Medicine

Nicholas Stephen Macklon

MB ChB, MD, FRCOG

Primary position:
Professor of Obstetrics and Gynaecology
Other positions:
Honorary Consultant Gynaecologist , Director, Complete Fertility Centre, Southampton

Background

The University of Southampton

Nick Macklon trained in Edinburgh, and carried out his doctoral research in Glasgow before taking a Fellowship in Fetal Medicine in Rotterdam where he was subsequently appointed Senior Lecturer and Director of the Assisted Conception Unit. In 2005 he was appointed Professor of Periconceptional Medicine and Infertility at the Utrecht University Medical Centre, where he became Head of the Department of Reproductive Medicine and Gynaecology. In 2009 he was appointed to the Chair in Obstetrics and Gynaecology in Southampton, where he is also Director of the Complete Fertility Centre Southampton.

Professor Macklon has published more than 100 Pubmed cited articles in the fields of ovarian stimulation and endometrial receptivity.
In addition to contributing chapters to standard texts in the field, he has published two books, the award winning IVF in the Medically Complicated Patient, and more recently the Textbook of Periconceptional Medicine. External appointments include Past Chairman of the ESHRE Special Interest Group on Reproductive Endocrinology, Founding Board Member of the Dutch Society of Reproductive Medicine. He is currently editorial board member of Reproduction, Fertility and Sterility and Reproductive Biomedicine Online. He holds Visiting Professorships in Adelaide University, Australia, and Utrecht University, The Netherlands.

Qualifications

MB, ChB, University of Edinburgh (1987)
Membership of Royal College of Obstetricians and Gynaecologists (1992)
Diploma in Advanced Obstetric Ultrasound RCOG & RCR (1994)
MD, University of Edinburgh (1996)
UK Specialist Register (No. 3265453) (1996-present)
Dutch Specialist Register (S.R.C.) (1997-present)
Fellowship of the Royal College of Obstetricians and Gynaecologists (2005)
Subspecialist in Reproductive Medicine, Dutch College of O and G (2006-present)

Appointments held

Professor and Head of Department, Obstetrics and Gynaecology, University of Southampton (2009-present)

Director, Complete Fertility Centre Southampton (HFEA Person Responsible) (2009-present)

Honorary Professor of Periconceptional Medicine, University Medical Centre Utrecht (2009-present)

Head, Dept of Reproductive Medicine and Gynaecology, UMC Utrecht (2008–2009)

Professor of Infertility and Periconceptional Medicine and Consultant in Obstetrics and Gynaecology, UMC Utrecht (2005–2009)

Senior Lecturer in Obstetrics and Gynaecology, Erasmus MC, Rotterdam (1997-2005)

Head, Division of Reproductive Medicine (2004-2005)

Head, Obstetrics and Gynaecology Outpatient Clinic (2000-2001)

Deputy Head, Division of Reproductive Medicine (1999-2003)

Head, Assisted Conception Unit (1997-2001)

Clinical Lecturer and Senior Registrar in Obstetrics and Gynaecology, University of Glasgow (1994-1997)

Subspecialist Fellow in Fetal-Maternal Medicine, Erasmus Medical Centre Rotterdam (1995-1996)

Academic Registrar in Obstetrics and Gynaecology, University of Glasgow (1993-1994)

Research Fellow in Obstetrics and Gynaecology, University of Glasgow (1992-1993)

Specialist Registrar in Obstetrics and Gynaecology, Royal Infirmary of Edinburgh (1991-1992)

Senior House Officer in Neonatal Paediatrics, Royal Infirmary of Edinburgh (1989-1990)

Senior House Officer in Obstetrics and Gynaecology, Royal Infirmary of Edinburgh (1988-1989)

House Officer in Surgery Hereford County Hospital (1988)

House Officer in Medicine, Eastern General Hospital Edinburgh (1987-1988)

