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The University of Southampton
Biological Sciences

The Native-Like Structure of the M2 Proton Channel of Influenza A obtained from Lipid Bilayer Preparations Seminar

Time:
13:00
Date:
18 January 2012
Venue:
Building 27, Seminar room 2001 (L/R1)

For more information regarding this seminar, please telephone Margaret Miles on 023 8059 3349 or email m.s.miles@southampton.ac.uk .

Event details

Professor Timothy A. Cross, as part of the British Biophysical Society International Lecture Tour, will present his research on the M2 Proton Channel of Influenza A.

A comparison of 8 structures of M2 deposited in the PDB from solution NMR in detergent micelles, x-ray crystallography with M2 in an octylglucoside and polyethylene glycol environment, as well as solid state NMR of oriented samples in liquid crystalline lipid bilayers. A detailed mechanism for the shuttling of protons across the viral membrane will be described based on the structural, biochemical and physiological data. In addition recent spectra of M2 in E. coli membranes will be shown and prospects for using such spectra in structural characterization and in structural validation will be discussed.

NMR Spectroscopy and Imaging Director, Florida State
Professor Timothy Cross
M2 Proton Channel

Speaker information

Professor Timothy A Cross, NMR Spectroscopy and Imaging Director. NHMFL and Earl Frieden Professor of Chemistry and Biochemistry, Florida State

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