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Biological SciencesPostgraduate study

Mr Joel D Allen MBiochem

Postgraduate research student

Mr Joel D Allen's photo

Mr Joel Allen is a postgraduate research student within Biological Sciences, University of Southampton.

MBiochem in Molecular and Cellular Biochemistry, University of Oxford.

Research interests

The extensive diversity of the HIV-1 Envelope glycoprotein (Env) has hindered vaccine design, exemplified by the scarcity of broad and potent neutralising antibodies in infected patients. The extensive N-linked glycosylation that covers the antigenic protein surface has emerged as a promising target for vaccination as an increasing number of broadly neutralising antibodies have been isolated from a subset of infected patients. Immunogens that recreate the glycosylation of viral Env are being developed to elicit these protective antibodies prior to infection. An important part of this design process is to characterise the glycosylation of these candidate immunogens to ensure the epitopes for these bnAbs are present. The Crispin laboratory have developed a methodology to define the glycosylation of candidate immunogens on both a global and site-specific level and applied this to a leading soluble trimeric vaccine candidate. Joel has utilised this method to elucidate the changes in glycosylation resulting from a diverse range of immunogen design platforms and to compare the glycosylation of soluble immunogens with viral derived Env.

Research project: Engineering glycosylation in HIV-1 vaccine design

Supervisor:

Professor Max Crispin

Funding Agency: Consortium for HIV/AIDS Vaccine Development (CHAVD)

Research group

Molecular and Cellular Biosciences

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Mr Joel D Allen
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ
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