APC/C Cell Cycle Machinery; Mechanisms of Action and Role in Cancer Therapy Event

Event details

A seminar presented by invited speaker Professor Hiro Yamano, of the UCL Cancer Institute. Abstract: Proteolysis is the breakdown of proteins into amino acids, which is an essential process not only providing building blocks for new protein synthesis but also allowing cell and tissue regeneration and degradation of damaged and regulatory proteins during cell division, transcription, signal transduction and the immune response. In our laboratory we study one of the key cellular enzymes involved in this ubiquitin-mediated proteolysis, the anaphase-promoting complex/cyclosome (APC/C). Our latest development, APC/C re-constitution using the MultiBac system, will enable us to manipulate APC/C function at will and together with the Xenopus egg system, detailed analysis of vertebrate APC/Cs can be achieved to a level never attained before. We are on the verge of discovering a most critical step by which APC/C co-activator Cdc20 is allowed to interact and activate the APC/C ubiquitin ligase via its N-terminal conserved motif. We will discuss the mechanisms of action and regulation of the APC/C ubiquitin ligase with our latest data.