Medicine

Syed Hasan Arshad

MBBS, DM, FRCP

Primary position:
Professor of Allergy and Clinical Immunology
Other positions:
Director of the David Hide Asthma and Allergy Research Centre, Isle of Wight.

Background

The University of Southampton

Professor Arshad was appointed to the Chair of Allergy and Clinical Immunology in 2009. He is also a consultant Physician at Southampton University Hospital Trust and Director of The David Hide Asthma and Allergy Research Centre in Isle of Wight. Having graduated in Medicine from the University of Karachi, he trained in General Medicine and then specialised in Respiratory Medicine in the UK. He completed his DM from Southampton University working on prediction and prevention of asthma and allergic disease. Following a post-doc fellowship at the Johns Hopkins University in Baltimore, and a Senior Lectureship at Keele University, he was appointment to his current position in Southampton.

Professor Arshad leads a group that investigates natural history, genetic and environmental risk factors and prevention of asthma and allergic disease. He is a clinical epidemiologist with expertise in birth cohort studies, clinical trials, and the immunological and genetic basis of asthma and allergy. His research is based within the Faculty of Medicine and at The David Hide Asthma and Allergy Research Centre on the Isle of Wight. The group includes both clinical and non-clinical scientists, clinical research fellows and nurses.

In the last 10 years, Professor Arshad has attracted grants of over £10 million, published over 100 articles in peer reviewed journals, authored or edited 9 books and 6 book chapters, and supervised several MSc, DM and PhD students. He has contributed to national and international guidelines, including the European guidelines for asthma and allergy prevention and National Institute of Health (US) guidelines for the diagnosis and management of food allergy. He is also a member of the expert panel of the National Institute of Health (US), to review grants and formulate strategy for research. He was awarded Pfizer Visiting Professor to the Michigan State University, Michigan, USA in 2004 and recently his David Hide Centre team won the "excellence in research" award at the Isle of Wight NHS Trust annual award ceremony.

Qualifications

MBBS, Medicine and Surgery, Dow Medical College, (1979)
MRCP, Medicine, Royal College of Physicians (UK), (1986)
DM, Allergy, University of Southampton, (1993)
FRCP, Medicine, Royal College of Physicians (London), (2002)

Appointments held

Clinical Research Fellow, David Hide Asthma and Allergy Centre and University of Southampton. 1988-2002

Post-doctorate Fellow, Johns Hopkins University, Baltimore, Maryland. 1993-1994

Consultant Physician, St. Mary’s Hospital, Isle of Wight and Director of David Hide Asthma and Allergy Research Centre, Isle of Wight. 1997-2003

Senior lecturer, Keele University, Keele, Staffordshire. 2003-2007

Reader, III Research Division, University of Southampton. 2007-2009

Professor of Allergy and Clinical Immunology, University of Southampton. 2009-present

Professor Syed Hasan Arshad's photo

Publications

The University of Southampton's electronic library (e-prints)

