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The University of Southampton
Biological Sciences

Understanding the regulation of inflammasomes in brain injury and disease Event

speaker
Time:
13:00
Date:
7 February 2018
Venue:
Nightingale Building 67, Room 1003, Highfield Campus

For more information regarding this event, please telephone Selina Barry on 023 80 594794 .

Event details

Biological Sciences Invited Speaker Programme 2017-18

 

Abstract: Inflammation is known to contribute to the worsening of acute cerebrovascular, and chronic neurodegenerative diseases. Understanding mechanisms of inflammation may identify new therapeutic targets for the treatment of these devastating diseases. Inflammasomes are key regulators of inflammation. Inflammasomes are multi-molecular complexes that catalyse the activation and secretion of pro-inflammatory members of the interleukin-1 (IL-1) family of cytokines. IL-1 is known to contribute to the worsening of acute cerebrovascular disease and the NLRP3 inflammasome is suggested to contribute to cognitive decline in models of dementia. Thus my lab is interested in the regulation of inflammasomes and how they can be targeted in disease. I will present an overview of our recent and latest work highlighting the advances being made in the basic biology of inflammasome activation and IL-1 secretion. I will also discuss our efforts to target inflammasomes including drug repurposing strategies, and the development of completely new inhibitors.

 

Speaker information

Dr David Brough,The University of Manchester, Division of Neuroscience & Experimental Psychology.

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