Professor Nicholas Stephen Macklon's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Brosens, J.J., Salker, M.S., Teklenburg, G., Nautiyal, J., Salter, S., Lucas, E.S., Steel, H.J., Christian, M., Chan, Y.W., Boomsma, C.M., Moore, J.D., Hartshorne, G.M., Sućurović, S., Mulac-Jericevic, B., Heijnen, C.J., Quenby, S., Groot Koerkamp, M.J., Holstege, F.C., Shmygol, A. and Macklon, N.S. (2014) Uterine selection of human embryos at implantation. Scientific Reports, 4, (3894), 1-8. (doi:10.1038/srep03894). (PMID:24503642).
Richardson, M.C., Guo, M., Fauser, B.C.J.M. and Macklon, N.S. (2013) Environmental and developmental origins of ovarian reserve. Human Reproduction Update (doi:10.1093/humupd/dmt057). (PMID:24287894).
Weimar, C.H., Post Uiterweer, E.D., Teklenburg, G., Heijnen, C.J. and Macklon, N.S. (2013) Reprint of: in-vitro model systems for the study of human embryo-endometrium interactions. Reproductive BioMedicine Online, 27, (5), 461-476. (doi:10.1016/j.rbmo.2013.10.004). (PMID:24161843). (In Press).
Hamdine, O., Macklon, N.S., Eijkemans, M.J., Laven, J.S., Cohlen, B.J., Verhoeff, A., van Dop, P.A., Bernardus, R.E., Lambalk, C.B., Oosterhuis, G.J., Holleboom, C.A., van den Dool-Maasland, G.C., Verburg, H.J., van der Heijden, P.F., Blankhart, A., Fauser, B.C. and Broekmans, F.J. (2013) Comparison of early versus late initiation of GnRH antagonist co-treatment for controlled ovarian stimulation in IVF: a randomized controlled trial. Human Reproduction, 1-9. (doi:10.1093/humrep/det374). (PMID:24129613).
Altmae, Signe, Esteban, Francisco J., Stavreus-Evers, Anneli, Simon, Carlos, Giudice, Linda, Lessey, Bruce A., Horcajadas, Jose A., Macklon, Nick S., D'Hooghe, Thomas, Campoy, Christina, Fauser, Bart, Salamonsen, Lois A. and Salumets, Andres (2013) Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium. Human Reproduction Update, 19, (5) (doi:10.1093/humupd/dmt048). (PMID:24082038).
Ockhuijsen, Henrietta D.L., van den Hoogen, Agnes, Macklon, Nicholas S. and Boivin, Jacky (2013) The PRCI study: design of a randomized clinical trial to evaluate a coping intervention for medical waiting periods used by women undergoing a fertility treatment. BMC Women's Health, 13, 35. (doi:10.1186/1472-6874-13-35). (PMID:24004640).
Sharkey, Andrew M. and Macklon, Nick S. (2013) The science of implantation emerges blinking into the light. Reproductive BioMedicine Online (doi:10.1016/j.rbmo.2013.08.005). (PMID:24055396). (In Press).
Weimar, Charlotte H.E., Post Uiterweer, Emiel D., Teklenburg, Gijs, Heijnen, Cobi J. and Macklon, Nick S. (2013) In-vitro model systems for the study of human embryo-endometrium interactions. Reproductive BioMedicine Online (doi:10.1016/j.rbmo.2013.08.002). (PMID:24055530).
Koot, Y.E. and Macklon, N.S. (2013) Embryo implantation: biology, evaluation, and enhancement. Current Opinion in Obstetrics & Gynecology, 25, (4), 274-279. (doi:10.1097/GCO.0b013e3283630d94). (PMID:23787799).
Weimar, C.H., Macklon, N.S., Post Uiterweer, E.D., Brosens, J.J. and Gellersen, B. (2013) The motile and invasive capacity of human endometrial stromal cells: implications for normal and impaired reproductive function. Human Reproduction Update, 19, (5), 542-557. (doi:10.1093/humupd/dmt025). (PMID:23827985).
Kermack, A.J. and Macklon, N.S. (2013) Preconception care and fertility. Minerva Ginecologica, 65, (3), 253-269. (PMID:23689168).
Larsen, E.C., Christiansen, O.B., Kolte, A.M. and Macklon, N.S. (2013) New insights into mechanisms behind miscarriage. BMC Medicine, 11, 154. (doi:10.1186/1741-7015-11-154). (PMID:23803387).
Shreeve, N., Cagampang, F., Sadek, K., Tolhurst, M., Houldey, A., Hill, C. M., Brook, N., Macklon , N. and Cheong, Y. (2013) Poor sleep in PCOS; is melatonin the culprit? Human Reproduction, 28, (5), 1348-1353. (doi:10.1093/humrep/det013 ). (PMID:23438443).
Cheong, Ying, Boomsma, Carolien, Heijnen, Cobi and Macklon, Nick (2013) Uterine secretomics: a window on the maternal-embryo interface. Fertility and Sterility, 99, (4), 1093-1099. (doi:10.1016/j.fertnstert.2013.01.144). (PMID:23433513).
Schwenke, M., Knofler, M., Velicky, P., Weimar, C.H., Kruse, M., Samalecos, A., Wolf, A., Macklon, N.S., Bamberger, A.M. and Gellersen, B. (2013) Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors. PLoS ONE, 8, (1), e54336-[14pp]. (doi:10.1371/journal.pone.0054336). (PMID:23349855).
Ockhuijsen, H.D., Boivin, J., van den Hoogen, A. and Macklon, N.S. (2013) Coping after recurrent miscarriage: uncertainty and bracing for the worst. Journal of Family Planning & Reproductive Health Care (doi:10.1136/jfprhc-2012-100346). (PMID:23329740).
Newman, T.A., Bailey, J.L., Stocker, L., Macklon, N.S. and Cheong, Y. (2013) Expression of neuronal markers in the endometrium of women with and without endometriosis. Human Reproduction (In Press).
Groenewoud, E.R., Cantineau, A.E., Kollen, B.J., Macklon, N.S. and Cohlen, B.J. (2013) What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Human Reproduction Update, 19, (5), 458-470. (doi:10.1093/humupd/dmt030). (PMID:23820515).
Musters, A.M., Koot, Y.E., van den Boogaard, N.M., Kaaijk, E., Macklon, N.S., van der Veen, F., Nieuwkerk, P.T. and Goddijn, M. (2012) Supportive care for women with recurrent miscarriage: a survey to quantify women's preferences. Human Reproduction (doi:10.1093/humrep/des374). (PMID:23213179).
Koot, Y.E.M., Teklenburg, G., Salker, M.S., Brosens, J.J. and Macklon, N.S. (2012) Molecular aspects of implantation failure. Biochim Biophys Acta, 1822, (12), 1943-1950. (doi:10.1016/j.bbadis.2012.05.017). (PMID:22683339).
Groenewoud, Eva R., Macklon, Nick S., Cohlen, Ben J. and ANTARCTICA trial study group (2012) Cryo-thawed embryo transfer: natural versus artificial cycle. A non-inferiority trial.(ANTARCTICA trial). BMC Womens Health, 12, (1), 27. (doi:10.1186/1472-6874-12-27). (PMID:22950651).
Weimar, Charlotte H.E., Kavelaars, Annemieke, Brosens, Jan J., Gellersen, Birgit, de Vreeden-Elbertse, Johanna M.T., Heijnen, Cobi J. and Macklon, Nick S. (2012) Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos. PLoS ONE, 7, (7), e41424-[8pp]. (doi:10.1371/journal.pone.0041424). (PMID:22848492).
Sadek, Khaled H., Cagampang, F.R., Bruce, K.D., Macklon , N. and Cheong, Ying (2012) Variation in stability of housekeeping genes in healthy and adhesion-related mesothelium. Fertility and Sterility, 98, (4), 1023-1027. (doi:10.1016/j.fertnstert.2012.06.033). (PMID:22795637).
Sadek, Khaled, Cagampang, F.R., Bruce, K.D., Macklon , N. and Cheong, Ying (2012) Variation in stability of housekeeping genes in health and adhesion-related mesothelium. Fertility and Sterility (doi:10.1016/j.fertnstert.2012.06.033). (PMID:22795637). (In Press).
Boomsma, Carolien M., Keay, Stephen D. and Macklon, Nick S. (2012) Peri-implantation glucocorticoid administration for assisted reproductive technology cycles. Cochrane Database Systematic Review (doi:10.1002/14651858.CD005996.pub3). (PMID:22696356).
Guo, M., Eijkemans, M.J., Goverde, A.J., Fauser, B.C. and Macklon, N.S. (2012) Comparison of the phenotype of Chinese versus Dutch Caucasian women presenting with polycystic ovary syndrome and oligo/amenorrhoea. Human Reproduction, 27, (5), 1481-1488. (doi:10.1093/humrep/des018). (PMID:22402209).
Teklenburg, Gijs, Weimar, Charlotte H. E., Fauser, Bart C. J. M., Macklon, Nick, Geijsen, Niels, Heijnen, Cobi J., Chuva de Sousa Lopez, Susana M. and Kuijk, Ewart W. (2012) Cell lineage specific distribution of H3K27 trimethylation accumulation in an in vitro model for human implantation. PLoS ONE (doi:10.1371/journal.pone.0032701). (PMID:22412909).
