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The University of Southampton
Biological Sciences

Intrinsically Disordered Proteins: Cellular Complexity and Human Diseases? Event

Research image
Time:
13:00
Date:
7 June 2017
Venue:
Life Sciences Building 85, Room 2207, Highfield Campus

For more information regarding this event, please telephone Selina Barry on 24794 or email S.J.Barry@soton.ac.uk .

Event details

Biological Sciences Seminar Series Programme 2016/17

 

Abstract: In 1973, Christian Anfinsen postulated that the unique three-dimensional structure of a protein is determined by its amino acid sequence. This work laid the foundation for the sequence-structure-function paradigm, i.e. the sequence of a protein determines its structure, and structure determines function. However, a class of polypeptide segments called Intrinsically Disordered Regions (IDRs) defies this postulate. In this lecture, I will first review emerging ideas about how disordered regions contribute to protein function. I will then discuss how different regulatory mechanisms such as alternative splicing and asymmetric mRNA localization can increase the functional versatility of proteins containing disordered regions. Finally, I will discuss how disordered regions contribute to human disease and the emergence of complexity in life.

Speaker information

Dr Madan Babu Mohan,University of Cambridge,Regulatory Genomics and Systems Biology

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