisms, and longitudinal studies of determinants of implantation failure. We are also exploring new markers for in-vivo conception in the human.

The study of the impact of nutritional status on the human reproductive tract

Having pioneered the analysis of endometrial secretions to determine the receptivity of the uterus to implantation, we are now working with Judith Eckert and Franchesca Houghton to develop this technique to allow interrogation of the nutritional environment of the preimplantation human embryo. This work will enable us to identify modulatable factors to optimise this environment and lead to new interventions aimed at increasing succeful implantation and crucial early growth.

Periconceptional intervention studies to improve fertility outcomes

Lifestyle factors have been shown to be major determinants of fertility and the success of fertility treatments like IVF. Our group has been one of those pioneering the introduction of preconceptional health optimisation into routine fertility treatment programs. Linked to this is an ongoing program of intervention studies aimed at refining these interventions.

Academic unit(s)

Human Development and Health Academic Units

Affiliate academic unit(s)

Human development and physiology Research group

Research project(s)

Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing

Mechanisms by which assisted conception treatments may affect embryo development and health into adulthood.

Head of Department of Obstetrics and Gynaecology
Leader of HDH Research Program ‘Mother, Pregnancy and Child .
Supervising ACFs
Lecturing on BM programme
Group tuition to 3rd and 5th year Medical Students
Supervising Student research projects
Invited speaker at international symposia
Consultant to various biotech companies
Visiting Professor of reproductive Medicine in Adelaide and Utrecht
External Assessor for University of Valencia Medical School
Member of MRC Unit Quinquennial Review board.
Director of Complete Fertility Centre Southampton.
Leading research groups in Southampton and Utrecht
Supervising PhD and MD students

Postgraduate student supervision

Past PhD Projects supervised

N. Beckers Novel Interventions in the Luteal Phase after Assisted Reproduction 2006
E.Heijnen New paradigms in IVF treatments 2006
M.Verberg Clinical Outcomes from Mild IVF Strategies 2007
C. de Klerk Psychological Aspects of Assisted Reproduction 2008
A. Badawy Novel approaches to ovulation induction 2008
M. vd. Gaast Endometrial Receptivity in Assisted Reproduction 2009
J. Boxmeer Nutritional Determinants of Outcome in Infertility Treatment. 2009
C.Boomsma Immunological Determinants of Endometrial Receptivity 2009
A. Darwish Clinical studies in reconstructive fertility surgery 2009
G. Teklenburg Preimplantation embryo-signalling 2010
M. Sterrenburg Reducing the burden of ovarian stimulation 2011

Current PhD projects supervised

M. Santos Early embryo development
O.Hamdine Refining the GnRH antagonist protocol
H. Ockhuysen Periconceptional interventions for stress reduction in IVF and recurrent miscarriage
Y. Koot The endometrial factor in infertility and early pregnancy loss.
L. Weimar Molecular mechanisms in implantation failure
G. Meng Environmental determinants of ovarian function
S. Lu Intrauterine monitoring

Article(s)

Book(s)

Book Section(s)

