Medicine

Paul Little

MBBS, BA, MD, DLSHTM, MRCP, FRCGP, FMedSci

Primary position:
Professor of Primary Care Research

Background

The University of Southampton

Professor Little was the first GP to be awarded a Wellcome HSR training fellowship (for research on health promotion), and the first to be awarded an MRC Clinician Scientist Fellowship (for research on common self-limiting illness), and in addition current major areas of research are in enabling behaviour change both for health professionals and also in empowering patients.

Qualifications

BA Physiology, Oxford (1981)
MBBS, London (1984)
MRCP, London (1989)
MD, London (1992)
MRCGP, London (1992)
DLSHTM, London (1995)
MSc, LSHTM (1995)
FRCGP, London (2000)
FMedSci, London (2010)

Appointments held

Wellcome HSR Fellow,
University of Southampton (1993-1997)

MRC Clinician Scientist,
University of Southampton (1998-2003)

Current Post: Professor of Primary Care Research.

Aldermoor Health Centre, Southampton University commenced 1/2/2003

Professor Paul Little's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Anthierens, Sibyl, Tonkin-Crine, Sarah, Cals, Jochen W., Coenen, Samuel, Yardley, Lucy, Brookes-Howell, Lucy, Fernandez-Vandellos, Patricia, Krawczyk, Jaroslaw, Godycki-Cwirko, Maciek, Llor, Carl, Butler, Christoper C., Verheij, Theo, Goossens, Herman, Little, Paul and Francis, Nick A. GRACE/CHAMP INTRO team (2014) Clinicians' views and experiences of interventions to enhance the quality of antibiotic prescribing for acute respiratory tract infections. General Journal of Internal Medicine, 1-9. (doi:10.1007/s11606-014-3076-6). (PMID:25373834).
Morrison, Leanne G, Hargood, Charlie, Lin, Sharon Xiaowen, Dennison, Laura, Joseph, Judith, Hughes, Stephanie, Michaelides, Danius T, Johnston, Derek, Johnston, Marie, Michie, Susan, Little, Paul, Smith, Peter WF, Weal, Mark J and Yardley, Lucy (2014) Understanding usage of a hybrid website and smartphone app for weight management: a mixed-methods study. Journal of Medical Internet Research, 16, (10), e201. (doi:10.2196/jmir.3579).
van Erp, Nicole, Little, Paul, Stuart, Beth, Moore, Michael, Thomas, Mike, Butler, Chris C., Hood, Kerenza, Coenen, Samuel, Goossens, Herman, Leven, Margareta and Verheij, Theo J.M. on behalf of the GRACE consortium (2014) Influence of lung function on course of disease and response to antibiotic therapy in adult primary care patients with acute cough: a post hoc analysis of patients enrolled in a prospective multicentre study. NPJ Primary Care Respiratory Medicine , 24, (14067), 1-7. (doi:10.1038/npjpcrm.2014.67). (PMID:25253123).
Cook, Johanna, Hayward, Gail, Thompson, Matthew, Hay, Alastair D., Moore, Michael, Little, Paul, Harman, Kim, Wolstenholme, Jane, Perera, Rafael, Voysey, Merryn, Allen, Julie, Breen, Maria and Heneghan, Carl (2014) Oral corticosteroid use for clinical and cost-effective symptom relief of sore throat: study protocol for a randomized controlled trial. Trials, 15, (365), 1-13. (doi:10.1186/1745-6215-15-365). (PMID:25238785).
McManus, Richard J., Mant, Jonathan, Haque, Sayeed, Bray, Emma P., Bryan, Stirling, Greenfield, Sheila M., Jones, Miren I., Jowett, Sue, Little, Paul, Penaloza, Cristina, Schwartz, Claire, Shackleford, Helen, Shovelton, Claire, Varghese, Jinu, Williams, Bryan and Hobbs, Richard (2014) Effect of self-monitoring and medication self-titration on systolic blood pressure in hypertensive patients at high risk of cardiovascular disease: the TASMIN-SR randomized clinical trial. JAMA The Journal of the American Medical Association, 312, (8), 799-808. (doi:10.1001/jama.2014.10057).
El-Gohary, Magdy, van Zuuren, E.J., Fedorowicz, Z., Burgess, H., Doney, L., Stuart, B., Moore , M and Little, P. (2014) Topical antifungal treatments for tinea cruris and tinea corporis. The Cochrane Database of Systematic Reviews, (8), CD009992. (doi:10.1002/14651858.CD009992.pub2).
Geraghty, A.W.A., Essery, R., Kirby, S., Little, P., Bronstein, A., Turner, D., Stuart, B., Andersson, A., Carlbring, P. and Yardley, L. (2014) Internet-based vestibular rehabilitation for adults over 50: protocol for a randomised controlled trial. BMJ Open, 4, (e005871), 1-11. (doi:10.1136/bmjopen-2014-005871). (PMID:25052178).
Gulliford, Martin C., van Staa, Tjeerd, Dregan, Alex, McDermott, Lisa, McCann, Gerard, Ashworth, Mark, Charlton, Judith, Little, Paul, Moore, Michael V. and Yardley, Lucy (2014) Electronic health records for intervention research: a cluster randomized trial to reduce antibiotic prescribing in primary care (eCRT Study). Annals of Family Medicine, 12, (4), 344-351. (doi:10.1370/afm.1659). (PMID:25024243).
Tonkin-Crine, S., Anthierens, S., Francis, N.A., Brugman, C., Fernandez-Vandellos, P., Krawczyk, J., Llor, C.., Yardley, L., Coenen, S., Godycki-Cwirko, M., Butler, C.C., Verheij, T.J.M., Goossens, H., Little, P. and Cals, J.W. on behalf of the GRACE INTRO team (2014) Exploring patients' views of primary care consultations with contrasting interventions for acute cough: a six-country European qualitative study. npj Primary Care Respiratory Medicine, 24, 14026-[6pp]. (doi:10.1038/npjpcrm.2014.26). (PMID:25030621).
Yardley, Lucy, Ware , L.J, Smith , E.R., Williams , S., Bradbury , K.J., Arden-Close, Emily, Mullee, M., Moore , M., Peacock , J.L., Lean, M.E.J., Margetts, B.M., Byrne, Christopher D., Hobbs , R.F.D. and Little, Paul (2014) Randomised controlled feasibility trial of a web-based weight management intervention with nurse support for obese patients in primary care. International Journal of Behavioral Nutrition and Physical Activity, 11, (1), 67. (doi:10.1186/1479-5868-11-67). (PMID:24886516).
Bishop, Felicity L., Yardley, Lucy, Prescott, P., Cooper, C., Little, Paul and Lewith, George T. (2014) Psychological covariates of longitudinal changes in back-related disability in patients undergoing acupuncture. Clinical Journal of Pain (In Press).
Ekberg, K., McDermott, J., Moynihan, C., Brindle, L., Little, P. and Leydon, G.M. (2014) The role of helplines in cancer care: Intertwining emotional support with information or advice seeking needs. Journal of Psychosocial Oncology, 1-42. (doi:10.1080/07347332.2014.897294). (PMID:24611530).
Little, P., Moore, M., Kelly, J., Williamson, I., Leydon, G., McDermott, L., Mullee, M. and Stuart, B. on behalf of the PIPS Investigators (2014) Delayed antibiotic prescribing strategies for respiratory tract infections in primary care: pragmatic, factorial, randomised controlled trial. British Medical Journal, 348: g1606, 1-8. (doi:10.1136/bmj.g1606). (PMID:24603565).
Little, P., Stuart, B., Hobbs, F.D., Butler, C.C., Hay , A.D., Delaney, B., Campbell, J., Broomfield, S., Barratt, P., Hood, K., Everitt, H., Mullee, M., Williamson, I., Mant, D. and Moore, M. DESCARTE investigators (2014) Antibiotic prescription strategies for acute sore throat: a prospective observational cohort study. The Lancet Infectious Diseases, 14, (3), 1-7. (doi:10.1016/S1473-3099(13)70294-9). (PMID:24440616).
Dennison, Laura, Morrison, Leanne , Lloyd, Scott, Phillips, Dawn, Stuart, Beth, Williams, Sarah, Bradbury, Katherine, Roderick, Paul, Murray, Elizabeth, Michie, Susan, Little, Paul and Yardley, Lucy. (2014) Does brief telephone support improve engagement with a web-based weight management intervention? Randomized controlled trial. Journal of Medical Internet Research, 16, (3), e95. (doi:10.2196/jmir.3199).
Santer, Miriam, Muller, Ingrid, Yardley, Lucy, Burgess, Hana, Selinger, Hannah, Stuart, Beth L and Little, Paul (2014) Supporting self-care for families of children with eczema with a Web-Based intervention plus health care professional support: pilot randomized controlled trial. Journal of Medical Internet Research, 16, (3), e70. (doi:10.2196/jmir.3035). (PMID:24594972).
Everitt, Hazel, McDermott, Lisa, Leydon, Geraldine, Yules, Harvey, Baldwin, David and Little, Paul (2014) GPs' management strategies for patients with insomnia: a survey and qualitative interview study. British Journal of General Practice, 64, (619), e112-e119. (doi:10.3399/bjgp14X677176).
Hamoen, Marleen, Broekhuizen, Berna D.L., Little, Paul, Melbye, Hasse, Coenen, Samuel, Goossens, Herman, Butler, Chris C., Francis, Nick A. and Verheij, Theo J.M. on behalf of the GRACE clinical study group (2014) Medication use in European primary care patients with lower respiratory tract infection: an observational study. British Journal of General Practice, 64, (619), e81-e91. (doi:10.3399/bjgp14X677130). (PMID:24567621).
Wang, K., Birring, Surinder S., Taylor, Kathryn, Fry, Norman K., Hay, Alastair D., Moore, Michael, Jin, Jing, Perera, Rafael, Farmer, Andrew, Little, Paul, Harrison, Timothy G, Mant, David and Harnden, Anthony (2014) Montelukast for postinfectious cough in adults: a double-blind randomised placebo-controlled trial. The Lancet Respiratory Medicine , 2, (1), 35-43. (doi:10.1016/S2213-2600(13)70245-5).
