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The University of Southampton
Biological SciencesPostgraduate study

Mr Dheelan-Rai Sydamah 

MRes Advanced Biological Science

Mr Dheelan-Rai Sydamah's photo

Dheelan Rai Sydamah is an MRes Advanced Biological Science student within Biological Sciences at the University of Southampton.

In 2017, I graduated with first class honours at Bournemouth University in Biological Sciences (BSc Hons). Here, I completed my independent research project in studying the role of GSK3b in diabetic nephropathy, a form of kidney disease associated with diabetes using Drosophila fruit flies as a model species.

Research interests

Research Area:

Within my current MRes, my research area focuses on colorectal cancer and the role of b-Catenin.

b-Catenin is a protein associated with the promotion of tumour growth (oncogenesis), and is known to be altered in cancers. In the context of cancer, various mutations cause b-Catenin to not be degraded and this causes shuttling of b-Catenin from the cytosol to the nucleus. Within the nucleus, b-Catenin can bind to transcription factors on cancer-promoting genes (oncogenes), leading to their transcription and subsequent cancer growth.

Whilst b-Catenin is known to be altered in terms of its cellular localisation in colorectal cancer, not much else is established in detail thus far. My project focuses on establishing the sub-cellular localisation of b-Catenin in colorectal cancer cells to better the understanding of where it localises, which can help further elude to its function. I will make use of cell fractionation through ultracentrifugation in order to separate cell organelles, and then run mass spectometry analysis to identify the abundance of b-Catenin and its associated proteins in each cell fragment.

Why I chose MRes Advanced Biological Sciences:

I completed my undergraduate degree with a wide array of knowledge from different fields of biology, however, I felt I needed and wanted a ‘hands-on’ experience in the laboratory, which is why I chose an MRes over an MSc.

After discussing the project idea, and seeing the top-class facilities here at Southampton, I was confident in choosing this MRes course as I knew it would be the ideal place to better myself as a scientist carrying out real research.

Aims for the future:

I aim to further my research skills and experience, in an industry setting to hopefully immerse myself and the skills I have already developed into a working environment.

Supervisor: Dr Rob Ewing

Research group

Molecular and Cellular Biosciences

Affiliate research group

MRes Advanced Biological Sciences

Mr Dheelan-Rai Sydamah
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
SO17 1BJ
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