Dr Spiros D Garbis BSc, PhD
Associate Professor , Head of Proteomics Unit for Cancer Sciences, Centre for Proteomics Research, Institute for Life Sciences, UK
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Dr. Spiros D. Garbis is an Associate Professor for the Faculty of Medicine and Head of Clinical Mass Spectrometry group for the Cancer Sciences Academic Unit. Dr. Garbis has USA industrial and forensic analytical toxicology experience and since his fulltime return to academia in 2004, he has been pivotal to the development and application of mass spectrometry proteomics and metabolomics methods in the discovery and validation of candidate biomarkers with potential clinical utility for the early diagnosis of cancer, cardiovascular and neurodegenerative disease linked to metabolic syndrome. A key theme of his research is to understand gene-nutrient interactions at the endophenotypic protein and metabolite level with the use of stable isotope tracer approaches in cell culture, animal models, and humans. Therefore, the inquiry on the functional interplay between spontaneous mutations of nutrient or pharmacologic receptors and their enzyme substrates may contribute to metabolic syndrome and derivative communicative (HIV and Tuberculosis) and non-communicative (cardiovascular, neurodegenerative and cancer) disease states.
Human physiology is remarkably pleiotropic in its nature, that is synergistically influenced by genetic, epigenetic, environmental and socioeconomic factors. Integrated ‘-Omic’ technologies can elucidate this physiologic complexity with increasing precision. Translating these technologies into clinical practice in the form of a blood test will help realize the personalization of medicine.
A key research objective of Dr. Garbis is the development of a non-invasive blood test that can assist clinical decision making. Such a blood test will not only influence the choice of drugs needed for personalized therapy, but will also assist the prevention of disease. In this capacity, this early and non-invasive clinical assessment will enable a less reactive medicinal interventyion, focused on health maintenance and disease prevention rather than disease therapy. Dr. Garbis research efforts over the past decade have contributed in the ability to measure molecular perturbations from the local tissue level up to the systemic circulation level.
Dr. Garbis is highly active in research, generating >£1M in research/enterprise income, is a holder of a UK patent on prostate cancer with a productive publication track record. Dr. Garbis presents his research at invited talks in the UK, international conferences and workshops. His academic group consists of 5 shared PhD students, 2 shared post docs, and 1 shared research associate.
He regularly lectures to undergraduate and postgraduate science and medical students on Pharmacology. Dr. Garbis is funded by the Cancer Research UK, European Union, EPSRC, BBSRC, the Wessex Cancer Trust and the Wessex Medical Research. Dr. Garbis is an ad hoc reviewer for many grant awarding bodies including the BBSRC and is a member of the editorial board for the journal Integrated–Omics, and Journal of Proteomics and Bioinformatics. Dr. Garbis is a visiting Professor of King Saud University and St. Georges University of London and was instrumental in the establishment of a biomarker validation consortium with Prof. Eleftherios P. Diamandis at the University of Toronto, Prof. Kyriacos Kyriacou of the Cyprus Institute of Neurobiology and Genetics, Dr. Chris Sutton of the University of Bradford. He is also a full member of the American Chemical Society, the American Society for Mass Spectrometry and the American Society for Nutrition.
Ph.D. in Pharmacognosy, University of Illinois (2003)
B.Sc. in Chemistry, University of Illinois (1989)
11/2011 – 02/2013 Lecturer, Faculty of Medicine, Cancer Sciences and Clinical and Experimental Medicine Divisions, University of Southampton
02/2004 – 10/2011 Level-4 Lecturer, Centre for Basic Science, Division of Biotechnology, Biomedical Research Foundation of the Academy of Athens
02/2004 – 10/2011 Head of Proteomics Laboratory, Centre for Basic Science, Division of Biotechnology, Biomedical Research Foundation of the Academy of Athens
08/2003 – 01/2004 Compulsory military duty: Radiologist/Biochemist, Medical Core, Hellenic Army, Hellenic Republic
01/1998 – 07/2003 Research Assistant, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, USA
05/1996 – 11/2001 Analytical Chemist, Department of Quality Control, Now Foods, Bloomingdale, IL, USA
06/1994 – 01/1998 Forensic Scientist, Illinois Racing Board Laboratory, State of Illinois, Chicago, IL, USA
05/1990 – 05/1994 Research and Development Chemist, Zellweger Analytics-MDA Scientific (Currently Honeywell Analytics), Lincolnshire, IL, USA.