Lau, Rosa, Stevenson , Fiona, Ong, Bie Nio, Dziedzic, Krysia, Everitt, Hazel, Kennedy, Anne, Kontopantelis, Evangelos, Little, Paul, Qureshi, Nadeem, Rogers, Anne, Treweek, Shaun, Peacock, Richard and Murray, Elizabeth (2014) Addressing the evidence to practice gap for complex interventions in primary care: a systematic review of reviews protocol. BMJ Open, 4, 1-7. (doi:10.1136/bmjopen-2014-005548). (PMID:24958212).
Gulliford, M.C., Dregan, A., Moore, M.V., Ashworth, M., van Staa, T., McGann, G., Charlton, J., Yardley, L., Little, P. and McDermott, L. (2014) Continued high rates of antibiotic prescribing to adults with respiratory tract infection: survey of 568 UK general practices. BMJ Open, 4, (10), e006245-[6pp]. (doi:10.1136/bmjopen-2014-006245 ). (PMID:25348424).
Jones , Lucy, Roberts, L., Little, Paul, Mullee, M., Cleland, J.A. and Cooper, C (2014) Shared decision-making in back pain consultations: An illusion or reality? European Spine Journal, 1-17.
Moore, Michael, Stuart, Beth, Coenen, Samuel, Butler, Chris C., Goossens, Herman, Verheij , Theo J.M. and Little, Paul on behalf of the GRACE consortium (2014) Amoxicillin for acute lower respiratory tract infection in primary care: subgroup analysis of potential high-risk groups. British Journal of General Practice, 64, (619), e75-e80. (doi:10.3399/bjgp14X677121). (PMID:24567620).
Little, Paul, Stuart, Beth, Hobbs, F.D. Richard, Butler, Chris C., Hay, Alastair D., Campbell, John, Delaney, Brendan, Broomfield, Sue, Barratt, Paula, Hood, Karenza, Everitt, Hazel, Mullee, Mark, Williamson, Ian, Mant, David and Moore, Michael on behalf of the DESCARTE investigators (2013) Predictors of suppurative complications for acute sore throat in primary care: prospective clinical cohort study. British Medical Journal, 347:f6867, 1-14. (doi:10.1136/bmj.f6867).
Yardley, L., Douglas, E., Anthierens, S., Tonkin-Crine, S., O'Reilly, G., Stuart, B., Geraghty, A.W., Arden-Close, E., van der Velden, A.W., Goosens, H., Verheij, T.J., Butler, C.C., Francis, N.A. and Little, P. GRACE consortium (2013) Evaluation of a web-based intervention to reduce antibiotic prescribing for LRTI in six European countries: quantitative process analysis of the GRACE/INTRO randomised controlled trial. Implementation Science, 8, (134), 1-10. (doi:10.1186/1748-5908-8-134). (PMID:24238118).
Little, Paul, Moore, Michael, Hobbs, F.D.R., Mant, David, McNulty, Cliodna, Williamson, Ian, Cheng, Edith, Stuart, Beth, Kelly, Joanne, Barnett, Jane and Mullee, Mark PRISM investigators (2013) PRImary care Streptococcal Management (PRISM) study: identifying clinical variables associated with Lancefield group A β-haemolytic streptococci and Lancefield non-Group A streptococcal throat infections from two cohorts of patients presenting with an acute sore throat. BMJ Open, 3, (10), e003943. (doi:10.1136/bmjopen-2013-003943 ). (PMID:24163209).
Little, P.S., Moore, M., Kelly, J., Williamson, I., Leydon, G., McDermott, L., Mullee, M. and Stuart, B. on behalf of the PIPS investigators (2013) Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial. BMJ, 347:f6041, 1-13. (doi:10.1136/bmj.f6041).
Little, P., Hobbs, F.D.R., Moore, M., Mant, D., Williamson, I., McNulty, C., Cheng, Y.E., Leydon, G., McManus, R., Kelly, J., Barnett, J., Glasziou, P. and Mullee, M. on behalf of the PRISM investigators (2013) Clinical score and rapid antigen detection test to guide antibiotic use for sore throats: randomised controlled trial of PRISM (primary care streptococcal management). BMJ, 347:f5806, 1-10. (doi:10.1136/bmj.f5806 ). (PMID:24114306).
Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J.W., Melbye, H., Santer, M., Moore, M., Coenen, S., Butler, C., Hood, K., Kelly, M., Godycki-Cwirko, M., Mierzecki, A., Torres, A., Llor, C., Davies, M., Mullee, M., O'Reilly, G., van der Velden, A., Geraghty, A.W., Goossens, H., Verheij, T. and Yardley, L. on behalf of the GRACE consortium (2013) Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial. The Lancet, 382, (9899), 1175-1182. (doi:10.1016/S0140-6736(13)60994-0). (PMID:23915885).
Kendrick, T and Little, P. (2013) Use of PHQ-9 scores to guide treatment decisions in primary care (letter). British Journal of General Practice, 63, (613), 405-406. (doi:10.3399/bjgp13X670624).
El-Gohary, Magdy, Hay, Alastair D., Coventry, Peter, Moore, Michael, Stuart, Beth and Little, Paul (2013) Corticosteroids for acute and subacute cough following respiratory tract infection: a systematic review. Family Practice, 1-9. (doi:10.1093/fampra/cmt034). (PMID:23836094).
Dima, Alexandra, Lewith, George T., Little, Paul S., Moss-Morris, Rona, Foster, Nadine E. and Bishop, Felicity L. (2013) Identifying patients’ beliefs about treatments for chronic low back pain in primary care: a focus group study. British Journal of General Practice, 63, (612), e490-e498. (http://dx.doi.org/10.3399/bjgp13X669211).
Bruton, Anne, Kirby, Sarah, Arden-Close, Emily, Taylor, L, Webley, F, George, S, Yardley, L, Price, D, Moore, M., Little, P., Holgate, S., Djukanovic, R., Lee, AJ, Raftery, J., Chorozoglou, M, Versnel, J, Pavord, I, Stafford-Watson, M and Thomas, M. (2013) The BREATHE study: Breathing REtraining for Asthma - Trial of Home Exercises. A protocol summary of a randomised controlled trial. Primary Care Respiratory Journal, 22, (2), PS1-PS7. (doi:10.4104/pcrj.2013.00047).
van Vugt, Saskia F., Broekhuizen, Berna D.L., Lammens, Christine, Zuithoff, Nicolaas P.A., de Jong, Pim A., Coenen, Samuel, Ieven, Margareta, Butler, Chris C., Goossens, Herman, Little, Paul and Verheij, Theo J.M. GRACE Consortium (2013) Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. BMJ, 346, f2450. (doi:10.1136/bmj.f2450). (PMID:23633005).
Everitt, Hazel, Moss-Morris, Rona, Sibelli, Alice, Tapp, Laura, Coleman, Nicholas, Yardley, Lucy, Smith, Peter and Little, Paul (2013) Management of irritable bowel syndrome in primary care: the results of an exploratory randomised controlled trial of mebeverine, methylcellulose, placebo and a self-management website. BMC Gastroenterology, 13, (68), 1-13. (doi:10.1186/1471-230X-13-68). (PMID:23602047).
Worsley, Peter, Warner, Martin, Mottram, Sarah, Gadola, Stephan D., Veeger, H.E.J, Hermens, H, Morrissey, D, Little, Paul, Cooper, C., Carr, A and Stokes, M. (2013) Motor control retraining exercises for shoulder impingement: effects on function, muscle activation, and biomechanics in young adults. Journal of Shoulder and Elbow Surgery, 22, (4), 11-19. (doi:10.1016/j.jse.2012.06.010).
Santer, Miriam, Burgess, Hana, Yardley, Lucy, Ersser, Steven J., Lewis-Jones, Sue, Muller, Ingrid, Hugh, Catherine and Little, Paul (2013) Managing childhood eczema: qualitative study exploring carers' experiences of barriers and facilitators to treatment adherence. Journal of Advanced Nursing, 69, (11), 2493-2501. (doi:10.1111/jan.12133). (PMID:23528163).
Little, Paul, Stuart, Beth, Moore, Michael, Coenen, Samuel, Butler, Christopher C., Godycki-Cwirko, Maciek, Mierzecki, Artur, Chlabicz, Slawomir, Torres, Antoni, Almirall, Jordi, Davies, Mel, Schaberg, Tom, Molstad, Sigvard, Blasi, Francesco, De Sutter, An, Kersnik, Janko, Hupkova, Helena, Touboul, Pia, Hood, Kerenza, Mullee, Mark, O'Reilly, Gillian, Brugman, Curt, Goossens, Herman and Verheij, Theo GRACE consortium (2013) Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial. The Lancet Infectious Diseases, 13, (2), 123-129. (doi:10.1016/S1473-3099(12)70300-6). (PMID:23265995).
Yardley, L., Williams, S., Bradbury, K., Garip, G., Renouf, S., Ware, L., Dorling, H., Smith, E. and Little, P. (2013) Integrating user perspectives into the development of a web-based weight management intervention. Clinical Obesity, 2, (5-6), 132-141. (doi:10.1111/cob.12001).
Wood, F., Phillips, C., Brookes-Howell, L., Hood, K., Verheij, T., Coenen, S., Little, P., Melbye, H., Godycki-Cwirko, M., Jakobsen, K., Worby, P., Goossens, H. and Butler, C.C. (2013) Primary care clinicians' perceptions of antibiotic resistance: a multi-country qualitative interview study. Journal of Antimicrobial Chemotherapy, 68, (1), 237-243. (doi:10.1093/jac/dks338). (PMID:22949622).
van Vugt, S.F., Verheij, T.J., de Jong, P.A., Butler, C.C., Hood, K., Coenen, S., Goossens, H., Little, P. and Broekhuizen, B.D. GRACE Group (2013) Diagnosing pneumonia in patients with acute cough: clinical judgment compared to chest radiography. European Respiratory Journal, 42, (4), 1076-1082. (doi:10.1183/09031936.00111012 ). (PMID:23349450).
