Medicine

Richard Holt

MA, MB, BChir, PhD, FRCP, FHEA

Primary position:
Professor in Diabetes and Endocrinology
Other positions:
Honorary Consultant Physician

Background

The University of Southampton

Richard Holt trained at the University of Cambridge and the London Hospital Medical College. He undertook his post-graduate training in diabetes and endocrinology in the South East Thames Region. While a Medical Research Council Clinical Training Fellow, he completed a PhD on the growth hormone – insulin-like growth factor axis in childhood liver disease. He was appointed as Senior Lecturer in Endocrinology & Metabolism at the University of Southampton in May 2000, was promoted to Reader in March 2006 and became Professor in Diabetes and Endocrinology in September 2008.

Richard’s current research interests are broadly focussed around clinical diabetes and endocrinology. These encompass studies of the relationship between mental illness on diabetes and the psychosocial aspects of diabetes. Richard also has interests in the physiology of GH and has worked to develop a test for GH abuse in sport.

Richard’s clinical responsibilities include the diabetes and pregnancy clinic, young adult diabetes clinic and the cystic fibrosis related diabetes service. He is the immediate past Chair of the Council of Health Care Professionals of Diabetes UK.

Qualifications

1983-1986 St Catharine's College, Cambridge University MA, MB BChir
1986-1989 The London Hospital Medical College
1992 The Royal College of Physician MRCP
1994-1998 King's College School of Medicine & Dentistry PhD
2006 The Royal College of Physician FRCP
2007 Higher Education Academy FHEA 

Appointments Held

Current appointment

Sept 08 - present Professor in Diabetes and Endocrinology
University of Southampton

May 00 - present Honorary Consultant Physician
Southampton University Hospitals Trust

Previous appointments

Aug 89 - Jan 90 House Physician
The Royal London Hospital, Whitechapel

Feb 90 - Jul 90 House Surgeon
Oldchurch Hospital, Romford, Essex

Sept 90 - Sept 92 Medical SHO rotation
The Royal London Hospital, Whitechapel

Sept 90 - Nov 90 SHO in Genito-urinary Medicine

Dec 90 - Feb 91 SHO in Accident and Emergency

Mar 91 - May 91 SHO in General Medicine

Jun 91 - Aug 91 SHO in the Care of the Elderly

Sept 91 - Feb 92 SHO in Nephrology

Mar 92 - Sept 92 SHO in General Medicine Harold Wood Hospital, Essex

Oct 92 - Sept 94 SE Thames Registrar rotation in General Medicine,
Endocrinology and Diabetes

Oct 92 - May 93 Medical Registrar
Thanet District Hospital, Margate, Kent

Jun 93 - Jan 94 Registrar in Medicine and Endocrinology
Professorial Dept of Medicine, King's College Hospital, London

Feb 94 - Sep 94 Registrar in Medicine and Diabetes
King's College Hospital, London

Oct 94 - Mar 98 Medical Research Council Clinical Training Fellow
King's College School of Medicine and Dentistry, London

Honorary Senior Registrar in General Medicine, Endocrinology and Diabetes
Dept of Medicine, King's College Hospital, London

Apr 98 - Mar 99 Senior Registrar in General Medicine, Endocrinology and Diabetes
Eastbourne District General Hospital, Eastbourne

Apr 99 – Apr 00 Lecturer in Diabetes and Endocrinology
Guy's, King's & St Thomas' School of Medicine
King's College, London

Honorary Specialist Registrar
Guy’s & St Thomas's Hospitals

May 00 – Feb 06 Senior Lecturer in Endocrinology and Metabolism
University of Southampton

