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Dr Surinder Sahota BSc (Hons), PhD

Reader in Immunogenetics

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Dr Surinder Sahota is Reader in Immunogenetics within Medicine at the University of Southampton, and was appointed to this position in 2006. In the Faculty, Dr Sahota is a Principal Investigator in the Cancer Sciences Academic Unit. He is best known for exploiting immunogenetic imprints in the tumour genome to define clonal origins of the B-cell neoplasm multiple myeloma (MM), and its benign precursor disease monoclonal gammopathy of undetermined significance (MGUS).

Dr Sahota has utilised this and other molecular and cellular immunological approaches to author more than 70 journal articles in defining tumour origins and behaviour in B-cell malignancy.

He is also Co-ordinator and work-package leader for large EU-wide networks of investigators probing MM and lymphoma disease, and has led or jointly led a number of bids under the FP6, FP7 and more recently the H2020 programmes to seek funding from the European Commission. Successfully funded networks have included MSCNET (FP6; Euro 3 million) and OVER-MyR (FP7; Euro 3 million), both investigating MM disease. Dr Sahota also peer-reviews for many of the leading national and international cancer grant funding bodies, including in the EU and USA. In 2015, Dr Sahota joined the Scientific Advisory Committee of the International Waldenstrom’s macroglobulinemia (WM) Foundation (USA). In the UK, he is a member of the WMUK Doctors Forum Advisory Committee and of the WM GECIP on the Genome England 100,000 Genomes Project. Previously he was a member of the national UK Myeloma Forum Scientific Committee. Dr Sahota has also been a member of the Advisory Scientific Boards of International Workshops on MM and WM, and is advisor to national biotech boards delivering conferences on Applications of Next Generation DNA Sequencing in Cancer.


BSc (Hons), Biochemistry, University of London 1977
PhD, University of London 1984

Appointments held

Postdoctoral Scholar and Lecturer, Department of Microbiology, University of California Los Angeles, USA

Postdoctoral Fellow, Department of Clinical Biochemistry, St. George’s Hospital Medical School / Department of Medical Oncology, Charing Cross & Westminster Hospital Medical School, University of London

Postdoctoral Fellow / Senior Research Fellow / LRF Senior Scientist, Cancer Sciences Division, School of Medicine, University of Southampton

Reader, Faculty of Medicine, University of Southampton 2006 –






Research interests

My interests lie in seeking evidence for genomic changes acquired somatically in malignant B-cells that inform disease pathogenesis and that can be exploited to test functional outcomes in tumour cells in promoting survival. I am also interested in exploiting molecular and cellular features of malignant B-cells as targets for immunotherapy, specifically as targets for DNA vaccines.

Research Projects

Immunogenetic imprints in tumour cells to decipher and study disease pathogenesis and progression

Genomics of malignant B-cells using NGS (including at the single cell level)

Antigen discovery and DNA vaccine delivery in B-cell tumours

Academic unit(s)

Cancer Sciences Academic Unit

Affiliate academic unit(s)

Cancer Sciences Research group

Postgraduate student supervision

2004 – present: PhD supervision (Principle / Co-Supervisor)

Faculty of Medicine

Postgraduate Research Programmes (PRS) Committee
PRS Student Progress Committee
Integrated PhD Programme Group

Cancer Sciences Academic Unit

CSD Management Committee
CRUK Centre Governance Board
CRUK Centre Executive Group

National responsibilities

Peer-review of journal articles for: Blood, Cancer Research, Leukemia, Haematologica, British Journal of Haematology, Leukemia Research, International Journal of Cancer, Immunology, PLoS One, American Journal of Pathology, FEBS Letters, BioMed Central (BMC Genomics), Genes, Chromosomes & Cancer; FASEB Journal, Journal of Leukocyte Biology, J Pathology, Clinical Lymphoma and Myeloma, Cancer Biology & Therapy, Cancer Biology & Therapy, Journal of Histochemistry & Cytochemistry

Peer-review of grant applications to: MRC, Leukaemia & Lymphoma Research Fund, Cancer Research UK, Kay Kendall Leukaemia Foundation, Breast Cancer Campaign, Yorkshire Cancer Research, Cancer Research Ireland, Association for International Cancer Research, Stichting tegen Kanker (Belgian Foundation Against Cancer), Fonds Wetenschappelijk (FWO) Research Foundation, Belgium, United States-Israel Binational Science Foundation, Israel, Israel Science Foundation, International Waldenstrom’s macroglobulinemia Foundation (USA), International Myeloma Foundation (USA), Multiple Myeloma Research Foundation (USA).

Advisory Board: 11th International Workshop on Multiple Myeloma and 4th International Workshop on Waldenstrom’s macroglobulinemia (2007)

Other Professional Activities:
Member European Myeloma Network (Workpackage Leader)
Member of UK Myeloma Forum
Member of UK Myeloma Forum Scientific Committee


Book Section(s)

Cancer Sciences Academic Unit Staff Post-graduate Lead

Cancer Sciences Academic Unit Pastoral Advisor (for Postgraduates)

CRUK Centre. Training Lead (non-clinical)

BIOL3037 Immunology. Course Co-ordinator & Lecturer. Organise course curriculum and delivery to Year 3 undergraduates, taught at Highfield Campus

BIOL6038 Immunology. Course Co-ordinator & Tutor (Highfield Campus)

BIOL3043 Molecular and Cellular Pathology. Lecturer on Cancer Vaccines (Highfield Campus)

Course Facilitator BM4 Medicine (Year 1)

BM5 Year 2 Immunology. Lecturer on B-cell immunology

MMedSci. Course Tutor (research evaluation) / Invited Chair (‘Inspire’ programme)

4 Yr Integrated PhD Cancer Pathway. Co-ordinator Research Rotation Projects. Interview Panel (appointments & progress viva voce). Project Supervisor.

4th Year Study-in-depth medical undergraduates. Project Supervisor.

Dr Surinder Sahota
Phone: (023) 8120 8768 Fax: (023) 8120 1385 Email:

Room Number: SGH/CSB/MP891

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