Coenen, S., Francis, N., Kelly, M., Hood, K., Nuttall, J., Little, P., Verheij, T.J., Melbye, H., Goossens, H. and Butler, C.C. on behalf of GRACE study group (2013) Are patient views about antibiotics related to clinician perceptions, management and outcome? A multi-country study in outpatients with acute cough. PLoS ONE, 8, (10), e:76691. (doi:10.1371/journal.pone.0076691).
Leydon, Gerry M., McDermott, Lisa, Moore, Michael, Williamson, Ian, Hobbs, Richard, Lambton, Tessa, Cooper, Rebecca, Henderson, Hugo, Kelly, Jo, Barnett, Jane, Middleton, Karen and Little, Paul on behalf of the PRISM Investigators (2013) A qualitative study of GP, NP and patient views about the use of rapid streptococcal antigen detection tests (RADTs) in primary care: "swamped with sore throats?". BMJ Open, 3, (4), e002460. (doi:10.1136/bmjopen-2012-002460).
Eardley, S., Brien, S., Little, P., Prescott, P. and Lewith , G. (2013) Professional kinesiology practice for chronic low back pain: single-blind, randomised controlled pilot study. Forschende Komplementaedizin / Research in Complementary Medicine, 20, (3), 180-188. (doi:10.1159/000346291). (PMID:23860019).
van der Velden, A.W., Pijpers, E.J., Kuyvenhoven, M.M., Tonkin-Crine, S.K.G., Little, P. and Verheij , T.J.M. (2012) Effectiveness of physician-targeted interventions to improve antibiotic use for respiratory tract infections. British Journal of General Practice, 62, (605), e801-e807. (doi:10.3399/bjgp12X659268). (PMID:23211259).
Vugt, S.V., Broekhuizen, L., Zuithoff, N., Butler, C., Hood, K., Coenen, S., Goossens, H., Little, P., Almirall, J., Blasi, F., Chlabicz, S., Davies, M., Godycki-Cwirko, M., Hupkova, H., Kersnik, J., Moore, M., Schaberg, T., De Sutter, A., Torres, A. and Verheij, T. GRACE Project Group (2012) Airway obstruction and bronchodilator responsiveness in adults with acute cough. Annals of Family Medicine, 10, (6), 523-529. (doi:10.1370/afm.1416). (PMID:23149529).
Vugt, S. van, Broekhuizen, L., Zuithoff, N., De Jong, P., Butler, C., Hood, K., Coenen, S., Goossens, H., Little, P., Almirall, J., Blasi, F., Chlabicz, S., Davies, M., Godycki-Cwirko, M., Hupkova, H., Kersnik, J., Mierzecki, A., Molstad, S., Moore, M., Schaberg, T., De Sutter, A., Torres, A., Touboul, P. and Verheij, T. (2012) Incidental chest radiographic findings in adult patients with acute cough. The Annals of Family Medicine, 10, (6), 510-515. (doi:10.1370/afm.1384 ).
Anthierens, Sibyl, Tonkin-Crine, Sarah, Douglas, Elaine, Fernandez-Vandellos, Patricia, Krawczyk, Jaroslaw, Llor, Carl, Cals, Jochen W., Francis, Nick A., Yardley, Lucy, Coenen, Samuel, Verheij, Theo, Goossens, Herman and Little, Paul GRACE INTRO study team (2012) General Practitioners' views on the acceptability and applicability of a web-based intervention to reduce antibiotic prescribing for acute cough in multiple European countries: a qualitative study prior to a randomised trial. BMC Family Practice, 13, (101) (doi:10.1186/1471-2296-13-101). (PMID:23110756).
Francis, Nick A., Gillespie, David, Nuttall, Jacqueline, Hood , Kerenza, Little, Paul, Verheij, Theo, Goossens, Herman, Coenen, Samuel and Butler, Christopher C. (2012) Delayed antibiotic prescribing and associated antibiotic consumption in adults with acute cough. British Journal of General Practice, 62, (602), e639-e646. (doi:10.3399/bjgp12X653561). (PMID:22947585).
Tonkin-Crine, Sarah, Yardley, Lucy, Coenen, Samuel, Fernandez-Vandellos, Patricia, Krawczyk, Jaroslaw, Touboul, Pia, Verheij, Theo and Little, Paul (2012) Strategies to promote prudent antibiotic use: exploring the views of professionals who develop and implement guidelines and interventions. Family Practice, 1-8. (doi:10.1093/fampra/cms043).
El-Gohary, Magdy, Burgess, Hana, Doney, L., Johnson, E., Stuart, Beth, Moore, Michael, Hearn, P. and Little, Paul (2012) Topical antifungal treatments for tinea cruris and tinea corporis (Protocol). Cochrane Database of Systematic Reviews, 8, (CD0099) (doi:10.1002/14651858.CD009992).
McDermott, Clare, Coppin, Richard, Little, Paul and Leydon, Geraldine (2012) Hospital admissions from nursing homes: a qualitative study of GP decision making. British Journal of General Practice, 62, (601), e538-e545. (doi:10.3399/bjgp12X653589). (PMID:22867677).
Jani, Bhautesh, Bikker, Annemieke P., Higgins, Maria, Fitzpatrick, Bridie, Little, Paul, Watt, Graham C.M. and Mercer, Stewart W. (2012) Patient centredness and the outcome of primary care consultations with patients with depression in areas of high and low socioeconomic deprivation. British Journal of General Practice, 62, (601), e576-e581. (doi:10.3399/bjgp12X653633). (PMID:22867682).
Brookes-Howell, Lucy, Hood, Kerenza, Cooper, Lucy, Little, Paul, Verheij, Theo, Coenen, Samuel, Godycki-Cwirko, Maciek, Melbye, Hasse, Borras-Santos, Alicia, Worby, Patricia, Jakobsen, Kristin, Goossens, Herman and Butler, Christopher C. (2012) Understanding variation in primary medical care: a nine-country qualitative study of clinicians' accounts of the non-clinical factors that shape antibiotic prescribing decisions for lower respiratory tract infection. BMJ Open, 2, (4), e000796 . (doi:10.1136/bmjopen-2011-000796 ). (PMID:22918670).
Latter, Sue, Smith, Alesha, Blenkinsopp, Alison, Nicholls, Peter G., Little, Paul and Chapman, Stephen (2012) Are nurse and pharmacist independent prescribers making clinically appropriate prescribing decisions? An analysis of consultations. Journal of Health Services Research and Policy, 17, (3), 149-156. (doi:10.1258/jhsrp.2012.011090). (PMID:22734082).
Yardley, Lucy, Barker, Fiona, Muller, Ingrid, Turner, David, Kirby, Sarah, Mullee, Mark, Morris, Anna and Little, Paul (2012) Clinical and cost-effectiveness of booklet based vestibular rehabilitation for chronic dizziness in primary care: single blind, parallel group, pragmatic, randomised controlled trial. British Medical Journal, 344, (e2237), e2237-[14pp]. (doi:10.1136/bmj.e2237). (PMID:22674920).
Francis, Nick A., Gillespie, David, Nuttall, Jacqueline, Hood, Kerenza, Little, Paul, Verheij, Theo, Coenen, Samuel, Cals, Jochen W., Goossens, Herman and Butler, Christopher C. GRACE Project Group (2012) Antibiotics for acute cough: an international observational study of patient adherence in primary care. British Journal of General Practice, 62, (599), e429-e437. (doi:10.3399/bjgp12X649124). (PMID:22687236).
Flower, Andrew, Liu, Jian Ping, Lewith, George, Little, Paul S. and Li, Qing (2012) Chinese herbal medicine for endometriosis. Cochrane Database of Systematic Reviews , 16, (5), CD006568. (doi:10.1002/14651858.CD006568.pub3). (PMID:22592712).
Brookes-Howell, Lucy, Hood, Kerenza, Cooper, Lucy, Coenen, Samuel, Little, Paul, Verheij, Theo, Godycki-Cwirko, Maciek, Melbye, Hasse, Krawczyk, Jaroslaw, Borras-Santos, Aalicia, Jakobsen, Kristin, Worby, Patricia, Goossens, Herman and Butler, Christopher C. (2012) Clinical influences on antibiotic prescribing decisions for lower respiratory tract infection: a nine country qualitative study of variation in care. BMJ Open, 2, (3), e000795. (doi:10.1136/bmjopen-2011-000795). (PMID:22619265).
Santer, Miriam, Burgess, Hana, Yardley, Lucy, Ersser, Steven, Lewis-Jones, Sue, Muller, Ingrid, Hugh, Catherine and Little, Paul (2012) Experiences of carers managing childhood eczema and their views on its treatment: a qualitative study. British Journal of General Practice, 62, (597), 261-267. (doi:10.3399/bjgp12X636083). (PMID:22520913).
Westwood, Greta Patricia, Pickering, Ruth, Latter, S., Little, Paul, Gerard, Karen, Lucassen, Anneke and Temple, Karen (2012) A cluster-randomised factorial trial of a primary care specialist genetics service. British Journal of General Practice
Francis, N.A., Cals, J.W., Butler, C.C., Hood, K., Verheij, T., Little, P., Goossens, H. and Coenen, S. GRACE Project Group (2012) Severity assessment for lower respiratory tract infections: potential use and validity of the CRB-65 in primary care. Primary Care Respiratory Journal, 21, (1), 65-70. (doi:10.4104/pcrj.2011.00083). (PMID:21938349).
Westwood, Greta, Pickering, Ruth, Latter, Sue, Little, Paul, Gerard, Karen, Lucassen, Anneke and Temple, I Karen (2012) A primary care specialist genetics service: a cluster-randomised factorial trial. British Journal of General Practice, 62, (596), 191-197. (doi:10.3399/bjgp12X630089). (PMID:22429436).
White, Peter, Bishop, Felicity L., Prescott, Philip, Scott, Clare, Little, Paul and Lewith, George (2012) Practice, practitioner or placebo? A multifactorial, mixed methods randomized controlled trial of acupuncture. Pain, 153, (2), 455-462. (doi:10.1016/j.pain.2011.11.007).
Jones, Miren I., Greenfield, Shiela M., Bray, Emma P., Baral-Grant, Sabrina, Hobbs, F.D., Holder, Roger, Little, Paul, Mant, Jonanthan, Virdee, Satnam K., Williams, Bryan and McManus, Richard J. (2012) Patients' experiences of self-monitoring blood pressure and self-titration of medication: the TASMINH2 trial qualitative study. British Journal of General Practice, 62, (595), e135-e142. (doi:10.3399/bjgp12X625201). (PMID:22520791).
