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The University of Southampton
Biological SciencesPostgraduate study
Email:
jwc1g13@soton.ac.uk

Mr Jack William Craddock BSc (Hons)

Postgraduate Research Student in Biological Sciences

Mr Jack William Craddock's photo

Mr Jack Craddock is a Postgraduate Research Student working in the area of microbiology and biofilms within Biological Sciences at the University of Southampton.

2016-present: Postgraduate Research Student in Biological Sciences. University of Southampton, UK.
2013-2016: BSc Biomedical Sciences 1st Class (Hons). University of Southampton, UK.

Research interests

Pseudomonas aeruginosa is an opportunistic pathogen which commonly causes chronic infections in the lungs of Cystic Fibrosis patients. These chronic infections can be attributed to P. aeruginosa biofilm formation. Biofilm formation occurs when the intracellular levels of cyclic dimeric guanosine monophosphate (c-di-GMP) are high, in construct to biofilm dispersal which occurs when c-di-GMP levels are low.

My current research is investigating into Nitric Oxide sensory domains and their role in the turnover of c-di-GMP. This project combines microbiology, structural biology and biochemistry for the identification and characterisation of potential protein targets.

Phd Supervisors: Prof. Jeremy Webb, Dr. Ivo Tews
Phd Research: Identification of NO-sensing protein domains that regulate bacterial pathogenesis and biofilm formation in Pseudomonas aeruginosa.
Funding provider: Griffiths Memorial Trust, University of Southampton Vice Chancellor’s Award

Research group

Molecular and Cellular Biosciences

Research project(s)

Dispersal of Biofilm in Cystic Fibrosis using Low Dose Nitric Oxide

Using low dose nitric oxide to disperse bacterial biofilms in cystic fibrosis and improve antibiotic efficacy.

Demonstrator

BIOL2038 Environmental Microbiology

BIOL2044 Medical Microbiology

Mr Jack William Craddock
Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
Southampton
SO17 1BJ

Room Number: 85/3041

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