Airborne particulate matter of less than 10μm diameter (PM10) has been linked to a number of damaging health effects, mainly involving the lungs and cardiovascular system. The major route of exposure to such PM is via inhalation, followed by deposition in the conducting airways and alveoli. It is thought that transition metal (TM)-rich PM may be particularly toxic due to the ability of TMs to catalyse formation of toxic reactive oxygen species, which damage cells by oxidising lipids, proteins, and nucleic acids.
1. Collect size-fractionated PM from underground railway station.
2. Analyse chemical composition and morphology (Geochemistry Group).
3. Measure PM-mediated reactive oxygen generation.
4. Examine whether underground PM can elicit antioxidant and pro-inflammatory responses, or cause cell death, in airway epithelial cell cultures (Brooke Lab, Faculty of Medicine).
Matthew Loxham (Postgraduate research student)
Professor Martin Palmer (Project supervisor)
Professor Damon Teagle (Project supervisor)
Professor Donna Davies (Project supervisor)
Loxham M, Cooper MJ, Gerlofs-Nijland ME, Cassee FR, Davies DE, Palmer MR, Teagle DAH (2013) Physicochemical characterization of airborne particulate matter at a mainline underground railway station. Submitted to Environ Sci Technol