Foster, Nadine and Little, Paul (2012) Methodological issues in pragmatic trials of complex interventions in primary care. British Journal of General Practice, 62, (594), 10-11. (doi:10.3399/bjgp12X616238). (PMID:22520661).
Downing, Harriet, Thomas-Jones, Emma, Gal, Micaela, Waldron, Cherry-Ann, Sterne, Jonathan, Hollingworth, William, Hood, Kerenza, Delaney, Brendan, Little, Paul, Howe, Robin, Wootton, Mandy, Macgowan, Alastair, Butler, Christopher C. and Hay, Alastair D. DUTY study team (2012) The diagnosis of urinary tract infections in young children (DUTY): protocol for a diagnostic and prospective observational study to derive and validate a clinical algorithm for the diagnosis of UTI in children presenting to primary care with an acute illness. BMC Infectious Diseases, 12, (158), 158. (doi:10.1186/1471-2334-12-158). (PMID:22812651).
Miller, S., Yardley, L. and Little, P. PRIMIT team (2012) Development of an intervention to reduce transmission of respiratory infections and pandemic flu: measuring and predicting hand-washing intentions. Psychology, Health & Medicine, 17, (1), 59-81. (doi:10.1080/13548506.2011.564188). (PMID:21644184).
Little, Paul, Hobbs, F.D. Richard, Mant, David, McNulty, Cliona A.M., Mullee, Mark and PRISM investigators (2012) Incidence and clinical variables associated with streptococcal throat infections: a prospective diagnostic cohort study. British Journal of General Practice, 62, (604), 787-794. (doi:10.3399/bjgp12X658322). (PMID:23211183).
Yardley, L., Miller, S., Schlotz , W. and Little, P. (2011) Evaluation of a Web-based intervention to promote hand hygiene: exploratory randomized controlled trial. Journal Medical Internet Research, 13, (4), e107. (doi:10.2196/jmir.1963). (PMID:22155673).
Wood, F., Brookes-Howell, L., Hood, K., Cooper, L., Verheij, T., Goossens, H., Little, P., Godycki-Cwirko, M., Adriaenssens, N., Jakobsen, K. and Butler, C.C. (2011) A multi-country qualitative study of clinicians' and patients' views on point of care tests for lower respiratory tract infection. Family Practice, 28, (6), 661-669. (doi:10.1093/fampra/cmr031). (PMID:21653924).
Yardley, L., Miller, S., Teasdale, E. and Little, P. (2011) Using mixed methods to design a web-based behavioural intervention to reduce transmission of colds and flu. Journal of Health Psychology, 16, (2), 353-364. (doi:10.1177/1359105310377538).
Loveman, Emma, Gospodarevskaya, Elena, Clegg, Andy, Bryant, Jackie, Harris, Petra, Bird, Alex, Scott, David A., Davidson, Peter, Little, Paul and Coppin, Richard (2011) Ear wax removal interventions: a systematic review and economic evaluation. British Journal of General Practice, 61, (591), e680-e683. (doi:10.3399/bjgp11X601497 ). (PMID:22152851).
Greene, G., Hood, K., Little, P., Verheij, T., Goossens, H., Coenen, S. and Butler, C.C. (2011) Towards clinical definitions of lower respiratory tract infection (LRTI) for research and primary care practice in Europe: an international consensus study. Primary Care Respiratory Journal, 20, (3), 299-306. (doi:10.4104/pcrj.2011.00034). (PMID:21509421).
Nuttall, J., Hood, K., Verheij, T.J., Little, P., Brugman, C., Veen, R.E., Goossens, H. and Butler, C.C. (2011) Building an international network for a primary care research program: reflections on challenges and solutions in the set-up and delivery of a prospective observational study of acute cough in 13 European countries. BMC Family Practice, 12, (78) (doi:10.1186/1471-2296-12-78). (PMID:21794112).
Tonkin-Crine, Sarah, Yardley, Lucy and Little, Paul (2011) Antibiotic prescribing for acute respiratory tract infections in primary care: a systematic review and meta-ethnography. Journal of Antimicrobial Chemotherapy, 66, 2215-2223. (doi:10.1093/jac/dkr279).
Tonkin-Crine, Sarah, Yardley, Lucy, Coenen, Samuel, Fernandez-Vandellos, Patricia, Krawczyk, Jaroslaw, Touboul, Pia, Verheij, Theo and Little, Paul (2011) GPs' views in five European countries of interventions to promote prudent antibiotic use. British Journal of General Practice, 61, (586), 337-338. (doi:10.3399/bjgp11X572445).
Gulliford, Martin C., Van Staa, Tjeerd P., McDermott, Lisa, Dregan, Alex, McCann, Gerard, Ashworth, Maek, Charlton, Judith, Grieve, Andrew P., Little, Paul, Moore, Michael and Yardley, Lucy Electronic Cluster Randomised Trial Research Team eCRT Research Team (2011) Cluster randomised trial in the General Practice Research Database: 1. Electronic decision support to reduce antibiotic prescribing in primary care (eCRT study). Trials, 12, (115), 1-6 [6pp]. (doi:10.1186/1745-6215-12-115). (PMID:21569237).
Adriaenssens, Niels, Coenen, Samuel, Tonkin-Crine, Sarah, Verheij, Theo J.M., Little, Paul and Goossens, Herman on behalf of the ESAC Project Group (2011) European surveillance of Antimicrobial Consumption (ESAC): disease-specific quality indicators for outpatient antibiotic prescribing. BMJ Quality & Safety, 20, 764-772. (doi:10.1136/bmjqs.2010.049049). (PMID:21441602).
Butler, C.C., Kelly, M.J., Hood, K., Schaberg, T., Melbye, H., Serra-Pratf, M., Blasi, F., Little, P., Verheij, T., Molstad, S., Godycki-Cwirko, M., Edwards, P., Almirall, J., Torres, A., Rautakorpi, U-M., Nuttall, J., Goossens, H. and Coenen, S. (2011) Antibiotic prescribing for discoloured sputum in acute cough/LRTI. European Respiratory Journal (doi:10.1183/09031936.00133910).
Coppin, Richard, Wicke, Dorothy and Little , Paul (2011) Randomized trial of bulb syringes for earwax: impact on health service utilization. Annals of Family Medicine, 9, 110-114. (doi:10.1370/afm.1229). (PMID:21403136).
Lasseter, G.M., McNulty, C.A.M. and Hobbs, F.D.R. et al. for the PRImary care Streptococcal Management (PRISM) Investigators Group (2011) Effect of swab type on the analytical sensitivity of five point-of-care tests for group A streptococci. British Journal of Biomedical Science, 68, (2), 91-94. (PMID:21706921).
Flower, Andrew, Lewith, George T. and Little, Paul (2011) A feasibility study exploring the role of Chinese herbal medicine in the treatment of endometriosis. The Journal of Alternative and Complementary Medicine, 17, (8), 691-699. (doi:10.1089/acm.2010.0073).
Flower, Andrew, Lewith, George and Little, Paul (2010) Combining rigour with relevance: a novel methodology for testing Chinese herbal medicine. Journal of Ethnopharmacology, 134, (2), 373-378. (doi:10.1016/j.jep.2010.12.025). (PMID:21187138).
Yardley, Lucy, Dennison, Laura, Coker, Rebecca, Webley, Fran, Middleton, Karen, Barnett, Jane, Beattie, Angela, Evans, Maggie, Smith, Peter W.F. and Little, Paul (2010) Patients' views of receiving lessons in the Alexander Technique and an exercise prescription for managing back pain in the ATEAM trial. Family Practice, 27, (2), 198-204. (doi:10.1093/fampra/cmp093). (PMID:20032168).
Yardley, Lucy, Joseph, Judith, Michie, Susan, Weal, Mark, Wills, Gary and Little, Paul (2010) Evaluation of a web-based intervention providing tailored advice for self-management of minor respiratory symptoms: exploratory randomized controlled trial. Journal of Medical Internet Research, 12, (4), e66. (doi:10.2196/jmir.1599). (PMID:21159599).
McDermott, Lisa, Yardley, Lucy, Little, Paul, Ashworth, Mark, Gulliford, Martin and Research Team, eCRT (2010) Developing a computer delivered, theory based intervention for guideline implementation in general practice. BMC Family Practice, 11, (90), 90-[10pp]. (doi:10.1186/1471-2296-11-90).
Butler, Christopher C., Hood , Kerenza, Kelly, Mark J., Goossens, Herman, Verheij, Theo, Little, Paul, Melbye, Hasse, Torres, Antoni, Molstad, H, Godycki-Cwirko, Maciek, Almirall, Jordi, Blasi, Francesco, Schaberg, Tom, Edwards, Peter, Rautakorpi, Ulla-Maija, Hupkova, Helena, Wood, Joseph, Nuttall, Jacqui and Coenen, Samuel (2010) Treatment of acute cough/lower respiratory tract infection by antiobiotic class and associated outcomes: a 13 European country observational study in primary care. Journal of Antimicrobial Chemotherapy, 65, (11), 2472-2478. (doi:10.1093/jac/dkq336). (PMID:20852271).
Yardley, Lucy, Morrison, Leanne G, Andreou, Panayiota, Joseph, Judith and Little, Paul (2010) Understanding reactions to an internet-delivered health-care intervention: accommodating user preferences for information provision. BMC Medical Informatics and Decision Making, 10, (52), [10pp]. (doi:10.1186/1472-6947-10-52). (PMID:20849599).
McManus, Richard J., Mant, Jonathan, Bray, Emma P., Holder, Roger, Jones, Miren I., Greenfield, Sheila, Kaambwa, Billingsley, Banting, Miriam, Bryan, Stirling, Little, Paul, Williams, Bryan and Hobbs, F.D. Richard (2010) Telemonitoring and self-management in the control of hypertension (TASMINH2): a randomised controlled trial. The Lancet, 376, (9736), 163-172. (doi:10.1016/S0140-6736(10)60964-6). (PMID:20619448).
