Transcriptions and RNA Fate Event

Abstract: Eukaryotic genomes are pervasively transcribed on both strands and, in addition to the pre-mRNAs, there is extensive antisense transcription, transcription over promoters, and overlapping transcription between convergent genes and genes organized in tandem. Analyzing nascent transcription at high resolution during the yeast metabolic cycle uncovers evidence for extensive transcriptional interference between genes. Furthermore, we show that antisense transcription alters the chromatin structure and this influences the fate of the encoded transcripts. The new relationship between transcription and RNA fate will be discussed.