Article

Ziyab, Ali H., Karmaus, Wilfried, Zhang, Hongmei, Holloway, John W., Steck, Susan E., Ewart, Susan and Arshad, Syed Hasan (2014) Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort. Clinical & Experimental Allergy (doi:10.1111/cea.12321). (In Press).
Docherty, L.E., Rezwan, F.I., Poole, R.L., Jagoe, H., Lake, H., Lockett, G.A., Arshad, H., Wilson, D.I., Holloway, J.W., Temple, I.K. and Mackay, D.J.G. (2014) Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genes. Journal of Medical Genetics, 51, (4), 229-238. (doi:10.1136/jmedgenet-2013-102116).
Patil, Veeresh K, Holloway, John W, Zhang, Hongmei, Soto-Ramirez, Nelis, Ewart, Susan, Arshad, S Hasan and Karmaus, Wilfried (2013) Interaction of prenatal maternal smoking, interleukin 13 genetic variants and DNA methylation influencing airflow and airway reactivity. Clinical Epigenetics, 5, (1), 22. (doi:10.1186/1868-7083-5-22). (In Press).
Alexander, Melannie, Karmaus, Wilfried, Holloway, John W., Zhang, Hongmei, Roberts, Graham, Kurukulaaratchy, Ramesh J., Arshad, Syed Hasan and Ewart, Susan (2013) Effect of GSTM2-5 polymorphisms in relation to tobacco smoke exposures on lung function growth: a birth cohort study. BMC Pulmonary Medicine, 13, (1), 56. (doi:10.1186/1471-2466-13-56).
Ziyab, Ali H., Davies, Gwyneth A., Ewart, Susan, Hopkin, Julian M., Schauberger, Eric M., Wills-Karp, Marsha, Holloway, John W., Arshad, Syed, Zhang, Hongmei and Karmaus, Wilfried (2013) Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study. BMC Medical Genetics, 14, (1) (doi:10.1186/1471-2350-14-67). (PMID:23815671).
Ziyab, A.H., Karmaus, W., Holloway, J.W., Zhang, H, Ewart, S. and Arshad, S.H. (2013) DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants. Journal of the European Academy of Dermatology and Venereology, 27, (3), e420-e423. (doi:10.1111/jdv.12000). (PMID:23003573).
Yousefi, Mitra, Karmaus, Wilfried, Zhang, Hongmei, Roberts, Graham, Matthews, Sharon, Clayton, Bernie and Arshad, Syed Hasan (2013) Relationships between age of puberty onset and height at age 18 years in girls and boys. World Journal of Pediatrics, [9pp.]. (doi:10.1007/s12519-013-0399-z). (PMID:23335183).
Soto-Ramírez, Nelís, Arshad, Syed Hasan, Holloway, John W, Zhang, Hongmei, Schauberger, Eric, Ewart, Susan, Patil, Veeresh and Karmaus, Wilfried (2013) The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years. Clinical Epigenetics, 5, (1), 1. (doi:10.1186/1868-7083-5-1). (PMID:23286427).
Arshad, S.H., Dharmage, S.C., Ferreira, F., Fixman, E.D., Gadermaier, G., Hauser, M., Sampson, A.P., Teran, L.M., Wallner, M. and Wardlaw, A.J. (2012) Developments in the field of allergy in 2011 through the eyes of Clinical and Experimental Allergy. Clinical and Experimental Allergy, 42, (12), 1697-1723. (doi:10.1111/cea.12037). (PMID:23181787).
Scott, Martha, Roberts, Graham, Kurukulaaratchy, Ramesh J., Matthews, Sharon, Nove, Andrea and Arshad, S. Hasan (2012) Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years. Thorax, 67, (12), 1046-1051. (doi:10.1136/thoraxjnl-2012-202150). (PMID:22858926).
Roberts, G., Zhang, H., Karmaus, W., Raza, A., Scott, M., Matthews, S., Kurukulaaratchy, R.J., Dean, T. and Arshad, S.H. (2012) Trends in cutaneous sensitization in the first 18 years of life: results from the 1989 Isle of Wight birth cohort study. Clinical & Experimental Allergy, 42, (10), 1501-1509. (doi:10.1111/j.1365-2222.2012.04074.x). (PMID:22994347).
Raza, Abid, Kurukulaaratchy, Ramesh J., Grundy, Jane D., Clayton, C. Bernie, Mitchell, Frances A., Roberts, Graham, Ewart, Susan, Sadeghnejad, Alireza and Arshad, S Hasan (2012) What does adolescent undiagnosed wheeze represent? Findings from the Isle of Wight Cohort. European Respiratory Journal, 40, (3), 580-588. (doi:10.1183/09031936.00085111). (PMID:22267759).
Lødrup Carlsen, Karin C., Roll, Stephanie, Carlsen, Kai-Håkon, Mowinckel, Petter, Wijga, Alet H., Brunekreef, Bert, Torrent, Maties, Roberts, Graham, Arshad, S. Hasan, Kull, Inger, Krämer, Ursula, von Berg, Andrea, Eller, Esben, Høst, Arne, Kuehni, Claudia, Spycher, Ben, Sunyer, Jordi, Chen, Chih-Mei, Reich, Andreas, Asarnoj, Anna, Puig, Carmen, Herbarth, Olf, Mahachie John, Jestinah M., Van Steen, Kristel, Willich, Stefan N., Wahn, Ulrich, Lau, Susanne and Keil, Thomas (2012) Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts. PLoS ONE, 7, (8), e43214. (doi:10.1371/journal.pone.0043214). (PMID: 22952649).