Little, P., Turner, S., Rumsby, K., Jones, R., Warner, G., Moore, M., Lowes, J.A., Smith, H., Hawke, C., Leydon, G. and Mullee, M. (2010) Validating the prediction of lower urinary tract infection in primary care: sensitivity and specificity of urinary dipsticks and clinical scores in women. British Journal of General Practice, 60, (576), 495 -500. (doi:10.3399/bjgp10X514747). (PMID:20594439).
Beattie, Angela, Shaw, Alison, Yardley, Lucy, Little, Paul and Sharp, Debbie (2010) Participating in and delivering the ATEAM trial (Alexander technique lessons, exercise, and massage)interventions for chronic back pain: a qualitative study of professional perspectives. Complementary Therapies in Medicine, 18, (3-4), 119 -127. (doi:10.1016/j.ctim.2010.05.037).
Stanton, N., Hood, K., Kelly , M.J., Nuttall, J., Gillespie, D., Verheij, T., Little, P., Godycki-Cwirko, M., Goossens, H. and Butler, C.C. (2010) Are smokers with acute cough in primary care prescribed antibiotics more often, and to what benefit? - An observational study in 13 European countries. European Respiratory Journal, 35, (4), 761-767. (doi:10.1183/​09031936.00168409). (PMID:20032009).
Brown, Elizabeth C.F., Little, Paul and Leydon, Geraldine M. GRACE Project Group (2010) Communication challenges of HPV vaccination. Family Practice, 27, (2), 224-229. (doi:10.1093/fampra/cmp087).
Turner, David, Little, Paul, Raftery, James, Turner, Sheila, Smith, Helen, Rumsby, Kate and Mullee, Mark on behalf of the UTIS team (2010) Cost effectiveness of management strategies for urinary tract infections: results from randomised controlled trial. BMJ, 340, c346. (doi:10.1136/bmj.c346). (PMID:20139218).
Leydon, G.M., Turner, S., Smith , H. and Little, P. and on behalf of the UTIS team (2010) Women’s views about management and cause of urinary tract infection: qualitative interview study. British Medical Journal, 340, c279. (doi:10.1136/bmj.c279). (PMID:20139217).
Little, P., Merriman, R., Turner, S., Rumsby, K., Warner, G., Lowes, J.A., Smith, H., Hawke, C., Leydon, G., Mullee, M. and Moore, M.V. (2010) Presentation, pattern, and natural course of severe symptoms, and role of antibiotics and antibiotic resistance among patients presenting with suspected uncomplicated urinary tract infection in primary care: observational study. British Medical Journal, 340, b5633-[6pp]. (doi:10.1136/bmj.b5633). (PMID:20139213).
Little, P., Moore, M.V., Turner, S., Rumsby, K., Warner, G., Lowes, J.A., Smith, H., Hawke, C., Leydon, G., Arscott, A., Turner, D. and Mullee, M. (2010) Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial. BMJ, 340, c199. (doi:10.1136/bmj.c199). (PMID:20139214).
Clegg, A., Loveman, E., Gospodarevskaya, E., Harris, P., Bird, A., Bryant, J., Scott, D.A., Davidson, P., Little, P. and Coppin , R. (2010) The safety and effectiveness of different methods of ear wax removal: a systematic review and economic evaluation. Health Technology Assessment, 14, (28), 1-191. (doi:10.3310/hta14280). (PMID:20546687).
Everitt, Hazel A., Moss-Morris, Rona E., Sibelli, Alice, Tapp, Laura, Coleman, Nicholas S., Yardley, Lucy, Smith, Peter W. and Little, Paul S. (2010) Management of irritable bowel syndrome in primary care: feasibility randomised controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website (MIBS trial). BMC Gastroenterology, 10, (136) (doi:10.1186/1471-230X-10-136 ).
Leydon, G.M., Turner, S., Smith, Helen and Little, P. UTIS Team (2010) Women's views about management and cause of urinary tract infection: qualitative interview study. BMJ, 340, c279. (doi:10.1136/bmj.c279).
Yardley, Lucy, Dennison, Laura, Coker, Rebecca, Webley, Frances, Middleton, Karen, Barnett, Jane, Beattie, Angela, Evansc, Maggie, Smith, Peter and Little, Paul (2009) Patients’ views of receiving lessons in the Alexander Technique and an exercise prescription for managing back pain in the ATEAM trial. Family Practice, 1-7. (doi:10.1093/fampra/cmp093).
Yardley, Lucy, Dennison, Laura, Coker, Rebecca, Webley, Frances, Middleton, Karen, Barnett, Jane, Beattie, Angela, Evans, Maggie, Smith, Peter and Little, Paul (2009) Patients’ views of using the Alexander technique and exercise for managing back pain. Family Practice, 27, (2), 198-204. (doi:10.1093/fampra/cmp093). (PMID:20032168).
Williamson, Ian, Benge, Sarah, Barton, Sheila, Petrou, Stavros, Letley, Louise, Fasey, Nicky, Haggard, Mark and Little, Paul (2009) Topical intranasal corticosteroids in 4-11 year old children with persistent bilateral otitis media with effusion in primary care: double blind randomised placebo controlled trial. British Medical Journal, 339, (b4984), 1-8. (doi:10.1136/bmj.b4984).
Gulliford, M., Latinovic, R., Charlton, J., Little , Paul, van Staa, T. and Ashworth, M. (2009) Selective decrease in consultations and antibiotic prescribing for acute respiratory tract infections in UK primary care up to 2006. Journal of Public Health, 31, (4), 512-520. (doi:10.1093/pubmed/fdp081). (PMID:19734168).
Lasseter, Gemma M., McNulty, Cliodna A.M., Hobbs, F.D. Richard, Mant, David, Little, Paul and Leydon, Geraldine M. PRISM Investigators (2009) In vitro evaluation of five rapid antigen detection tests for group A beta-haemolytic streptococcal sore throat infections. Family Practice, 26, (6), 437-444. (doi:10.1093/fampra/cmp054).
Yardley, Lucy, Kirby, Sarah, Barker, Fiona, Little, Paul, Raftery, James, King, Debbie, Morris, Anna and Mullee, Mark (2009) An evaluation of the cost-effectiveness of booklet-based self-management of dizziness in primary care, with and without expert telephone support. BMC Ear, Nose and Throat Disorders, 9, (13), 1-12. (doi:10.1186/1472-6815-9-13).
Moore, Michael, Little, Paul, Rumsby, Kate, Kelly, Jo, Watson, Louise, Warner, Greg, Fahey, Tom and Williamson, Ian (2009) Effect of antibiotic prescribing strategies and an information leaflet on longer-term re-consultation for acute lower respiratory tract infection. British Journal of General Practice, 59, (567), 728-734. (doi:10.3399/bjgp09X472601). (PMID:19843421).
Little, Paul (2009) Sore throat in primary care. BMJ, 339, b2476. (doi:10.1136/bmj.b2476).
Williamson, I., Benge, S., Barton, S., Petrou, S., Letley, L., Fasey, N., Abangma, G., Dakin, H. and Little, P. (2009) A double-blind randomised placebo-controlled trial of topical intranasal corticosteroids in 4- to 11-year-old children with persistent bilateral otitis media with effusion in primary care. Health Technology Assessment, 13, (37), 1-274. (doi: 10.3310/hta 13370).
Leydon, Geraldine M., Turner, Sheila, Smith, Helen, Little, Paul and Moore, M.V. on behalf of the UTIS team (2009) The journey from self-care to GP care: a qualitative interview study of women presenting with symptoms of urinary tract infection. British Journal of General Practice, 59, (564), e219-e225. (doi:10.3399/bjgp09X453459). (PMID:19566988).
Flower, Andrew, Liu, Jian Ping, Chen, Sisi, Lewith, George and Little, Paul (2009) Intervention review: Chinese herbal medicine for endometriosis. Cochrane Database of Systematic Reviews, (3), 1-43. (doi:10.1002/14651858.CD006568.pub2). (PMID:19588398).
Butler, C.C., Hood, K., Verheij, T., Little, P., Melbye, H., Nuttall, J., Kelly, M.J., Mölstad, S., Godycki-Cwirko, M., Almirall, J., Torres, A., Gillespie, D., Rautakorpi, U., Coenen, S. and Goossens, H. (2009) Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ, 338, b2242. (doi:10.1136/bmj.b2242). (PMID:19549995).
Little, P., Turner, S., Rumsby, K., Warner, G., Moore, M., Lowes, J.A., Smith, H., Hawke, C., Turner, D., Leydon, G.M., Arscott, A. and Mullee, M. (2009) Dipsticks and diagnostic algorithms in urinary tract infection: development and validation, randomised trial, economic analysis, observational cohort and qualitative study. Health Technology Assessment, 13, (19), 1-96. (doi:10.3310/hta13190). (PMID:19364448).
McManus, Richard J., Bray, Emma P., Mant, Jonathan, Holder, Roger, Greenfield, Sheila, Bryan, Stirling, Jones, Miren I., Little, Paul, Williams, Bryan and Hobbs, F.D. Richard (2009) Protocol for a randomised controlled trial of telemonitoring and self-management in the control of hypertension: telemonitoring and self-management in hypertension. [ISRCTN17585681]. BMC Cardiovascular Disorders, 9, (6), 1-9. (doi:10.1186/1471-2261-9-6).
Pockney, P., Primrose, J., George, S., Jayatilleke, N., Leppard, B., Smith, H., Little, P., Kneebone, R. and Lowy, A. (2009) Recognition of skin malignancy by general practitioners: observational study using data from a population-based randomised controlled trial. British Journal of Cancer, 100, (1), 24-27. (doi:10.1038/sj.bjc.6604810).