  • The IVF patient, international travel and vaccinations - Tijani, H. and Macklon, N.S.. In IVF in the Medically Complicated Patient, Second Edition: A Guide to Management - Macklon, N.S. (ed.)
    Published:
    2014
    Published by:
    London, GB
    Series:
    Reproductive Medicine and Assisted Reproductive Techniques Series
    Page Range:
    205-216
  • The patient at risk from thrombosis - Macklon, N.S.. In IVF in the Medically Complicated Patient, Second Edition: A Guide to Management - Macklon, N. S. (ed.)
    Published:
    2014
    Published by:
    London, GB
    Series:
    Reproductive Medicine and Assisted Reproductive Techniques Series
    Page Range:
    21-29
  • Ovulation stimulation and cycle management in IVF - Cheong, Y., Ginsburg, Elizabeth S. and Macklon, N.. In In Vitro Fertilization: A Comprehensive Guide
    Published:
    2012
    Published by:
    New York, US
    Page Range:
    31-54
  • The patient with thrombophilia - Cheong, Y. and Macklon, N.S.. In Assisted Reproduction Techniques: Challenges and Management Options
    Published:
    2011
    Published by:
    Oxford, GB
  • Recurrent implantation failure - Macklon, Nick and Boomsma, Carlean. In Early Pregnancy - Farquharson, Roy G and Stephenson, Mary D (eds.)
    Published:
    2010
    Published by:
    Cambridge, UK
  • New concepts in ovarian stimulation - Cheong, Y., Brook, N. and Macklon, N.S.. In Human Assisted Reproductive Technology: Future Trends in Laboratory & Clinical Practice - Gardner, David K., Rizk, Botros R.M.B. and Falcone, Tommaso (eds.)
    Published:
    2010
    Published by:
    Cambridge, GB
  • Medical approaches to ovarian stimulation for infertility - Macklon, N. and Fauser, B.C.J.M.. In Yen and Jaffe's Reproductive Endocrinology
    Published:
    2009
    Published by:
    Philadelphia, US
    Page Range:
    689-724
  • Turner's syndrome and oocyte donation - Macklon, Nick. In Donor Egg IVF
    Published:
    2009
    Published by:
    New Delhi, IN
    Page Range:
    420-426
  • The luteal phase - Fatemi, H., Devroey, P., Fauser, B.C.J.M. and Macklon, Nicholas. In Textbook of Periconceptional Medicine
    Published:
    2008
    Published by:
    London
    Page Range:
    297-307
  • Medical strategies to improve ART outcome: current evidence - Boomsma, C.M. and Macklon, N.S.. In Infertility and Assisted Reproduction - Botros, R.M.B. Rizk, Garcia-Velasco, Juan A., Sallam, Hassan N. and Makrigiannakis, Antonis (eds.)
    Published:
    2008
    Published by:
    Cambridge, GB
    Page Range:
    349-360
  • The physiology of reproduction - Fauser, B.C. and Macklon, N.. In Obstetrics and Gynaecology
    Published:
    2007
    Published by:
    Amsterdam, NL
  • The patient at risk of thrombosis - Macklon, N.S.. In IVF in the Complicated Patient: Practical Management Options - Macklon, N.S. (ed.)
    Published:
    2005
    Published by:
    London, GB
  • 'Controlled' ovarian stimulation: who's kidding who? - Macklon, N. In Gynaecology, Obstetrics and Reproductive Medicine Daily - Slager, E., Fauser, B., van Geijn, H., Brolmann, H. and Vervest, H. (eds.)
    Published:
    2005
    Published by:
    Amsterdam, The Netherlands
    Series:
    International Congress Series
    Volume:
    1279
    Page Range:
    35-38
    doi:
    10.1016/j.ics.2004.12.053
  • Ovulation induction with clomiphene or gonadotropins - Lambalk, C.B., Huirne, J.A.F., Macklon, N.S., Fauser, B.C.J.M. and Homburg, R.. In Gynaecology, Obstetrics, and Reproductive Medicine in Daily Practice - Slager, E., Fauser, B., van Geijn, H., Brolmann, H. and Vervest, H. (eds.)
    Published:
    2005
    Published by:
    Amsterdam, NL
    Series:
    International Congress Series
    Volume:
    1279
    Page Range:
    16-23
    doi:
    10.1016/j.ics.2005.01.009
  • Gonadotropin ovulation induction - Macklon, Nick S., Fauser, Bart C.J.M. and Adashi, Eli Y.. In The Ovary - Leung, Peter C.K. (ed.)
    Published:
    2004
    Published by:
    New York, US
    Page Range:
    441-449
  • Indications for IVF: from diagnosis to prognosis - Macklon, Nicholas S., Pieters, Math H.E.C. and Fauser, Bart C.J.M.. In Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives: 2nd edition - Gardner, David K., Weismann, Ariel, Howles, Colin M. and Shoham, Zeev (eds.)
    Published:
    2004
    Published by:
    London
    Page Range:
    495-506
  • Medical approaches to ovarian stimulation for infertility - Macklon, N. and Fauser, B.C.J.M.. In Yen and Jaffe's Reproductive Endocrinology. 5th edition - Strauss, J. and Barbieri, R. (eds.)
    Published:
    2004
    Published by:
    Philadelphia, US
    Page Range:
    965-1012
  • Indications for IVF treatment: from diagnosis to prognosis - Macklon, Nick S. and Fauser, B.C.J.M.. In Textbook of Assisted Reproductive Technology: Laboratory and Clinical Perspectives. 2nd edition - Gardner, David K., Weissman, Ariel, Howles, Colin M. and Shobham, Zeev (eds.)
    Published:
    2004
    Published by:
    London, GB
    Page Range:
    495-505
  • The step-down protocol - Macklon, N. and Fauser, B.C.J.M.. In Ovulation Induction. European Practice in Obstetrics and Gynaecology - Tarlatzis, B.C. (ed.)
    Published:
    2003
    Published by:
    Paris, FR