Sadek, K. H. , Cagampang, F. R., Bruce, K. D., Shreeve, N., Macklon, N.S. and Cheong, Ying (2012) Variation in stability of housekeeping genes in endometrium of healthy and polycystic ovarian syndrome women. Human Reproduction, 27, (1), 251-256. (doi:10.1093/humrep/der363 ). (PMID:22052386).
van Leeuwen, F. E., Klip, H., Mooij, T. M., van de Swaluw, A. M., Lambalk, C. B., Kortman, M., Laven, J. S., Jansen, C. A., Helmerhorst, F. M., Cohlen, B. J., Willemsen, W. N., Smeenk JM, J. M., Simons, A. H., van der Veen, F., Evers, J.L., van Dop, P.A., Macklon, N. S. and Burger, C. W. (2011) Risk of borderline and invasive ovarian tumours after ovarian stimulation for in vitro fertilization in a large Dutch cohort. Human Reproduction, 26, (12), 3456-3465. (doi:10.1093/humrep/der322). (PMID:22031719).
Groenewoud , E. R., Kollen , B. J., Macklon, N. S. and Cohlen, B. J. (2011) Spontaneous LH surges prior to hCG administration in unstimulated-cycle frozen-thawed embryo transfer do not influence pregnancy rates. Reproductive BioMedicine Online (doi:10.1016/j.rbmo.2011.11.003). (PMID:22197128).
Ockhuijsen, Henriëtta D. L., Gamel , Claudia J., van den Hoogen , Agnes and Macklon, Nicholas S. (2011) Integrating preconceptional care into an IVF programme. Journal of Advanced Nursing (doi:10.1111/j.1365-2648.2011.05829.x). (PMID:22032346).
Macklon, Nick S. (2011) Polycystic ovary syndrome. BMJ, 343, (d6407) (doi:10.1136/bmj.d6407). (PMID:21998338).
Koot, Y.E., Boomsma, C.M., Eijkemans, M.J., Lentjes, E.G. and Macklon, N.S. (2011) Recurrent pre-clinical pregnancy loss is unlikley to be a "cause" of unexplained infertility. Human Reproduction, 26, (10), 2636-2641. (doi:10.1093/humrep/der217). (PMID:21784735).
van Disseldorp, Jereon, Franke, Lude, Eijkemans , Rene, Broekmans, Frank, Macklon, Nick, Wijmenga, Cisca and Fauser, Bart (2011) Genome-wide analysis shows no genomic predictors of ovarian response to stimulation by exogenous FSH for IVF. Reproductive BioMedicine Online, 22, (4), 382-388. (doi:10.1016/j.rbmo.2010.12.006). (PMID:21316307).
Hammiche, Fatima, Vujkovic, Marijana, Wilburg, Willeke, de Vries, Jeanne H.M., Macklon, Nick S., Laven, Joop S.E. and Steegers-Theunissen, Régine P.M. (2011) Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology. Fertility and Sterility, 95, (5), 1820-1823. (doi:10.1016/j.fertnstert.2010.11.021 ). (PMID:21130435).
Sadek, Khaled, Macklon, Nick, Bruce, Kim, Cagampang, Felino and Cheong, Ying (2011) Hypothesis: Role for the circadian Clock system and sleep in the pathogenesis of adhesions and chronic pelvic pain? Medical Hypotheses, 76, (3), 543-546. (doi:10.1016/j.mehy.2010.11.020). (PMID:21146320).
Kuijk, Ewart W., Chuva de Sousa Lopes , Susana M., Geijsen, Niels, Macklon, Nick and Roelen, Bernard A.J. (2011) The different shades of mammalian pluripotent stem cells. Human Reproduction Update, 17, (2), 254-271. (doi:10.1093/humupd/dmq035). (PMID:20705693).
Sterrenburg, M.D., Veltman-Verhulst, S.M., Eijkemans, M.J.C., Hughes, E.G., Macklon, N.S., Broekmans, F.J. and Fauser, B.C.J.M. (2011) Clinical outcomes in relation to the daily dose of recombinant follicle-stimulating hormone for ovarian stimulation in in vitro fertilization in presumed normal responders younger than 39 years: a meta-analysis. Human Reproduction Update, 17, (2), 184-196. (doi:10.1093/humupd/dmq041). (PMID:20843965).
Teklenburg, G., Salker, Madhuri, Macklon, Nick S. and Brosens, Jan J. (2010) The molecular basis of recurrent pregnancy loss: impaired natural embryo selection. Molecular Human Reproduction, 16, (12), 886-896. (doi:10.1093/molehr/gaq079). (PMID:20847090).
Guo, M., Chen, Z.J., Macklon, N.S., Westerveld, H.E., Eijkemans, M.J., Fauser, B.C. and Goverde, A.J. (2010) Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria. Reproductive BioMedicine Online, 21, (4), 572-580. (doi:10.1016/j.rbmo.2010.04.032). (PMID:20800551).
Santos, Margarida Avo, Teklenburg, Gijs, Macklon, Nick S., Van Opstal, Diane, Schuring-Blom, G Heleen, Krijtenburg, Pieter-Jaap, de Vreeden-Elbertse, Johanna, Fauser, Bart C and Baart, Esther B (2010) The fate of the mosaic embryo: chromosomal constitution and development of Day 4, 5 and 8 human embryos. Human Reproduction, 25, (8), 1916-1926. (doi:10.1093/humrep/deq139). (PMID:20519247).
Mutsaerts, Meike A.Q., Groen, Henk, ter Bogt, Nancy C.W., Bolster, Johanna H.T., Land, Jolande A., Bemelmans, Wanda J.E., Kuchenbecker, Walter K.H., Hompes, Peter G.A., Macklon, Nick S., Stolk , Ronald P., van der Veen , Fulco, Maas, Jacques W.M., Klijn, Nicole F., Kaaijk, Eugenie M., Oosterhuis, Gerrit J.E., Bouckaert, Peter X.J.M., Schierbeek, Jaap M., van Kasteren , Yvonne M., Nap, Annemiek W., Broekmans, Frank J., Brinkhuis, Egbert A., Koks, Carolien A.M., Burggraaff, Jan M., Blankhart , Adrienne S., Perquin, Denise A., Gerards, Marie H., Mulder, Robery J.A.B., Gondrie, Ed T.C.M., Mol , Ben W.J. and Hoek, Annemieke (2010) The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial. BMC Womens Health, 10, 22. (doi:10.1186/1472-6874-10-22). (PMID:20579357).
Salker, Madhuri, Teklenburg, Gijs, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J., Lokugamage, Amalie U., Rai, Raj, Landles, Christian, Roelen, Bernard A.J., Quenby, Siobhan, Kuijk, Ewart W., Kavelaars, Annemieke, Heijnen, Cobi J., Regan, Lesley, Macklon, Nick S. and Brosens, Jan J. (2010) Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLOS One, 5, (4), e10287-e10287. (doi:10.1371/journal.pone.0010287).
Teklenburg, Gijs, Salker, Madhuri, Molokhia, Mariam, Lavery, Stuart , Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J., Lokugamage, Amali U., Rai, Raj, Landles, Christian, Roelen, Bernard A. J., Quenby, Siobhan, Kuijk, Ewart W., Kavelaars, Annemieke, Heijnen, Cobi J., Regan, Jan J. and Macklon, Nick S. (2010) Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation. PLoS One. , 5, (4), e10258. (doi:10.1371/journal.pone.0010258).
van Tol, Helena T. A., Vernooij, Johannes C. M., Colenbrander, Ben, Gutknecht, Dagmar, Macklon, Nicholas S. and Roelen, Bernard A. J. (2010) Expression of leptin receptor mRNA in cumulus cells is correlated with expression of PTX3. Reproductive Biomedicine Online (doi:10.1016/j.rbmo.2010.03.003). (Submitted).
Vujkovic, M., de Vries , J. H., Lindemans, J., Macklon , N., van der Spek , P. J., Steegers, E. A. and Steegers-Theunissen , R. P. (2010) The preconception mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy. Fertility and Sterility (In Press).
Avo de Santos, Margarida, Kuijk, Ewart W. and Macklon, Nick S. (2010) The impact of ovarian stimulation on the embryo. Reproduction, 139, (1), 23-34. (doi:10.1530/REP-09-0187).
Santos, Margarida Avo, Kuijk, Ewart W. and Macklon, Nick S. (2010) The impact of ovarian stimulation for IVF on the developing embryo. Reproduction, 139, (1), 23-34. (doi:10.1530/REP-09-0187).
Boomsma, Carolien M., Kavelaars, Annemieke, Eijkemans, Marinus J.C., Fauser, Bart C.J.M., Heijnen, Cobi J. and Macklon, Nick S. (2009) Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo. Fertility and Sterility, 94, (5), 1764-1768. (doi:10.1016/j.fertnstert.2009.10.044).
Haadsma, M.L., Mooij , T.M., Groen, H., Burger, C.W., Lambalk, C.B., Broekmans, F.J., van Leeuwen , F.E., Bouman, K., Hoek, A., Schats, R., Macklon, N.S., Laven, J.S., Jansen, C.A., Helmerhorst, F.M., Naaktgeboren, N., Cohlen, B.J., Braat, D.D., Kremer, J.A., Willemsen, W.N., Bots, R.S., Simons, A.H., van der Veen, F., Evers, J.L. and van Dop, P.A. (2009) A reduced size of the ovarian follicle pool is associated with an increased risk of a trisomic pregnancy in IVF-treated women. Human Reproduction, 25, (2), 552-558. (doi:10.1093/humrep/dep404 ).