Hollinghurst, Sandra, Sharp, Debbie, Ballard, Kathleen, Barnett, Jane, Beattie, Angela, Evans, Maggie, Lewith, George, Middleton, Karen, Oxford, Frances, Webley, Fran and Little, Paul (2008) Randomised controlled trial of Alexander technique lessons, exercise, and massage (ATEAM) for chronic and recurrent back pain: economic evaluation. British Medical Journal, 337, (a2656), 1-8. (doi:10.1136/bmj.a2656). (PMID:19074232).
Hall, Sue, Lewith, George, Brien, Sarah and Little, Paul (2008) An exploratory pilot study to design and assess the credibility of a Sham kinesiology treatment. Forschende Komplementarmedizin, 15, 321-326. (doi:10.1159/000170401).
Little, Paul, Lewith, George, Webley, Fran, Evans, Maggie, Beattie, Angela, Middleton, Karen, Barnett, Jane, Ballard, Kathleen, Oxford, Frances, Smith, Peter, Yardley, Lucy, Hollinghurst, Sandra and Sharp, Debbie (2008) Randomised controlled trial of Alexander Technique for chronic and recurrent back pain. British Medical Journal, 42, (12), 965-968. (doi:10.1136/bmj.a884). (PMID:19096019).
Coppin, R., Wicke, D. and Little, P. (2008) Earwax. British Journal of General Practice, 58, (549), 284-284. (doi:10.3399/bjgp08X279995). (PMID:18387246).
Coppin, Richard, Wicke, Dorothy and Little, Paul (2008) Managing earwax in primary care: efficacy of self-treatment using a bulb syringe. British Journal of General Practice, 58, (546), 44-49. (doi:10.3399/bjgp08X263811).
Moore, M., Little, P., Rumsby, K., Kelly, J., Watson, L., Warner, G., Fahey, T. and Williamson, I. (2008) Predicting the duration of symptoms in lower respiratory tract infection. British Journal of General Practice, 58, (547), 88-92. (doi:10.3399/bjgp08X264045).
Hall, S., Lewith, G., Brien, S. and Little, P. (2008) A review of the literature in applied and specialised kinesiology. Forschende Komplementarmedizin, 15, (1), 40-46. (doi:10.1159/000112820).
Williamson, I. and Little, P. (2008) Otitis media with effusion: the long and winding road? Archives of Disease in Childhood, 93, (4), 268-269. (doi:10.1136/adc.2006.112383).
Williamson, I.G., Rumsby, K., Benge, S., Moore, M., Smith, P.W., Cross, M. and Little, P. (2007) Antibiotics and topical nasal steroid for treatment of acute maxillary sinusitis: a randomized controlled trial. JAMA The Journal of the American Medical Association, 298, (21), 2487-2496. (doi:10.1001/jama.298.21.2487). (PMID:18056902).
Coenen, Samuel, Ferech, Matus, Haaijer-Ruskamp, Flora M., Butler, Chris C., Stichele, Robert H. Vander, Verheij, Theo J. M., Monnet, Dominique L., Little, Paul and Goossens, Herman (2007) European Surveillance of Antimicrobial Consumption (ESAC): quality indicators for outpatient antibiotic use in Europe. Quality and Safety in Health Care, 16, (6), 440-445. (doi:10.1136/qshc.2006.021121).
Flower, Andrew, Lewith, George T. and Little, Paul (2007) Seeking an oracle: using the Delphi process to develop practice guidelines for the treatment of endometriosis with Chinese herbal medicine. Journal of Alternative and Complementary Medicine, 13, (9), 969-976. (doi:10.1089/acm.2006.6283).
Moore, Michael and Little, Paul (2007) Humidified air inhalation for treating croup: a systematic review and meta-anlaysis. Family Practice, 24, (4), 295-301. (doi:10.1093/fampra/cmm022). (PMID:17602176).
Dunn, Nick, Lane, Dan, Everitt, Hazel and Little, Paul (2007) Use of antibiotics for sore throat and incidence of quinsy. British Journal of General Practice, 57, (534), 45-49. (PMID:17244424).
Williamson, I., Benge, S., Moore, M., Kumar, S., Cross, M. and Little, P. (2006) Acute sinusitis: which factors do FPs believe are most diagnostic and best predict antibiotic efficacy? Journal of Family Practice, 55, (9), 789-796. (PMID:16948963).
Little, P., Turner, S., Rumsby, K., Warner, G., Moore, M., Lowes, J.A., Smith, H., Hawke, C. and Mullee, M. (2006) Developing clinical rules to predict urinary tract infection in primary care settings: sensitivity and specificity of near patient tests (dipsticks) and clinical scores. British Journal of General Practice, 56, (529), 606-612. (PMID:16882379).
Moore, M. and Little, P. (2006) [Review]. Humidified air inhalation for treating croup. Cochrane Library, (3), 1-18. (doi:10.1002/14651858.CD002870.pub2).
Everitt, Hazel A., Little, Paul S. and Smith, Peter W.F. (2006) A randomised controlled trial of management strategies for acute infective conjunctivitis in general practice. British Medical Journal, 333, (7563) (doi:10.1136/bmj.38891.551088.7C). (PMID:16847013).
Williamson, Ian, Benge, Sarah, Mullee, Mark and Little, Paul (2006) Consultations for middle ear disease, antibiotic prescribing and risk factors for reattendance: a case-linked cohort study. British Journal of General Practice, 56, (524), 170-175.
Westwood, G., Pickering, R.M., Latter, S., Lucassen, A., Little, P. and Temple, I.K. (2006) Feasibility and acceptability of providing nurse counsellor genetics clinics in primary care. Journal of Advanced Nursing, 53, (5), 591-604. (doi:10.1111/j.1365-2648.2006.03760.x).
Little, P., Moore, M., Warner, G., Dunleavy, J. and Williamson, I. (2006) Longer term outcomes from a randomised trial of prescribing strategies in otitis media. British Journal of General Practice, 56, (524), 176-182.
Ulven, Trond, Frimurer, Thomas M., Receveur, Jean-Marie, Little, Paul Brian, Rist, Øystein, Norregaard, Pia K. and Hogberg, Thomas (2005) 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode. Journal of Medicinal Chemistry, 48, (18), 5684-5697. (doi:10.1021/jm050103y).
Little, Paul, Rumsby, Kate, Kelly, Joanne, Watson, Louise, Moore, Michael, Warner, Gregory, Fahey, Tom and Williamson, Ian (2005) Information leaflet and antibiotic prescribing strategies for acute lower respiratory tract infection: a randomized controlled trial. Journal of the American Medical Association, 293, (24), 3029-3035. (doi:10.1001/jama.293.24.3029).
Moore, Michael, Little, Paul, Williamson, Ian, Warner, G and Coppin, R (2005) A pain in the neck for steroids (letter). British Journal of General Practice, 55, (514), 393 - 394.
Coppin, Richard J., Wicke, Dorothy M. and Little, Paul S. (2005) Managing nocturnal leg cramps — calf-stretching exercises and cessation of quinine treatment: a factorial randomised controlled trial. British Journal of General Practice, 55, (512), 186-191.
Little, Paul (2005) Delayed prescribing of antibiotics for upper respiratory tract infection. British Medical Journal, 331, (7512), 301-302. (doi:10.1136/bmj.331.7512.301).
Westwood, G., Little, P., Pickering, R.M., Temple, I.K., Latter, S.M. and Lucassen, A.M. (2005) Referrals to clinical genetics services: GPs' attitudes and practice. Journal of Medical Genetics, 42, pp.S27.
Pockney, Pete, Primrose, John, Kinley, Helen, George, Steve, Lattimer, Val, Smith, Helen, Little, Paul, Lowy, Adam and Kneebone, Roger (2004) Impact of the introduction of fee for service payments on types of minor surgical procedures undertaken by general practitioners: observational study. Journal of Public Health, 26, (3), 264-267. (doi:10.1093/pubmed/fdh152).
Coppin, Richard, Wicke, Dorothy, Mehta, Raj and Little, Paul (2004) Management of earwax in primary care—postal survey of UK GPs and practice nurses. Family Practice, 21, (4), 413-414. (doi:10.1093/fampra/cmh410).
Little, P., Dorward, M., Gralton, S., Hammerton, L., Pillinger, J., White, P., Moore, M., McKenna, J. and Payne, S. (2004) A randomised controlled trial of three pragmatic approaches to initiate increased physical activity in sedentary patients with risk factors for cardiovascular disease. British Journal of General Practice, 54, (500), 189-195.
Little, Paul, Dorward, Martina, Warner, Greg, Moore, Michael, Stephens, Katharine, Senior, Jane and Kendrick, Tony (2004) Randomised controlled trial of effect of leaflets to empower patients in consultations in primary care. British Medical Journal, 328, (7437), 441-444. (doi:10.1136/bmj.37999.716157.44).
Little, Paul, Dorward, Martina, Warner, Greg, Stephens, Katharine, Senior, Jane and Moore, Michael (2004) Importance of patient pressure and perceived pressure and perceived medical need for investigations, referral, and prescribing in primary care: nested observational study. British Medical Journal, 328, (7437), 444-446. (doi:10.1136/bmj.38013.644086.7C).
Little, Paul (2004) Advice to parents has limited effect—where next? British Medical Journal, 329, (7460), 269. (doi:10.1136/bmj.329.7460.269).
Little, P. (2004) Advice to parents has limited effect--where next? British Medical Journal, 329, (7460), 269. (doi:10.1136/bmj.329.7460.269).
Westwood, G., Temple, I.K., Lucassen, A.M., Pickering, R.M., Latter, S.M. and Little, P. (2004) A clustered randomised controlled trial of the location of genetic counsellor clinical genetics appointments. Journal of Medical Genetics, 41, pp.S45.
