Understanding and exploiting the cell's ability to repair double-stranded DNA breaks Event

 

Abstract: Double-stranded DNA breaks are a potentially lethal form of damage and, accordingly, cells have developed multiple strategies for the recognition and repair of these lesions. In this talk, I will discuss molecular mechanisms for the repair of broken DNA with a particular emphasis on the early stages of the homologous recombination pathway of bacterial cells. I will also show how our developing understanding of DNA break repair might be exploited in biotechnology applications, such as the potentiation of antibacterial agents and the optimisation of genome editing.