Teklenburg, G. and Macklon, N.S. (2009) Review: In vitro models for the study of early human embryo-endometrium interactions. Reproductive Sciences , 16, (9), 811-818. (doi:10.1177/1933719109334966).
La Marca, A., Broekmans, F.J., Volpe, A., Fauser, B.C. and Macklon, N.S. (2009) Anti-Mullerian hormone (AMH): what do we still need to know? Human Reproduction, 24, (9), 2264-2275. (doi:10.1093/humrep/dep210).
Boxmeer, Jolanda C., Smit, Marji, Utomo, Elaine, Romijn, Johannes C., Eijkemans, Marinus J.C., Lindemans, Jan, Laven, Joop S.E., Macklon, Nick S., Steegers, Eric A.P. and Steegers-Theunissen, Regine P.M. (2009) Low folate in seminal plasma is associated with increased sperm DNA damage. Fertility and Sterility, 92, (2), 548-556. (doi:10.1016/j.fertnstert.2008.06.010). (PMID:18722602).
Boomsma, C.M., Kavelaars, A., Eijkemans, M.J., Lentjes, E.G., Fauser, B.C., Heijnen, C.J. and Macklon, N.S. (2009) Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Human Reproduction, 24, (6), 1427-1435. (doi:10.1093/humrep/dep011).
Boxmeer, Jolanda C., Macklon, Nick S., Lindemans, Jan, Beckers, Nicole G.M., Eijkemans, Marinus J.C., Laven, Joop S.E., Steegers, Eric A.P. and Steegers-Theunissen, Régine P.M. (2009) IVF outcomes are associated with biomarkers of the homocysteine pathway in monofollicular fluid. Human Reproduction, 24, (5), 1059-1066. (doi:10.1093/humrep/dep009 ).
van Mourik, Maaike S.M., Macklon, Nick S. and Heijnen, Cobi J. (2009) Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment. Journal of Leukocyte Biology, 85, (1), 4-19. (doi:10.1189/jlb.0708395).
Verberg, M.F.G., Eijkemans, M.J.C., Macklon, N.S., Heijnen, E.M.E.W., Baart, E.B., Hohmann, F.P., Fauser, B.C.J.M. and Broekmans, F.J. (2009) The clinical significance of the retrieval of a low number of oocytes following mild ovarian stimulation for IVF: a meta-analysis. Human Reproduction Update, 15, (1), 5-12. (doi:10.1093/humupd/dmn053 ).
Verberg, M.F.G., Macklon, Nicholas S., Nargund, G., Frydman, R., Devroey, P., Broekmans, F.J. and Fauser, B.C.J.M. (2009) Mild ovarian stimulation for IVF. Human Reproduction Update, 15, (1), 13-29. (doi:10.1093/humupd/dmn056).
Boomsma, C.M., Kavelaars, A., Eijkemans, M.J.C., Amarouchi, K., Teklenburg, G., Gutknecht, D., Fauser, B.C.J.M., Heijnen, C.J. and Macklon, N. (2009) Cytokine profiling in endometrial secretions: a non-invasive window on endometrial receptivity. Reproductive BioMedicine Online , 18, (1), 85-94.
Vujkovic, M., de Vries, J.H., Dohle, G.R., Bonsel, G.J., Lindemans, J., Macklon, N.S., van der Spek, P.J., Steegers, E.A.P. and Steegers-Theunissen, R.P.M. (2009) Associations between dietary patterns and semen quality in men undergoing IVF/ICSI treatment. Human Reproduction, 24, (6), 1304-1312. (doi:10.1093/humrep/dep024 ).
Baart, Esther , Macklon, N.S. and Fauser, B.J.C.M. (2009) Ovarian stimulation and embryo quality. Reproductive Biomedicine Online, 18, supplement 2, 45-50.
van der Gaast, M.H., Macklon, N., Beier-Hellwig, K., Krusche, C.A., Fauser, B.C., Beier, H.M. and Classen-Linke, I. (2009) The feasibililty of a less invasive method to assess endometrial maturation--comparison of simultaneously obtained uterine secretion and tissue biopsy. British Journal of Obstetrics & Gynaecology, 116, (2), 304-312. (doi:10.1111/j.1471-0528.2008.02039.x).
Kortman, M. and Macklon, N.S. (2008) Oocyte donation in postmenopausal women: medical and ethical considerations. Obstetrics, Gynaecology &Reproductive Medicine, 18, (6), 168-169. (doi:10.1016/j.ogrm.2008.04.005).
Boxmeer, Jolanda C., Steegers-Theunissen, Régine P.M., Lindemans, Jan, Wildhagen, Mark F., Martini, Elena, Steegers, Eric A.P. and Macklon, Nick S. (2008) Homocysteine metabolism in the pre-ovulatory follicle during ovarian stimulation. Human Reproduction, 23, (11), 2570-2576. (doi:10.1093/humrep/den292).
van der Gaast, M.H., Classen-Linke, I., Krusche, C.A., Beier-Hellwig, K., Fauser, B.C. , Beier, H.M. and Macklon, N.S. (2008) Impact of ovarian stimulation on mid-luteal endometrial tissue and secretion markers for receptivity. Reproductive Biomedicine Online, 17, (4), 553-563. (doi:10.1016/S1472-6483(10)60244-1).
Verberg, M.F., Eijkemans, M.J., Heijnen, E.M., Broekmans, F.J., de Klerk, C., Fauser, B.C. and Macklon, N.S. (2008) Why do couples drop-out from IVF treatment? A prospective cohort study. Human Reproduction, 23, (9), 2050-2055. (doi:10.1093/humrep/den219).
Goddijn, M., van den Boogaard, E., Steepers, E.A., Erwich, J.J., Macklon, N. and Steegers-Theunissen, R.P. (2008) The guideline 'Recurrent Miscarriage' (first revision) of the Dutch society for obstetrics and gynaecology. Nederlands Tijdschrift voor Geneeskunde , 152, (30), 1665-1670.
Boomsma, Carolien M. and Macklon, Nicholas S. (2008) Does glucocorticoid therapy in the peri-implantation period have an impact on IVF outcomes? Current Opinion in Obstetrics & Gynecology, 20, (3), 249-256. (doi:10.1097/GCO.0b013e3282f8aff5).
Boxmeer, Jolanda C., Brouns, R. Montserrate, Lindemans, Jan, Steegers, Eric A.P., Martini, Elena, Macklon, Nick S. and Steegers-Theunissen, Régine P. (2008) Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans. Fertility and Sterility, 89, (6), 1766-1770. (doi:10.1016/j.fertnstert.2007.06.036).
Jacod, B.C., Lichtenbelt, K.D., Schuring-Blom, G.H., Laven, J.S.E., van Opstal, D., Eijkemans, M.J.C. and Macklon, N.S. (2008) Does confined placental mosaicism account for adverse perinatal outcomes in IVF pregnancies? Human Reproduction, 23, (5), 1107-1112. (doi:10.1093/humrep/den062).
Verberg, Marieke F.G., Eijkemans, Marinus J.C., Macklon, Nicholas S., Heijnen, Esther M.E.W., Fauser, Bart C.J.M. and Broekmans, Frank J. (2008) Predictors of ongoing pregnancy after single-embryo transfer following mild ovarian stimulation for IVF. Fertility and Sterility, 89, (5), 1159-1165. (doi:10.1016/j.fertnstert.2007.05.020).
Heijnen , E.M., Eijkemans, M.J., de Klerk , C., Polinder , S., Beckers , N.G. , Klinkert , E.R., Broekmans , F.J., Passchier, J., te Velde, E.R., Macklon, N.S. and Fauser, B.C. (2008) Reduction of patient discomfort, risks and costs, but not pregnancies, by a mild strategy for in-vitro fertilization. Nederlands Tijdschrift voor Geneeskunde , 152, (14), 809-816.
Macklon, Nick S., vaan der Gaast, Mark H., Hamilton, Amy, Fauser, Bart C.J.M. and Giudice, Linda C. (2008) The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation. Reproductive Sciences, 15, (4), 357-365. (doi:10.1177/1933719107311781).
Polinder, S., Heijnen, E.M.E.W., Macklon, N.S., Habbema, J.D.F., Fauser, B.J.C.M. and Eijkemans, M.J.C. (2008) Cost-effectiveness of a mild compared with a standard strategy for IVF: a randomised comparison using cumulative term live birth as the primary endpoint. Human Reproduction, 23, (2), 316-323. (doi:10.1093/humrep/dem372).
de Klerk, C., Hunfield, J.A.M., Heijnen, E.M.E.W, Eijkemans, M.J.C. , Fauser, B.C.J.M., Passchier, J. and Macklon, N.S. (2008) Low negative affect prior to treatment is associated with a decreased chance of live birth from a first IVF cycle. Human Reproduction, 23, (1), 112-116. (doi:10.1093/humrep/dem357).
Boomsma, Carolien M, Fauser, Bart C.J.M and Macklon, Nick S (2008) Pregnancy complications in women with polycystic ovary syndrome. Seminars in Reproductive Medicine, 26, (1), 72-84. (doi:10.1055/s-2007-992927).
Nargund, G., Fauser, B.C.J.M., Macklon, N.S., Ombelet, W., Nygren, K. and Frydman, R. (2007) The ISMAAR proposal on terminology for ovarian stimulation for IVF. Human Reproduction, 22, (11), 2801-2804. (doi:10.1093/humrep/dem285). (PMID:17855409).