Arshad, S. Hasan, Karmaus, Wilfried, Raza, Abid, Kurukulaaratchy, Ramesh J., Matthews, Sharon M., Holloway, John W., Sadeghnejad, Alireza, Zhang, Hongmei, Roberts, Graham and Ewart, Susan L. (2012) The effect of parental allergy on childhood allergic diseases depends on the sex of the child. Journal of Allergy and Clinical Immunology, 130, (2), 427-434.e6. (doi:10.1016/j.jaci.2012.03.042). (PMID:22607991).
Venter, Carina and Arshad, Syed H (2012) Guideline fever: an overview of DRACMA, US NIAID and UK NICE guidelines. Current Opinion in Allergy and Clinical Immunology, 12, (3), 302-315. (doi:10.1097/ACI.0b013e3283535893). (PMID:22499144).
Ziyab, Ali H., Karmaus, Wilfried, Yousefi, Mitra, Ewart, Susan, Schauberger, Eric, Holloway, John W., Zhang, Hongmei and Arshad, Syed Hasan (2012) Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age. PLoS ONE, 7, (3), e32721. (doi:10.1371/journal.pone.0032721). (PMID:22403702).
Kurukulaaratchy, Ramesh J., Raza, Abid, Scott, Martha, Williams, Paula, Ewart, Susan, Matthews, Sharon, Roberts, Graham and Arshad, S.H. (2012) Characterisation of asthma that develops during adolescence; findings from the Isle of Wight Birth Cohort. Respiratory Medicine, 106, (3), 329-337. (doi:10.1016/j.rmed.2011.12.006). (PMID:22212639).
Kurukulaaratchy, Ramesh J, Karmaus, Wilfried and Arshad, Syed Hasan (2012) Sex and atopy influences on the natural history of rhinitis. Current Opinion in Allergy and Clinical Immunology, 12, (1), 7-12. (doi:10.1097/ACI.0b013e32834ecc4e). (PMID:22157156).
Raza, A., Kurukulaaratchy, R.J., Grundy, J.D., Clayton, C.B., Mitchell, F.A., Roberts, G., Ewart, S., Sadeghnejad, A. and Arshad, S.H. (2012) What does adolescent undiagnosed-wheeze represent? Findings from the Isle of Wight Cohort. European Respiratory Journal (doi:10.1183/09031936.00085111). (PMID:22267759).
Schauberger, Eric M., Ewart, Susan L., Arshad, Syed H., Huebner, Marianne, Karmaus, Wifried, Holloway, John W., Friderici, Karen H., Ziegler, Julie T., Zhang, Hongmei, Rose-Zerilli, Matthew J., Barton, Sheila J., Holgate, Stephen T., Kilpatrick, Jeffrey R., Harley, John B., Lajoie-Kadoch, Stephane, Harley, Isaac, Hamid, Qutayba, Kurukulaaratchy, Ramesh J., Seibold, Max A., Avila, Pedro C., Rodriguez-Cintrón, William, Rodriguez-Santana, Jose R., Hu, Donglei, Gignoux, Christopher, Romieu, Isabelle, London, Stephanie, Burchard, Esteban G., Langefeld, Carl D. and Wills-Karp, Marsha (2011) Identification of ATPAF1 as a novel candidate gene for asthma in children. Journal of Allergy and Clinical Immunology, 128, (4), 753-760.e11. (doi:10.1016/j.jaci.2011.04.058). (PMID:21696813).
Soto-Ramírez, N., Alexander, M., Karmaus, W., Yousefi, M., Zhang, H., Kurukulaaratchy, R.J., Raza, A., Mitchell, F., Ewart, S. and Arshad, S.H. (2011) Breastfeeding is associated with increased lung function at 18 years of age: a cohort study. European Respiratory Journal, 39, (4), 985-991. (doi:10.1183/​09031936.00037011). (PMID:21852333).
Zhang, Hongmei, Karmaus, Wilfried, Gan, Jianjun, Bao, Weichao, Zhao, Yan D., Rahardja, Dewi, Holloway, John W., Scott, Martha and Arshad, Syed Hasan (2011) Adjusting wheal size measures to correct atopy misclassification. International Journal of General Medicine, 2011, (4), 597-606. (doi:10.2147/IJGM.S22193). (PMID:3680811).
Scott, Martha, Kurukulaaratchy, Ramesh J. and Arshad, Syed Hasan (2011) Definitions are important and not all wheeze is asthma. Thorax, 66, (7), 633. (doi:10.1136/thx.2010.143941). (PMID:20834017).
Babu, Suresh K., Puddicombe, Sarah M., Arshad, Hasan S., Wilson, Susan J., Ward, Jonathan, Gozzard, Neil, Higgs, Gerry, Holgate, Stephen T. and Davies, Donna E. (2011) Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma. Clinical Immunology, 140, (1), 18-25. (doi:10.1016/j.clim.2011.03.005). (PMID:21459047).
Kurukulaaratchy, R.J., Karmaus, W., Raza, A., Matthews, S., Roberts, G. and Arshad, S.H. (2011) The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life. Clinical & Experimental Allergy, 41, (6), 851-859. (doi:10.1111/j.1365-2222.2011.03765.x). (PMID:21561494).
Venter, Carina and Arshad, Syed Hasan (2011) Epidemiology of food allergy. Pediatric Clinics of North America, 58, (2), 327-349. (doi:10.1016/j.pcl.2011.02.011). (PMID:21453805).
Boyce, Joshua A., Assa'ad, Amal, Burks, A Wesley, Jones, Stacie M., Sampson, Hugh A., Wood, Robert A., Plaut, Marshall, Cooper, Susan F., Fenton, Matthew J., Arshad, S Hasan, Bahna, Sami L., Beck, Lisa A., Byrd-Bredbenner, Carol, Camargo, Carlos A., Eichenfield, Lawrence, Furuta, Glenn T., Hanifin, Jon M., Jones, Carol, Kraft, Monica, Levy, Bruce D., Lieberman, Phil, Luccioli, Stefano, McCall, Kathleen M., Schneider, Lynda C., Simon, Ronald A., Simons, F. Estelle R., Teach, Stephen J., Yawn, Barbara P. and Schwaninger, Julie M. (2011) Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. Nutrition Research, 31, (1), 61-75. (doi:10.1016/j.nutres.2011.01.001). (PMID:21310308).
