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The University of Southampton
Biological Sciences

The meiotic checkpoint in mouse oocytes: a duel role in protecting genomic integrity Event

Time:
13:00 - 14:00
Date:
10 February 2015
Venue:
University of Southampton Highfield Campus Life Sciences Building 85, Room 2207

For more information regarding this event, please telephone Kim Lipscombe on 02380597747 or email K.R.Lipscombe@soton.ac.uk .

Event details

The talk will cover recent insights into how oocytes control the first meiotic division that gives rise to the egg. In particular, how they respond to the challenges of correctly segregating their chromosomes, and to damaged DNA.

Genomic integrity is of great importance during the production of a fertilisable egg. Eggs with the wrong number of chromosomes, or highly damaged DNA will be unsuitable for further development, potentially leading to apparent subfertility, miscarriage or offspring with chromosomal abnormalities.

The talk will cover recent insights into how oocytes control the first meiotic division that gives rise to the egg. In particular, how they respond to the challenges of correctly segregating their chromosomes, and to damaged DNA.

Surprisingly these two different challenges have much common ground at the molecular level and raise interesting questions about the roles of checkpoints in oocyte physiology.

Speaker information

Simon Lane

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