Feb 06 – Aug 08 Reader of Endocrinology and Metabolism
University of Southampton

Professor Richard Holt's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Barnard, K., Peveler, R.C. and Holt, R.I.G. (2013) Antidepressant medication as a risk factor for Type 2 Diabetes and impaired glucose regulation. Diabetes Care, 36, (10), 3337-3345. (doi:10.2337/dc13-0560).
Murphy, H. R., Bell, R., Holt, R.I.G., Maresh, M., Todd, D., Hawdon, J., Young, B., Holman, N., Hillson, R. and Lewis-Barned, N. (2013) The national pregnancy in diabetes audit: Measuring the quality of diabetes pregnancy care. Diabetic Medicine, 30, (9), 1014-1016. (doi:10.1111/dme.12277). (PMID:23819584).
Holt, R.I.G., Phillips, D.I.W., Jameson, K.A., Cooper, C., Dennison, E.M. and Peveler, R.C. The Hertfordshire Cohort Study Group (2013) The relationship between depression, anxiety and cardiovascular disease: findings from the Hertfordshire Cohort Study. Journal of Affective Disorders, 150, (1), 84-90. (doi:10.1016/j.jad.2013.02.026). (PMID:23507368).
Guha, Nishan, Cowan, David A., Sonksen, Peter H. and Holt, R.I.G. (2013) Insulin-like growth factor-I (IGF-I) misue in athletes and potential methods for detection. Analytical and Bioanalytical Chemistry (doi:10.1007/s00216-013-7229-y).
Nicolucci, A., Kovacs Burns, K., Holt, R.I.G., Comaschi, M., Hermanns, N., Ishii, H., Kokoszka, A., Pouwer, F., Skovlund, S.E., Stuckey, H., Tarkun, I., Vallis, M., Wens, J. and Peyrot, M. (2013) Diabetes Attitudes, Wishes and Needs second study (DAWN2: cross-national benchmarking of diabetes-related psychosocial outcomes for people with diabetes. Diabetic Medicine, 30, (7), 767-777. (doi:10.1111/dme.12245).
Kovacs Burns, K, Nicolucci, A, Holt, R.I.G., Willaing, I and Hermanns, N (2013) The Diabetes Attitudes, Wishes and Needs second study(DAWN2) cross-national benchmarking indicators for family members living with people with diabetes. Diabetic Medicine, 30, (7), 778-788. (doi:10.1111/dme.12239). (PMID:23701236).
Mommersteeg, P.M., Herr, R., Pouwer, F., Holt, R.I.G. and Loerbroks, A. (2013) The association between diabetes and an episode of depressive symptoms in the 2002 World Health Survey: an analysis of 231 797 individuals from 47 countries. Diabetic Medicine, 30, (6) (doi:10.1111/dme.12193). (PMID:23614792).
Velloso, C.P., Aperghis, M., Godfrey, R., Blazevich, A J., Bartlett, C., Cowan, D., Holt, R.I.G., Bouloux, P., Harridgre, S.D.R. and Goldspink, G. (2013) The effects of two weeks of recombinant growth hormone administration on the response of IGF-I and N-terminal pro-peptide of collagen type III (P-III-NP) during a single bout of high resistance exercise in resistance trained young men. Growth Hormone and IGF Research, 23, (3), 76-80. (doi:10.1016/j.ghir.2013.01.002). (PMID:23433656).
Velloso, C.P., Aperghis, M., Godfrey, R., Blazevich, A.J., Bartlett, C., Cowan, D., Holt, R.I.G., Bouloux, P., Harridge, S.D. and Goldspink, G. (2013) The effect of two weeks of recombinant growth hormone administration on the response of IGF-I and N-terminal pro-peptide of collagen type III (P-III_NP) during a single bout of high resistance exercise in resistance trained young men. Growth Hormone & IGF Research, 23, (3), 76-80.
Holt, R.I.G., Nicolucci, A., Kovacs Burn, K., Escalante, M., Forbes, A., Hermanns, N., Kalra, S., Massi-Benedetti, M., Mayorov, A., Menendez-Torre, E., Munro, N., Skovlund, S.E., Tarkun, I., Wens, J. and Peyrot, M. (2013) Diabetes Attitudes, Wishes and Needs: second study (DAWN): cross-national comparisons on barriers and resources for optimal care-healthcare professional perspective. Diabetic Medicine (doi:10.0000/dme.12242). (PMID:23710839).
Holt, Richard, Nicolucci, A., Kovacs Burns, K., Escalante, M., Forbes, A., Hermanns, N., Kalra, S., Massi-Benedetti, M., Mayorov, A., Menéndez-Torre, E., Munro, N., Skovlund, S.E., Tarkun, I., Wens, J., Peyrot, M. and the DAWN2 Study Group (2013) Diabetes attitudes, wishes and needs: second study (DAWN2). Cross-national comparisons on barriers and resources for optimal care-healthcare professional perspective. Diabetic Medicine, 30, (7), 789-798. (doi:10.1111/dme.12242). (PMID:23710839).
Jones, Emma, Sinclaire, Julia M.A., Holt, Richard I.G. and Barnard, Katharine (2013) Social networking and understanding alcohol-associated risk for people with type 1 diabetes: friend or foe? Diabetes Technology & Therapeutics, 15, (4) (doi:10.1089/dia.2012.0327).
Lambert, K. and Holt, R.I.G. (2013) The use of insulin analogues in pregnancy. Diabetes, Obesity, and Metabolism (doi:10.1111/dom.12098). (PMID:23489521).