  • Sindrome del ovario poliquitico. induccion de la ovualacion con gonadotropinas - Macklon, Nicholas S. and Fauser, B.C.J.M.. In Reproducción Humana - Remohí, J., Pellicer, A., Simón, C. and Navarro, J. (eds.)
    Published:
    2002
    Published by:
    Madrid, ES
  • Indications for IVF treatment - Macklon, N., Pieters, M.H.E.C. and Fauser, B.C.J.M.. In A Comprehensive Textbook of Assisted Reproductive Technology: Laboratory and Clinical Perspectives - Gardner, David K., Weissman, Ariel, Howles, Colin M and Shobham, Zeev (eds.)
    Published:
    2001
    Published by:
    London, GB
  • Behandelingen van voortplantingsstoornissen - Macklon, N. and Fauser, B.C.J.M.. In Zwanger van de Kinderwens: Visies, Feiten & Vragen over Voortplantingstechnologie - de Joode, Susanne (ed.)
    Published:
    2001
    Published by:
    The Hague, The Netherlands
  • Novel protocols for ovarian stimulation - Macklon, Nick S. and Fauser, B.C.J.M.. In GnRH Analogues - Devroey, Paul, Diamond, Michael P. and DeCherney, Alan H. (eds.)
    Published:
    2001
    Published by:
    Philadelphia, United States of America
    Series:
    Infertility and Reproductive Medicine Clinics of North America, 12 (1)
    Page Range:
    141-150
  • Oorzaken van voortplantingsstoornissen - Macklon, Nick S. and Fauser, B.C.J.M.. In Zwanger van de Kinderwens: Visies, Feiten & Vragen over Voortplantingstechnologie - de Joode, Susanne (ed.)
    Published:
    2001
    Published by:
    The Hague, The Netherlands
  • Follicle development before and during the menstrual cycle - Macklon, N.S. and Fauser, B.C.J.M.. In Female Reproductive Aging - Te Velde, E.R., Pearson, P.L. and Broekmans, F.J. (eds.)
    Published:
    2000
    Published by:
    London, GB
    Series:
    Studies in Profertility Series
    Volume:
    9
    Page Range:
    111-122
  • Current status of GnRH agonists in ART - De Jong, D., Macklon, Nick S. and Fauser, B.C.J.M.. In Manual of Ovulation Induction - Perloe , M. and Sills , E.S. (eds.)
    Published:
    2000
    Published by:
    India, Republic of, IN
  • Minimal ovarian stimulation for IVF: extending the 'follicle stimulating hormone window' - de Jong, Diederick, Macklon, N.S. and Fauser, B.C.J.M.. In Towards Reproductive Certainty, Fertility and Genetics beyond 1999: The Plenary Proceedings of the 11th World Congress - Jansen, R. and Mortimer, D. (eds.)
    Published:
    1999
    At event:
    11th World Congress
    Published by:
    London, GB
    Page Range:
    195-199
  • FSH and follicular development - Fauser, Bart C.J.M. and Macklon, N.S.. In Towards Reproductive Certainty, Fertility and Genetics beyond 1999 - Proceedings of the 11th World Congress on In Vitro Fertilization and Human Reproductive Genetics - Jansen, R. and Mortimer, D. (eds.)
    Published:
    1999
    Published by:
    London, GB
    Page Range:
    177-185
  • Ovarian stimulation in patients with polycystic ovarian syndrome - Macklon, N and Fauser, BCJM. In Gonadotrophins and Fertility in the Woman - Adashi, Eli Y., Baird, David T. and Crosignani, P.G. (eds.)
    Published:
    1999
    At event:
    Relazioni presentate al Convegno tenuto a Madrid nel 1998
    Published by:
    Geneva, Switzerland
    Series:
    Serono Fertility Series
    Volume:
    3
  • Minimal ovarian hyperstimulation protocols for in-vitro fertilization - Macklon, N.S. and Fauser, B.C.J.M.. In New Technologies for Gynaecologic and Obstetric Investigation - Genazzani, A.R. and Artini, P.G. (eds.)
    Published:
    1999
    Published by:
    Rome, IT
  • Role of estradiol in oocyte maturation and fertilization - Macklon, N. and Fauser, B.C.J.M.. In The Role of LH in Folliculogenesis and Ovulation Induction - Filicori, M. (ed.)
    Published:
    1999
    Published by:
    Bologna, IT
  • Ovulation induction: step-up and step-down regimens - Macklon, N. and Fauser, B.C.J.M.. In Proceedings of the XVI World Congress on Fertility and Reproductive Medicine - Kempers, Rodger D., Cohen, J., Hanley, A.F. and Younger, J.B. (eds.)
    Published:
    1998
    At event:
    54th Annual Meeting of the American Society for Reproductive Medicine
    Published by:
    Amsterdam, NL
    Series:
    International Congress Series, 1183
    Page Range:
    529-536
  • Optimalising protocols for ovulation induction - Macklon, Nicholas S., Imani, Babek and Fauser, B.C.J.M.. In Female Infertility Therapy - Shoham, Zeev, Howles, Colin M. and Jacobs, Howard S. (eds.)
    Published:
    1998
    Published by:
    London, GB
    Page Range:
    75-84
  • Therapy: ovulation induction with step down regimens - Macklon, N.S. and Fauser, BCJM. In Polycystic Ovarian Syndrome
    Published:
    1998
    Published by:
    Norwell, US
    Series:
    Endocrine Updates

Monograph(s)

Lecturing to undergraduate and postgraduates

Clinical teaching and tutorials

Project supervision and assessment

Professor Nicholas Stephen Macklon
Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 801, South Academic Block, Tremona Road, Southampton, SO16 6YD or Faculty of Medicine, University of Southampton, Building 85, Life Sciences Building, Highfield Campus, Southampton, SO171BJ

Email: N.S.Macklon@soton.ac.uk

Share this profileFacebookGoogle+TwitterWeibo

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×