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The University of Southampton
Biological Sciences

Synthetic biochemistry of the microtubule cytoskeleton: Mechanistic insight from reverse engineering Event

CfBS Invited Seminar Speaker
Time:
13:00 - 14:00
Date:
11 November 2015
Venue:
Building 85, Room 2207

For more information regarding this event, please telephone Rachel Harris on 02380-598148 or email R.M.Harris@soton.ac.uk .

Event details

How the components of the microtubule cytoskeleton work together as a system is not understood. I will present recent progress in understanding molecular mechanisms of cytoskeleton function through reverse engineering of dynamic behaviour.

Abstract: The cytoskeleton is essential for the internal organization of eukaryotic cells. Microtubules, motors and other proteins form a mechano-chemical network that determines the dynamic and adaptable nature of intracellular order. Distinct forms of cytoskeletal architectures are required for correct cell division and cell differentiation. How the components of the microtubule cytoskeleton work together as a system is not understood. We address these questions combining concepts of physical biochemistry and quantitative cell biology. Our aim is to understand in quantitative terms the molecular mechanisms underlying cytoskeleton architecture and function. Here, I will present recent progress in understanding molecular mechanisms of cytoskeleton function through reverse engineering of dynamic behavior. The focus will be on the regulation of microtubule dynamics and microtubule nucleation. The power of in vitro reconstitutions in combination with fluorescence microscopy will be illustrated in the context of regulatory proteins binding preferentially to dynamic microtubule ends.

Speaker information

Dr Thomas Surrey,The Francis Crick Institute,Invited Speaker at the Centre for Biological Sciences Seminar Series

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