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The University of Southampton
Biological Sciences

Molecular mechanisms that cause aneuploidy Event

Dr Viji Draviam
Time:
13:00 - 14:00
Date:
30 November 2016
Venue:
Nightingale Building 67, Room 1007, Highfield Campus

For more information regarding this event, please telephone Selina Barry on 24794 or email S.J.Barry@soton.ac.uk .

Event details

Biological Sciences Seminar Series Programme 2016 - 2017

 

Abstract: Chromosomal instability (CIN) is a hallmark of aggressive cancers and acute drug resistance. CIN can arise from errors in the process of segregating DNA during cell division. To ensure the accurate segregation of DNA, it is essential that chromosomes are properly attached to microtubules. My research team explores a) how cells ensure proper chromosome-microtubule attachment and b) what are the oncogenic consequences of defective attachments. By developing high-resolution microscopy tools to visualize how microtubules capture chromosomes, we showed that a multi-step ‘end-on conversion’ process governs the plane of chromosome-microtubule attachment in human cells; chromosomes first attach to 'microtubule-walls' and then convert this attachment to 'microtubule-ends'. We find that a failure in end-on conversion can lead to chromosome mis-segregation. Importantly, three of the eight end-on conversion regulators we identified are already implicated in CIN found in cancers, highlighting the oncological significance of the process.

 

Speaker information

Dr Viji Draviam-Sastry,Queen Mary University London,Dr. Draviam’s research is aimed at understanding how cytoskeletal forces are generated and controlled within human cells.

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