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The University of Southampton
Biological SciencesPostgraduate study

Mr Connor Maltby BSc

Postgraduate Research Student in Molecular and Cellular Biosciences

Mr Connor Maltby's photo

Connor Maltby is a third year PhD research student within biological sciences, investigating how secondary structures within the 5’UTR of neuronal mRNAs induce translational control, and promote their subsequent transport and local synthesis.

Academic Qualifications

2013-2016: First Class (Hons) BSc Biomedical Sciences. School of Biological Sciences, University of Southampton, UK.

Positions of responsibility

President of the Biological Sciences Postgraduate Society (BSPS)

Research interests

My undergraduate degree exposed me to many aspects of the molecular biosciences, where my interests and passions grew in the direction of molecular neuroscience. As part of my third year project, I carried out research within Dr Rob Ewing’s lab into the protein protein interactions that underpin and couple aberrant wnt signalling to the hypermethylation of key tumour suppressor genes in colorectal cancer. This deeply broadened my knowledge and interests in both genetics, epigenetic regulation and their roles in pathophysiology.

My PhD research incorporates many of these concepts and techniques, broadening our knowledge into the specific mechanisms that control distal localisation of a small subset of neuronal mRNAs that drives specific local protein translation. Neurons are highly polar cells that project to distant areas of the brain and body, having unique local proteomes that allow for differential characteristics and functionalities across areas of the neuron.

This research is potentially key to furthering our understandings into how many neurodevelopmental and psychiatric conditions such as schizophrenia and autistic spectrum disorders can arise from dysfunctional mRNA transport and protein expression throughout the brain.

PhD Supervisors: Dr Mark Coldwell & Dr Katrin Deinhardt
PhD Research: The Regulation of Neuronal mRNA Transport & Protein Synthesis by G-Quadruplex Structures
Funding: The Gerald Kerkut Charitable Trust

Research group

Molecular and Cellular Biosciences

Affiliate research group

Southampton Neuroscience Group (SoNG)

Membership of External Organisations

The Biochemical Society
British Neuroscience Association

Other positions

President of the Biological Sciences Postgraduate Society (BSPS)

Demonstrator

Biol1007 Macromolecules of Life
Biol2010 Flow of Genetic Information
Biol2011 Molecular Cellular Biochemistry

Mr Connor Maltby
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ
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