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The University of Southampton
Biological Sciences

Dr Scott Kimber PhD

Research Fellow in Epigenetic Signalling

Dr Scott Kimber's photo

Scott Kimber is a Research Fellow in Epigenetic Signalling in Biological Sciences.

Career history

2019-Present: Research Fellow in Epigenetic Signalling. University of Southampton, UK.
2015-2018: Postdoctoral Training Fellow in Functional Genomics and Systems Biology. Institute of Cancer Research, UK.
2014-2015: Research Fellow in Biochemistry. University of Southampton, UK.

Academic Qualifications

2010-2014: PhD Biochemistry. University of Southampton, UK.
2007-2010: BSc (Hons) Biochemistry. University of Southampton, UK.

Research interests

My PhD project was involved the recognition of 5-methylcytosine using the DNA repair enzyme uracil DNA glycosylase (UDG). This research has exploited UDG’s sensitivity to a methyl group at the 5 position of pyrimidines its mutation allowed recognition of cytosine, generating a cytosine DNA glycosylase (CDG).

Upon completion of my PhD I undertook a postdoctoral role attempting to identify new antibacterials for the purpose of biological warfare defence. This focused on discovering inhibitors towards the allosteric GTP binding site of uridine monophosphate kinase (UMPK). I then became a postdoctoral training fellow at the Institute of Cancer Research investigating the pathogenesis of myeloma. Here I specifically tried to understand the underlying genomic architecture of myeloma by using chromosome conformation capture to identify genomic interactions. I also employed the use of CRISPR technology to target known myeloma oncogenes to assess changes in phenotype that could lead to improved patient risk identification and disease treatment. Currently I am employing whole genome analysis techniques to understand the epigentic signalling of phosphoinositides within the nucleus.

Other research interests include the recognition, targeting and modification of DNA (or nucleic acids) that may be used therapeutically or functionalised in the form of nanostructures in the field of bionanotechnology.

Research group

Molecular and Cellular Biosciences

Affiliate research group

Institute for Life Sciences (IfLS)

Research project(s)

The regulation of epigenetic signalling by nuclear phosphoinositides

Epigenetic signalling and nuclear phosphoinositides.

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Dr Scott Kimber
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
SO17 1BJ
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