Boyce, Joshua A., Assa'a, Amal, Burks, A. Wesley, Jones, Stacie M., Sampson, Hugh A., Wood, Robert A., Plaut, Marshall, Cooper, Susan F., Fenton, Matthew J., Arshad, Syed H., Bahna, Sami L., Beck, Lisa A., Byrd-Bredbenner, Carol, Camargo, Carlos A., Eichenfield, Lawrence, Furuta, Glenn T., Hanifin, Jon M., Jones, Carol, Kraft, Monica, Levy, Bruce D., Lieberman, Phil, Luccioli, Stefano, McCall, Kathleen M., Schneider, Lynda C., Simon, Ronald A., Simons, F Estelle R., Teach, Stephen J., Yawn, Barbara P. and Schwaninger, Julie M. NIAID-sponsored Expert Panel (2011) Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel Report. Nutrition, 27, (2), 253-267. (PMID:21215925).
Boyce, Joshua A., Assa'ad, Amal, Burks, A. Wesley, Jones, Stacie M., Sampson, Hugh A., Wood, Robert A., Plaut, Marshall, Cooper, Susan F., Fenton, Matthew J., Arshad, S. Hasan, Bahna, Sami L., Beck, Lisa A., Byrd-Bredbenner, Carol, Camargo, Carlos A., Eichenfield, Lawrence, Furuta, Glenn T., Hanifin, Jon M., Jones, Carol, Kraft, Monica, Levy, Bruce D., Lieberman, Phil, Luccioli, Stefano, McCall, Kathleen M., Schneider, Lynda C., Simon, Ronald A., Simons, F Estelle R., Teach, Stephen J., Yawn, Barbara P. and Schwaninger, Julie M. (2011) Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel report. Journal of the American Academy of Dermatology, 64, (1), 175-192. (doi:10.1016/j.jaad.2010.11.020). (PMID:21167411).
Boyce, Joshua A., Assa'ad, Amal, Burks, A. Wesley, Jones, Stacie M., Sampson, Hugh A., Wood, Robert A., Plaut, Marshall, Cooper, Susan F., Fenton, Matthew J., Arshad, S. Hasan, Bahna, Sami L., Beck, Lisa A., Byrd-Bredbenner, Carol, Camargo, Carlos A., Eichenfield, Lawrence, Furuta, Glenn T., Hanifin, Jon M., Jones, Carol, Kraft, Monica, Levy, Bruce D., Lieberman, Phil, Luccioli, Stefano, McCall, Kathleen M., Schneider, Lynda C., Simon, Ronald A., Simons, F Estelle R., Teach, Stephen J., Yawn, Barbara P. and Schwaninger, Julie M. NIAID-Sponsored Expert Panel (2010) Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel Report. Journal of Allergy and Clinical Immunology, 126, (6), 1105-1118. (PMID:21134568).
Ziyab, A.H., Raza, A., Karmaus, W., Tongue, N., Zhang, H., Matthews, S., Arshad, S.H. and Roberts , G. (2010) Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study. Clinical & Experimental Allergy, 40, (12), 1776-1784. (doi:10.1111/j.1365-2222.2010.03633.x). (PMID:21059120).
Ziyab, A.H., Raza, A., Karmaus, W., Tongue, N., Zhang, H., Matthews, S., Arshad, S.H. and Roberts, G. (2010) Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study. Clinical and Experimental Allergy, 40, (12), 1776-1784. (doi:10.1111/j.1365-2222.2010.03633.x). (PMID:21059120).
Boyce, Joshua A., Assa'ad, Amal, Burks, A. Wesley, Jones, Stacie M., Sampson, Hugh A., Wood, Robert A., Plaut, Marshall, Cooper, Susan F., Fenton, Matthew J., Arshad, S. Hasan, Bahna, Sami L., Beck, Lisa A., Byrd-Bredbenner, Carol, Camargo, Carlos A., Eichenfield, Lawrence, Furuta, Glenn T., Hanifin, Jon M., Jones, Carol, Kraft, Monica, Levy, Bruce D., Lieberman, Phil, Luccioli, Stefano, McCall, Kathleen M., Schneider, Lynda C., Simon, Ronald A., Simons, F. Estelle R., Teach, Stephen J., Yawn, Barbara P. and Schwaninger, Julie M. NIAID-sponsored expert panel (2010) Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. [in special issue: Guidelines for the Diagnosis and Management of Food Allergy in the United States: Report of the NIAID-Sponsored Expert Panel] Journal of Allergy and Clinical Immunology, 126, (6), S1-S58. (doi:10.1016/j.jaci.2010.10.007). (PMID:21134576).
Edwards, Alan Martin, Matthews, Sharon and Arshad, Syed Hasan (2010) Systemic absorption of sodium cromoglicate from a new cutaneous emulsion (Altoderm ®) in children with atopic dermatitis. European Journal of Dermatology, 20, (6), 864-865. (PMID:20959272).
Holloway, John W., Arshad, Syed H. and Holgate, Stephen T. (2010) Using genetics to predict the natural history of asthma? Journal of Allergy and Clinical Immunology, 126, (2), 200-209. (doi:10.1016/j.jaci.2010.06.006).
Selby, Anna, Claton, Bernie, Grundy, Jane, Pike, Katy, Drew, Kirsty, Raza, Abid, Kurukulaaratchy, Ramesh, Arshad, S. Hasan and Roberts, Graham (2010) Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable? Respiratory Research, 11, (43) (doi:10.1186/1465-9921-11-43). (PMID:20416092).
Scott, Martha, Raza, Abid, Karmaus, Wilfried, Mitchell, Frances, Grundy, Jane, Kurukulaaratchy, Ramesh J., Arshad, S. Hasan and Roberts, Graham (2010) Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study. Thorax, 65, (3), 258-262. (doi:10.1136/thx.2009.125443 ).
