'Traffic light' test could prevent hundreds of people developing alcohol-related cirrhosis
A simple 'traffic light' test that detects hidden liver fibrosis and cirrhosis in high risk populations could reduce harmful drinking rates and potentially prevent hundreds of alcohol-related deaths a year.
Devised by Dr Nick Sheron and colleagues at University of Southampton and Southampton General Hospital, the Southampton Traffic Light (STL) test, which costs about £50, could be used by GPs in the community.
Published in the October 2013 issue of the British Journal of General Practice (BJGP), the STL appeared to help reduce drinking rates in people with the highest risk of liver disease.
Liver disease develops silently without symptoms, and many people have no idea they have liver failure until it is too late – one third of people admitted to hospital with end-stage liver disease die within the first few months. However, a simple test available in primary care could diagnose disease much earlier, enabling those at risk to change their behaviour and save lives.
The STL test combines several different tests and clinical markers which are given a score that indicates the patient’s likelihood of developing liver fibrosis and liver cirrhosis.*
The result comes in three colours: red means that the patient probably has liver scarring (fibrosis) and may even have cirrhosis, green means that there is no cirrhosis and the patient is highly unlikely to die from liver disease over the next five years. Amber means there is at least a 50:50 chance of scarring and patients are advised to reduce or avoid drinking to avert further disease progression.
During the study, funded by the National Institute for Health Research (NIHR) Research for Patient Benefit Programme, the STL test was used on 393 heavy drinkers identified through a questionnaire administered by their GP surgery. Results from the test showed there were 45 (12 per cent) red patients, 157 (40 per cent) amber and 191 (49 per cent) green. In the vast majority of patients (75 per cent) with a red test, the usual panel of liver blood tests were entirely normal, so there was no way that GPs would have been able to pick up the hidden liver disease and warn their patients of the impending problem.
Follow up questionnaires were sent to participants a year later to assess their drinking habits. Results showed that 65 per cent of the harmful/dependent drinkers with a red and amber STL results reduced drinking to a non-harmful amount, nearly twice as many as those with green STL (35 per cent) results.
Dr Nick Sheron, lead author and Head of Clinical Hepatology at the University of Southampton, and consultant hepatologist at Southampton General Hospital, said: “Patients are developing alcohol-related liver disease in the community but it is not being picked up until they are admitted to hospital, by which time it is too late for many of them. Since 1996 there have been about 4,000 admissions to Southampton General Hospital with cirrhosis and 75 per cent of them won’t have known they had it.
“It is possible that hundreds of lives could be saved by having a simple test, like the STL test, available in the community, not to mention NHS resources. Our results show that overall, of those attending the STL test, 42 per cent reduced their drinking rate. But what is even better is that the really high risk group of harmful drinkers, 65 per cent reduced their alcohol intake to a non-harmful level.”
Study co-author and GP Dr Michael Moore said: “Liver death rates in the UK have doubled over the last 15 years mostly attributed to consumption of alcohol. Liver disease is a silent killer. In primary care, minor abnormalities of existing liver tests are quite common but we struggle to know how best to investigate these further and who warrants specialist intervention. The traffic light test has the advantage of highlighting those at highest risk who should be investigated further and those in whom the risk is much lower where a watchful approach is more appropriate. Alcohol has harmful effects other than on the liver and of course we recommend to all those drinking at hazardous levels to cut down. Using this test appears to provide additional motivation to those at greatest risk of liver disease.”
Notes for editors
*The Southampton Traffic Light (STL) algorithm combines two serum markers of fibrosis, collagen p3 n peptide (P3NP) and hyaluronic acid (HA), together with platelet count, and is calculated with a complex exponential function derived from logistic regression analysis by entering the blood test results on to a web based calculator: www.livertrafficlight.info
For more information contact: Becky Attwood, Media Relations Officer, University of Southampton, 023 8059 5457, 07545 422512, or firstname.lastname@example.org