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The University of Southampton
Biological Sciences

Brains, bodies, bugs and balances: understanding and targeting neuroimmune mechanisms in stroke Event

Brains, bodies, bugs and balances
14:00 - 15:00
23 November 2016
Nightingale Building 67, Room 1007, Highfield Campus

For more information regarding this event, please telephone Selina Barry on 24794 or email .

Event details

Biological Sciences Seminar Series Programme 2016 - 2017


Abstract: Stroke is a major cause of mortality and disability through both direct damage to the brain and complications arising in the brain (e.g. swelling) and elsewhere in the body (e.g. pneumonia). Neuroimmune mechanisms are increasingly recognised as involved in these various pathological sequelae. As in other tissues, inflammatory and immune activity may have harmful and beneficial effects on the brain after stroke. Systemic immunological activity is also markedly perturbed after stroke, including protective anti-microbial defence systems. There is therefore a complex brain and body-wide influence of the immune system on injury, repair and recovery after stroke. Successful therapeutic immunomodulatory approaches for stroke will need to account for this complexity. In this talk, I will present some of our recent work investigating how neuroimmune processes locally in the brain and systemically influence key determinants of stroke outcome and discuss their relevance for developing new therapeutic approaches.

Speaker information

Dr Barry McColl,The University of Edinburgh,Dr Barry McColl works for The Roslin Institute, University of Edinburgh where he established his own research group in the Division of Neurobiology. The major aims of his group’s work are to understand how neuroimmune interactions contribute to normal brain homeostasis and how the immune system influences acute and chronic neurodegeneration.

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