Venter, C., Arshad, S. Hasan, Grundy, J., Pereira, B., Clayton, C. Bernie, Voigt, K., Bateman, B., Higgins, B. and Dean, T. (2010) Time trends in the prevalence of peanut allergy: three cohorts of children from the same geographical location in the UK. Allergy, 65, (1), 103-108. (doi:10.1111/j.1398-9995.2009.02176.x).
Arshad, S. (2010) Environmental control for secondary prevention of asthma. Clinical & Experimental Allergy, 40, (1), 2-4. (doi:10.1111/j.1365-2222.2009.03407.x). (PMID:20205691).
Ogbuanu , Ikechukwu U., Karmaus, Wilfried J., Zhang, Hongmei, Sabo-Attwood, Tara, Ewart, Susan, Roberts, Graham and Arshad , Syed Hasan (2010) Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study. Allergy, Asthma & Clinical Immunology, 6, (6) (doi:10.1186/1710-1492-6-6). (PMID:20403202).
Arshad, S. Hasan (2009) Does exposure to indoor allergens contribute to the development of asthma and allergy? Current Allergy and Asthma Reports, 10, (1), 49-55. (doi:10.1007/s11882-009-0082-6 ). (PMID:20425514).
Holgate, Stephen T., Arshad, Hasan S., Roberts, Graham C., Howarth, Peter H., Thurner, Philipp J. and Davies, Donna E. (2009) A new look at the pathogenesis of asthma. Clinical Science, 118, (7), 439-450. (doi:10.1042/CS20090474). (PMID:20025610).
Holgate, Stephen T., Roberts, Graham, Arshad, Hasan S., Howarth, Peter H. and Davies, Donna E. (2009) The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. Proceedings of the American Thoracic Society, 6, (8), 655-659. (doi:10.1513/pats.200907-072DP). (PMID:20008870).
van den Berge, M., Arshad, S.H., Magnussen, H., Hamelmann, E., Kanniess, F. and Postma, D.S. (2009) Similar efficacy of ciclesonide versus prednisolone to treat asthma worsening after steroid tapering. Respiratory Medicine, 103, (8), 1216-1223. (doi:10.1016/j.rmed.2009.01.024). (PMID:19297141).
Venter, Carina, Pereira, Brett, Voigt, Kerstin, Grundy, Jane, Clayton, C. Bernie, Higgins, Bernie, Arshad, S. Hasan and Dean, Taraneh (2009) Factors associated with maternal dietary intake, feeding and weaning practices, and the development of food hypersensitivity in the infant. Pediatric Allergy and Immunology, 20, (4), 320-327. (doi:10.1111/j.1399-3038.2008.00832.x). (PMID:19220769).
YuanYuan, Gu, Harley, Isaac T.W., Bremer, Lindsay B., Aronow, Bruce J., Vietor, Ilja, Harley, John B., Kilpatrick, Jeffrey R., Langefeld, Carl D., Williams, Adrienne H., Jegga, Anil G., Chen, Jing, Wills-Karp, Marsha, Flick, Leah M., Arshad, S. Hasan, Ewart, Susan L., Thio, Chloe L., Filippi, Marie-Dominique, Leighton Grimes, H. Leighton, Drumm, Mitchell L., Cutting, Garry R., Knowles, Michael R. and Karp, Christopher L. (2009) Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature, 458, (7241), 1039-1042. (doi:10.1038/nature07811). (PMID:19673948).
Scott, M., Kurukulaaratchy, R. J., Raza, A. and Arshad, S. H. (2009) Understanding the nature and outcome of childhood wheezing. European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology, 33, (3), 700-710. (doi:10.1183/09031936.00149408).
Ogbuana, I.U., Karmaus, W., Arshad, S.H., Kurukulaaratchy, R.J. and Ewart, S. (2009) The effect of breastfeeding duration on lung function at age 10 years; a prospective birth cohort study. Thorax, 64, (1), 62-66. (doi:10.1136/thx.2008.101543). (PMID:19001004).
Ogbuanu, I.U., Karmaus, W., Arshad, S.H., Kurukulaaratchy, R.J. and Ewart, S. (2009) Effect of breastfeeding duration on lung function at age 10 years: a prospective birth cohort study. Thorax, 64, (1), 62-66. (doi:10.1136/thx.2008.101543). (PMID:19001004).
Kurukulaaratchy, Ramesh J., Matthews, Sharon M. and Arshad, S. Hasan (2008) The natural history of fatal childhood asthma: a case from the Isle of Wight birth cohort. Journal of Asthma, 45, (10), 944-947. (doi:10.1080/02770900802404090). (PMID:19085587).
Raza, A., Kurukulaaratchy, R.J. and Arshad , S.H. (2008) Predicting risk of asthma in wheezing infants. Thorax, 63, (9), 842. (doi:10.1136/thx.2008.100222).
Arshad, S.H., Karmaus, W., Kurukulaaratchy, R., Sadeghnejad, A., Huebner, M. and Ewart, S. (2008) Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood. The British Journal of Dermatology, 158, (6), 1315-1322. (doi:10.1111/j.1365-2133.2008.08565.x).
Venter, C., Pereira, B., Voigt, K., Grundy, J., Clayton, C.B., Higgins, B., Arshad, S. and Dean, T. (2008) Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life. Allergy, 63, (3), 354-359. (doi:10.1111/j.1398-9995.2007.01570.x).