Boxmeer, Jolanda C., Smit, Marij, Weber, Robertus F., Lindemans, Jan, Romijn, Johannes C., Eijkemans, Marinus J., Macklon, Nicholas S. and Steegers-Theunissen, Regine P. (2007) Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures. Journal of Andrology, 28, (4), 521-527. (doi:10.2164/jandrol.106.001982). (PMID:17287458).
Verberg, M.F.G., Eijkemans, M.J.C., Macklon, N.S., Heijnen, E.M.E.W., Fauser, B.C.J.M. and Broekmans, F.J. (2007) Predictors of low response to mild ovarian stimulation initiated on cycle day 5 for IVF. Human Reproduction, 22, (7), 1919-1924. (doi:10.1093/humrep/dem089). (PMID:17485438).
Hunault, Claudine C., te Velde, Egbert R., Weima, Sjerp M., Macklon, Nicholas S., Eijkemans, Marinus J. C., Klinkert, Ellen R. and Habbema, J. Dik F. (2007) A case study of the applicability of a prediction model for the selection of patients undergoing in vitro fertilization for single embryo transfer in another center. Fertility and Sterility, 87, (6), 1314-1321. (doi:10.1016/j.fertnstert.2006.11.052). (PMID:17307175).
Baart, Esther B., Martini, Elena, Eijkemans, Marinus J, Van Opstal, Diane, Beckers, Nicole G.M., Verhoeff, Arie, Macklon, Nicholas S. and Fauser, Bart C.J.M. (2007) Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Human Reproduction, 22, (4), 980-988. (doi:10.1093/humrep/del484). (PMID:17204525).
Heijnen, Esther M. E. W., Eijkemans, Marinus J. C., De Klerk, Cora, Polinder, Suzanne, Beckers, Nicole G. M., Klinkert, Ellen R., Broekmans, Frank J., Passchier, Jan, Te Velde, Egbert R., Macklon, Nick S. and Fauser, Bart C. J. M. (2007) A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial. The Lancet, 369, (9563), 743-749. (PMID:18491824).
Verberg, M F G, Macklon, N.S., Heijnen, E M E W and Fauser, B C J M (2007) ART: iatrogenic multiple pregnancy? Best Practice & Research Clinical Obstetrics & Gynaecology, 21, (1), 129-143. (doi:10.1016/j.bpobgyn.2006.09.011). (PMID:17074535).
Boomsma, Carolien M., Keay, Stephen D. and Macklon, Nick S. (2007) Peri-implantation glucocorticoid administration for assisted reproductive technology cycles. Cochrane Database of Systematic Reviews, (1), CD005996. (doi:10.1002/14651858.CD005996.pub2). (PMID:17253574).
Boomsma, C.M., Eijkemans, M.J.C., Hughes, E.G., Visser, G.H.A., Fauser, B.C.J.M. and Macklon, N.S. (2006) A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. Human Reproduction Update, 12, (6), 673-683. (doi:10.1093/humupd/dml036). (PMID:16891296).
Boomsma, C. M. and Macklon, N. S. (2006) What can the clinician do to improve implantation? Reproductive BioMedicine Online, 13, (6), 845-855. (doi:10.1016/S1472-6483(10)61034-6). (PMID:20483397).
Kortman, M., de Wert, G.M.W.R., Fauser, B.C. and Macklon, N.S. (2006) Pregnancy at a later age with the help of oocyte donation. Nederlands Tijdschrift Voor Geneeskunde, 150, (47), 2591-2595. (PMID:17203696).
van der Gaast, M.H., Eijkemans, M.J.C., van der Net, J.B., de Boer, E.J., Burger, C.W., van Leeuwen, F.E., Fauser, B.C.J.M. and Macklon, N.S. (2006) Optimum number of oocytes for a successful first IVF treatment cycle. Reproductive BioMedicine Online, 13, (4), 476-480. (doi:10.1016/S1472-6483(10)60633-5). (PMID:17007663).
Heijnen, E.M.E.W., Eijkemans, M.J.C., Hughes, E.G., Laven, J.S.E., Macklon, N.S. and Fauser, B.C.J.M. (2006) A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome. Human Reproduction Update, 12, (1), 13-21. (doi:10.1093/humupd/dmi036). (PMID:16123051).
Beckers, Nicole G. M., Platteau, Peter, Eijkemans, Marinus J., Macklon, Nicholas S., de Jong, Frank H., Devroey, Paul and Fauser, Bart C. J. M. (2006) The early luteal phase administration of estrogen and progesterone does not induce premature luteolysis in normo-ovulatory women. European Journal of Endocrinology, 155, (2), 355-363. (doi:10.1530/eje.1.02199). (PMID:16868151).
Boxmeer, Jolanda C., Fauser, Bart C. J. M. and Macklon, Nick S. (2006) Effect of B vitamins and genetics on success of in-vitro fertilisation. The Lancet, 368, (9531), 200. (PMID:16844484).
Macklon, Nick S., Stouffer, Richard L., Giudice, Linda C. and Fauser, Bart C. J. M. (2006) The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocrine Reviews, 27, (2), 170-207. (doi:10.1210/er.2005-0015). (PMID:16434510).
de Klerk, C., Heijnen, E.M.E.W., Macklon, N.S., Duivenvoorden, H.J., Fauser, B.C.J.M., Passchier, J. and Hunfeld, J.A.M. (2006) The psychological impact of mild ovarian stimulation combined with single embryo transfer compared with conventional IVF. Human Reproduction, 21, (3), 721-727. (doi:10.1093/humrep/dei395). (PMID:16311295).
Baart, E. B, Martini, E., van den Berg, I., Macklon, N. S., Galjaard, R-J. H., Fauser, B. C. J. M. and Van Opstal, D (2006) Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF. Human Reproduction, 21, (1), 223-233. (doi:10.1093/humrep/dei291). (PMID:16155075).
Bischof, P., Aplin, J.D., Bentin-Ley, U., Brannstrom, M., Casslen, B., Castrillo, J.L., Classen-Linke, I., Critchley, H.O.D., Devoto, L., D'Hooghe, T., Horcajadas, J.A., Groothuis, P., Ivell, R., Pongrantz, I., Macklon, N.S., Sharkey, A., Vicovac, L., White, J.O., Winterhager, E., von Wolff, M., Simon, C. and Stavreus-Evers, A. (2006) Implantation of the human embryo: research lines and models. From the implantation research network 'Fruitful'. Gynecologic and Obstetric Investigation, 62, (4), 206-216. (doi:10.1159/000094005). (PMID:16785734).
Macklon, N.S. and Fauser, B C J M (2005) Ovarian reserve. Seminars in Reproductive Medicine, 23, (3), 248-256. (PMID:16059831).
Fauser, Bart C.J.M., Devroey, Paul and Macklon, Nick S. (2005) Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet, 365, (9473), 1807-1816. (doi:10.1016/S0140-6736(05)66478-1). (PMID:16084249).
de Klerk, C., Hunfeld, J.A.M., Duivenvoorden, H.J., den Outer, M.A., Fauser, B.C.J.M., Passchier, J. and Macklon, N.S. (2005) Effectiveness of a psychosocial counselling intervention for first-time IVF couples: a randomized controlled trial. Human Reproduction, 20, (5), 1333-1338. (doi:10.1093/humrep/deh748). (PMID:15650042).
Heijnen, E.M.E.W., Macklon, N.S. and Fauser, B.C.J.M. (2004) What is the most relevant standard of success in assisted reproduction? The next step to improving outcomes of IVF: consider the whole treatment. Human Reproduction, 19, (9), 1936-1938. (doi:10.1093/humrep/deh368). (PMID:15217998).
Devroey, Paul, Bourgain, Claire, Macklon, Nicholas S. and Fauser, Bart C. J. M. (2004) Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends in Endocrinology and Metabolism, 15, (2), 84-90. (doi:10.1016/j.tem.2004.01.009). (PMID:15036255).
Huirne, Judith A.F., Lambalk, Cornelis B., van Loenen, Andre C.D., Schats, Roel, Hompes, Peter G.A., Fauser, Bart C.J.M. and Macklon, Nick S. (2004) Contemporary pharmacological manipulation in assisted reproduction. Drugs, 64, (3), 297-322. (PMID:14871171).
Macklon, N. S. and Fauser, B. C. J. M. (2003) Mild stimulation in in vitro fertilization. Annals of the New York Academy of Sciences, 997, 105-111. (doi:10.1111/(ISSN)1749-6632). (PMID:14644815).
Beckers, Nicole G.M., Macklon, Nicholas S., Eijkemans, Marinus J., Ludwig, Michael, Felberbaum, Ricardo E., Diedrich, Klaus, Bustion, Shelly, Loumaye, Ernest and Fauser, Bart C.J.M. (2003) Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. Journal of Clinical Endocrinology & Metabolism, 88, (9), 4186-4192. (doi:10.1210/jc.2002-021953). (PMID:12970285).
Macklon, N.S. and Fauser, B C (2003) Transfer of only a single embryo in in-vitro fertilisation. Nederlands Tijdschrift Voor Geneeskunde, 147, (27), 1301-1304. (PMID:12868156).
Fekkes, M., Buitendijk, S.E., Verrips, G.H.W., Braat, D.D.M., Brewaeys, A.M.A., Dolfing, J.G., Kortman, M., Leerentveld, R.A. and Macklon, N.S. (2003) Health-related quality of life in relation to gender and age in couples planning IVF treatment. Human Reproduction, 18, (7), 1536-1543. (doi:10.1093/humrep/deg276). (PMID:12832385).
