Mechanistic insights into endosomal cargo sorting: implications for human health Event

Abstract: The recycling of cell surface proteins within the endosomal network is a ubiquitous process that is increasingly recognized as a major regulator of cell homeostasis, signaling and also development. Historically, recycling has been regarded as a relatively passive process, where the majority of internalized transmembrane cargo are either degraded in lysosomes or brought back to the cell surface via unspecific “bulk membrane flow” as the default pathway. An abundance of recent work increasingly challenges this view as newly discovered endocytic cargo adaptors, coat complexes, regulatory mechanisms and also inter-organelle crosstalk suggest that endocytic recycling is a highly regulated, sequence and cargo specific process that adapts to cellular cues such as signaling, migratory state or energy status. Our research seeks to define those evolutionary conserved mechanisms that regulate endocytic recycling. I will discuss our latest research into the mechanics and regulation of endosomal recycling and how impaired recycling is increasingly linked to neuronal pathologies, such as Alzheimer’s and Parkinson's disease.