The University of Southampton
Medicine

Dr Rahul Tare MSc, PhD

Lecturer - Musculoskeletal Science and Bioengineering

Dr Rahul Tare's photo
Related links

Dr Rahul Tare is Lecturer - Musculoskeletal Science and Bioengineering within Medicine and Engineering at the University of Southampton.

My research harnesses a multidisciplinary approach encompassing human stem cells, tissue engineering and acoustofluidics to generate 3-D cartilage grafts, and seeks to gain insight into the development of skeletal diseases through improved appreciation of molecular regulation of skeletogenesis.

Dr Rahul Tare is a molecular biologist specialising in skeletal biology. Rahul’s research focuses on stem cells, tissue engineering and skeletal development, and his group is primarily based within the Centre for Human Development, Stem Cells and Regeneration (FoM) and Bioengineering Sciences (FEE).

Potential students and researchers interested in the above mentioned areas of research are encouraged to contact Rahul.

Qualifications

PhD, University of Southampton, UK (2002)
Postgraduate Certificate in Academic Practice, University of Southampton, UK (2013)

Appointments held

Lecturer, Faculties of Medicine and Engineering & the Environment, University of Southampton (May 2010 onwards)

Senior Postdoctoral Career Track Fellow, Bone and Joint Research Group, University of Southampton (Jan 2009 – Apr 2010)

Postdoctoral Career Track Fellow, Bone and Joint Research Group, University of Southampton (July 2008 – Dec 2008)

Postdoctoral Research Fellow, Bone and Joint Research Group, University of Southampton (Mar 2004 – June 2008)

Postdoctoral Research Fellow, Department of Cell Biology, University of Massachusetts Medical School, Worcester, USA (Oct 2002 – Feb 2004)

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Rahul’s group is actively engaged in research encompassing stem cells, tissue engineering and skeletal development. The work has been instrumental in developing strategies for isolation of skeletal stem cells (SSCs), elucidating the SSC phenotype and defining conditions to manipulate SSC differentiation into principal stromal lineages. A multidisciplinary approach encompassing skeletal cells, acoustofluidics and mathematical modelling has been harnessed to bioengineer robust cartilage grafts. The group also seek to understand the molecular basis of skeletal development and disease through improved appreciation of the role of molecular chaperones and co-chaperones in chondrocyte and osteoblast development.

Research projects

1. Immunoselection of optimal skeletal stem cell population for cartilage tissue engineering.
2. Development of multiwell acoustofluidic perfusion bioreactor platform for tissue engineering.
3. Application of the acoustofluidic perfusion bioreactor for bioengineering cartilage from human embryonic stem cell-derived chondrocytes.
4. Analysis of the effects of conditional knockout of the Bag-1 (Bcl-2-associated athanogene-1) gene on skeletal development.
5. Elucidation of the role of molecular chaperones (HSC/HSP-70) and cochaperones (BAG-1) in the regulation of skeletal stem cell osteogenic differentiation and maintenance of the articular chondrocyte phenotype.

Collaborators

Faculty of Engineering and the Environment – Prof Martyn Hill, Dr Peter Glynne-Jones, Dr Bram Sengers, Dr Martin Stolz, Dr Xunli Zhang
Faculty of Medicine – Prof Richard Oreffo, Prof Graham Packham, Dr Franchesca Houghton, Mr Ramsey Cutress
External – Prof Kenneth Ka Ho Lee (Chinese University of Hong Kong), Prof Paul Townsend (University of Manchester)

Funding

European Calcified Tissue Society, Wessex Medical Research, Rosetrees Trust, Research Grants Council of Hong Kong (General Research Fund), University of Southampton PhD scholarships

Primary research group: Bone and Joint Diseases, Bioengineering Science

Micromass cultures
Figure 1
Cartilage explants
Figure 2
MSCs from human BM
Figure 3

Academic unit(s)

Human Development and Health Academic Units

Affiliate academic unit(s)

Human development and physiology Research group

1. Primary PhD supervisor

Current:

Lauren Jevons (2015)
Umesh Jonnalagadda (2013)

Past:

Siwei Li (2010)
Joanna Greenhough (2011)


2. Second PhD supervisor

Current:

Elizabeth Lemm (2012)
Agnieszka Janeczek (2011)
Catarina Moura (2014)
Daniel Tang (2014)

Past:

Sam Dias (2011)

3. Personal tutor

4. Bone and Joint research group representative at SBOM poster presentation sessions

5. Member of the University Senate

6. Member of Academic Unit Operations Group

7. Member of PCAP Mentors Group

8. Member of Academic Unit PGR Student Working Group

9. Representative for the IfLS Repair & Regeneration theme

Articles

Book Chapters

1. BM5 programme (Year I)

a. Lectures on:

 (i) Basic bone and cartilage biology
(ii) Calcium homeostasis

b. Prepare OBA and EMI questions on above topics

2. BM5 programme (Year IV)

a. Lectures on:

 (i) Basic bone and cartilage biology (refresher session)
(ii) Metabolic bone diseases

b. Supervise BMedSc and MMedSc study-in-depth project students and mark project reports

3. BM4 programme (Year II)

a. Lecture on Calcium homeostasis

b. Prepare OBA and EMI questions on above topic

c. Facilitation

4. 4-year Integrated Stem Cell PhD programme (Year I/MRes programme)

a. Lecture on Stem cells and Regenerative Medicine

b. Journal clubs on:

  (i) Pluripotent stem cells
 (ii) Adult stem cells for orthopaedic applications
(iii) Mark journal club reports

c. Supervise lab rotations, mark project reports and conduct progress reviews

5. Faculty of Medicine PGR student induction programme

a. Lectures on:

 (i) Role of epigenetics in regulation of gene expression
(ii) PCR and Real-time qPCR

6. BEng Mechanical Engineering (Faculty of Engineering and the Environment)

a. Lectures on:

 (i) Tissue engineering (as part of Functional materials in Orthopaedics)
(ii) Biomaterials (2 lectures)

b. Supervise IP (individual project) and GDP (group design project) students, mark project reports and posters

7. MSc Diabetes Best Practice

Deputy for Foundations of Diabetes module

Dr Rahul Tare
University of Southampton
Faculties of Medicine & Engineering and the Environment
Institute of Developmental Sciences
Room: DS D09
Mailpoint: 887
Southampton General Hospital
Tremona Road
Southampton
SO16 6YD
Or
University of Southampton
Building 85 Institute for Life Sciences
Highfield Campus
Southampton
SO171BJ

Room number: DS D09
Telephone: +44 (0)23 8120 5257,
Email: R.Tare@soton.ac.uk

Room Number:SGH/DS D09/MP887

Share this profile Facebook Google+ Twitter Weibo

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×