Little, Paul, Kelly, Jo, Barnett, Jane, Dorward, Martina, Margetts, Barrie and Warm, Daniel (2004) Randomised controlled factorial trial of dietary advice for patients with a single high blood pressure reading in primary care. British Medical Journal, 328, (7447), 1054-1057. (doi:10.1136/bmj.38037.435972.EE).
Kumar, Satinder, Little, Paul and Britten, Nicky (2003) Why do general practitioners prescribe antibiotics for sore throat? Grounded theory interview study. British Medical Journal, 326, (7381), 138. (doi:10.1136/bmj.326.7381.138).
Everitt, H., Kumar, S. and Little, P. (2003) A qualitative study of patients' perceptions of acute infective conjunctivitis. British Journal of General Practice, 53, (486), 36-41.
Little, P. (2003) Penicillin for acute sore throat in children: randomised, double blind trial. British Medical Journal, 327, (7427), 1327-1328. (doi:10.1136/bmj.327.7427.1324).
Simon, Chantal, Little, Paul, Birtwistle, Jon and Kendrick, Tony (2003) A questionnaire to measure satisfaction with community services for informal carers of stroke patients: construction and initial piloting. Health and Social Care in the Community, 11, (2), 129-137. (doi:10.1046/j.1365-2524.2003.00408.x).
Thompson, Rachel L., Summerbell, Carolyn D., Hooper, Lee, Higgins, Julian P.T., Little, Paul S., Talbot, Diane and Ebrahim, Shah (2003) Relative efficacy of differential methods of dietary advice: a systematic review. The American Journal of Clinical Nutrition, 77, (4), 1052S-1057S.
Everitt, Hazel and Little, Paul (2002) How do GPs diagnose and manage acute infective conjunctivitis? A GP survey. Family Practice, 19, (6), 658-660. (doi:10.1093/fampra/19.6.658).
Roberts, Lisa, Little, Paul, Chapman, Judith, Cantrell, Ted, Pickering, Ruth and Langridge, John (2002) The back home trial: general practitioner-supported leaflets may change back pain behavior. Spine, 27, (17), 1821-1828. (doi:10.1097/00007632-200209010-00002).
Little, Paul, Barnett, Jane, Barnsley, Lucy, Marjoram, Jean, Fitzgerald-Barron, Alex and Mant, David (2002) Comparison of agreement between different measures of blood pressure in primary care and daytime ambulatory blood pressure. British Medical Journal, 325, (7358), 254-257. (doi:10.1136/bmj.325.7358.254).
Little, Paul, Barnett, Jane, Barnsley, Lucy, Marjoram, Jean, Fitzgerald-Barron, Alex and Mant, David (2002) Comparison of acceptability of and preferences for different methods of measuring blood pressure in primary care. British Medical Journal, 325, (7358), 258-259. (doi:10.1136/bmj.325.7358.258).
Watson, L., Margetts, B., Howarth, P., Dorward, M., Thompson, R. and Little, P. (2002) The association between diet and chronic obstructive pulmonary disease in subjects selected from general practice. European Respiratory Journal, 20, (2), 313-318.
Little, Paul, Watson, Louise, Morgan, Stephen and Williamson, Ian (2002) Antibiotic prescribing and admissions with major suppurative complications of respiratory tract infections: a data linkage study. British Journal of General Practice, 52, (476), 187-193.
Little, P. (2002) X-rays for back pain? [Editorial]. British Journal of General Practice, 52, (480), 534-535.
Little, Paul, Gould, Clare, Moore, Michael, Warner, Greg, Dunleavey, Joan and Williamson, Ian (2002) Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial. British Medical Journal, 325, (7354), 22-24. (doi:10.1136/bmj.325.7354.22).
Little, Paul (2002) Where next with antibiotics and respiratory tract infections? Journal of Family Practice, 51, (4), 337-338.
Roberts, L., Little, P., Cantrell, T., Chapman, J., Langridge, J. and Pickering, R. (2002) Recruiting patients with back pain in primary care. Journal of Bone and Joint Surgery, 84B, supplement 2
Little, P., Somerville, J., Williamson, I., Warner, G., Moore, Michael, Wiles, R., George, S., Smith, Ann and Peveler, Robert (2001) Psychosocial, lifestyle and health status variables in predicting high attendance among adults. British Journal of General Practice, 51, (473), 987 -994.
Little, Paul, Everitt, Hazel, Williamson, Ian, Warner, Greg, Moore, Michael, Gould, Clare, Ferrier, Kate and Payne, Sheila (2001) Observational study of effect of patient centredness and positive approach on outcomes of general practice consultations. British Medical Journal, 323, (7318), 908-911. (doi:10.1136/bmj.323.7318.908).
Watson, Louise, Little, Paul, Moore, Michael, Warner, Greg and Williamson, Ian (2001) Validation study of a diary for use in acute lower respiratory tract infection. Family Practice, 18, (5), 553-554. (doi:10.1093/fampra/18.5.553).
Little, Paul, Griffin, Simon, Dickson, Nigel and Sadler, Carolyn (2001) Unwanted pregnancy and contraceptive knowledge: identifying vulnerable groups from a randomized controlled trial of educational interventions. Family Practice, 18, (4), 449-453.
Little, Paul, Somerville, Jane, Williamson, Ian, Warner, Greg, Moore, Michael, Wiles, Rose, George, Steve, Smith, Ann and Peveler, Robert (2001) Randomised controlled trial of self management leaflets and booklets for minor illness provided by post. British Medical Journal, 322, (7296), 1214-1217. (doi:10.1136/bmj.322.7296.1214).
Little, Paul and Byrne, Christopher D. (2001) Abdominal obesity and the "hypertriglyceridaemic waist" phenotype. It's probably not yet time to implement screening. British Medical Journal, 322, (7288), 687-689. (doi:10.1136/bmj.322.7288.687).
Little, Peter (2001) The end of all human DNA maps? Nature Genetics, 27, (3), 229-230. (doi:10.1038/85766).
Little, P., Everitt, H., Williamson, I., Warner, G., Moore, M., Gould, C., Ferrier, K. and Payne, S. (2001) Preferences of patients for patient centred approach to consultation in primary care: observational study. British Medical Journal, 322, (7284), 468-472. (doi:10.1136/bmj.322.7284.468).
Little, Paul, Gould, Clare, Williamson, Ian, Moore, Michael, Warner, Greg and Dunleavey, Joan (2001) Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. British Medical Journal, 322, (7282), 336-342. (doi:10.1136/bmj.322.7282.336).
Little, Paul, Somerville, Jane, Williamson, Ian, Warner, Greg, Moore, Michael, Wiles, Rose, George, Steve, Smith, Ann and Peveler, Robert (2001) Family influences in a cross-sectional survey of higher child attendance. British Journal of General Practice, 51, (473), 977-982.
Little , P., Gould, C., Williamson, I., Moore, M., Warner, G. and Dunleavey, J. (2001) Delayed prescribing of antibiotics increased duration of acute otitis media symptoms in children but reduced diarrhoea. Evidence-Based Nursing, 4, (4), 107. (doi:10.1136/ebn.4.4.107).
Thompson, R.L., Summerbell, C.D., Hooper, L., Higgins, J.P.T., Little, P.S., Talbot, D. and Ebrahim, S. (2001) Dietary advice given by a dietitian versus other health professional or self-help resources to reduce blood cholesterol. Cochrane Database of Systematic Reviews, (3) (doi:10.1002/14651858.CD001366).
Little, P., Williamson, I., Warner, G. and Moore, M.V. (2000) Length of penicillin treatment of streptococcal infections: care must be taken when extrapolating data (letter). BMJ, 320, (7250), 1666. (doi:10.1136/bmj.320.7250.1665). (PMID:10905831).
Little, P.S., Cantrell, E.C., Roberts, L., Chapman, J., Langridge, J. and Pickering, R. (1998) Why do GPs perform investigations? the medical and social agendas in arranging back X-rays. Family Practice, 15, (3), 264-265. (PMID:9694186).
Chapman, J., Smith, L., Sheldon, F., Little, P.S., Cantrell, T., Langridge, J. and Pickering, R. (1997) The ‘back home’ leaflet: developing a self-management leaflet for people with acute low back pain. Journal of Back and Musculoskeletal Rehabilitation, 9, (1), 61-63. (doi:10.1016/S1053-8127(97)00053-5).
Little, P.S., Williamson, Ian, Warner, G., Gould, C., Gantley, M. and Kinmonth, A.L. (1997) Open randomised trial of prescribing strategies in managing sore throat. BMJ, 314, 722. (doi:10.1136/bmj.314.7082.722 ).
Moore, M.V., Little, P.S., Williamson, I. and Warner, G. (1997) Scoring system for throat infection (letter). British Journal of General Practice, 47, (416), 181-182. (PMID:9167326).
Chapman, J., Smith, L., Little, Paul S., Cantrell, T., Langridge, J. and Pickering, R. (1997) The 'back home' leaflet: developing a self-management leaflet for people with acute low back pain. Journal of Back and Musculoskeletal Rehabilitation, 9, (1), 61-63. (doi:10.3233/BMR-1997-9118). (PMID:24572955).
Little, P.S., Smith, L., Cantrell, T., Chapman, J., Langridge, J. and Pickering, R. (1996) General practitioners' management of acute back pain: a survey of reported practice compared with clinical guidelines. BMJ, 312, (7029), 485-488. (doi:10.1136/bmj.312.7029.485). (PMID:8597683).