Beckers, Nicole G.M., Macklon, Nicholas S., Devroey, Paul, Platteau, Peter, Boerrigter, Peter J. and Fauser, Bart C.J.M. (2003) First live birth after ovarian stimulation using a chimeric long-acting human recombinant follicle-stimulating hormone (FSH) agonist (recFSH-CTP) for in vitro fertilization. Fertility and Sterility, 79, (3), 621-623. (doi:10.1016/S0015-0282(02)04804-5). (PMID:12620451).
Macklon, Nicholas S. and Fauser, Bart C.J.M., Barbiere, Robert, Crowley, William F. and Martyn, Kathryn A. (eds.) (2003) Overview of ovulation induction. Uptodate
van der Gaast, M.H., Beier-Hellwig, K., Fauser, B.C.J.M., Beier, H.M. and Macklon, N.S. (2003) Endometrial secretion aspiration prior to embryo transfer does not reduce implantation rates. Reproductive BioMedicine Online, 7, (1), 105-109. (doi:10.1016/S1472-6483(10)61737-3). (PMID:12930588).
de Jong, D., Eijkemans, M. J. C., Beckers, N. G. M., Pruijsten, R. V., Fauser, B C J M and Macklon, N. S. (2002) The added value of embryo cryopreservation to cumulative ongoing pregnancy rates per IVF treatment: is cryopreservation worth the effort? Journal of Assisted Reproduction and Genetics, 19, (12), 561-568. (PMID:12503888).
Macklon, N.S., Pieters, M.H.E.C., Hassan, M.A., Jeucken, P.H.M., Eijkemans, M.J.C. and Fauser, B.C.J.M. (2002) A prospective randomized comparison of sequential versus monoculture systems for in-vitro human blastocyst development. Human Reproduction, 17, (10), 2700-2705. (doi:10.1093/humrep/17.10.2700). (PMID:12351551).
Hunault, Claudine C., Eijkemans, Marinus J.C., te Velde, Egbert R., Macklon, Nicholas S. and Habbema, J. Dik F. (2002) A reanalysis of a reanalysis! The path to enlightenment. Fertility and Sterility, 78, (3), 650-1. (PMID:11730774).
Beckers, Nicole G.M., Macklon, Nicholas S., Eijkemans, Marinus J.C. and Fauser, Bart C.J.M. (2002) Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging. Fertility and Sterility, 78, (2), 291-297. (doi:10.1016/S0015-0282(02)03227-2). (PMID:12137865).
van Santbrink, E.J., Eijkemans, M.J., Macklon, N.S. and Fauser, B.C. (2002) FSH response-dose can be predicted in ovulation induction for normogonadotropic anovulatory infertility. European Journal of Endocrinology, 147, (2), 223-226. (doi:10.1530/eje.0.1470223). (PMID:12153744).
Macklon, N. S., Geraedts, J. P. M and Fauser, B. C. J. M. (2002) Conception to ongoing pregnancy: the 'black box' of early pregnancy loss. Human Reproduction Update, 8, (4), 333-343. (doi:10.1093/humupd/8.4.333). (PMID:12206468).
Hunault, Claudine C., Eijkemans, Marinus J.C., Pieters, Math H.E.C., te Velde, Egbert R., Habbema, J. Dik F., Fauser, Bart C.J.M. and Macklon, Nicholas S. (2002) A prediction model for selecting patients undergoing in vitro fertilization for elective single embryo transfer. Fertility and Sterility, 77, (4), 725-732. (doi:10.1016/S0015-0282(01)03243-5). (PMID:11937124).
Macklon, Nicholas S. and Fauser, Bart C.J.M. (2002) Gonadotropin therapy for the treatment of anovulation and for ovarian hyperstimulation for IVF. Molecular and Cellular Endocrinology, 186, (2), 159-161. (doi:10.1016/S0303-7207(01)00660-8). (PMID:11900890).
Van Der Gaast, M.H., Beckers, N.G.M., Beier-Hellwig, K., Beier, H.M., Macklon, N.S. and Fauser, B.C.J.M. (2002) Ovarian stimulation for IVF and endometrial receptivity - the missing link. Reproductive BioMedicine Online, 5, (3), supplement 1, 36-43. (PMID:12537780).
de Jong, Diederick, Macklon, Nicholas S., Eijkemans, Marinus J.C., Mannaerts, Bernadette M.J.L., Coelingh Bennink, Herjan J.T. and Fauser, Bart C.J.M. (2001) Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran/Antagon). Fertility and Sterility, 75, (4), 688-693. (doi:10.1016/S0015-0282(00)01789-1). (PMID:12057752).
De Jong, Diederick, Van Hooren, Eric G., Macklon, Nicholas S., Mannaerts, Bernadette M.J.L. and Fauser, Bart C.J.M. (2001) Pregnancy and birth after GnRH agonist treatment for induction of final oocyte maturation in a woman undergoing ovarian stimulation for ICSI, using a GnRH antagonist (Orgalutran/Antagon) to prevent a premature LH surge: a case report. Journal of Assisted Reproduction and Genetics, 18, (1), 30-33. (doi:10.1023/A:1026498629324). (PMID:11292993).
Fauser, B.C., Laven, J.S., de Jong, D. and Macklon, N.S. (2000) Gonadotrophin-releasing hormone antagonists: application in ovary-stimulating and sex-steroid dependent disorders. Nederlands tijdschrift voor geneeskunde, 144, (8), 370-374. (PMID:10703589).
Macklon, N.S. and Fauser, B.C. (2000) Impact of ovarian hyperstimulation on the luteal phase. Journal of Reproduction and Fertility, 55, 101-108. (PMID:10889839).
Macklon, Nicholas S. (1999) Diagnosis of deep venous thrombosis and pulmonary embolism in pregnancy. Current Opinion in Pulmonary Medicine, 5, (4), 233-237. (PMID:10407693).
Macklon, Nicholas S., Laudy, Jacqueline A. M., Mulder, Paul G. H. and Wladimiroff, Juriy W. (1999) Behavior-state-dependent changes in human fetal pulmonary blood flow velocity waveforms. Obstetrics and Gynecology, 93, (2), 184-188. (PMID:9932552).
Macklon, N. S. and Fauser, B. C. J. M. (1999) Aspects of ovarian follicle development throughout life. Hormone Research, 52, (4), 161-170. (doi:10.1159/000023456). (PMID:10725781).
Macklon, N.S. and Fauser, B.C. (1998) Follicle development during the normal menstrual cycle. Maturitas, 30, (2), 181-188. (PMID:9871911).
Macklon, N.S., Hop, W.C. and Wladimiroff, J.W. (1998) Fetal cardiac function and septal thickness in diabetic pregnancy: a controlled observational and reproducibility study. British Journal of Obstetrics and Gynaecology, 105, (6), 661-666. (doi:10.1111/j.1471-0528.1998.tb10182.x). (PMID:9647158).
de Jong, D., Macklon, N.S., Mannaerts, B.M., Coelingh Bennink, H.J. and Fauser, B.C. (1998) High dose gonadotrophin-releasing hormone antagonist (ganirelix) may prevent ovarian hyperstimulation syndrome caused by ovarian stimulation for in-vitro fertilization. Human Reproduction, 13, (3), 573-575. (doi:10.1093/humrep/13.3.573). (PMID:9572414).
Macklon, Nicholas S. and Greer, Ian A. (1997) The deep venous system in the puerperium: an ultrasound study. British Journal of Obstetrics and Gynaecology, 104, (2), 198-200. (doi:10.1111/j.1471-0528.1997.tb11044.x). (PMID:9070138).
Macklon, Nicholas S., Greer, Ian A. and Bowman, Adrian W. (1997) An ultrasound study of gestational and postural changes in the deep venous system of the leg in pregnancy. British Journal of Obstetrics and Gynaecology, 104, (2), 191-197. (doi:10.1111/j.1471-0528.1997.tb11043.x). (PMID:9070137).
Macklon, N.S. and Greer, I.A. (1996) Venous thromboembolic disease in obstetrics and gynaecology: the Scottish experience. Scottish Medical Journal, 41, (3), 83-86. (PMID:8807703).
Macklon, N.S., Greer, I.A., Reid, A.W. and Walker, I.D. (1995) Thrombocytopenia, antithrombin deficiency and extensive thromboembolism in pregnancy: treatment with low-molecular-weight heparin. Blood Coagulation & Fibrinolysis, 6, (7), 672-675. (PMID:8562839).
Macklon, N.S. and Greer, I.A. (1995) Compression stockings and posture: a comparative study of their effects on the proximal deep veins of the leg at rest. British Journal of Radiology, 68, (809), 515-518. (doi:10.1259/0007-1285-68-809-515). (PMID:7788238).
Macklon, N.S., Barry, J. and Greer, I.A. (1995) Duplex ultrasound screening for deep venous thrombosis in the puerperium. British Journal of Obstetrics and Gynaecology, 102, (3), 255-256. (doi:10.1111/j.1471-0528.1995.tb09104.x). (PMID:7794853).

