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The University of Southampton
Biological Sciences

A mechanism for regulation of phospholipase C gamma Seminar

12 November 2012
Building 85 Room 2207

For more information regarding this seminar, please telephone Beatrice Murphy on 023 8059 5374 or email .

Event details

Phosphatidylinositol-phospholipase Cs (PI-PLCs) constitute a critical component of second messenger-generating system that operates downstream of a great number of cell surface receptors, important for development, cell proliferation and motility (and possibly cell death). Dysregulation of these enzymes is associated with various pathological conditions.

Recently we have been working on PLCγ1 which acts predominantly downstream of growth factor receptor tyrosine kinases and contains a pseudocyclic regulatory element known as the specific array. We have used a combination of NMR, X-ray crystallography, small angle X-ray scattering and biochemical measurements to investigate the role of the specific array, leading us to propose a mechanism for the role it plays in the activation of lipase activity.

Phospholipase C gamma

Speaker information

Dr Paul Driscoll, Division of Molecular Structure, National Institute for Medical Research. MRC

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