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Miss Odel Soren BSc (Hons) AMRSB

Postgraduate Research Student in Microbiology

Miss Odel Soren's photo

Odel Soren is a third year Postgraduate Research Student at the University of Southampton.

Academic Qualifications

2011-2014: BSc Biomedical Science 1st Class (Hons). St Georges, University of London, UK.

Research interests

During the final year of my undergraduate degree and subsequent employment as a research assistant, my work focused on antibiotic resistance in Gram-negative bacteria and the use of combination therapy to tackle and prevent resistance.

My current research interests are to investigate methods of combating biofilm tolerance of the ubiquitous and opportunistic pathogen Pseudomonas aeruginosa. This organism poses an immense therapeutic burden for individuals with cystic fibrosis (CF), the most common fatal genetic condition in the UK. Chronic pulmonary infection with P. aeruginosa affects over 60% of CF patients over the age of 18, is seldom eradicated, and causes inflammation, irreversible lung damage and ultimately respiratory failure.

As part of a multi-institution Strategic Research Centre, we are seeking to develop: ‘better detection, better understanding and better treatment’ of P. aeruginosa biofilm infection in CF. My project focuses on the latter of these 3 aims. Previous research has shown that low dose nitric oxide (NO) can disperse P. aeruginosa biofilms, however, an appropriate and convenient way of administering NO to the lungs of CF patients is lacking. I am investigating the use of novel and targeted NO-releasing pro-drugs and their ability to aid in the clearance of clinical P. aeruginosa biofilms.

Supervisors: Prof. Jeremy Webb, Dr. Rob Howlin, Dr. Gary Connett, Prof. Saul Faust

PhD Research: Using novel nitric oxide based therapies to improve the effectiveness of antibiotic therapy against Pseudomonas aeruginosa biofilms in cystic fibrosis

Funding: Cystic Fibrosis Trust UK

Affiliate Research Groups: Institute for Life Sciences (IfLS) & NIHR Wellcome Trust Clinical Research Facility

Research group

Biomedical Sciences

Research project(s)

Combating Pseudomonas aeruginosa biofilm tolerance and antibiotic resistance in cystic fibrosis

This project will exploit novel nitric oxide based therapies to improve the effectiveness of antibiotics against Pseudomonas aeruginosa biofilms.

External affiliations

Imperial College London, as part of the Strategic Research Centre

Membership of External Organisations

(Associate Member of) Royal Society of Biology (RSB)

Microbiology Society

American Society of Microbiology (ASM)

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Miss Odel Soren
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
University of Southampton
Highfield Campus
SO17 1BJ

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