Peyrot, M., Burns, K.K., Davies, M., Hermanns, N., Holt, R.I.G., Kalra, S., Nicolucci, A., Pouwer, F., Wens, J., Willaing, I. and Skovlund, S.E. (2013) Diabetes Attitudes Wishes and Needs 2 (DAWN2): a multinational, multi-stakeholder study of psychosocial issues in diabetes and person-centred diabetes care. Diabetes Research and Clinical Practice, 99, (2), 174-184. (doi:10.1016/j.diabres.2012.11.016).
Holt, R.I.G. (2013) A review of reviews: a virtual issue. Diabetes Obesity and Metabolism, 15, (1), 1-2. (doi:10.1111/dom.12044). (PMID:23241070).
Holt, R.I.G. and Kalra, Sanjay (2013) A new DAWN: Improving the psychosocial management of diabetes. Indian Journal of Endocrinology and Metabolism, 17, (7), 95-99. (doi:10.4103/2230-8210.119515).
Holt, R.I.G. (2013) Detecting growth hormone misuse in athletes. Indian Journal of Endocrinology and Metabolism, 17, (7), supplement 1, 18-22. (doi:10.4103/2230-8210.119494).
Patel, M.B., Makepeace, A.E., Jameson, K.A., Masterton, L.M., Holt, R.I., Swaminathan, R., Javaid, M.K., Cooper, C. and Arden, N.K. (2012) Weight in infancy and adult calcium absorption as determinants of bone mineral density in adult men: the hertfordshire cohort study. Calcified Tissue International, 91, (6), 416-422. (doi:10.1007/s00223-012-9648-8.). (PMID:23010962).
Erotokritou-Mulligan , Ioulietta, Guha, Nishan, Stow, Michael, Bassett , E. Eryl, Bartlett, Christiaan, Cowan, David A., Sonksen, Peter H. and Holt, Richard I. G. (2012) The development of decision limits for the implementation of the GH-2000 detection methodology using current commercial insulin-like growth factor-I and amino-terminal pro-peptide of type III collagen assays. Growth Hormone and IGF Research, 22, (2), 53-58. (doi:10.1016/j.ghir.2011.12.005). (PMID:22305721).
Barnard, K., Sinclair, J. M. A., Lawton , J., Young, A. J. and Holt, R .I. G. (2012) Alcohol-associated risks for young adults with Type 1 diabetes: a narrative review. Diabetic Medicine, 29, (4), 434-440. (doi:10.1111/j.1464-5491.2012.03579.x). (PMID:22248115).
Roy, T., Lloyd, C.E., Pouwer, F., Holt, R.I.G. and Sartorius, N. (2012) Screening tools used for measuring depression among people with Type 1 and Type 2 diabetes: a systematic review. Diabetic Medicine, 29, (2), 164-75. (doi:10.1111/(ISSN)1464-5491). (PMID:21824180).
Wong, Mo Lee and Holt, Richard I. G. (2011) The potential dangers of mephedrone in people with diabetes: a case report. Drug Testing and Analysis, 3, (7-8), 464-465. (doi:10.1002/dta.316). (PMID:21755609).
Holt, Richard I.G. (2011) Detecting growth hormone abuse in athletes. Analytical and Bioanalytical Chemistry, 401, (2), 449-462. (doi:10.1007/s00216-011-5068-2). (PMID:21590497).
Citrome, Leslie, Holt, Richard I.G., Walker, Daniel J. and Hoffmann, Vicki Poole (2011) Weight gain and changes in metabolic variables following olanzapine treatment in schizophrenia and bipolar disorder. Clinical Drug Investigation, 31, (7), 455-482. (doi:10.2165/11589060-000000000-00000). (PMID:21495734).
Holt, R. I. G., Young, B. S., Hitman, G. A. and Alberti, K. G. (2011) The publication of Diabetes UK position statements and care recommendations. Diabetic Medicine, 28, (5), 507. (doi:10.1111/j.1464-5491.2011.03247.x). (PMID:21281335).
Round, J.A., Jacklin, P., Fraser, R.B., Hughes, R.G., Mugglestone, M.A. and Holt, R.I.G. (2011) Screening for gestational diabetes mellitus: cost-utility of different screening strategies based on a woman's individual risk of disease. Diabetologia, 54, (2), 256-263. (doi:10.1007/s00125-010-1881-y). (PMID:20809381).
Holt, R. I. G., Barnett, A. H. and Bailey, C. J. (2010) Bromocriptine: old drug, new formulation and new indication. Diabetes Obesity and Metabolism, 12, (12), 1048-1057. (doi:10.1111/j.1463-1326.2010.01304.x). (PMID:20977575).
Holt, R.I.G., Barnett, A.H. and Bailey, C.J. (2010) Bromocriptine: old drug, new formulation and new indication. Diabetes, Obesity and Metabolism, 12, (12), 1048-1057. (doi:10.1111/j.1463-1326.2010.01304.x). (PMID:20977575).
Gosden, Charlotte, Edge, Julie A., Holt, Richard I.G., James , June, Turner, Bridget, Winocour , Peter, Walton, Chris, Nagi, Dinesh, Williams, Rhys and Matyka, Krystyna (2010) The fifth UK paediatric diabetes services survey: meeting guidelines and recommendations? Archive of Disease in Childood, 95, (10), 837-840. (doi:10.1136/adc.2009.176925). (PMID:20605860).
Holt, Richard I.G. (2010) Osteoporosis in people with severe mental illness: a forgotten condition. Maturitas, 67, (1) (doi:10.1016/j.maturitas.2010.06.004 ). (PMID:20591586). (In Press).
