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The University of Southampton
Biological Sciences

The impact of multiple forms of synaptic plasticity at hippocampal mossy fibre synapses Seminar

13 May 2013
Building 85 Room 2209

For more information regarding this seminar, please telephone Beatrice Murphy on 023 8059 5374 or email .

Event details

Mossy fibre synapses between dentate granule cells and CA3 pyramidal neurons in the hippocampus have unique and fascinating structural and functional properties.

We have a limited comprehension of why their properties are so specialised and, furthermore, even though synaptic plasticity at these synapses has been studied for many decades we have almost no evidence for a role for mossy fibre synaptic plasticity in behaviour. We have recently studied multiple different forms of synaptic plasticity at mossy fibre synapses and argue that each serves a separate purpose to regulate the transfer of information from the dentate gyrus to CA3 networks.

Mossy fibre synapse

Speaker information

Dr Jack Mellor, MRC Centre for Synaptic Plasticity. University of Bristol

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