Molecular insights into growth restriction of the placenta Seminar
For more information regarding this seminar, please telephone Beatrice Murphy on 023 8059 5374 or email B.J.Murphy@southampton.ac.uk .
Event details
Intrauterine growth restriction (IUGR) is a serious condition, affecting around 10% of pregnancies in the UK and leading to increased risk of perinatal death and chronic disease through developmental programming.
There may be many potential causes, but the majority ultimately impact on development and function of the placenta. I will focus on the roles of endoplasmic reticulum stress and the AKT/mTOR pathway, and their effects on protein synthesis. Data will be presented showing similarities between IUGR pregnancies at sea level and normal pregnancies at high altitude, suggesting a spectrum of responses from the homeostatic to the pathological. Evidence from a mouse mutant model, in which the phosphorylation of eIF2α has been inactivated, will also be discussed.
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Speaker information
Professor Graham Burton , Department of Physiology, Development and Neuroscience. University of Cambridge