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The University of Southampton
Biological Sciences

Dr Thomas A. Ryan BSc (IND), PhD

Research Fellow

Dr Thomas A. Ryan's photo

Tom Ryan joined as a Research Fellow in Biological Sciences at the University of Southampton in May 2017.

Career History

2017–present: Research Fellow. Biological Sciences, University of Southampton, UK.
2015–2017: Research Fellow. Leeds Institute of Biomedical and Clinical Sciences, Faculty of Medicine and Health, University of Leeds, UK.
2010–2011: Research Placement Student. AstraZeneca, Brixham Environmental Lab, Brixham, Devon, UK.

Academic Qualifications

2012–2016: PhD. Mitochondrial dysfunction and oxidative stress in Parkinson’s. University of Leeds, UK.
2008–2012: Biological Sciences (with Industrial Placement) BSc – 2:1. University of Leeds, UK.




Research interests

During my PhD at the University of Leeds, where I began my scientific career, I studied the cellular response to mitochondrial dysfunction and oxidative stress in neurons and how this was implicated in Parkinson’s disease. Through this I developed an interest in the regulation of cell signalling pathways and how autophagic/mitophagic systems function. I am particularly interested in how dysfunction in these pathways can be pathological drivers of human disease, such as neurodegeneration. Following this, I worked as a Research Fellow investigating the role of primary cilia, antennae-like organelles regulating a range of signalling pathways, in the development of ovarian cancer.

My current role in Dr Tumbarello’s lab at the University of Southampton is to investigate the role of a protein complex in the endolysosomal and autophagic pathways. I am looking to define the spatial and temporal regulation of this complex and how its activity interlinks with autophagy and mitophagy in cells. In order to investigate the mechanisms involved in these vesicular pathways I employ a range of cellular, molecular and biochemical approaches.

Research group

Molecular and Cellular Biosciences

Affiliate research group

Biomedical Sciences

Research project(s)

Investigating the mechanisms of Parkin-mediated mitophagy

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Dr Thomas A. Ryan
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
SO17 1BJ

Room Number: 85/3041

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