Huebner , M, Kim, D, Ewart, S, Karmaus, W, Sadeghnejad, A and Arshad, Syed Hasan (2008) Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort. Journal of Allergy and Clinical Immunology, 121, (2), 408-414. (doi:10.1016/j.jaci.2007.09.020 ). (PMID:18037162).
Sadeghnejad, Alireza, Karmaus, Wilfried, Arshad, S. Hasan, Kurukulaaratchy, Ramesh, Huebner, Marianne and Ewart, Sesan (2008) IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma of childhood, a longitudinal study. Respiratory Research, 9, (2) (doi:10.1186/1465-9921-9-2). (PMID:18186920).
Høst, Arne, Halken, Susanne, Muraro, Antonella, Dreborg, Sten, Niggemann, Bodo, Aalberse, Rob, Arshad, Syed H., von Berg, Andrea, Carlsen, Kai-Håkon, Duschén, Karel, Eignmann, Philippe A., Hill, David, Jones, Catherine, Mellon, Michael, Oldeus, Göran, Oranje, Arnold, Pascual, Christina, Prescott, Susan, Sampson, Hugh, Svartengren, Magnus, Wahn, Ulrich, Warner, Jill A., Warner, John O., Vandenplas, Yvan, Wickman, Magnus and Zeiger, Robert S. (2008) Dietary prevention of allergic diseases in infants and small children. Pediatric Allergy and Immunology, 19, (1), 1-4. (doi:10.1111/j.1399-3038.2007.00680.x). (PMID:18199086).
Sadeghnejad, Alireza, Karmaus, Wilfried, Arshad, S. Hasan, Kurukulaaratchy, Ramesh, Huebner, Marianne and Ewart, Susan (2008) IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study. Respiratory Research, 9, (2), [10pp.]. (doi:10.1186/1465-9921-9-2). (PMID:18186920).
Karmaus, Wilfreid, Dobai, Alina L, Ogbuanu, Ikechukwu , Arshad, Syed Hasan, Matthews, Sharon and Ewart, Susan (2008) Long-term effects of breastfeeding, maternal smoking during pregnancy, and recurrent lower respiratory tract infections on asthma in children. Journal of Asthma , 45, (8), 688-695. (doi:10.1080/02770900802178306 ). (PMID:11905550).
Ramadas, R.A., Sadeghnejad, A., Karmaus, W., Arshad, S.H., Matthews, S., Huebner, M., Kim, D.Y. and Ewart, S.L. (2007) Interleukin-1R antagonist gene and pre-natal smoke exposure are associated with childhood asthma. European Respiratory Journal, 29, (3), 502-508. (doi:10.1183/09031936.00029506).
Dean, Taraneh, Venter, Carina, Pereira, Brett, Arshad, S. Hasan, Grundy, Jane, Clayton, C. Bernie and Higgins, Bernie (2007) Patterns of sensitization to food and aeroallergens in the first 3 years of life. Journal of Allergy and Clinical Immunology, 120, (5), 1166-1171. (doi:10.1016/j.jaci.2007.06.042).
Worth, Allison, Arshad, S. Hasan and Sheikh, Aziz (2007) Occupational dermatitis in a hairdresser. British Medical Journal, 335, (7616), p.399. (doi:10.1136/bmj.39252.524317.94).
Sadeghnejad, Alireza, Karmaus, Wilfried, Arshad, S. Hasan and Ewart, Susan (2007) IL13 gene polymorphism association with cord serum immunoglobulin E. Pediatric Allergy and Immunology, 18, (4), 288-292. (doi:10.1111/j.1399-3038.2006.00524.x).
Haqqee, Raana and Arshad, Syed Hasan (2007) Brittle asthma. Current Respiratory Medicine Reviews, 3, (1), 7-13. (doi: 10.2174/157339807779941712).
Arshad, Syed Hasan, Bateman, Belinda, Sadeghnejad, Alireza, Gant, Carole and Matthews, Sharon M. (2007) Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study. Journal of Allergy and Clinical Immunology, 119, (2), 307-313. (doi:10.1016/j.jaci.2006.12.621).
Venter, Carina, Pereira, Brett, Grundy, Jane, Clayton, C.B., Arshad, S.H. and Dean, Taraneh (2006) Prevalence of sensitization reported and objectively assessed food hypersensitivity amongst six-year-old children: a population-based study. Pediatric Allergy and Immunology, 17, (5), 356-363. (doi:10.1111/j.1399-3038.2006.00428.x).
Kurukulaaratchy, Ramesh J., Matthews, Sharon and Arshad, S.H. (2006) Relationship between childhood atopy and wheeze: what mediates wheezing in atopic phenotypes? Annals of Allergy, Asthma and Immunology, 97, (1), 84-91. (doi:10.1016/S1081-1206(10)61375-0 ).
Ridout, S., Matthews, S., Gant, C., Twiselton, R., Dean, T. and Arshad, S.H. (2006) The diagnosis of Brazil nut allergy using history, skin prick tests, serum-specific immunoglobulin E and food challenges. Clinical & Experimental Allergy, 36, (2), 226-232. (doi:10.1111/j.1365-2222.2006.02426.x).
Kurukulaaratchy, Ramesh J., Matthews, Sharon, Waterhouse, Linda and Arshad, S. Hasan (2003) Factors influencing symptom expression in children with bronchial hyperresponsiveness at 10 years of age. Journal of Allergy and Clinical Immunology, 112, (2), 311-316. (doi:10.1067/mai.2003.1623).
Grundy, Jane, Matthews, Sharon, Bateman, Belinda, Dean, Taraneh and Arshad, Syed Hasan (2002) Rising prevalence of allergy to peanut in children: Data from 2 sequential cohorts. Journal of Allergy and Clinical Immunology, 110, (5), 784-789. (doi:10.1067/mai.2002.128802).
 