Holt, Richard I.G., Erotokritou-Mulligan, Ioulietta, McHugh, Cathy, Bassett , E. Eryl, Bartlett , Christiaan, Fityan, Adam, Bacon, Jenny L., Cowan, David A. and Sonksen, Peter H. (2010) The GH-2004 project: the response of IGF1 and type III pro-collagen to the administration of exogenous GH in non-Caucasian amateur athletes. European Journal of Endocrinology, 163, (1), 45-54. (doi:10.1530/EJE-09-0978). (PMID:20421332).
Holt, Richard I.G., Pendlebury, John, Wildgust, Hiram J. and Bushe, Chris J. (2010) Intentional weight loss in overweight and obese patients with severe mental illness: 8-year experience of a behavioral treatment program. Journal of Clinical Psychiatry, 71, (6), 800-805. (doi:10.4088/JCP.09m05627gre). (PMID:20361917).
Holt, Richard I.G. and Peveler, Robet C. (2010) Antipsychotics and hyperprolactinaemia: mechanisms, consequences and management. Clinical Endocrinology (doi:10.1111/j.1365-2265.2010.03814.x). (PMID:20455888).
Erotokritou-Mulligan, Ioulietta, Bassett, E. Eryl, Cowan, David A., Bartlett, Christiaan, Milward, Polly, Sartorio, Alessandro, Sönksen, Peter H. and Holt, Richard I.G. (2010) The use of growth hormone (GH)-dependent markers in the detection of GH abuse in sport: physiological intra-individual variation of IGF-I, type 3 pro-collagen (P-III-P) and the GH-2000 detection score. Clinical Endocrinology, 72, (4), 520-526. (doi:10.1111/j.1365-2265.2009.03668.x).
Erotokritou-Mulligan , Ioulietta and Holt, Richard I.G. (2010) Insulin-like growth factor I and insulin and their abuse in sport. Endocrinology and Metabolism Clinics of North America, 39, (1), 33-43. (doi:10.1016/j.ecl.2009.10.003).
Holt, R.I.G. (2010) Progression of treatment strategies in type 2 diabetes. US Endocrinology, 6, 34-41.
Guha, Nishan., Erotokritou-Mulligan, Ioulietta., Burford, Caroline., Strobridge, Gail., Brigg, Joanna., Drake, Tamsin., Bassett, Eryl E., Cowan, David., Bartlett, Christiaan, Sonksen, Peter H. and Holt, Richard I.G. (2010) Serum insulin-like growth factor-I and pro-collagen type III n-terminal peptide in adolescent elite athletes: implications for the detection of growth hormone abuse in sport. Journal of Clinical Endocrinology and Metabolism, 95, (6), 2969-2976. (doi:10.1210/jc.2010-0008).
Guha, Nishan, Dashwood, Alexander, Thomas , Nicholas, Skingle, A., Sonksen, Peter H. and Holt, R.I.G. (2009) IGF-I abuse in sport. Current Drug Abuse Reviews, 2, (3), 263-272.
Holt, Richard I.G. (2009) Is human growth hormone an ergogenic aid? Drug Testing and Analysis , 1, (9-10), 412-418. (doi:10.1002/dta.58).
Holt, Richard I.G. (2009) Detecting growth hormone abuse in athletes. [in special issue: Growth Hormone: Barriers to the Implementation of Human Growth Hormone Testing in Sport] Drug Testing and Analysis, 1, (9-10), 426-433. (doi:10.1002/dta.59 ).
Erotokritou-Mulligan, Loulietta, Bassett, E. Eryl, Cowan, David, Bartlett, Christiaan, Milward, Polly, Sartorio, Alessandro, Sonksen, Peter H. and Holt, Richard I.G. (2009) The use of growth hormone (GH)-dependent markers in the detection of GH abuse in sport: Physiological intra-individual variation of IGF-I, type 3 pro-collagen (P-III-P) and the GH-2000 detection score. Clinical Endocrinology, 1-27. (doi:10.1111/j.1365-2265.2009.03668.x). (In Press).
Holt, Richard I.G. and Peveler, Robert C. (2009) Obesity, serious mental illness and antipsychotic drugs. Diabetes, Obesity and Metabolism, 11, (7), 665-679. (doi:10.1111/j.1463-1326.2009.01038.x).
Holt, R.I.G., Phillips, D.I.W., Jameson, K.A., Cooper, C., Dennison, E.M. and Peveler, R.C. The Hertfordshire Cohort Study Group (2009) The relationship between depression and diabetes mellitus: findings from the Hertfordshire Cohort Study. Diabetic Medicine, 26, (6), 641-648. (doi:10.1111/j.1464-5491.2009.02742.x).
Holt, Richard I.G., Erotokritou-Mulligan, Ioulietta, Ridley, Sean A., McHugh, Cathy M., Bassett, E. Eryl, Cowan, David A., Bartlett, Christiaan and Sonksen, Peter H. (2009) A determination of the pre-analytical storage conditions for insulin like growth factor-I and type III procollagen peptide. Growth Hormone & IGF Research, 19, (1), 43-50. (doi:10.1016/j.ghir.2008.06.001).
Erotokritou-Mulligan, Ioulietta, Bassett, E. Eryl, Cowan, David A., Bartlett, Christiaan, McHugh, Cathy, Sonksen, Peter H. and Holt, Richard I.G. (2009) Influence of ethnicity on IGF-I and procollagen III peptide (P-III-P) in elite athletes and its effect on the ability to detect GH abuse. Clinical Endocrinology, 70, (1), 161-168. (doi:10.1111/j.1365-2265.2008.03319.x).
