Intracellular trafficking of VEGFR Seminar
For more information regarding this seminar, please telephone Margaret Miles on 023 8059 3349 or email m.s.miles@southampton.ac.uk .
Event details
Alice Scott’s research concentrates on the intracellular trafficking that VEGFR2 undergoes in endothelial cells.
Angiogenesis is the process in which new blood vessels are formed from existing vessels. Ischemic tissues, such as tumours, secrete growth factors in order to increase the blood supply. Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis in both normal physiology and pathology.
The inner layer of blood vessels is composed of endothelial cells, which express a number of receptors that can bind to VEGF. The receptor that generates the most significant angiogenic response is VEGF Receptor 2 (VEGFR2).
Our research concentrates on the intracellular trafficking that VEGFR2 undergoes in endothelial cells. We have shown that within unstimulated endothelial cells, VEGFR-2 is segregated into two spatially and temporally distinct pools. There is a cell surface pool as well as an internal storage pool.
Venue: Building 85, Seminar room 2207
Speaker information
Alice Scott , University of Bristol. We carry out various biochemical assays in order to determine how the presence of VEGF affects the distribution of the receptor.