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The University of Southampton
Biological Sciences

The disassembly of DNA replication machinery at the end of replication Event

DNA Replication disassembly
13:00 - 14:00
9 November 2016
Nightingale Building 6, Room 1007, Highfield Campus

For more information regarding this event, please telephone Selina Barry on 24794 or email .

Event details

Biological Sciences Seminar Series Programme 2016 - 2017


Abstract: To ensure duplication of the whole genome DNA replication initiates from thousands of replication origins. The replication forks move through the chromatin until they encounter forks from the neighbouring origins. During the termination of replication forks the replisomes disassemble by an unknown mechanism and topisomerase II resolves the daughter DNA molecules. If not resolved properly, the terminating forks are at high risk of stalling and fork reversal, leading to DNA damage and genomic instability.

Our recent work provides first insight into the mechanism of replisome disassembly during eukaryotic DNA replication termination and sheds light onto the way the terminating replication forks are resolved efficiently to maintain the stable genome. I will introduce the concepts of DNA replication, present data leading to our model of replisome disassembly and discuss the importance of this process for cell viability.



Speaker information

Dr Aga Gambus,School of Cancer Sciences, University of Birmingham,In 2012 Aga was awarded the Medical Research Council Career Development Award and Birmingham Fellowship to start her own independent research group at the School of Cancer Sciences, University of Birmingham. The focus of her current research is to understand how the post-translational modification of proteins by members of the ubiquitin family (UBLs): specifically ubiquitin and SUMOs, regulate the process of DNA replication.

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