Holt, R.I.G., Abdelrahman, T., Hirsch, M., Dhesi, Z., George, T., Blincoe, T. and Peveler, R.C. (2009) The prevalence of undiagnosed metabolic abnormalities in people with serious mental illness. Journal of Psychopharmacology (doi:10.1177/0269881109102788). (In Press).
Holt, Richard I.G. (2008) Regulation's threat to research. Research is no longer attractive. British Medical Journal, 337, (a2918) (doi:10.1136/bmj.a2918).
Holt, R.I.G., Clarke, P., Parry, E.C. and Coleman, M.A.G. (2008) The effectiveness of glibenclamide in women with gestational diabetes. Diabetes, Obesity and Metabolism, 10, (10), 906-911. (doi:10.1111/j.1463-1326.2007.00828.x).
Winocour, Peter H, Gosden, Charlotte, Walton, Chris, Turner, Bridget, Nagi, Dinesh and Holt, Richard I.G (2008) The conflict between specialist diabetes services and acute-general internal medicine for consultant diabetologists in the UK in 2006. Clinical Medicine, 8, (4), 377-380.
Winocour, P.H., Gosden, C., Walton, C., Nagi, D., Turner, B., Williams, R., James, J. and Holt, R.I. (2008) Association of British Clinical Diabetologists (ABCD) and Diabetes-UK survey of specialist diabetes services in the UK, 2006. 1. The consultant physician perspective. Diabetic Medicine, 25, (6), 643-650. (doi:10.1111/j.1464-5491.2008.02449.x). (PMID:18544101).
Holt, Richard I.G. (2008) Medical causes and consequences of hyperprolactinaemia. A context for psychiatrists. Journal of Psychopharmacology, 22, (Suppl 2), 28-37. (doi:10.1177/0269881107087951).
Peveler, Robert C., Branford, David, Citrome, Leslie, Fitzgerald, Peter, Harvey, Philip W., Holt, Richard I.G., Howard, Louise, Kohen, Dora, Jones, Ian, O'Keane, Veronica, Pariente, Carmine M., Pendlebury, John, Smith, Shubulade M. and Yeomans, David (2008) Antipsychotics and hyperprolactinaemia: clinical recommendations. Journal of Psychopharmacology, 22, supplement 2, 98-103. (doi:10.1177/0269881107087346). (PMID:18477626).
Holt, R.I. and Sonksen, P.H. (2008) Growth hormone, IGF-I and insulin and their abuse in sport. British Journal of Pharmacology, 154, (3), 542-556. (doi:10.1038/bjp.2008.99).
Smith, M., Hopkins, D., Peveler, R.C., Holt, R.I.G., Woodward, M. and Ismail, K. (2008) First- v. second-generation antipsychotics and risk for diabetes in schizophrenia: systematic review and meta-analysis. The British Journal of Psychiatry, 192, (6), 406-411. (doi:10.1192/bjp.bp.107.037184).
Pendlebury, J. and Holt, R.I.G. (2008) Supporting the lifestyle modification and treatment of type 2 diabetes for people with sever mental illness. European Diabetes Nursing, 5, (2), 58-63. (doi:10.1002/edn.110).
Holt, Richard (2008) Antipsychotics, metabolic side effects and the elderly. Geriatric Medicine, 38, (6), 399-402.
Holt, R.I.G. (2008) Improving pregnancy outcomes for women with diabetes. Practical Diabetes International, 25, (5), 172-174. (doi:10.1002/pdi.1239).
Sonksen, P.H. and Holt, R.I.G. (2008) Commentary on Graham et al.: Physical Effects of Short-Term rhGH Administration in Abstinent Steroid Dependency. Hormone Research in Paediatrics, 69, (6), 355-356. (doi:10.1159/000117391).
Kar, P. and Holt, R.I. (2008) The effect of sulphonylureas on the microvascular and macrovascular complications of diabetes. Cardiovascular Drugs and Therapy, 22, (3), 207-213. (doi:10.1007/s10557-008-6090-2).
Erotokritou-Mulligan, I., Bassett, E.E., Bartlett, C., Cowan, D., McHugh, C., Seah, R., Curtis, B., Wells, V., Harrison, K., Sonksen, P.H. and Holt, R.I. (2008) The effect of sports injury on Insulin-like growth factor-I and Type 3 Procollagen: implications for detection of growth hormone abuse in athletes. Journal of Clinical Endocrinology & Metabolism, 93, (7), 2760-2763. (doi:10.1210/jc.2007-2801).
Javaid, M. Kassim and Holt, Richard I.G. (2008) Understanding osteoporosis. Journal of Psychopharmacology, 22, supplement 2, 38-45. (doi:10.1177/0269881107087955).
Holt, R.I.G., Hirsch, M., Abdelrahman, T., Blincoe, T.G. and Peveler, R.C. (2008) The high prevalence of undiagnosed metabolic abnormalities in people with severe mental illness. Diabetic Medicine, 25, (s1), p.158. (doi:10.1111/j.1464-5491.2008.02388.x).
Citrome, Leslie L., Holt, Richard I.G., Zachry, Woodie M., Clewell, Jerry D., Orth, Paul A., Karagianis, Jamie L. and Hoffmann, Vicki Poole (2007) Risk of treatment-emergent diabetes mellitus in patients receiving antipsychotics. The Annals of Pharmacotherapy, 41, (10), 1593-1603. (doi:10.1345/aph.1K141).
