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The University of Southampton
Biological Sciences

Regenerative roles of microglia and macrophages in the central nervous system Event

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Time:
13:00
Date:
25 October 2017
Venue:
Life Sciences Building 85, Highfield Campus

For more information regarding this event, please telephone Selina Barry on 023 80 594794 or email S.J.Barry@soton.ac.uk .

Event details

Biological Sciences Invited Speaker Programme 2017-18

Abstract: The prime example of effective regeneration in the central nervous system is that of remyelination, whereby re-ensheathment of axons with myelin restores electrical impulse conduction and trophic/ metabolic support. Remyelination fails in a multitude of neurological disorders, which is considered to contribute to the axonal damage/ loss correlating to clinical decline. The lack of approved therapies promoting remyelination highlights the need to elucidate the underpinning mechanisms. Our work investigates the regenerative role of microglia and macrophages in supporting remyelination, in terms of understanding the cellular and molecular mechanisms regulating their activation, identification of the regenerative factors they produce, and delineating distinction and complementarity in function compared to monocyte-derived macrophages.

 

Speaker information

Dr Veronique Miron,The University of Edinburgh,Lecturer and Principal Investigator. Dr Miron's research focuses on investigating the regenerative properties of inflammation to drive central nervous system white matter regeneration, with implications for neurological disorders with high worldwide prevalence (such as cerebral palsy and MS).

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