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Email:: M.Baker@soton.ac.uk

Dr Michael Baker BSc, DPhil

Senior Teaching Fellow

Dr Michael Baker is a Senior Teaching Fellow within Biological Sciences at the University of Southampton, joining in 2021.

Career history:

2021-Present: Senior Teaching Fellow, University of Southampton, UK

2018-2021: Lecturer in Biochemistry (Teaching Focused), University of Birmingham, UK

2016-2017: Teaching Fellow, University of Warwick, UK

Academic qualifications:

2018-2020: PGCHE, University of Birmingham UK

2012-2016: DPhil in Protein Biochemistry, University of Warwick, UK

2008-2012: BSc Biochemistry with Intercalated Year, University of Warwick, UK

Research

Publications

Teaching

Contact

Research interests

My research interests lie in understanding the structure and function of proteins. In particular those involved in clathrin mediated endocytosis, one of the fundamental pathways for macromolecules to enter cells.

The pathway contributes to diverse processes from cholesterol metabolism to synaptic vesicle recycling and can be hijacked by pathogenic toxins or viruses to gain entry to cells. This process is governed by multiple transient interactions between proteins, cargo and the plasma membrane. How these interactions change to control vesicle growth has been the focus on my research. Our work has contributed to a greater understanding of the structure of the clathrin coat (which provides the scaffold to create a new vesicle), and its interaction with adaptor proteins, which interact variously with clathrin and other components to regulate vesicle formation and recycling.

Research group

Molecular and Cellular Biosciences

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Articles

Morris, K., Jones, J., Halebian, M., Wu, S., Baker, M., Armanche, J-P., Ibarra, A., Session, R., Cameron, A., Cheng, Y., & Smith, C. (2019). Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly. Nature Structural & Molecular Biology, 26, 890-898. https://doi.org/10.1038/s41594-019-0292-0
Baker, M., Sinden, N., Smith, D., Kreft, J-U., Dafforn, T., & Stockley, R. (2015). α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease. American Journal of Physiology: Lung Cellular and Molecular Physiology, 308(2), 179.
Whiting, G., Baker, M., & Rijpkema, S. (2012). Development of an in Vitro Potency Assay for Anti-anthrax Lethal Toxin Neutralizing Antibodies. Toxins, 4(1), 28-41.

Review

Smith, S., Baker, M., Halebian, M., & Smith, C. (2017). Weak molecular interactions in clathrin-mediated endocytosis. Frontiers in Molecular Biosciences, 4, 72. https://doi.org/10.3389/fmolb.2017.00072

Official Role

Module Co-coordinator:

BIOL3027 Selective Toxicity
BIOL3018 Molecular Pharmacology
BIOL6095 Skills in Molecular Biosciences

BIOL1028 Chemistry of Life
BIOL2048 Principles of Pharmacology
BIOL2049 Pharmacology
BIOL2056 Cell Biology
BIOL3022 Cell Signalling in Health and Disease
BIOL3034 Laboratory Research Project

Dr Michael Baker
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ

Room Number : 85/4031-3

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