Erotokritou-Mulligan, Ioulietta, Bassett, E. Eryl, Kniess, Astrid, Sönksen, Peter H. and Holt, Richard I.G. (2007) Validation of the growth hormone (GH)-dependent marker method of detecting GH abuse in sport through the use of independent data sets. Growth Hormone & IGF Research, 17, (5), 416-423. (doi:10.1016/j.ghir.2007.04.013).
Holt, H.B., Wild, S.H., Wareham, N., Ekelund, U., Umpleby, M., Shojaee-Moradie, F., Holt, R.I.G., Phillips, D.I. and Byrne, C.D. (2007) Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity. Diabetologia, 50, (8), 1698-1706. (doi:10.1007/s00125-007-0705-1).
James, J., Gosden, C. and Holt, R.I.G. (2007) Agenda for Change and NHS reconfiguration. Practical Diabetes International, 24, (5), 247-251. (doi:10.1002/pdi.1111).
Holt, R.I.G. and Peveler, R.C. (2007) The high prevalence of undiagnosed metabolic compications in people with severe mental illness. European Psychiatry, 22, (Supplement 1), p.S115. (doi:10.1016/j.eurpsy.2007.01.367).
Holt, R.I. (2007) Beyond reasonable doubt: catching the growth hormone cheats. Pediatric Endocrinology Review, 4, (3), 228-232.
Moon, R.J., Bascombe, L.A. and Holt, R.I. (2007) The addition of metformin in type 1 diabetes improves insulin sensitivity, diabetic control, body composition and patient well-being. Diabetes, obesity and metabolism, 9, (1), 143-145.
Poole, R.B., Holt, R.I. and Arden, N.K. (2007) A case of leg pain and weakness in a man with diabetes. Journal of Clinical Pathology, 60, (8), 938-939. (doi:10.1136/jcp.2005.032458).
Nakane, H., Holt, R.I., Kudo, T. and Morinobu, S. (2007) Antipsychotics and diabetes. Japanese Journal of Clinical Psychopharmacology, 10, (5), 901-908.
Holt, Richard I. and Peveler, Robert C. (2006) Association between antipsychotic drugs and diabetes. Diabetes, Obesity & Metabolism, 8, (2), 125-135. (doi:10.1111/j.1463-1326.2005.00495.x).
Flanagan, D.E., Holt, R.I., Owens, P.C., Cockington, R.J., Moore, V.M., Robinson, J.S.I.F. and Phillips, D.I. (2006) Gender differences in the insulin-like growth factor axis response to a glucose load94. Acta Physiologica, 187, 371-378. (doi:10.1111/j.1748-1716.2006.01581.x).
Smith, M., Hopkins, D., Peveler, R., Holt, R., Woodward, M. and Ismail, K. (2006) What is the evidence for an increased risk for diabetes mellitus in people with schizophrenia who are prescribed atypical antipsychotics compared to those prescribed typical antipsychotics? Journal of Psychopharmacology, 20, (Supplement 5), p.A40.
Holt, R.I.G. and Peveler, R.C. (2006) Antipsychotic drugs and diabetes: an application of the Austin Bradford Hill criteria. Diabetologia, 49, (7), 1467-1476. (doi:10.1007/s00125-006-0279-3).
Holt, R.I.G. and Peveler, R.C. (2005) Schizophrenia: the diabetes link. Independent Nurse, (4), 14-15.
Holt, Richard (2005) Discussing diabetes. Practice Nursing, 16, (4), 162.
Browne, D. and Holt, R.I.G. (2005) Making babies, the diabetes way. Balance, 204, 39-41.
Holt, Richard I.G., Bushe, Chris and Citrome, Leslie (2005) Diabetes and schizophrenia 2005: are we any closer to understanding the link? Journal of Psychopharmacology, 19, (6 Suppl), 56-65. (doi:10.1177/0269881105058379).
Norman, Patricia, Clarke, Penny, Coleman, Matthew A.G. and Holt, Richard I.G. (2005) Improving staff understanding of gestational diabetes - use of self-audit. Clinical Governance Bulletin, 5, (5), 9-10.
Patel, M.B.R., Arden, N.K., Masterson, L.M., Phillips, D.I.W., Swaminathan, R., Syddall, H.E., Byrne, C.D., Wood, P.J., Cooper, C. and Holt, R.I.G. (2005) Investigating the role of the growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD). Bone, 37, (6), 833-841. (doi:10.1016/j.bone.2005.06.016).
Clarke, Penny, Coleman, Matthew A.G. and Holt, Richard I.G. (2005) Alternative site self blood glucose testing is preferred by women with gestational diabetes. Diabetes Technology and Therapeutics, 7, (4), 604-608. (doi:10.1089/dia.2005.7.604).
Poole, R.B., Harrold, C.P., Burridge, J.H., Byrne, C.D. and Holt, R.I.G. (2005) Electrical muscle stimulation acutely mimics exercise in neurologically intact individuals but has limited clinical benefits in patients with type 2 diabetes. Diabetes, Obesity and Metabolism, 7, (4), 344-351. (doi:10.1111/j.1463-1326.2004.00400.x).
Holt, R.I.G. (2005) Metabolic and lifestyle issues and severe mental illness - new connections to well-being. Journal of Psychopharmacology, 19, (suppl. 6), 118-122.
Holt, Richard I.G. (2005) Obesity - an epidemic of the twenty-first century: an update for psychiatrists. Journal of Psychopharmacology, 19, (6 Suppl), 6-15. (doi:10.1177/0269881105058377).
Holt, Richard I.G. (2005) Diabetes morbidity in schizophrenia. Practice Nursing, 16, (4), 172-175.