Conference or Workshop Item

Essery, R., Geraghty, A., Kirby, S., Little, P., Bronstein, A., Andersson, G., Carlbring, P., Stuart, B., Turner, D. and Yardley, L. (2014) The development of balance retraining: an online intervention to support the self-management of dizziness in older adults. In, DHP Annual Conference, York, GB, 10 - 12 Sep 2014.

Monograph

Little, Paul, Stuart, Beth, Stokes, Maria, Nicholls, Carolyn, Roberts, Lisa, Preece, Stephen, Cacciatore, Tim, Brown, Simon, Lewith, George, Geraghty, Adam, Yardley, Lucy, O'Reilly, Gilly, Chalk, Caroline, Sharp, Debbie and Smith, Peter (2014) Alexander technique and Supervised Physiotherapy Exercises in back paiN (ASPEN): a four-group randomised feasibility trial. Southampton, GB, NIHR Journals Library, 106pp. (Efficacy and Mechanism Evaluation, (doi:10.3310/eme01020) , 1:2).
Little, Paul, Hobbs, FD Richard, Moore, Michael, Mant, David, Williamson, Ian, McNulty, Cliodna, Lasseter, Gemma, Cheng, MY Edith, Leydon, Geraldine, McDermott, Lisa, Turner, David, Pinedo-Villanueva, Rafael, Raftery, James, Glasziou, Paul and Mullee, Mark (2014) PRImary care Streptococcal Management (PRISM) study: in vitro study, diagnostic cohorts and a pragmatic adaptive randomised controlled trial with nested qualitative study and cost-effectiveness study. Southampton, GB, NIHR Journals Library, 132pp. (HTA Journal Series, (doi:10.3310/hta18060) , 18 6).
Latter, Sue, Blenkinsopp, Alison, Smith, Alesha, Chapman, Steve, Tinelli, Michela, Gerard, Karen, Little, Paul, Celino, Nicola, Granby, Trudy, Nicholls, Peter and Dorer, Gill (2011) Evaluation of nurse and pharmacist independent prescribing. Southampton, GB , Keele, GB, Faculty of Health Sciences, University of Southampton; School of Pharmacy, Keele University on behalf of Department of Health, 374pp.
George, S., Pockney, P., Primrose, J., Smith, H., Little, P., Kinley, H., Kneebone, R., Lowy, A., Leppard, B., Jayatilleke, N. and McCabe, C. (2008) A prospective randomised comparison of minor surgery in primary and secondary care. The MiSTIC trial. Tunbridge Wells, GB, Gray, 72pp. (Health Technology Assessment, 12 23).
 

Research

Research Interests

Two main areas of interest: health promotion and the management of common self-limiting illnesses. These topics link evidence about effectiveness with the effect of management of patient beliefs and behaviour, better understanding the importance of the patient centred approach to the consultation.

CANcer Diagnosis Decision rules (CANDID)

Health promotion

Back Pain
ATEAM trial

This was an MRC funded trial of the Alexander Technique (a technique to improve and modify poor postural and body ‘use’ habits) and exercise prescription by GPs for back pain (the ATEAM trial). It demonstrated significant benefits for pain and function in the longer term.

ASPEN trial

Following the ATEAM trial EME have now funded this study to investigate the mechanisms of Alexander Technique and the mechanism of recovery in back pain with both physiotherapy and the Alexander Technique.

ARC Fellowship (Lisa Roberts)

I am co-investigator and mentor for this project which aims to understand communication in physiotherapy consultations and will then develop and pilot and intervention to modify consultation behaviour.

Internet based behaviour support

A major focus of interest is in developing internet based behavioural support for a range of conditions:
Obesity (the HTA funded POWeR trial)
Hypertension (SMILE trial, funded by the National School for Primary Care Research)
Infection transmission (The MRC PRIMIT trial)
Irritable bowel syndrome (NIHR funded, lead by Hazel Everitt)
Eczema (NIHR funded, lead by Miriam Santer)


The management of common infections

UTIS study
Following our work in trialling antibiotic prescribing strategies in several respiratory infections we have also recently completed a study to develop clinical scoring algorithm for urinary tract infections leading to a trial of different management approaches.

GRACE
We have just completed two major trials as part of a large European Union Network of Excellence project (GRACE) for Lower respiratory tract infection - which is the commonest acute condition managed in primary care.
RCT of amoxicillin: this trial which is coming to a close has randomized 2061 individuals in 12 Networks across Europe and the results are likely to dominate the management of lower respiratory tract infection (LRTI) in primary care for some time.

GRACE INTRO
The second GRACE trial developed from another EU project we share (CHAMP), developed and tailored web based communication training packages for health professionals in 6 EU countries. We randomized 246 practices across Europe and recruited more than 4000 patients in this trial - which assessed whether an internet based behavioural intervention to modify communication in the consultation can modify health professional antibiotic prescribing for LRTI.

DESCARTE
This is a large prognostic cohort study in acute sore throat (more than 13000 patients have been recruited) funded by the MRC.

PRISM
This is an HTA funded study to develop and perform a randomized trial (which has recruited more than 1500 patients) of strategies for using rapid tests and clinical scores for sore throat.

PRIMIT
The MRC have funded us to develop and trial an infection control website requiring complex intervention development.

Internet Dr
An MRC studentship was used to develop web based self help advice using the MRC Framework for the development of complex interventions.

NIHR PRIME Programme grant
This supports several studies on the management of acute and recurrent infections:
PIPS: steam, paracetamol and ibuprofen for acute respiratory infections.
SNIFS: nasal irrigation and steam for recurrent sinusitis.
TASTE: probiotics and xylitol for recurrent sore throat.
3C’s study (Cough Complication Cohort): a large prospective cohort similar to DESCARTE but for LRTI
Internet Dr trial (following the development referred to above).

Academic unit:  Primary Care & Population Sciences Academic Units

Affiliate academic units:  Primary care Research group

Research projects

CANDID Cancer Diagnosis Decision Rules

FAME Fatigue: acute Fatigue Assessment and Management in Everyday practice

BARACK-D Benefits of aldosterone receptor antagonism in chronic kidney disease

BATHE Bath additives in the treatment of childhood eczema

BREATHE (Breathing Retraining for Asthma Trial of Home Exercise)

Although effective medicinal treatment exists for asthma, many people continue to have distressing symptoms and impaired quality of life. People with asthma have expressed interest in non-drug asthma treatments, particularly in breathing exercises. Several recent studies have shown benefits from a short course of breathing exercises taught by a respiratory physiotherapist for people with asthma who remained symptomatic despite usual treatment. We believe that many NHS patients could potentially benefit from these exercises, but unfortunately, there is currently not enough access to suitable trained physiotherapists able to provide such a service. We propose to provide the same breathing training programme that we have previously shown to be effective when taught 'face-to-face' by a physiotherapist in the form of a DVD, or internet download. Patients will use this in their own home at times convenient to them, in addition to their standard treatment (e.g. with inhalers). We will find out whether this type of instruction is better than the 'usual care' that is currently provided, and whether it is as good as the 'face to face' physiotherapist instruction (which is more expensive and less convenient for patients).

Creating a taxonomy to harness the placebo effect in UK primary care

Acupuncture for Back Pain: Evaluating Patient Outcomes and Their Determinants

Treatment Beliefs in Back Pain

Benefits of the Alexander Technique for sufferers with low back pain

Positive Online Weight Reduction (POWeR)

Developing a nurse-delivered behavioural intervention to support weight loss in obese adults

Positive Online Weight Reduction Plus (POWeR+)

Assessing Cognitive behavioural Therapy in Irritable Bowel Syndrome (ACTIB)

Responsibilities

Undergraduate teaching

Responsibility for critical appraisal paper in MBBS finals.
Clinical teaching for MBBS.

Postgraduate student and research fellow supervision

I supervise 3 PhD students, 3 Academic Clinical Fellows, and mentor 2 senior postdoctoral awards and a Clinical Research Fellow.
I also do regular teaching at GP workshops and clinical postgraduate meetings.

Divisional responsibilities

Member of Management team for Primary Care and Population Sciences Division.

National and International Responsibilities

Head of Southampton primary care group for National Primary Care HODs group and also for the National School for Primary Care Research.
Director of NIHR Programme Grants for Applied Research (PGfAR) Board
Member of REF panel for Public Health, Health services and Primary care.
Fellow of the Academy of Medical Sciences

Teaching Responsibilities

Clinical Teaching in Primary care for undergraduates.

Lecturing on research methods (critical appraisal and the development of complex interventions).

Supervision of Post-graduates and research fellows.

Post-graduate teaching for clinicians.

Media

8 November 2013
New test for patients with sore throats cuts antibiotic use by nearly a third. Please click here for full news item.

30 July 2013
Internet-based training could help in the fight against antibiotic resistance. Please click here for full news item.

14 December 2012
Commonly prescribed antibiotics ineffective for treating uncomplicated chest infections. Please click here for full news item.

Contact

Professor Paul Little
Primary Medical Care
Aldermoor Health Centre
Aldermoor Close
Southampton
SO16 5ST

Room Number: AHC/