Book

Macklon, Nicholas, Greer, Ian and Steegers, Eric (eds.) (2008) Textbook of periconceptional medicine, London, GB, Informa Healthcare
Macklon, Nicholas S. (ed.) (2005) IVF in the medically complicated patient: a guide to management, London, GB, Taylor and Francis

Book Section

Cheong, Y., Ginsburg, Elizabeth S. and Macklon, N. (2012) Ovulation stimulation and cycle management in IVF. In, In Vitro Fertilization: A Comprehensive Guide. New York, US, Springer Science & Business Media, 31-54.
Cheong, Y. and Macklon, N.S. (2011) The patient with thrombophilia. In, Assisted Reproduction Techniques: Challenges and Management Options. Oxford, GB, Blackwell. (In Press).
Macklon, Nick and Boomsma, Carlean (2010) Recurrent implantation failure. In, Farquharson, Roy G and Stephenson, Mary D (eds.) Early Pregnancy. Cambridge, UK, Cambridge University Press. (In Press).
Cheong, Y., Brook, N. and Macklon, N.S. (2010) New concepts in ovarian stimulation. In, Gardner, David K., Rizk, Botros R.M.B. and Falcone, Tommaso (eds.) Human Assisted Reproductive Technology: Future Trends in Laboratory & Clinical Practice. Cambridge, GB, Cambridge University Press. (In Press).
Macklon, Nick (2009) Turner's syndrome and oocyte donation. In, Donor Egg IVF. New Delhi, IN, Jaypee Brothers Medical Publishers, 420-426.
Macklon, N. and Fauser, B.C.J.M. (2009) Medical approaches to ovarian stimulation for infertility. In, Yen and Jaffe's Reproductive Endocrinology. Philadelphia, US, Saunders, Elsevier Inc., 689-724.
Fatemi, H., Devroey, P., Fauser, B.C.J.M. and Macklon, Nicholas (2008) The luteal phase. In, Textbook of Periconceptional Medicine. London, Informa Healthcare, 297-307.
Boomsma, C.M. and Macklon, N.S. (2008) Medical strategies to improve ART outcome: current evidence. In, Botros, R.M.B. Rizk, Garcia-Velasco, Juan A., Sallam, Hassan N. and Makrigiannakis, Antonis (eds.) Infertility and Assisted Reproduction. Cambridge, GB, Cambridge University Press, 349-360.
Fauser, B.C. and Macklon, N. (2007) The physiology of reproduction. In, Obstetrics and Gynaecology. Amsterdam, NL, Elsevier.
Macklon, N.S. (2005) The patient at risk of thrombosis. In, Macklon, N.S. (ed.) IVF in the Complicated Patient: Practical Management Options. London, GB, Taylor and Francis.
Macklon, N (2005) 'Controlled' ovarian stimulation: who's kidding who? In, Slager, E., Fauser, B., van Geijn, H., Brolmann, H. and Vervest, H. (eds.) Gynaecology, Obstetrics and Reproductive Medicine Daily. Amsterdam, The Netherlands, Elsevier, 35-38. (International Congress Series , 1279). (doi:10.1016/j.ics.2004.12.053).
Lambalk, C.B., Huirne, J.A.F., Macklon, N.S., Fauser, B.C.J.M. and Homburg, R. (2005) Ovulation induction with clomiphene or gonadotropins. In, Slager, E., Fauser, B., van Geijn, H., Brolmann, H. and Vervest, H. (eds.) Gynaecology, Obstetrics, and Reproductive Medicine in Daily Practice. Amsterdam, NL, Elsevier, 16-23. (International Congress Series, 1279). (doi:10.1016/j.ics.2005.01.009 ).
Macklon, Nick S., Fauser, Bart C.J.M. and Adashi, Eli Y. (2004) Gonadotropin ovulation induction. In, Leung, Peter C.K. (ed.) The Ovary. New York, US, Elsevier Academic Press, 441-449.
Macklon, Nicholas S., Pieters, Math H.E.C. and Fauser, Bart C.J.M. (2004) Indications for IVF: from diagnosis to prognosis. In, Gardner, David K., Weismann, Ariel, Howles, Colin M. and Shoham, Zeev (eds.) Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives: 2nd edition. London, Informa Healthcare, 495-506.
Macklon, Nick S. and Fauser, B.C.J.M. (2004) Indications for IVF treatment: from diagnosis to prognosis. In, Gardner, David K., Weissman, Ariel, Howles, Colin M. and Shobham, Zeev (eds.) Textbook of Assisted Reproductive Technology: Laboratory and Clinical Perspectives. 2nd edition. London, GB, Taylor & Francis, 495-505.
Macklon, N. and Fauser, B.C.J.M. (2004) Medical approaches to ovarian stimulation for infertility. In, Strauss, J. and Barbieri, R. (eds.) Yen and Jaffe's Reproductive Endocrinology. 5th edition. Philadelphia, US, Elsevier Science, 965-1012.
Macklon, N. and Fauser, B.C.J.M. (2003) The step-down protocol. In, Tarlatzis, B.C. (ed.) Ovulation Induction. European Practice in Obstetrics and Gynaecology. Paris, FR, Elsevier.
Macklon, Nicholas S. and Fauser, B.C.J.M. (2002) Sindrome del ovario poliquitico. induccion de la ovualacion con gonadotropinas. In, Remohí, J., Pellicer, A., Simón, C. and Navarro, J. (eds.) Reproducción Humana. Madrid, ES, McGraw-Hill.
Macklon, N., Pieters, M.H.E.C. and Fauser, B.C.J.M. (2001) Indications for IVF treatment. In, Gardner, David K., Weissman, Ariel, Howles, Colin M and Shobham, Zeev (eds.) A Comprehensive Textbook of Assisted Reproductive Technology: Laboratory and Clinical Perspectives. London, GB, Martin Dunitz.
Macklon, Nick S. and Fauser, B.C.J.M. (2001) Novel protocols for ovarian stimulation. In, Devroey, Paul, Diamond, Michael P. and DeCherney, Alan H. (eds.) GnRH Analogues. Philadelphia, United States of America, W.B. Saunders, 141-150. ( Infertility and Reproductive Medicine Clinics of North America, 12 (1)).
Macklon, N. and Fauser, B.C.J.M. (2001) Behandelingen van voortplantingsstoornissen. In, de Joode, Susanne (ed.) Zwanger van de Kinderwens: Visies, Feiten & Vragen over Voortplantingstechnologie. The Hague, The Netherlands, Rathenau Instituut.
Macklon, Nick S. and Fauser, B.C.J.M. (2001) Oorzaken van voortplantingsstoornissen. In, de Joode, Susanne (ed.) Zwanger van de Kinderwens: Visies, Feiten & Vragen over Voortplantingstechnologie. The Hague, The Netherlands, Rathenau Instituut.
Macklon, N.S. and Fauser, B.C.J.M. (2000) Follicle development before and during the menstrual cycle. In, Te Velde, E.R., Pearson, P.L. and Broekmans, F.J. (eds.) Female Reproductive Aging. London, GB, Parthenon, 111-122. (Studies in Profertility Series, 9).
De Jong, D., Macklon, Nick S. and Fauser, B.C.J.M. (2000) Current status of GnRH agonists in ART. In, Perloe , M. and Sills , E.S. (eds.) Manual of Ovulation Induction. India, Republic of, IN, Bhalchandra Press.
de Jong, Diederick, Macklon, N.S. and Fauser, B.C.J.M. (1999) Minimal ovarian stimulation for IVF: extending the 'follicle stimulating hormone window'. In, Jansen, R. and Mortimer, D. (eds.) Towards Reproductive Certainty, Fertility and Genetics beyond 1999: The Plenary Proceedings of the 11th World Congress. 11th World Congress London, GB, Informa Healthcare, 195-199.
Fauser, Bart C.J.M. and Macklon, N.S. (1999) FSH and follicular development. In, Jansen, R. and Mortimer, D. (eds.) Towards Reproductive Certainty, Fertility and Genetics beyond 1999 - Proceedings of the 11th World Congress on In Vitro Fertilization and Human Reproductive Genetics. London, GB, Informa Healthcare, 177-185.
Macklon, N and Fauser, BCJM (1999) Ovarian stimulation in patients with polycystic ovarian syndrome. In, Adashi, Eli Y., Baird, David T. and Crosignani, P.G. (eds.) Gonadotrophins and Fertility in the Woman. Relazioni presentate al Convegno tenuto a Madrid nel 1998 Geneva, Switzerland, Serono. (Serono Fertility Series, 3).
Macklon, N.S. and Fauser, B.C.J.M. (1999) Minimal ovarian hyperstimulation protocols for in-vitro fertilization. In, Genazzani, A.R. and Artini, P.G. (eds.) New Technologies for Gynaecologic and Obstetric Investigation. Rome, IT, CIC Edizioni Internationali.
Macklon, N. and Fauser, B.C.J.M. (1999) Role of estradiol in oocyte maturation and fertilization. In, Filicori, M. (ed.) The Role of LH in Folliculogenesis and Ovulation Induction. Bologna, IT, Monduzzi.
Macklon, N. and Fauser, B.C.J.M. (1998) Ovulation induction: step-up and step-down regimens. In, Kempers, Rodger D., Cohen, J., Hanley, A.F. and Younger, J.B. (eds.) Proceedings of the XVI World Congress on Fertility and Reproductive Medicine. 54th Annual Meeting of the American Society for Reproductive Medicine Amsterdam, NL, Elsevier Science, 529-536. (International Congress Series, 1183).
Macklon, Nicholas S., Imani, Babek and Fauser, B.C.J.M. (1998) Optimalising protocols for ovulation induction. In, Shoham, Zeev, Howles, Colin M. and Jacobs, Howard S. (eds.) Female Infertility Therapy. London, GB, Martin Dunitz, 75-84.
Macklon, N.S. and Fauser, BCJM (1998) Therapy: ovulation induction with step down regimens. In, Polycystic Ovarian Syndrome. Norwell, US, Kluwer Academic Publishers. (Endocrine Updates).