Research

Research Interests

Asthma and allergy and major public health problems and their prevalence are increasing. Professor Arshad’s research covers 4 linked areas; (i) epidemiology, genetic, epigenetic and environmental risk factors in asthma and allergy including the link between obesity and asthma, (ii) allergy prevention, (iii) pathogenetic mechanisms in the development and persistence of asthma and allergy (iv) prevalence and diagnosis of food allergy. His research aims to improve the understanding of the development and persistence of asthma and allergic disease and test novel strategies for primary prevention.

(i) Epidemiology, natural history, genetic and environmental risk factors and epigenetic mechanisms in the origins and progression of asthma and allergy: Professor Arshad recruited the Isle of Wight birth cohort and has overseen regular assessments of these children from birth to 18 years of age. He oversees a programme of studies investigating gene-gene and gene-environment interactions and epigenetic regulation in the development of asthma and allergy, using the longitudinally collected cohort data and samples. These studies have been supported by several project grants from the National Institute of Health, USA. There is close collaboration with national and international groups working in this area. He holds joint grants and publications with Professor Karmaus, an epidemiologist from the University of South Carolina and Professor Ewart, a geneticist at Michigan State University. He also collaborates with investigators leading other UK birth cohorts such as Manchester Asthma Study funded by Medical Research Council and European network of birth cohorts (funded by EU).

A further project relates to the recruitment of children born to the participants of the Isle of Wight birth cohort (now aged 24) into a study investigating genetic, epigenetic, and environmental exposures in the development of asthma and allergic disease. Specifically, he is investigating if certain environmental factors influence genetic expression via epigenetic mechanism (e.g. DNA methylation), if the effect on immune responses can be passed on to the subsequent generation and what factors inhibit or reverse this process. Another aim is to predict disease development using epigenentic markers.

(ii) Primary and secondary prevention of asthma and allergy: His translational studies in this research area are funded by the National Institute of Health Research. The Isle of Wight primary prevention study was the first to test the effectiveness of a strict food and house dust mite allergen avoidance regime during infancy aimed at preventing allergic disease in high risk children. Contrary to findings of single allergen reduction strategies that have little or no clinical effect, the use of multifaceted interventions started from birth reduced allergic sensitisation and asthma by 25% to 50% (compared to control group). Another ongoing project, as part of the Respiratory Biomedical Research Unit, is investigating the effect of house-dust mite sub-lingual immunotherapy for primary prevention of asthma and allergy in high risk children. The first results of this randomised controlled trial will be available in 2014.