Zhang, Junlong, Holt, Richard I.G., Wild, Sarah H., Poole, Ruth B., Holt, Helen and Byrne, Christopher D. (2005) Letters: observations. Plasma adiponectin concentrations are independently predicted by fat insulin sensitivity in women and by muscle insulin sensitivity in men. Diabetes Care, 28, (3), 755-756. (doi:10.2337/diacare.28.3.755).
Holt, R.I.G., Syddall, H.E., Phillips, D.I.W., Martyn, C.N., Gluckman, P.D., Breier, B.H., Wood, P.J. and Fall, C.H. (2004) Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts. Acta Physiologica Scandinavica, 180, (4), 359-366. (doi:10.1111/j.1365-201X.2004.01262.x).
Holt, R.I.G. (2004) 'Schizophrenia and Diabetes 2003' Expert Consensus Meeting, Dublin, 3-4 October 2003: consensus summary. [in special issue: Schizophrenia and diabetes 2003: an expert consensus meeting] British Journal of Psychiatry, 184, (47), s112-s114.
Holt, R.I.G. (2004) The metabolic effects of growth hormone. CME Bulletin Endocrinology and Diabetes, 5, (1), 11-17.
Bushe, Chris and Holt, Richard (2004) Prevalence of diabetes and impaired glucose tolerance in patients with schizophrenia. British Journal of Psychiatry, 184, (suppl. 47), s67-s71.
Dinan, Ted, Peveler, Robert and Holt, Richard (2004) Understanding schizophrenia and diabetes. British Journal of Hospital Medicine, 65, (8), 485-488.
Holt, Richard I.G. (2004) Diagnosis, epidemiology and pathogenesis of diabetes mellitus: an update for psychiatrists. British Journal of Psychiatry, 184, (47), s55-s63.
Holt, R.I.G. and Gallen, I. (2004) Time to move beyond glycosylated haemoglobin. Diabetic Medicine, 21, (7), 655-656. (doi:10.1111/j.1464-5491.2004.01318.x).
Holt, R.I.G., Peveler, R.C. and Byrne, C.D. (2004) Schizophrenia, the metabolic syndrome and diabetes. Diabetic Medicine, 21, (6), 515-523. (doi:10.1111/j.1464-5491.2004.01199.x).
Holt, R.I.G. and Peveler, R.C. (2004) Schizophrenia, abnormalities in glucose metabolism and diabetes. Therapeutic Focus, 1-9.
Holt, Richard (2003) Growth hormone: a potential treatment option in diabetes? Diabetes Voice, 48, (2), 22-24.
Holt, R.I.G., Simpson, H.L. and Sönksen, P.H. (2003) The role of the growth hormone-insulin-like growth factor axis in glucose homeostasis. Diabetic Medicine, 20, (1), 3-15. (doi:10.1046/j.1464-5491.2003.00827.x).
Kajantie, Eero, Fall, Caroline H., Seppala, Markku, Koistinen, Riita, Dunkel, Leo, Yliharsila, Hilkka, Osmond, Clive, Andersson, Sture, Barker, David J.P., Forsen, Tom, Holt, Richard I.G., Phillips, David I.W. and Eriksson, Johan (2003) Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth. Journal of Clinical Endocrinology and Metabolism, 88, (3), 1059-1065. (doi:10.1210/jc.2002-021380).
Holt, R.I.G. and Byrne, C.D. (2003) The clinical implications of the Heart Protection Study. Cardiovascular Risk Abstracts, 1, 5-7.
Holt, R.I.G., Syddall, H.E., Phillips, D.I.W., Martyn, C.N., Gluckman, P.D., Breier, B.H. and Wood, P.J. (2003) The relation between birth weight, weight at 1 year and adult height and the growth hormone - IGF axis in late middle age. Pediatric Research, 53, (6), p.40A.
Wood, Rachel, Sandeman, Derek D., Gawne-Cain, Mary L. and Holt, Richard I.G. (2002) Meningitis four years after treatment of macroprolactinoma. Journal of the Royal Society of Medicine, 95, (10), 501-502.
Holt, R.I. and Byrne, C.D. (2002) Intrauterine growth, the vascular system, and the metabolic syndrome. Seminars in Vascular Medicine, 2, (1), 33-43. (doi:10.1055/s-2002-23094).
Holt, R.I.G. (2002) Intrauterine growth and fetal programming of endocrine axes. Current Medical Literature in Endocrinology, 2, (2), 1-7.
Holt, Richard I.G. (2002) Fetal programming of the growth hormone-insulin-like growth factor axis. Trends in Endocrinology and Metabolism, 13, (9), 392-397. (doi:10.1016/S1043-2760(02)00697-5).
Holt, Richard I.G., Webb, Emma, Pentecost, Claire and Sonksen, Peter H. (2001) Aging and physical fitness are more important than obesity in determining exercise-induced generation of GH. Journal of Clinical Endocrinology and Metabolism, 86, (12), 5715-5720. (doi:10.1210/jc.86.12.5715).
Holt, R.I.G. and Bending, J.J. (2001) The management of cardiovascular risk factors in diabetes in a district hospital clinic. Diabetes Today, 4, (3), 70-76.
Holt, Richard I.G., Miklaszewicz, Pawel, Cranston, Iain C., Russell-Jones, David, Rees, P. John and Sonksen, Peter H. (2001) Computer assisted learning is an effective way of teaching endocrinology. Clinical Endocrinology, 55, (4), 537-542. (doi:10.1046/j.1365-2265.2001.01346.x).