Monograph

Macklon, N. and Fauser, B.C.J.M. (1999) Overview of ovulation induction. Maryland, US, The Endocrine Society
 

Research

Research Interests

The major challenge which remains to be addressed in the treatment of infertility is failure of the embryo to implant. Moreover, peri-implantation and periconceptional events are now recognized as key determinants of perinatal outcomes and long term health in the offspring. My groups current research therefore focuses on developing novel means of assessing and modulating endometrial receptivity in the human, embryo-endometrial interactions, and periconceptional determinants of health.

I currently supervise a number of PhD projects in these fields in Utrecht and Southampton, as listed above.

Our newly built tertiary Fertility Centre which includes IVF treatment provides a superb setting in which to pursue our work in these fields. Our location adjacent to the Institute of Developmental Science, within the Academic Unit of Human Developmental Health, provides a unique combination of facilities and collaborative opportunities to further our work in this field.

Current ongoing research themes include:

The embryo selection window and recurrent miscarriage

Working with Jan Brosens, we have developed a novel paradigm for the role of human decidualised endometrium to sense embryo quality and prevent implantation of poorly viable embryos. We are now investigating how this selection mechansism may be disrupted in women with recurrent miscarriage.

The fate of the early human embryo

Our group coined the now widely used term describing the ‘Black Box of early Pregnancy Loss’ Over the past few years we have carried out a number of studies aimed understanding the fate of the preimplantation and post implantation human embryo. These studies involve in-vitro culture system to study chromosome repair mechanisms, and longitudinal studies of determinants of implantation failure. We are also exploring new markers for in-vivo conception in the human.

The study of the impact of nutritional status on the human reproductive tract

Having pioneered the analysis of endometrial secretions to determine the receptivity of the uterus to implantation, we are now working with Judith Eckert and Franchesca Houghton to develop this technique to allow interrogation of the nutritional environment of the preimplantation human embryo. This work will enable us to identify modulatable factors to optimise this environment and lead to new interventions aimed at increasing succeful implantation and crucial early growth.

Periconceptional intervention studies to improve fertility outcomes

Lifestyle factors have been shown to be major determinants of fertility and the success of fertility treatments like IVF. Our group has been one of those pioneering the introduction of preconceptional health optimisation into routine fertility treatment programs. Linked to this is an ongoing program of intervention studies aimed at refining these interventions.

Academic unit:  Human Development and Health

Responsibilities

Head of Department of Obstetrics and Gynaecology
Leader of HDH Research Program ‘Mother, Pregnancy and Child .
Supervising ACFs
Lecturing on BM programme
Group tuition to 3rd and 5th year Medical Students
Supervising Student research projects
Invited speaker at international symposia
Consultant to various biotech companies
Visiting Professor of reproductive Medicine in Adelaide and Utrecht
External Assessor for University of Valencia Medical School
Member of MRC Unit Quinquennial Review board.
Director of Complete Fertility Centre Southampton.
Leading research groups in Southampton and Utrecht
Supervising PhD and MD students

Postgraduate student supervision

Past PhD Projects supervised

N. Beckers Novel Interventions in the Luteal Phase after Assisted Reproduction 2006
E.Heijnen New paradigms in IVF treatments 2006
M.Verberg Clinical Outcomes from Mild IVF Strategies 2007
C. de Klerk Psychological Aspects of Assisted Reproduction 2008
A. Badawy Novel approaches to ovulation induction 2008
M. vd. Gaast Endometrial Receptivity in Assisted Reproduction 2009
J. Boxmeer Nutritional Determinants of Outcome in Infertility Treatment. 2009
C.Boomsma Immunological Determinants of Endometrial Receptivity 2009
A. Darwish Clinical studies in reconstructive fertility surgery 2009
G. Teklenburg Preimplantation embryo-signalling 2010
M. Sterrenburg Reducing the burden of ovarian stimulation 2011

Current PhD projects supervised

M. Santos Early embryo development
O.Hamdine Refining the GnRH antagonist protocol
H. Ockhuysen Periconceptional interventions for stress reduction in IVF and recurrent miscarriage
Y. Koot The endometrial factor in infertility and early pregnancy loss.
L. Weimar Molecular mechanisms in implantation failure
G. Meng Environmental determinants of ovarian function
S. Lu Intrauterine monitoring

Teaching Responsibilities

Lecturing to undergraduate and postgraduates

Clinical teaching and tutorials

Project supervision and assessment

Contact

Professor Nicholas Stephen Macklon
Faculty of Medicine
University of Southampton
Southampton General Hospital
Mailpoint 801
South Academic Block
Tremona Road
Southampton
SO16 6YD
or
Faculty of Medicine
University of Southampton
Building 85
Life Sciences Building
Highfield Campus
Southampton
SO171BJ

Email: N.S.Macklon@soton.ac.uk