(iii) Understanding the mechanism of development and persistence of asthma. (a) Early life immune responses and development of allergic disease: As part of the Respiratory Biomedical Research Unit, 300 infants at high and 60 infants at low heredity risk of allergy were recruited from birth. Assessments and sample collection during early childhood will improve understanding of the development of immune responses in early life and how immune tolerance develops naturally or induced, for example, by allergen immunotherapy. (b) Activation of the epithelial mesenchymal trophic unit (EMTU) and persistence of asthma: Asthma is a chronic inflammatory disorder of the conducting airways with distinct structural and functional abnormalities. In a Medical Research Council funded programme grant, adolescents from the birth cohort, with persistent and remitted asthma, were recruited and further characterized to assess airway function, bronchial responsiveness and atopy. Bronchial brushings and biopsies were obtained for immunohistochemistry and tissue engineering studies investigating activation of the EMTU and tissue remodelling in vivo and in vitro.

(iv) Food/Nut allergy: Professor Arshad has investigated the prevalence, natural history and diagnosis of peanut and brazil nut allergies over two decades. Recently, in association with Professor Tara Dean of Portsmouth University, he has assessed the prevalence of food sensitization and allergy in four cohorts of children on the Isle of Wight. Further studies are planned to investigate the role of component resolved diagnosis in food allergy and immunobiology of food allergy.

Academic unit:  Clinical and Experimental Sciences

Responsibilities

Postgraduate student supervision

Previous

1998 Diana Eccleston MSc.
2002 Ramesh Kuruklulaaratchy DM
2006 Alireza Sadeghnejad PhD
2009 Ike Ogbuanu PhD
2011 Abid Raza PhD

Current

1. Dr. Scott (Lead Supervisor) - DM (2009-2014): Primary prevention of asthma
2. Dr. Evens (Lead Supervisor) - DM (2011-2014): Persistance and remission of asthma
3. Dr. Michaelis (Co-supervisor) - PhD (2009-2013): Immunological mechanisms during childhood
4. Dr. Zolkipli (Co-supervisor) - PhD (2010-2014): Primary Prevention of asthma using immunotherapy
5. Dr. Patil (Lead Supervisor) - PhD (2011 - 2014): Epigenetics markers influence allergy risk
6. Miss Maslin (Co-supervisor) - PhD (2012-2015): Hydrolysed formulae in infancy influence taste in later childhood

7. Dr. Ziyab (Co-supervisor) - PhD (2010-2014): Obesity influences asthma and lung function (University of Memphis, US)

 

Expert Panel Member:

- NICE Diagnostic Advisory Committee for Exhaled Nitric Oxide in asthma (2012-2014)

- European Food Allergy guidelines committee (2012-2013)

- NIH (USA) Food Allergy guidelines committee (2009-2010)

- NIH (USA) Strategy for primary prevention of asthma (2011)

- NIH (USA) Birth Cohorts strategy (2012)

 

Expert Panel member of grant awarding bodies:

- RfPB South Central NIHR (2012-2014)

- NIH USA (since 2011)

- FP7-European Union (2009-2010)

 

Other National and International responsibilities:

- Council member of the British Society of Allergy & Clinical Immunology (2012-2014) and member, European Academy of Allergology & Clinical Immunology (2013)

- Associate Editor of the journal, Clinical & Experimental Allergy (since 2012)

- Invited Speaker and Session Chair at several National and International conferences (since 2001)

- Director, The David Hide Asthma and Allergy Research Centre, Isle of Wight: Formulate research strategy, supervise and bring funding to support research and education (since 1997)

- Organiser, Wessex Allergy Network (since 2007)

- Reviewer for international journals

- Pharma Industry collaboration to promote research in the UK (2011-cont.)

- Trustee, department charity: Asthma, Allergy and Inflammation Research (since 2008)

Teaching Responsibilities

 Undergraduate:

 - Lead role to develop Allergy curriculum for the BM course

 - Coordinator and teacher for the SSU Respiratory Module for BM year 3 until July 2013

 

Postgraduate:

 - MSc. Allergy, As food Allergy Module leader, organizes teaching for this modules, delivers lectures and group based teaching and mark assignments and dissertations.

 - Coordinate an overseas fellowship programme in allergy.

 

BM 3 and 4:

(until July 2013) As SSU Respiratory module coordinator, deliver lectures, organizes teaching and training by Respiratory Department at Southampton General Hospital and conduct assessments at the end of the module.

 

ST training:

Supervisor of specialist trainees in Allergy at Southampton General hospital.

 

Academic Foundation Programme:

As coordinator of Academic Foundation Programme, mentor and supervises F2 trainees.

 

GP/Trainee Education:

- Organise GP education days

- GP teaching sessions on a regular basis

- allergy registrars' national training day

Contact

Professor Syed Hasan Arshad
Faculty of Medicine
University of Southampton
Southampton General Hospital
Mailpoint 801
South Academic Block
Tremona Road
Southampton
SO16 6YD
or
Faculty of Medicine
University of Southampton
Building 85
Life Sciences Building
Highfield Campus
Southampton
SO171BJ

Room Number: SGH/LF68/MP810

Telephone: (023) 8120 5756
Email: S.H.Arshad@soton.ac.uk