Book

Holt, Richard and Hanley, Neil (2006) Essential endocrinology and diabetes. 5th revised edition, Oxford, GB, Blackwell, 288pp.

Book Section

Peveler, Robert C. and Holt, Richard I.G (2010) Psychiatric disorders and diabetes. In, Textbook of Diabetes. United Kingdom of Great Britain and Northern Ireland, GB, Wiley. (In Press).
Holt, R.I.G. and Peveler, R.C. (2009) Screening for diabetes and cardiovascular risk in people with serious mental illness. In, Metabolic Effects of Psychotropic Drugs. , Karger. (Modern Trends in Pharmacopsychiatry, 26).
Holt, R.I.G. (2008) An overview of human adrenal dysfunction. In, Hanley, N.A., Harvey, Philip W., Everett, David and Springall, Christopher (eds.) Adrenal Toxicology. , Informa Healthcare. (Target Organ Toxicology, 26).
 

Research

Research Interests

My research interests are focused around clinical diabetes and growth hormone. Within clinical diabetes, I have an active research programme examining the links between diabetes and mental illness and the psychosocial issues of diabetes. I have also undertaken research in diabetes in pregnancy and was a member of the NICE Diabetes and Pregnancy Guideline Development Group. I am working with the World Anti-Doping Agency and UK Sport to develop a test to detect athletes who are abusing GH.

The specific areas of research that I am pursuing are:

1. The development of a methodology to detect growth hormone abuse in sport the GH-2004 project. We have developed a test based on the measurement of two GH-dependent markers (IGF I and P-III-NP) that was introduced for the first time by the World Anti-Doping Agency at the London 2012 Olympic Games and led to the disqualification of two Russian powerlifters at the Paralympic Games. We are continuing to work with the World Anti-Doping Agency and UK Sport to improve the test and to ensure that it can be undertaken in all World Anti-Doping Agency accredited laboratories worldwide.

2. I have a major research interest in the relationship between severe mental illness and diabetes. There is considerable controversy about the mechanisms underlying this relationship and I have undertaken analyses to tease out the contribution of the antipsychotic drugs. I have recently received a £2 million grant from the NIHR HTA programme to undertake a study to adapt and test a lifestyle modification programme based on the NICE approved DESMOND programme to address the problem of obesity in people with schizophrenia. I am also a co-investigator on the PRIMROSE study, whose aim is to test a primary care nurse led intervention to improve the management of cardiovascular risk in people with severe mental illness.

3. I also have interests in the relationship between diabetes and depression and am developing a web-based cognitive behavioural therapy programme for people with diabetes and depression. Using the MRC Hertfordshire cohort study, we have the relationship between depressive symptoms and prevalent and incident cardiovascular disease.

4. I am a member of the international steering committee for the second Diabetes, Attitudes, Wishes and Needs study, whose aim is to understand the facilitators of and barriers to active diabetes self-management. The study involves a multinational survey of people with diabetes, family members and healthcare professionals

5. Within the field of gestational diabetes, we have evaluated the use of glibenclamide to control glycaemia during pregnancy and have questioned the value of universal glucose tolerance tests in the postnatal period. We have contributed to multicentre international trials of insulin analogues in pregnancy. We have also examined the best meters for monitoring glucose during pregnancy

Academic unit:  Human Development and Health

Responsibilities

Postgraduate student supervision

Currently supervising two PhD students

Faculty of Medicine

Member of the Research for Health and Medicine module steering committee
Undergraduate and postgraduate examiner

National and International responsibilities

Immediate past-Chair of the Council of Health Care Professionals of Diabetes UK
Leader of Diabetes UK Innovator in Diabetes Programme for Young Basic and Clinical Scientists
European Editor for Diabetic Medicine
Reviews Editor for Diabetes Obesity and Metabolism
Member of Society for Endocrinology
Member of the European Association for the Study of Diabetes – currently a member of the conference organizing committee
Fellow of the Higher Education Academy
Former member of NICE Diabetes and Pregnancy Guideline Development group
Former member of the NICE Diabetes Prevention Programme Development group
Member of Commission on Human Medicine Cardiovascular, diabetes and renal, respiratory and allergy expert advisory group

Teaching Responsibilities



• Richard is a personal tutor for 6 medical students.

• He provides diabetes teaching for both the BM4 and BM5 programmes

• He regularly supervise 4th year medical students for their research projects and lectures on the research for health and medicine course

• He is currently supervising 3 postgraduate research students.

• He is in regular demand to lecture on postgraduate continuing professional development courses for doctors, nurses and allied health professionals

Contact

Professor Richard Holt
Professor in Diabetes & Endocrinology
Human Development and Health Academic Unit
Faculty of Medicine
University of Southampton
The Institute of Developmental Sciences (IDS Building) MP887
University of Southampton
Southampton General Hospital
Tremona Road
Southampton SO16 6YD
UK

Room Number: SGH/DC015/MP887

Telephone: (023) 8120 4665
Facsimile: (023) 8120 5255
Email: R.I.G.Holt@soton.ac.uk